TCM Prescription: Kang Yan Tui Re Tablets



Prescription Description
Prescription IDTCMF4223
Pinyin NameKang Yan Tui Re Pian
Chinese Name抗炎退热片
English NameKang Yan Tui Re Tablets
Function Description喉痹, 疮疡
IndicationsPharyngitis
Disease ICD-11 Category CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的 ];
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC, TERT 8.06733
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, PIM1, PPARA, XDH 7.62513
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.5801
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSD17B1, MET, PPARA 6.65196
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.32329
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.07491
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.64416
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, SRC, TERT, TNKS, TNKS2, XDH 5.56524
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, SRC, TERT, TNKS, TNKS2, XDH 5.56383
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HSD17B1, KDR, MET, PPARA, SRC, TERT, TNKS, TNKS2, XDH 5.55231
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PPARA, SRC, TERT 5.06751
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPRS, SRC, TERT, TNKS2, TOP2A 5.06751
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, TERT, TOP2A, XDH 4.86452
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.79844
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.67653
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PPARA 4.58157
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, IGF1R, KDR, MET, MMP9, PIM1, SRC, TERT, TOP2A, XDH 4.58157
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 4.49508
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, IGF1R, KDR, MMP2, PPARA, SRC 4.45143
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 4.14116
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1 4.14116
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1 4.07122
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, IGF1R, MMP2, MMP9, PPARA, SRC 4.04414
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC, TERT 4.03051
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 4.01105
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 3.99269
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, IGF1R, KDR, MMP9, PIM1, SRC, TERT, TOP2A, XDH 3.98567
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, SRC, TERT, TNKS, TNKS2, XDH 3.97198
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.96845
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, TERT 3.96622
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 3.82147
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.75322
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 3.71327
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 3.6966
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.6966
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.6957
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 3.67376
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 3.63017
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, SRC, TERT 3.6117
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC, TERT, TOP2A 3.54219
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, TERT 3.53356
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, XDH 3.49439
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, SRC, TERT, TNKS, TNKS2, XDH 3.42542
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT, TNKS 3.32667
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.28554
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.28554
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA 3.26316
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.24093
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.24076
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.19186
[BP] GO:0009725 response to hormone AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, SRC 3.06078
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 2.99846
[BP] GO:0042127 regulation of cell proliferation AKR1B1, APP, CSNK2A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, TERT, XDH 2.9977
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.98525
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APEX1, APP, AXL, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, SRC 2.98525
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ALOX15, APEX1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP12, MMP9, PPARA, SRC, TERT 2.96981
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 2.95116
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIM1, SRC, TERT 2.95116
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.95116
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.87402
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.86601
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.83157
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.83157
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.83157
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.83157
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTPRS, SRC, TNKS, XDH 2.802
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.80055
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, SRC 2.80055
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KDR, SRC 2.7533
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.73735
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.73526
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.73082
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.70643
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.66742
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.6661
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.66587
[BP] GO:0030334 regulation of cell migration APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.60458
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTPRS, SRC, TNKS, XDH 2.60332
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, FABP3, FABP4, FLT3, MET, SRC, TERT 2.59611
[BP] GO:0034502 protein localization to chromosome AURKB, TERT, TNKS, TNKS2 2.59611
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.57123
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CSNK2A1, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, SRC, TNKS 2.55711
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.55524
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.54682
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, MMP9, SRC 2.50371
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, KDR, PPARA, PTPRS, SRC 2.50371
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.49242
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.4909
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.48675
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.4775
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, PPARA, SRC 2.4775
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.45102
[BP] GO:2000145 regulation of cell motility APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.44582
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.42297
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.40781
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.40781
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.38659
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.36275
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.36275
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CYP19A1, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTPRS, SRC, TERT, XDH 2.36194
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.34307
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.33182
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA 2.32559
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.2728
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, TERT 2.2728
[BP] GO:0070213 None TNKS, TNKS2 2.2649
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.2649
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.2649
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, SRC, TNKS, TOP2A 2.26457
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, FLT3, FUT7, GLO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPRS, SRC, TNKS, TNKS2, TOP2A, XDH 2.25826
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.2483
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.2483
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, TERT 2.24806
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 2.23953
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.23865
[BP] GO:0040012 regulation of locomotion APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.23252
[BP] GO:0051270 regulation of cellular component movement APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.22322
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.2051
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.20402
[BP] GO:0050896 response to stimulus ABCB1, ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, SRC, TERT, TOP2A 2.19644
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, KDR, SRC 2.19644
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, SRC 2.19458
[BP] GO:0030177 positive regulation of Wnt signaling pathway CSNK2A1, SRC, TERT, TNKS, TNKS2 2.18683
[BP] GO:1901989 None APEX1, APP, CYP1A1, TERT 2.16085
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AXL, CYP19A1, CYP1A2, CYP1B1, FABP4, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TNKS2 2.13375
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1 2.13312
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.13225
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, SRC 2.1281
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.12096
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MET, MMP9, SRC, XDH 2.11257
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, IGF1R, MMP2, MMP9, SRC 2.07276
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.05404
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA 2.05404
[BP] GO:0048869 cellular developmental process ACHE, APP, AXL, CBR1, CYP1A1, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, PTPRS, SRC, TERT, TOP2A 2.05389
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 2.05278
[BP] GO:0032212 positive regulation of telomere maintenance via telomerase AURKB, TNKS, TNKS2 2.01798
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA 2.00308
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, AKR1B1, AKR1B10, APEX1, APP, AURKB, AXL, CA1, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, GLO1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARA, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 2.15449
[CC] GO:0043226 organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA2, CA4, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, GLO1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARA, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 2.0315
[CC] GO:0044421 None ABCB1, ACHE, AKR1B1, AKR1B10, ALOX5, APP, AXL, CA1, CA2, CA4, CBR1, FABP3, FABP4, GLO1, MMP1, MMP12, MMP2, MMP9, PTPRS, SRC, TUBB3, XDH 1.95043
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.78004
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, CA1, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, KDR, MMP2, MMP9, PIM1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 1.72392
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 12.6518
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 12.3394
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, TNKS, XDH 11.5223
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 11.0317
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.59565
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.9158
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 6.10608
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, TERT, TNKS, TNKS2, TOP2A, XDH 5.56524
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, TERT, TNKS, TNKS2, TOP2A, XDH 5.09512
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, TNKS 4.57257
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, XDH 4.17258
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 4.17244
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 3.97198
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.92331
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.77088
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.73592
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.3574
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.95116
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.92315
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, PIM1, PTPRS, SRC, TOP2A, TUBB3, XDH 2.81957
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.55711
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, SRC 2.50371
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, XDH 2.47665
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.45102
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.43611


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 12.369
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.0843
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.1189
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.2094
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.8422
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.479
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.479
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.479
Metabolic pathways_Homo sapiens_hsa01100 CBR1, FUT7, AKR1B10, ALOX5, HSD17B1, ALOX15, CYP1A2, CYP1A1, AKR1B1, CYP19A1, XDH 3.0713
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.3541
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.6385
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.0286
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIM1, CYP1B1, MMP9, MET 2.3863
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15 2.528
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 2.1322
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.2918
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 2.1108
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 2.0909
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.9062
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15 1.9983
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.524
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.3462
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4981
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5109
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.4503
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.4407
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.2156
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4503
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4598
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.2156
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2847
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3754
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.4407
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.9702
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3 1.3005
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9702
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9983
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.9983
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.1078
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9884
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1263
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8979
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9646
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5491
Glioma_Homo sapiens_hsa05214 IGF1R 0.5957
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5491
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5957
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5824
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5491
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5784
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5491
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5491
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5491
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6038
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5491
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5491
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.6238
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5957
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.5289
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5289
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5289
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5432
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5491
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5412
Peroxisome_Homo sapiens_hsa04146 XDH 0.5491
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5491
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5865
Platelet activation_Homo sapiens_hsa04611 SRC 0.5129
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5491
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5163
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5491
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5865
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5129
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.5163
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4739
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4981
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.5016
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4917
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5129
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.3467
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4712
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4917
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.5016
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.4153
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4421
Axon guidance_Homo sapiens_hsa04360 MET 0.5089
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4712
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.4041
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4334
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.4144
Shigellosis_Homo sapiens_hsa05131 SRC 0.5957
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4421
Phagosome_Homo sapiens_hsa04145 TUBB3 0.4715
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.4537
cAMP signaling pathway_Homo sapiens_hsa04024 PPARA 0.4162
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6238
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4334
Malaria_Homo sapiens_hsa05144 MET 0.6621
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6796
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6893
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7201
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8083
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7913
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8633
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.857
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2626


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)