TCM Prescription: Jian Gan Le Granules



Prescription Description
Prescription IDTCMF4045
Pinyin NameJian Gan Le Ke Li
Chinese Name健肝乐颗粒
English NameJian Gan Le Granules
Function Description黄疸
IndicationsJaundice disorder, Jaundice
Disease ICD-11 Category SA01 [Jaundice disorder (TM1), 黄疸 (TM1) ];
ME10.1 [Unspecified jaundice, 未特指的黄疸 ];
Human Tissues Associated with IndicationLiver
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.51736
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.24629
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.69949
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 6.30667
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.6928
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH 5.68262
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.66381
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.66381
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.29497
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, HSD11B2, HSD17B2, TYR 5.29497
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 5.13285
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FUT7, GBA2, TYR, XDH 4.6882
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.67668
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.6288
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, TYR 4.31962
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FUT7, GBA2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH 4.10269
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 4.10269
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, TYR 4.10269
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.08455
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TNKS, TNKS2, XDH 3.83123
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, HSD17B2, TYR 3.82479
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.50695
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.42538
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR 3.41349
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.11832
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, HSD11B2 2.9846
[BP] GO:0009115 None AOX1, XDH 2.87385
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, GBA2, HSD11B1, HSD17B2, TYR 2.80515
[BP] GO:0010647 positive regulation of cell communication AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, PTPN1, TNKS, TNKS2, XDH 2.78549
[BP] GO:0023056 positive regulation of signaling AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, PTPN1, TNKS, TNKS2, XDH 2.77254
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.76269
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH 2.72813
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, HSD17B2, TYR 2.64091
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.58023
[BP] GO:0046110 None AOX1, XDH 2.4833
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.4833
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.4833
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.43221
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.43097
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH 2.32968
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, BCL2, CA2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FUT7, GBA2, HSD11B1, HSD17B2, TNKS2, TYR 2.24889
[BP] GO:0070213 None TNKS, TNKS2 2.24284
[BP] GO:0006145 None AOX1, XDH 2.24284
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.24284
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.19162
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AOX1, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 2.19162
[BP] GO:0043696 None CDK6, ESRRB 2.06443
[BP] GO:0043697 None CDK6, ESRRB 2.06443
[BP] GO:0007598 None F10, F3 2.06443
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1 2.02281
[CC] GO:0031233 None CA4, F10, F3 2.63978
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 2.3444
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, AOX1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, F10, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH 2.08365
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GBA2, HSD11B1, HSD11B2, HSD17B2 2.0404
[CC] GO:0000242 None TNKS, TNKS2 1.04288
[MF] GO:0046914 transition metal ion binding AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, PTPN1, TNKS, TYR, XDH 9.08899
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 9.01326
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH 7.55084
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.40761
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 6.14122
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.79646
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.19676
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.88317
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, PTPN1, TNKS, TNKS2, TYR, XDH 4.22094
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.15339
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 4.13394
[MF] GO:0043167 ion binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, HSD17B1, PTPN1, TNKS, TNKS2, TYR, XDH 4.05751
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.99839
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, PTPN1, TNKS 3.98449
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.95566
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.838
[MF] GO:0046872 metal ion binding ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, PTPN1, TNKS, TNKS2, TYR, XDH 3.8182
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.58444
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.35871
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 3.28114
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 3.19872
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.16841
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 3.12073
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 3.05402
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 3.05402
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, XDH 2.99715
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.87385
[MF] GO:0003845 None HSD11B1, HSD11B2 2.87385
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB 2.78549
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.49186
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.24284
[MF] GO:0008289 lipid binding ESR1, ESR2, ESRRA, ESRRB, F10, F3, HSD11B2, HSD17B1 2.12277
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.06443


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 11.1519
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 10.9598
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.4868
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 6.2369
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.8979
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.9194
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.7854
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.7047
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, CYP1B1, CDC25B 1.9767
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.9767
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.0045
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5867
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.195
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.4704
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.9767
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.4808
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9863
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.4704
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 BCL2, F3 1.3311
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.3971
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.4379
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.2705
Estrogen signaling pathway_Homo sapiens_hsa04915 ESR1, ESR2 1.3311
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.3629
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 1.1521
Hepatitis B_Homo sapiens_hsa05161 CDK6, BCL2 1.1106
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 1.1966
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 1.0757
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.9462
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, BCL2 0.7208
Pathways in cancer_Homo sapiens_hsa05200 CDK6, BCL2 0.6613
Glioma_Homo sapiens_hsa05214 CDK6 0.7208
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.7208
Prostate cancer_Homo sapiens_hsa05215 BCL2 0.6704
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.7208
Melanoma_Homo sapiens_hsa05218 CDK6 0.7208
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.7567
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.7242
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.7208
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.6613
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.6704
Melanogenesis_Homo sapiens_hsa04916 TYR 0.6605
Insulin resistance_Homo sapiens_hsa04931 PTPN1 0.6402
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2 0.6556
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.6613
Bile secretion_Homo sapiens_hsa04976 CA2 0.7208
Apoptosis_Homo sapiens_hsa04210 BCL2 0.5947
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 ESR1 0.6287
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.6613
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.7208
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.6287
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.6287
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.5947
Peroxisome_Homo sapiens_hsa04146 XDH 0.683
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.8008
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.6287
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.5947
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.5947
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.5947
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.5406
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.5847
Purine metabolism_Homo sapiens_hsa00230 XDH 0.5327
Proteoglycans in cancer_Homo sapiens_hsa05205 ESR1 0.5032
Focal adhesion_Homo sapiens_hsa04510 BCL2 0.5032
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.5327
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6 0.5032
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.4316
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.5242
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7857
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.8008
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.8008
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.8453
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.8008
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.9462
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.4924
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9307
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.9462
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9462
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9462
Other glycan degradation_Homo sapiens_hsa00511 GBA2 1.0757
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1521
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3971


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)