TCM Prescription: Gui Ling Ointment



Prescription Description
Prescription IDTCMF4015
Pinyin NameGui Ling Gao
Chinese Name龟苓膏
English NameGui Ling Ointment
Function Description口疮, 便秘, 热淋, 淋证, 带下病, 疮疡
IndicationsConstipation disorder, Heat stranguria disorder, Leukorrhea disorder
Disease ICD-11 Category SA57 [Constipation disorder (TM1), 便秘 (TM1) ];
SA91 [Heat stranguria disorder (TM1), 热淋 (TM1) ];
SC20 [Leukorrhea disorder (TM1), 带下病 (TM1) ];
Human Tissues Associated with IndicationLiver, Spleen, Large Intestine
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH742 NA 龟 TCMH742
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH2134 Smilax glabra 土茯苓 TCMH2134 CPBOL4081-11
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1005 Cannabis sativa 火麻仁 TCMH1005 ITSAJ4165-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR3C1, PPARD, PTGS2, RORC, SRC, TYR 12.9719
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PPARD, PTGS2, RORC, SRC, TYR 12.9719
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2 12.8049
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, NR3C1, PIK3CA, PPARA, PPARD, PTGS2, RORC, SRC, TYR 11.3701
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 10.4667
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR2C, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PPARD, PTGS2, RORC, SRC, TYR 10.3597
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARD 10.2629
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2C, KDR, KIT, MET, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, SRC, TNKS, TNKS2, XDH 10.1344
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC, SRC 9.86967
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PGR, PIM1, PPARD, PTGS1, PTGS2, SRC, XDH 9.86967
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, AR, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, PTGS2, RORC, SRC, TYR 9.50716
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 9.10162
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, RORC, SRC, TNKS2, TYR 9.10162
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HTR2C, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 9.08972
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HTR2C, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 9.06202
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC, SRC 8.77915
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, HTR2C, PIK3CA, PIM1, PPARA, PPARD, PTGS1, PTGS2, TYR, XDH 8.69767
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, PPARA, PPARD, RORC, SRC 8.57103
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, NR3C1, PPARA, PTGS2, SRC 8.41666
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, KIT, MMP2, NR3C1, PPARA, PTGS2, SRC 8.07405
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP2, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 7.93154
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.88641
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, APP, AR, AXL, BCL2, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, HTR2C, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PPARD, PTGS2, RORC, SRC, TNKS2, TYR 7.84333
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 7.82685
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 7.78873
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, SRC, XDH 7.72517
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, HTR2C, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.71038
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARD, PTGS2, PTPN1, SRC, XDH 7.68304
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, KIT, MMP9, PGR, PIK3CA, PIM1, PPARA, PPARD, PTGS2, RORC, SRC, TYR 7.51175
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, KIT, MET, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2 7.51175
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, PIK3CA, PPARA, PPARD, SRC, TYR 7.51175
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CYP1B1, F3, FLT3, HTR2C, KDR, KIT, MET, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, XDH 7.42553
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 7.33703
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, AR, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PPARD, PTGS2 7.33331
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, NR3C1, PIK3CA, PPARD, PTGS2, RORC, SRC 7.33331
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PPARD, PTGS1, PTGS2, TYR, XDH 7.26232
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.25511
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, HTR2C, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.22551
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, PPARD, PTGS2, RORC, SRC 7.2224
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGS2, SRC 7.03225
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR2C, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR 6.9636
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.89242
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 6.83305
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 6.5957
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2C, PPARD 6.5114
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TNKS, TNKS2 6.47159
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PPARD, PTGS2, PTPN1, SRC, XDH 6.4071
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.40168
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 6.34545
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.31012
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.27352
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, XDH 6.23237
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 6.15063
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 6.11909
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PPARD, PTGS2, PTPN1, SRC 6.11256
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PPARD, PTGS1, PTGS2 6.09657
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, ESR1, FLT3, KIT, MET, PIK3CB, PIM1, PPARD, SRC, TYR 6.01836
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AR, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PPARD, PTGS2, RORC, SRC 6.01821
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, CNR1, HTR2C, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 6.01821
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.99854
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.98409
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARD, PTGS2, PTPN1, SRC 5.95132
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.88539
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, KIT, MMP2, MMP9, PGR, PPARD, PTGS2, SRC 5.87028
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PPARD, PTGS2, SRC 5.79775
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.76852
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 5.75502
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, PGR, PPARD, PTGS2, SRC 5.68883
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 5.67599
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.65797
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC 5.61884
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, AR, BCL2, CA2, FLT3, HSD11B2, NR3C1, PTGS2, SRC 5.53044
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.50701
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CNR1, CYP1A1, FABP3, FLT3, HTR2C, KIT, PPARA, PTGS2, RORC, SRC 5.47086
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR2C, KDR, NR3C1, PTGS2, SRC 5.39082
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PPARD, PTGS1, PTGS2 5.37817
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 5.02016
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, PPARD, PTGS2, PTPN1, RORC, SRC 4.88869
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, F3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, SRC 4.88564
[BP] GO:0019371 None AKR1C3, CBR1, PTGS1, PTGS2 4.8439
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PPARD, PTGS2, SRC 4.75166
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2, PPARD 4.73367
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.61252
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, F3, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 4.59622
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F3, KIT, MET, PIK3CA, PIK3CB, SRC 4.57893
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.55099
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PPARD, PTGS2, PTPN1, SRC 4.55099
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, FLT3, HSD11B2, NR3C1, PTGS2, SRC 4.53672
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.53672
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.52899
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.52899
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.52899
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FLT3, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.46903
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HTR2C, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PPARD, PTGS2, PTPN1, SRC, TNKS, XDH 4.45155
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.39405
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PPARD, PTGS2, SRC 4.38047
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, PIK3CB, PPARD, SRC, XDH 4.35651
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PPARD, PTGS2, SRC 4.33687
[BP] GO:0032787 None AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PPARA, PPARD, PTGS1, PTGS2 4.28377
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 4.19652
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F3, HTR2C, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PPARD, PTGS2, SRC, TNKS2, XDH 4.19652
[BP] GO:0010038 response to metal ion AKR1C3, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGS2 4.14892
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HTR2C, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PPARD, PTGS2, PTPN1, SRC, TNKS, XDH 4.11773
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 4.11508
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC, TNKS 4.09126
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2C, KIT, PPARA, PTGS2, SRC 4.09071
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.07062
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, PPARD, TYR 4.05275
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 4.05126
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, BCL2, CDC25B, FLT3, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.04932
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 4.04509
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.04192
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3, GBA2 4.02202
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2C, KIT, SRC 4
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PPARD, PTGS2, SRC 3.97337
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.93963
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 3.92134
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, PPARD, PTGS2, SRC, TYR 3.91582
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2C, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, PPARD, PTGS2, RORC, SRC, TNKS, TNKS2 3.91582
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PPARD, PTGS2, SRC 3.88097
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, KIT, PIM1, SRC 3.88063
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KDR, KIT, MET, MMP2, MMP9, PGR, PPARD, PTGS2, RORC, SRC 3.87466
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, KIT, SRC 3.85202
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.81063
[BP] GO:0071396 cellular response to lipid AKR1C3, AR, AXL, CDK6, ESR1, FLT3, NR3C1, PPARD, RORC, SRC 3.80348
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AKR1C3, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.78553
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PPARD, PTGS2, SRC 3.77367
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, KIT, PGR, PPARA, RORC, SRC 3.68681
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 3.67585
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, ESR1, F3, FLT3, FUT7, GBA2, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.65894
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.62755
[BP] GO:0008217 None ADORA1, AR, CNR1, HSD11B2, PPARA, PTGS1, PTGS2 3.62545
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PPARD, PTGS2, SRC 3.61817
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.58202
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.57027
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PPARD, PTGS2, SRC 3.56506
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CDK6, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PPARD, PTGS2, PTPN1, SRC, XDH 3.55143
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, KIT, PTGS2 3.51296
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, KIT, PTGS2 3.51296
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2C, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, PPARD, PTGS2, RORC, SRC, TNKS, TNKS2 3.4871
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, PIK3CB, PTGS2, TNKS, TNKS2 3.48134
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, BCL2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PPARD, PTGS2, PTPN1, SRC, XDH 3.45962
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.43007
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.43007
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.43007
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, KDR, SRC 3.39539
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2C, MET, PIK3CA, PIK3CB, SRC 3.39539
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, F3, FABP4, FLT3, IGF1R, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, XDH 3.3867
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CNR1, CYP1A1, HSD11B2, PPARD, PTGS2, SRC, TYR 3.37322
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, PPARD 3.36514
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APP, AR, AURKB, BCL2, CNR1, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.35501
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 3.34856
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, BCL2, CDC25B, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.32721
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, FLT3, HTR2C, KDR, KIT, PIK3CB, PTPN1, SRC, XDH 3.31857
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.28135
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARD 3.27245
[BP] GO:0044242 None AKR1B10, AKR1C3, CYP1B1, FABP3, FABP4, GBA2, PPARD 3.26704
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PIM1, PPARA, PPARD, PTGS1, PTGS2, TYR 3.26704
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, MMP9, SRC 3.25491
[BP] GO:0009605 response to external stimulus ADORA1, AKR1C3, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, HSD11B2, KIT, MMP12, PPARD, PTGS2, SRC, TYR 3.2535
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, KIT, PTGS2 3.23922
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.23922
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.23896
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, KIT, MMP2, PPARA, PPARD, PTGS2, SRC, TYR 3.18334
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.15319
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.15102
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.09032
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.09032
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CNR1, CYP1A1, ESR1, KIT, PGR, PTGS2, SRC 3.05702
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.04901
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2C, KIT, SRC 3.04765
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.04765
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AKR1C3, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.04543
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, CNR1, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.04543
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.04543
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.04543
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, PPARD 3.04543
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, KDR, MET, MMP12, PPARA, PPARD, PTGS2 3.04287
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, MMP12, MMP2, PPARA, PPARD, PTGS2, PTPN1, SRC 3.02318
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.02221
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, CNR1, CYP1A1, PPARD, PTGS2, TYR 3.01552
[BP] GO:0071383 None AKR1C3, AR, FLT3, NR3C1, SRC 3.01276
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F3, HTR2C, KDR, KIT, PIK3CA, PIM1, PPARA, PPARD, PTGS2, RORC, SRC, TNKS2, XDH 3.01115
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.00041
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, AKR1C3, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.99869
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.99678
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, IGF1R, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, XDH 2.98984
[BP] GO:0022602 ovulation cycle process BCL2, ESR1, KIT, PGR, SRC 2.96725
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 2.95591
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, AR, ESR1, FLT3, IGF1R, KIT, MMP2, NR3C1, PTGS2, SRC 2.9541
[BP] GO:0010631 epithelial cell migration CYP1B1, KDR, KIT, PIK3CA, PPARD 2.94498
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR2C, KIT, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, PTPN1, SRC 2.93922
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PPARD, PTGS2, SRC 2.92809
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, AR, BCL2, CDC25B, FLT3, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.91657
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, NR3C1, PTGS2, SRC 2.90997
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.90997
[BP] GO:0007566 embryo implantation MMP2, MMP9, PPARD, PTGS2 2.89973
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, PPARD, RORC, SRC, TNKS, TNKS2 2.89944
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HTR2C, MET, PIK3CA, PIK3CB 2.89439
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.89439
[BP] GO:0016488 None AKR1B10, AKR1C3 2.89439
[BP] GO:0016487 None AKR1B10, AKR1C3 2.89439
[BP] GO:0016107 None AKR1B10, AKR1C3 2.89439
[BP] GO:0009115 None AOX1, XDH 2.89439
[BP] GO:0006714 None AKR1B10, AKR1C3 2.89439
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PIM1, PPARA, PPARD, PTGS1, PTGS2, TYR 2.88913
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.8883
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.87881
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CHRM4, CSNK2A1, F3, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TNKS, TNKS2 2.87881
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, HTR2C, KDR, SRC 2.86569
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PPARD, PTGS2, TYR 2.85622
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, NR3C1, PTGS2 2.85622
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESRRA, KIT, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SRC 2.85199
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESR1, F3, FLT3, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.84214
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, SRC 2.82434
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.8215
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PIM1, PPARA, PPARD, PTGS1, PTGS2, TYR 2.8215
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, PPARA, PPARD, PTGS2 2.81161
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, FLT3, HTR2C, IGF1R, KDR, KIT, PIK3CB, PTPN1, SRC, XDH 2.7976
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.79413
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.79382
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PPARD, PTGS2, SRC 2.79225
[BP] GO:0032845 None ADORA1, BCL2, HTR2C, SRC, TNKS, TNKS2 2.78704
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.77569
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, ESR1, HTR2C 2.75446
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HTR2C, KDR, KIT, PIM1, PPARD, PTGS2, SRC 2.74684
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, PPARD, PTPN1, RORC, SRC, TNKS, TNKS2 2.73971
[BP] GO:0071248 cellular response to metal ion AKR1C3, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.73008
[BP] GO:0001523 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, PPARD 2.69087
[BP] GO:0007154 None ADORA1, AKR1C3, AR, AXL, BCL2, CHRM1, CHRM2, CHRM4, CNR1, ESR2, HTR2C, PGR, PTGS2 2.67027
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, KIT, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TNKS, XDH 2.66875
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.63773
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.63773
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.63773
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.63773
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.59113
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.58084
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, KDR, KIT, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, SRC 2.57656
[BP] GO:0003014 None ADORA1, AKR1B1, AKR1C3, BCL2, HSD11B2 2.57369
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.56348
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, PPARD 2.55498
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.53559
[BP] GO:0050678 None AR, CDK6, F3, KDR, MMP12, PGR, PPARD, XDH 2.51575
[BP] GO:0030154 cell differentiation AKR1C3, ALPL, AR, AXL, BCL2, CBR1, CDK6, CYP1A1, ESR1, FABP4, FLT3, FUT7, KDR, KIT, MMP2, MMP9, PPARD, PTGS2, RORC 2.49926
[BP] GO:0060748 None AR, PGR 2.49926
[BP] GO:0046110 None AOX1, XDH 2.49926
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.49926
[BP] GO:0016095 None AKR1B10, AKR1C3 2.49926
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, CNR2, KIT, PIK3CA, PIK3CB, PTGS1, PTGS2 2.4841
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARD 2.47825
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, FUT7, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, SRC 2.46568
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.45423
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.43938
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.43212
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, MMP12, PPARA, PPARD 2.43013
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TNKS 2.42359
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, GBA2, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 2.42359
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.42016
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.40424
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, PPARA, PTGS2, SRC 2.37578
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.36957
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, KIT 2.36957
[BP] GO:0050900 leukocyte migration CNR2, FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.36248
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CHRM1, CNR1, HTR2C, MMP12, PPARD, PTGS2, PTPN1, SRC 2.3551
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CYP19A1, HTR2C, MMP12, MMP9, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, SRC 2.3551
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9 2.3551
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, KDR, KIT, MET, MMP12, MMP9, PIM1, PTGS2, SRC 2.3551
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, NR3C1, SRC 2.35096
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9, RORC 2.34013
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, PPARA, PPARD 2.34013
[BP] GO:0003008 None ADORA1, AKR1B1, AKR1C3, APP, BCL2, CHRM1, CNR1, CNR2, CYP1B1, HSD11B2, KIT, PIK3CA, PPARD, PTGS2, SRC, TYR 2.33422
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.33256
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.33256
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, CNR2 2.29359
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.28033
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CDK6, CYP1B1, FABP3, PPARD, PTGS2, XDH 2.27916
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.27786
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PPARD 2.26526
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.26526
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.25803
[BP] GO:0070213 None TNKS, TNKS2 2.25393
[BP] GO:0006145 None AOX1, XDH 2.25393
[BP] GO:0038171 None CNR1, CNR2 2.25393
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25393
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.24685
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.23472
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.23472
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.23472
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.23472
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, CNR2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.18172
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.18172
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 2.18172
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.18148
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, CNR2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.17167
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, ESR1, MET, SRC 2.17167
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, PTGS2 2.17167
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.17167
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, AKR1C3, APP, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, HTR2C, PIK3CA, PIK3CB, SRC 2.17151
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PTGS2, SRC, XDH 2.15775
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, AR, BCL2, CDC25B, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.15775
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.15133
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, ESR1, F3, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PPARD, PTPN1, SRC, TNKS, TNKS2 2.13737
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.13018
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, PPARD 2.13018
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PTGS2, SRC, XDH 2.13006
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, KIT, PIM1 2.12331
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, PIK3CA, TNKS2 2.10938
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, IGF1R, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.10598
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.10598
[BP] GO:0006693 None AKR1C3, PTGS1, PTGS2 2.10598
[BP] GO:0006692 None AKR1C3, PTGS1, PTGS2 2.10598
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PPARD, PTGS2 2.09589
[BP] GO:0043696 None CDK6, ESRRB 2.0828
[BP] GO:0043697 None CDK6, ESRRB 2.0828
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.0828
[BP] GO:0010641 None F3, SRC 2.0828
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.0828
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.08008
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1 2.08008
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.07172
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.07172
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.06776
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MMP12, MMP9, NR3C1, PGR, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.06515
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.03249
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTGS2, PTPN1, SRC 2.03215
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.02962
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.02962
[BP] GO:0001667 ameboidal-type cell migration CYP1B1, KDR, KIT, PIK3CA, PPARD 2.00977
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR2C, IGF1R, KDR, KIT, MET, MMP2, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR 3.28135
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.7609
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, ESR1, F3, FLT3, GBA2, HTR2C, IGF1R, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SRC 2.49926
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, NR3C2, PTGS1, PTGS2, PTPN1 2.16522
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F3, FLT3, HTR2C, IGF1R, KDR, MET 2.10598
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARD, PTPN1, RORC, TNKS, TYR, XDH 18.1432
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 11.8302
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PPARA, PPARD, PTPN1, RORC, TNKS 11.1451
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 10.9361
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, RORC 10.2668
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.0111
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 9.59535
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, PPARD, RORC 9.59535
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, PPARD, RORC 9.59535
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2C, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 8.50546
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2C, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 7.88641
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, HTR2C, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 7.82685
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.77762
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2C, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 7.51175
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 7.2804
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 6.99632
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2C, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 6.72388
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 6.62602
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.26492
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HTR2C, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, SRC 6.01836
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.43397
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.36184
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.89705
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.75166
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.55099
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 4.53672
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 4.2487
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 4.05126
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.02139
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 4.00476
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 3.95492
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NQO2, NR3C1 3.86775
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.82192
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.63257
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.61817
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.44963
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.44696
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.34856
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.15526
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.1148
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC 3.09862
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.04543
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 3.03892
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR2C 2.89973
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.89439
[MF] GO:0045550 None AKR1B10, AKR1C3 2.89439
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.89439
[MF] GO:0003845 None HSD11B1, HSD11B2 2.89439
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 2.73008
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.67007
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR2C, IGF1R, KDR, KIT, MET, MMP12, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, XDH 2.65158
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MMP9, NQO2, PGR, PTGS2, TYR, XDH 2.54308
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.49926
[MF] GO:0047718 None AKR1B10, AKR1C3 2.49926
[MF] GO:0004949 None CNR1, CNR2 2.49926
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR2C, IGF1R, KDR, KIT, MET, MMP12, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, XDH 2.45519
[MF] GO:0008227 None CHRM1, CHRM2, CHRM4, HTR2C 2.33256
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F3, FLT3, HTR2C, IGF1R, KDR, KIT, MET 2.2805
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F3, FLT3, HTR2C, IGF1R, KDR, KIT, MET 2.2805
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.25393
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.20021
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity KIT, MET, PIK3CA, PIK3CB 2.13018
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 2.12013
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARD, SRC, XDH 2.10598
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.10598
[MF] GO:0000978 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC 2.09023
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.0828
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity KIT, MET, PIK3CA, PIK3CB 2.08008
[MF] GO:0005504 None FABP3, FABP4, PPARD 2.07172
[MF] GO:0043565 None AR, BCL2, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, NR3C2, PGR, PPARA, PPARD, RORC 2.00371


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 10.8173
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 10.3754
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, IGF1R, AR, CDK6, PIK3CA, KIT, BCL2, MET, PPARD 8.0735
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.8173
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 5.808
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.808
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB, PPARD 5.808
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1C3, AKR1B1, PTGS2, TYR, GBA2, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.765
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 5.7685
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, PIK3CA, CHRM4, BCL2, PIK3CB 5.5226
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, PIK3CA, KIT, KDR, BCL2, PIK3CB, MET, IGF1R 5.1019
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, CNR2, CNR1, ADORA3, CHRM4, ADORA1, HTR2C, NR3C1 4.9578
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KIT, KDR, PIK3CB, MET, IGF1R 4.8665
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 4.6803
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.7693
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.0896
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.5281
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, AKR1C3, PTGS2, PTGS1 4.5177
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET 4.3737
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 4.2924
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.1799
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.2827
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, SRC, BCL2, PIK3CB, MMP9 4.0304
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA, PPARD 4.3326
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.2618
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.2724
Prostate cancer_Homo sapiens_hsa05215 AR, PIK3CA, BCL2, PIK3CB, IGF1R 3.9809
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 4.0304
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PGR, PIK3CB, CDC25B, IGF1R 3.7921
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, CHRM1, PIK3CA, ADORA1, PIK3CB, PPARA 3.3524
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, HTR2C, PTGS2, PTGS1 3.5275
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, PIK3CA, SRC, CHRM4, PIK3CB 3.2094
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KIT, KDR, PIK3CB, MET, IGF1R 3.0905
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.3982
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.9212
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, IGF1R 3.3524
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB, NR3C2 4.0945
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2C, PIK3CB 2.7326
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0389
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.0664
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.6613
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.5737
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.5789
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.0905
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.4431
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.488
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.488
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.488
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.2951
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.122
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.2665
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.1209
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.049
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9473
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.8047
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.7889
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.1593
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.9801
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.2837
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.3067
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.9062
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.2692
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB 2.4261
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.659
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.6358
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.9126
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.2692
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.5248
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.5677
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.6323
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.4917
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.5677
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2725
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.5277
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, KIT, PIK3CB 1.5031
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2085
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.4642
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.482
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.296
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3083
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.318
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM1, HTR2C 1.3057
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.318
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.2729
Axon guidance_Homo sapiens_hsa04360 MET 0.4055
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.5538
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7445
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.7528
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8925
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.9052
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9176
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PPARD 0.8834
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4824
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9602
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4987
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4978
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.0956
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5113
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.1341
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5123
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0956
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0707
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.0956
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1467
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.0812
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1021
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5144
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0812
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5134
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.0956
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1685
Gap junction_Homo sapiens_hsa04540 SRC, HTR2C 1.1685
Peroxisome_Homo sapiens_hsa04146 XDH 0.533
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5482
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5685
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5666
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5781
Bile secretion_Homo sapiens_hsa04976 CA2 0.5759
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3028
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.3409
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5804
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3157
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6
Shigellosis_Homo sapiens_hsa05131 SRC 0.6
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6209
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3409
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.334
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4276
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.514
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4364
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6811
Malaria_Homo sapiens_hsa05144 MET 0.6936
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7033
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.564
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6983
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6007
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7049
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.7033
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8874
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7817
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8539
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8389
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.764
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8739
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8739
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9003
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8636
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0746
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8925
Other glycan degradation_Homo sapiens_hsa00511 GBA2 1.0382
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1071
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4138
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2416


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)