Prescription Description
| Prescription ID | TCMF3960 |
| Pinyin Name | Fu Fang Shi Lin Tong Pian |
| Chinese Name | å¤æ–¹çŸ³æ·‹é€šç‰‡ |
| English Name | Fu Fang Shi Lin Tong Tablets |
| Function Description | 石淋, çƒæ·‹ |
| Indications | Stony stranguria disorder, Heat stranguria disorder, Acute prostatitis, Chronic prostatitis, Salmonella pyelonephritis, Chronic pyelonephritis, Cystitis, Urethritis |
| Disease ICD-11 Category |
SA90 [Stony stranguria disorder (TM1), 石淋 (TM1)
]; SA91 [Heat stranguria disorder (TM1), çƒæ·‹ (TM1) ]; GA91.Y [Other specified inflammatory and other diseases of prostate, 其他特指的å‰åˆ—腺炎性疾病 ]; GA91.0 [Chronic prostatitis, 慢性å‰åˆ—腺炎 ]; GC2Z [Diseases of the urinary system, unspecified, 泌尿系统疾病，未特指的 ]; GB55.Z [Chronic tubulo-interstitial nephritis, unspecified, 慢性肾å°ç®¡-间质肾炎，未特指的 ]; GC00 [Cystitis, 膀胱炎 ]; GC02.Y [Other specified urethritis and urethral syndrome, 其他特指的尿é“炎和尿é“综åˆå¾ ]; |
| Human Tissues Associated with Indication | Bladder |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH733 | Desmodium styracifolium | å¹¿é‡‘é’±è‰ | TCMH733 | ITSAK2600-14 |
| TCMH780 | Lygodium japonicum | æµ·é‡‘ç ‚ | TCMH780 | ITSAJ4232-14 |
| TCMH933 | Talcum | 滑石 | TCMH933 | |
| TCMH1953 | Pyrrosia lingua | 石韦 | TCMH1953 | GBVQ3369-13 |
| TCMH1714 | Lonicera japonica | å¿å†¬è—¤ | TCMH1714 | ITSAI3881-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
| TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
| TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
| TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
| TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
| TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
| TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
| TCMT187 | AR | Androgen Receptor | Nuclear receptor | P10275 |
| TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
| TCMT2 | MAPT | Microtubule-associated protein tau | Unclassified | P10636 |
| TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
| TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
| TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
| TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
| TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
| TCMT236 | ESR2 | Estrogen receptor beta | Nuclear receptor | Q92731 |
| TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
| TCMT254 | CBR1 | Carbonyl reductase [NADPH] 1 | Oxidoreductase | P16152 |
| TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
| TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
| TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
| TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
| TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
| TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
| TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
| TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
| TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
| TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
| TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
| TCMT344 | AOX1 | Aldehyde oxidase | Oxidoreductase | Q06278 |
| TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
| TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
| TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
| TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
| TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
| TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
| TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
| TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
| TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
| TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
| TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
| TCMT575 | PLA2G2A | Phospholipase A2 group IIA | Hydrolase | P14555 |
| TCMT591 | ESRRA | Estrogen-related receptor alpha | Nuclear receptor | P11474 |
| TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
| TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
| TCMT613 | NR3C1 | Glucocorticoid receptor | Nuclear receptor | P04150 |
| TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
| TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
| TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
| TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
| TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
| TCMT734 | MMP12 | Matrix metalloproteinase 12 | Hydrolase | P39900 |
| TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
| TCMT783 | NR3C2 | Mineralocorticoid receptor | Nuclear receptor | P08235 |
| TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
| TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
| TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
| TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
| TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
| TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
| TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
| TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
| TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
| TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
| TCMT83 | CD38 | Lymphocyte differentiation antigen CD38 | Unclassified | P28907 |
| TCMT87 | CYP2C9 | Cytochrome P450 2C9 | Oxidoreductase | P11712 |
| TCMT904 | PGR | Progesterone receptor | Nuclear receptor | P06401 |
| TCMT910 | ESRRB | Estrogen-related receptor beta | Nuclear receptor | O95718 |
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1208 | Escherichia coli K12 |
| TCMT1210 | Streptococcus sobrinus |
| TCMT1211 | Fusobacterium nucleatum |
| TCMT1212 | Verticillium dahliae |
| TCMT1213 | Neisseria gonorrhoeae |
| TCMT1215 | Pseudomonas aeruginosa PAO1 |
| TCMT1218 | Staphylococcus aureus |
| TCMT1221 | Human herpesvirus 4 |
| TCMT1222 | Plasmodium falciparum D6 |
| TCMT1223 | Staphylococcus epidermidis |
| TCMT1226 | Klebsiella pneumoniae |
| TCMT1229 | Enterococcus faecalis |
| TCMT1232 | Pseudomonas aeruginosa |
| TCMT1246 | Escherichia coli |
| TCMT1248 | Hepatitis C virus |
| TCMT1251 | Candida albicans |
| TCMT1253 | Penicillium chrysogenum |
| TCMT1255 | Human immunodeficiency virus 1 |
| TCMT1284 | Penicillium expansum |
| TCMT1286 | Bacillus cereus |
| TCMT1294 | Human parainfluenza virus 3 |
| TCMT1296 | Influenza A virus H3N2 |
| TCMT1346 | Helicobacter pylori |
| TCMT1349 | Helicobacter pylori SS1 |
| TCMT1361 | Neisseria meningitidis |
| TCMT1370 | Prevotella melaninogenica |
| TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
| TCMT1393 | Vibrio sp. |
| TCMT1412 | Salmonella typhimurium |
| TCMT1438 | Plasmodium falciparum |
| TCMT1442 | Leishmania donovani |
| TCMT1443 | Leishmania amazonensis |
| TCMT1444 | Fusarium oxysporum |
| TCMT1447 | Respiratory syncytial virus |
| TCMT1448 | Enterobacter aerogenes |
| TCMT1449 | Influenza A virus |
| TCMT1450 | Plasmodium falciparum 3D7 |
| TCMT1454 | Bacillus subtilis |
| TCMT1455 | Mycobacterium tuberculosis H37Rv |
| TCMT1458 | Filobasidiella neoformans |
| TCMT1462 | Streptococcus mutans |
| TCMT1463 | Mycobacterium tuberculosis |
| TCMT1465 | Entamoeba histolytica |
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0043401 | steroid hormone mediated signaling pathway | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC | 9.96404 |
| [BP] GO:0009755 | hormone-mediated signaling pathway | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC | 8.94792 |
| [BP] GO:0030522 | intracellular receptor signaling pathway | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, PPARA, RORC, SRC | 8.83184 |
| [BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 8.30091 |
| [BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA | 7.98231 |
| [BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC | 7.82902 |
| [BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, APP, AR, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TYR | 7.58014 |
| [BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 6.97691 |
| [BP] GO:0006352 | DNA-templated transcription, initiation | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC | 6.90326 |
| [BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 6.89854 |
| [BP] GO:0010033 | response to organic substance | AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PPARA, RORC, SRC, TYR | 6.84084 |
| [BP] GO:0033993 | response to lipid | AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, NR3C1, RORC, SRC, TYR | 6.63412 |
| [BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 6.36184 |
| [BP] GO:0044238 | primary metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 6.26432 |
| [BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2 | 6.25443 |
| [BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, APP, AR, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PGR, PIM1, SRC, XDH | 5.98018 |
| [BP] GO:0042221 | response to chemical | AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TYR | 5.91567 |
| [BP] GO:0014070 | response to organic cyclic compound | APP, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, NR3C1, RORC, SRC, TYR | 5.70842 |
| [BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, PIM1, PPARA, TYR, XDH | 5.67492 |
| [BP] GO:0048513 | animal organ development | ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, SRC, TYR | 5.6421 |
| [BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR | 5.61996 |
| [BP] GO:0071704 | organic substance metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 5.55242 |
| [BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MMP2, MMP9, PGR, PIM1, PPARA, RORC, SRC, TNKS2, TYR | 5.48458 |
| [BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, SRC, TNKS, TNKS2, XDH | 5.20054 |
| [BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, SRC, TNKS, TNKS2, XDH | 5.18232 |
| [BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 5.18112 |
| [BP] GO:0009719 | response to endogenous stimulus | AKR1B1, APP, AR, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, NR3C1, PPARA, SRC | 5.05783 |
| [BP] GO:0010035 | response to inorganic substance | AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC | 4.94253 |
| [BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 4.90999 |
| [BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, KDR, MET, PPARA, SRC, TNKS, TNKS2, XDH | 4.89779 |
| [BP] GO:0048523 | negative regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 4.68053 |
| [BP] GO:0009891 | positive regulation of biosynthetic process | APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2 | 4.65163 |
| [BP] GO:0032501 | multicellular organismal process | ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TNKS2, TYR | 4.65163 |
| [BP] GO:0030518 | intracellular steroid hormone receptor signaling pathway | AR, ESR1, ESR2, NR3C1, PGR, SRC | 4.65143 |
| [BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, MMP9, PGR, PIM1, PPARA, RORC, SRC, TYR | 4.61267 |
| [BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH | 4.5957 |
| [BP] GO:0010557 | positive regulation of macromolecule biosynthetic process | APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2 | 4.48673 |
| [BP] GO:0009725 | response to hormone | AKR1B1, AR, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, NR3C1, PPARA, SRC | 4.45875 |
| [BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, RORC, SRC | 4.42696 |
| [BP] GO:0015701 | bicarbonate transport | CA12, CA14, CA2, CA4, CA7 | 4.42359 |
| [BP] GO:0048519 | negative regulation of biological process | ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 4.40748 |
| [BP] GO:0031328 | positive regulation of cellular biosynthetic process | APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2 | 4.09072 |
| [BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 4.08168 |
| [BP] GO:0071407 | cellular response to organic cyclic compound | APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, RORC, SRC | 4.04395 |
| [BP] GO:0071310 | cellular response to organic substance | AKR1B1, APP, AR, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, RORC, SRC | 4.04395 |
| [BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH | 3.98196 |
| [BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APP, AR, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, RORC, SRC | 3.93115 |
| [BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, XDH | 3.9125 |
| [BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.89211 |
| [BP] GO:0009893 | positive regulation of metabolic process | ADORA1, APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 3.88642 |
| [BP] GO:0031325 | positive regulation of cellular metabolic process | ADORA1, APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 3.8552 |
| [BP] GO:0010604 | positive regulation of macromolecule metabolic process | ADORA1, APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 3.81964 |
| [BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC | 3.74521 |
| [BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC | 3.71064 |
| [BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP12, MMP9, SRC, TNKS, TNKS2, XDH | 3.71064 |
| [BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PPARA | 3.70131 |
| [BP] GO:0009967 | positive regulation of signal transduction | ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, SRC, TNKS, TNKS2, XDH | 3.69729 |
| [BP] GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2 | 3.68917 |
| [BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PIM1, SRC, XDH | 3.68508 |
| [BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP12, MMP9, SRC, TNKS, TNKS2, XDH | 3.64607 |
| [BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, SRC, TNKS, TNKS2, XDH | 3.64607 |
| [BP] GO:0044092 | negative regulation of molecular function | ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, SRC, TNKS | 3.59489 |
| [BP] GO:0009892 | negative regulation of metabolic process | ADORA1, APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 3.58113 |
| [BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, SRC | 3.39392 |
| [BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.32993 |
| [BP] GO:0006730 | one-carbon metabolic process | CA12, CA2, CA4, CA7 | 3.27845 |
| [BP] GO:0060736 | prostate gland growth | AR, CYP19A1, ESR1 | 3.20623 |
| [BP] GO:0007165 | signal transduction | ADORA1, ADORA3, AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2 | 3.10375 |
| [BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MMP9, PIM1, SRC, XDH | 3.06307 |
| [BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.98586 |
| [BP] GO:0010605 | negative regulation of macromolecule metabolic process | APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MMP12, MMP9, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 2.9661 |
| [BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 | 2.95457 |
| [BP] GO:0048583 | regulation of response to stimulus | ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, SRC, TNKS, TNKS2, XDH | 2.93667 |
| [BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 2.93667 |
| [BP] GO:0008283 | cell proliferation | ACHE, AR, AURKB, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR | 2.9265 |
| [BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 | 2.92237 |
| [BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.92225 |
| [BP] GO:0051130 | positive regulation of cellular component organization | APP, AR, AURKB, AXL, ESR1, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 | 2.89848 |
| [BP] GO:0009115 | None | AOX1, XDH | 2.88608 |
| [BP] GO:0006690 | icosanoid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 | 2.85913 |
| [BP] GO:0048511 | rhythmic process | AXL, CSNK2A1, ESR1, PGR, PPARA, RORC, SRC | 2.81601 |
| [BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, SRC, XDH | 2.81601 |
| [BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.81169 |
| [BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TYR | 2.80825 |
| [BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, AXL, CYP1B1, MMP9, SRC | 2.80143 |
| [BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.79062 |
| [BP] GO:0018212 | peptidyl-tyrosine modification | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.79031 |
| [BP] GO:0045893 | None | APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS | 2.78864 |
| [BP] GO:1903508 | None | APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS | 2.78864 |
| [BP] GO:1902680 | None | APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS | 2.78864 |
| [BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIM1, SRC | 2.78651 |
| [BP] GO:0006631 | fatty acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA | 2.74458 |
| [BP] GO:0032210 | regulation of telomere maintenance via telomerase | AURKB, SRC, TNKS, TNKS2 | 2.74423 |
| [BP] GO:1904355 | positive regulation of telomere capping | AURKB, TNKS, TNKS2 | 2.7385 |
| [BP] GO:0019369 | arachidonic acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1 | 2.71836 |
| [BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, AR, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 | 2.6664 |
| [BP] GO:0030198 | extracellular matrix organization | APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 | 2.64952 |
| [BP] GO:0043062 | extracellular structure organization | APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 | 2.64695 |
| [BP] GO:0043393 | regulation of protein binding | APP, AURKB, MET, MMP9, PPARA, SRC | 2.63695 |
| [BP] GO:0051716 | cellular response to stimulus | AKR1B1, APP, AR, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, RORC, SRC | 2.61722 |
| [BP] GO:0051254 | None | APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS | 2.59333 |
| [BP] GO:0034502 | protein localization to chromosome | AURKB, ESR1, TNKS, TNKS2 | 2.59033 |
| [BP] GO:0031324 | negative regulation of cellular metabolic process | APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, MET, MMP12, MMP9, NR3C1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 2.57438 |
| [BP] GO:1904356 | regulation of telomere maintenance via telomere lengthening | AURKB, SRC, TNKS, TNKS2 | 2.56744 |
| [BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, HSD17B1, HSD17B2 | 2.54191 |
| [BP] GO:0060748 | None | AR, PGR | 2.53171 |
| [BP] GO:0046110 | None | AOX1, XDH | 2.53171 |
| [BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.53171 |
| [BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 2.50706 |
| [BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS | 2.48885 |
| [BP] GO:2000573 | positive regulation of DNA biosynthetic process | AURKB, SRC, TNKS, TNKS2 | 2.48287 |
| [BP] GO:0030574 | collagen catabolic process | MMP1, MMP12, MMP2, MMP9 | 2.45902 |
| [BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC | 2.4587 |
| [BP] GO:0030520 | intracellular estrogen receptor signaling pathway | ESR1, ESR2, SRC | 2.4587 |
| [BP] GO:0051098 | regulation of binding | APP, AURKB, MET, MMP9, PPARA, SRC, TNKS | 2.41314 |
| [BP] GO:0032844 | regulation of homeostatic process | ADORA1, AURKB, CA2, CA7, KDR, SRC, TNKS, TNKS2 | 2.41303 |
| [BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.40858 |
| [BP] GO:0051172 | None | APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, MMP12, MMP9, NR3C1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 2.40858 |
| [BP] GO:0010629 | None | APP, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, KDR, MMP12, NR3C1, PGR, PPARA, RORC, SRC, XDH | 2.40858 |
| [BP] GO:0022414 | reproductive process | AKR1B1, APP, AR, AXL, CYP19A1, CYP1A1, ESR1, ESRRB, HSD17B2, MMP2, MMP9, PGR, SRC | 2.39255 |
| [BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SRC | 2.38717 |
| [BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.37724 |
| [BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, FLT3, KDR, MET, SRC, XDH | 2.37158 |
| [BP] GO:0071396 | cellular response to lipid | AR, AXL, ESR1, FLT3, NR3C1, RORC, SRC | 2.34815 |
| [BP] GO:0019222 | regulation of metabolic process | ACHE, ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 2.32233 |
| [BP] GO:0044243 | multicellular organismal catabolic process | MMP1, MMP12, MMP2, MMP9 | 2.31349 |
| [BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC | 2.31349 |
| [BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CYP1A1, FABP3, FLT3, PPARA, RORC, SRC | 2.31349 |
| [BP] GO:0070213 | None | TNKS, TNKS2 | 2.31349 |
| [BP] GO:0006145 | None | AOX1, XDH | 2.31349 |
| [BP] GO:0032847 | regulation of cellular pH reduction | CA2, CA7 | 2.31349 |
| [BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.31349 |
| [BP] GO:0071383 | None | AR, FLT3, NR3C1, SRC | 2.31025 |
| [BP] GO:0009966 | regulation of signal transduction | ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP12, MMP9, SRC, TNKS, TNKS2, XDH | 2.30986 |
| [BP] GO:1904353 | regulation of telomere capping | AURKB, TNKS, TNKS2 | 2.30785 |
| [BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC | 2.30106 |
| [BP] GO:0006807 | nitrogen compound metabolic process | ACHE, AKR1B1, AKR1B10, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 2.27021 |
| [BP] GO:1904357 | None | SRC, TNKS, TNKS2 | 2.26703 |
| [BP] GO:0032204 | None | AURKB, SRC, TNKS, TNKS2 | 2.24262 |
| [BP] GO:1901568 | fatty acid derivative metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 | 2.24262 |
| [BP] GO:0022617 | extracellular matrix disassembly | MMP1, MMP12, MMP2, MMP9 | 2.22705 |
| [BP] GO:0045934 | None | AR, AURKB, ESR1, ESR2, ESRRA, FABP4, MMP12, NR3C1, PPARA, RORC, SRC, TNKS, TNKS2 | 2.22666 |
| [BP] GO:0080090 | regulation of primary metabolic process | ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 2.20668 |
| [BP] GO:0071495 | cellular response to endogenous stimulus | AKR1B1, APP, AR, ESR1, FLT3, IGF1R, MMP2, NR3C1, SRC | 2.19571 |
| [BP] GO:1901655 | None | AKR1B1, AR, NR3C1, SRC | 2.19571 |
| [BP] GO:0032963 | collagen metabolic process | MMP1, MMP12, MMP2, MMP9 | 2.19571 |
| [BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1 | 2.19263 |
| [BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP12, MMP9, PPARA, SRC | 2.18771 |
| [BP] GO:0060255 | regulation of macromolecule metabolic process | ACHE, ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 2.18771 |
| [BP] GO:0051090 | regulation of DNA binding transcription factor activity | ADORA3, APP, AR, CYP1B1, ESR1, ESR2, PIM1 | 2.18771 |
| [BP] GO:0048869 | cellular developmental process | ACHE, APP, AR, AXL, CBR1, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, KDR, MET, MMP2, MMP9, PGR, RORC, SRC | 2.18735 |
| [BP] GO:0022900 | electron transport chain | AKR1B1, AOX1, CYP19A1, CYP1A2, XDH | 2.1819 |
| [BP] GO:0009987 | cellular process | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 2.1819 |
| [BP] GO:0035265 | organ growth | AR, CYP19A1, ESR1 | 2.17182 |
| [BP] GO:0048608 | reproductive structure development | AR, AXL, CYP19A1, ESR1, HSD17B2, SRC | 2.15027 |
| [BP] GO:0009889 | regulation of biosynthetic process | ADORA3, APP, AR, AURKB, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2 | 2.13262 |
| [BP] GO:0044259 | multicellular organismal macromolecule metabolic process | MMP1, MMP12, MMP2, MMP9 | 2.1266 |
| [BP] GO:0032228 | regulation of synaptic transmission, GABAergic | ADORA1, CA2, CA7 | 2.10873 |
| [BP] GO:0048609 | multicellular organismal reproductive process | AKR1B1, APP, AR, AXL, CYP1A1, ESR1, PGR, SRC | 2.10873 |
| [BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, ESR1, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TNKS, TNKS2, TYR, XDH | 2.09975 |
| [BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC | 2.09113 |
| [BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC | 2.08299 |
| [BP] GO:0010907 | None | ESRRB, PPARA, SRC | 2.07864 |
| [BP] GO:0035690 | cellular response to drug | AKR1B1, AXL, CYP1B1, KDR, NR3C1, SRC | 2.07664 |
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, CYP1B1, MMP9, SRC | 2.07662 |
| [BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, TYR | 2.06062 |
| [BP] GO:0032212 | positive regulation of telomere maintenance via telomerase | AURKB, TNKS, TNKS2 | 2.04714 |
| [BP] GO:0045944 | None | APP, AR, ESR1, ESRRA, ESRRB, MET, MMP12, NR3C1, PGR, PPARA, TNKS | 2.04498 |
| [BP] GO:0015711 | organic anion transport | CA12, CA14, CA2, CA4, CA7, FABP3, PPARA | 2.04038 |
| [BP] GO:1901654 | None | AKR1B1, AR, CSNK2A1, NR3C1, SRC | 2.03973 |
| [BP] GO:0046113 | None | AOX1, XDH | 2.03131 |
| [BP] GO:0031323 | regulation of cellular metabolic process | ACHE, ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 2.02246 |
| [BP] GO:0051171 | regulation of nitrogen compound metabolic process | ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 2.02246 |
| [BP] GO:0010556 | regulation of macromolecule biosynthetic process | ADORA3, APP, AR, AURKB, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, IGF1R, KDR, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2 | 2.00124 |
| [CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, SRC, TNKS, TNKS2, TYR, XDH | 2.02246 |
| [CC] GO:0043227 | membrane-bounded organelle | ACHE, ADORA1, AKR1B1, AKR1B10, AOX1, APP, AR, AURKB, AXL, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, IGF1R, KDR, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 1.8606 |
| [CC] GO:0005641 | nuclear envelope lumen | ALOX5, APP | 1.8396 |
| [CC] GO:0043231 | intracellular membrane-bounded organelle | ACHE, ADORA1, AKR1B1, AKR1B10, APP, AR, AURKB, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, IGF1R, KDR, MMP12, MMP2, NR3C1, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 1.56549 |
| [CC] GO:0005829 | cytosol | AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, CA2, CA7, CBR1, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, NR3C1, NR3C2, PGR, PIM1, SRC, TNKS, TNKS2, TYR, XDH | 1.5263 |
| [MF] GO:0046914 | transition metal ion binding | ALOX5, AOX1, APP, AR, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, TNKS, TYR, XDH | 18.9077 |
| [MF] GO:0003707 | steroid hormone receptor activity | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC | 11.4918 |
| [MF] GO:0043167 | ion binding | ACHE, ALOX5, AOX1, APP, AR, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 10.7102 |
| [MF] GO:0005496 | steroid binding | AR, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, NR3C2, PGR, RORC | 10.064 |
| [MF] GO:0008270 | zinc ion binding | AR, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, RORC, TNKS | 9.7225 |
| [MF] GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding | AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC | 8.94792 |
| [MF] GO:0004879 | nuclear receptor activity | AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC | 8.94792 |
| [MF] GO:0043169 | cation binding | ACHE, ALOX5, AOX1, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, TNKS, TNKS2, TYR, XDH | 7.44922 |
| [MF] GO:0046872 | metal ion binding | ALOX5, AOX1, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, TNKS, TNKS2, TYR, XDH | 6.94232 |
| [MF] GO:0004089 | carbonate dehydratase activity | CA12, CA14, CA2, CA4, CA7 | 6.55945 |
| [MF] GO:0008289 | lipid binding | AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC | 6.04468 |
| [MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC, TNKS, TNKS2, TYR, XDH | 5.79127 |
| [MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH | 4.84662 |
| [MF] GO:0038023 | signaling receptor activity | ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC | 4.83488 |
| [MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, AOX1, CBR1, HSD17B1, HSD17B2, XDH | 4.60522 |
| [MF] GO:0004872 | receptor activity | ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC | 4.18561 |
| [MF] GO:0005506 | iron ion binding | ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH | 4.18561 |
| [MF] GO:0060089 | molecular transducer activity | ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC | 4.0243 |
| [MF] GO:0016836 | hydro-lyase activity | CA12, CA14, CA2, CA4, CA7 | 3.99309 |
| [MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1 | 3.95116 |
| [MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.78659 |
| [MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1 | 3.77588 |
| [MF] GO:0004871 | signal transducer activity | ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC | 3.70833 |
| [MF] GO:0016835 | carbon-oxygen lyase activity | CA12, CA14, CA2, CA4, CA7 | 3.4477 |
| [MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.34507 |
| [MF] GO:0042562 | hormone binding | ACHE, AR, HSD17B1, IGF1R, NR3C1 | 3.20623 |
| [MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR | 2.98586 |
| [MF] GO:0016903 | None | AKR1B1, AKR1B10, AOX1, XDH | 2.95907 |
| [MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1 | 2.93667 |
| [MF] GO:0044877 | macromolecular complex binding | ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, SRC | 2.90458 |
| [MF] GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | ESR1, ESR2 | 2.88608 |
| [MF] GO:0004713 | protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.86096 |
| [MF] GO:0000978 | None | AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC | 2.86096 |
| [MF] GO:0009055 | electron transfer activity | AKR1B1, AOX1, CYP19A1, CYP1A2, XDH | 2.80143 |
| [MF] GO:0000987 | None | AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC | 2.77079 |
| [MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 | 2.64695 |
| [MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC | 2.53171 |
| [MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC | 2.53171 |
| [MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC | 2.40858 |
| [MF] GO:0001012 | None | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, RORC | 2.39615 |
| [MF] GO:0000977 | None | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, RORC | 2.39615 |
| [MF] GO:0032403 | protein complex binding | ACHE, ADORA1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, SRC | 2.38951 |
| [MF] GO:0048037 | cofactor binding | AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, SRC, XDH | 2.38717 |
| [MF] GO:0034056 | estrogen response element binding | ESR1, ESR2 | 2.31349 |
| [MF] GO:0004672 | protein kinase activity | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC | 2.31025 |
| [MF] GO:0042802 | identical protein binding | ACHE, AOX1, APP, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, PGR, TYR, XDH | 2.27021 |
| [MF] GO:0044212 | None | AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, PGR, PPARA, RORC | 2.24262 |
| [MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR | 2.24262 |
| [MF] GO:0001067 | None | AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, PGR, PPARA, RORC | 2.24069 |
| [MF] GO:0043565 | None | AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, NR3C2, PGR, PPARA, RORC | 2.1819 |
| [MF] GO:0030284 | estrogen receptor activity | ESR1, ESR2 | 2.1586 |
| [MF] GO:0000982 | None | AR, ESR1, ESRRA, NR3C1, PGR, PPARA, RORC | 2.13064 |
| [MF] GO:0001077 | None | AR, ESR1, ESRRA, NR3C1, PGR, PPARA | 2.13003 |
| [MF] GO:0001047 | None | ESR1, ESR2, ESRRB, MMP12, NR3C1 | 2.1266 |
| [MF] GO:0000976 | None | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, RORC | 2.11046 |
| [MF] GO:0051879 | Hsp90 protein binding | CSNK2A1, KDR, NR3C1 | 2.10873 |
| [MF] GO:0001228 | None | AR, ESR1, ESRRA, ESRRB, NR3C1, PGR, PPARA | 2.08372 |
| [MF] GO:0043546 | None | AOX1, XDH | 2.03131 |
| [MF] GO:1901363 | heterocyclic compound binding | ADORA1, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, XDH | 2.02246 |
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R | 8.3836 |
| Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 | 6.6031 |
| Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA2, CA4, CA7, CA14 | 7.5621 |
| Proteoglycans in cancer_Homo sapiens_hsa05205 | SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R | 4.706 |
| Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, AOX1, CYP1B1 | 4.2068 |
| Metabolic pathways_Homo sapiens_hsa01100 | CBR1, AKR1B1, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH | 3.9626 |
| Estrogen signaling pathway_Homo sapiens_hsa04915 | SRC, MMP2, MMP9, ESR1, ESR2 | 4.11 |
| Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9 | 4.2068 |
| Pathways in cancer_Homo sapiens_hsa05200 | AR, FLT3, MMP1, MMP2, MMP9, MET, IGF1R | 3.3157 |
| Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | CBR1, CYP1A2, CYP1A1, CYP1B1 | 3.4409 |
| Adherens junction_Homo sapiens_hsa04520 | CSNK2A1, SRC, MET, IGF1R | 3.4409 |
| PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.474 |
| Chemical carcinogenesis_Homo sapiens_hsa05204 | CBR1, CYP1A2, CYP1A1, CYP1B1 | 3.3157 |
| Prolactin signaling pathway_Homo sapiens_hsa04917 | SRC, ESR1, ESR2 | 2.257 |
| Retinol metabolism_Homo sapiens_hsa00830 | CYP1A2, CYP1A1, AOX1 | 2.3589 |
| Focal adhesion_Homo sapiens_hsa04510 | SRC, KDR, MET, IGF1R | 2.0129 |
| Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 2.149 |
| Rap1 signaling pathway_Homo sapiens_hsa04015 | SRC, KDR, MET, IGF1R | 1.9662 |
| Endocytosis_Homo sapiens_hsa04144 | SRC, KDR, MET, IGF1R | 1.7597 |
| Oocyte meiosis_Homo sapiens_hsa04114 | AR, PGR, IGF1R | 1.7781 |
| MicroRNAs in cancer_Homo sapiens_hsa05206 | PIM1, CYP1B1, MMP9, MET | 1.567 |
| Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, ADORA1 | 1.4535 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.4535 |
| Ras signaling pathway_Homo sapiens_hsa04014 | KDR, MET, IGF1R | 1.2527 |
| VEGF signaling pathway_Homo sapiens_hsa04370 | SRC, KDR | 1.426 |
| Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.4393 |
| Central carbon metabolism in cancer_Homo sapiens_hsa05230 | FLT3, MET | 1.376 |
| Melanoma_Homo sapiens_hsa05218 | MET, IGF1R | 1.3646 |
| Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET | 1.376 |
| Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5 | 1.426 |
| Tyrosine metabolism_Homo sapiens_hsa00350 | AOX1, TYR | 1.7781 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, PIM1 | 1.1545 |
| Prostate cancer_Homo sapiens_hsa05215 | AR, IGF1R | 1.2253 |
| Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET | 1.1311 |
| GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2 | 1.218 |
| Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | PGR, IGF1R | 1.1685 |
| Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.8592 |
| Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP1A2, AOX1 | 1.376 |
| Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | ADORA3, ADORA1, NR3C1 | 1.101 |
| Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | SRC, MET | 1.3107 |
| Serotonergic synapse_Homo sapiens_hsa04726 | APP, ALOX5 | 1.101 |
| Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.0227 |
| PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | KDR, MET, IGF1R | 0.9389 |
| Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | SRC, ESR1 | 1.0781 |
| Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.8236 |
| Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.7781 |
| Hepatitis B_Homo sapiens_hsa05161 | SRC, MMP9 | 0.9462 |
| Leukocyte transendothelial migration_Homo sapiens_hsa04670 | MMP2, MMP9 | 1.0781 |
| Sphingolipid signaling pathway_Homo sapiens_hsa04071 | ADORA3, ADORA1 | 1.0737 |
| Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | ESRRB, IGF1R | 0.9594 |
| Jak-STAT signaling pathway_Homo sapiens_hsa04630 | PIM1, AOX1 | 0.902 |
| Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 0.9674 |
| cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | ADORA3, ADORA1 | 0.8831 |
| cAMP signaling pathway_Homo sapiens_hsa04024 | ADORA1, PPARA | 0.7886 |
| ErbB signaling pathway_Homo sapiens_hsa04012 | SRC | 0.5626 |
| Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1 | 0.392 |
| Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | SRC | 0.3805 |
| Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.4232 |
| Viral carcinogenesis_Homo sapiens_hsa05203 | SRC | 0.3909 |
| Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.4142 |
| Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PPARA | 0.465 |
| Tuberculosis_Homo sapiens_hsa05152 | SRC | 0.4232 |
| GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.5626 |
| Platelet activation_Homo sapiens_hsa04611 | SRC | 0.513 |
| Oxytocin signaling pathway_Homo sapiens_hsa04921 | SRC | 0.453 |
| Insulin resistance_Homo sapiens_hsa04931 | PPARA | 0.5394 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.4353 |
| TNF signaling pathway_Homo sapiens_hsa04668 | MMP9 | 0.5394 |
| Wnt signaling pathway_Homo sapiens_hsa04310 | CSNK2A1 | 0.4829 |
| Measles_Homo sapiens_hsa05162 | CSNK2A1 | 0.4944 |
| Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | SRC | 0.5589 |
| FoxO signaling pathway_Homo sapiens_hsa04068 | IGF1R | 0.4984 |
| Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | IGF1R | 0.5619 |
| Chemokine signaling pathway_Homo sapiens_hsa04062 | SRC | 0.4142 |
| Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.5569 |
| Morphine addiction_Homo sapiens_hsa05032 | ADORA1 | 0.5626 |
| Cholinergic synapse_Homo sapiens_hsa04725 | ACHE | 0.5394 |
| Gap junction_Homo sapiens_hsa04540 | SRC | 0.5626 |
| HIF-1 signaling pathway_Homo sapiens_hsa04066 | IGF1R | 0.5541 |
| Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.5626 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.5113 |
| Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.5569 |
| Hepatitis C_Homo sapiens_hsa05160 | PPARA | 0.4984 |
| Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1 | 0.5626 |
| Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.5626 |
| Axon guidance_Homo sapiens_hsa04360 | MET | 0.5068 |
| Toxoplasmosis_Homo sapiens_hsa05145 | ALOX5 | 0.521 |
| NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1 | 0.5619 |
| Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.5619 |
| Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.6007 |
| Peroxisome_Homo sapiens_hsa04146 | XDH | 0.5626 |
| Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | IGF1R | 0.6293 |
| Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.5619 |
| Glioma_Homo sapiens_hsa05214 | IGF1R | 0.6293 |
| Long-term depression_Homo sapiens_hsa04730 | IGF1R | 0.6306 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.6115 |
| Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.6293 |
| Renal cell carcinoma_Homo sapiens_hsa05211 | MET | 0.6291 |
| Bile secretion_Homo sapiens_hsa04976 | CA2 | 0.6115 |
| Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | RORC | 0.6293 |
| Shigellosis_Homo sapiens_hsa05131 | SRC | 0.6293 |
| Malaria_Homo sapiens_hsa05144 | MET | 0.7064 |
| Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.7102 |
| Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | AOX1 | 0.7082 |
| Drug metabolism - other enzymes_Homo sapiens_hsa00983 | XDH | 0.7124 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | NR3C2 | 0.7734 |
| Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.8551 |
| Linoleic acid metabolism_Homo sapiens_hsa00591 | CYP1A2 | 0.8684 |
| Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | AOX1 | 0.8684 |
| Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.8837 |
| Circadian rhythm_Homo sapiens_hsa04710 | RORC | 0.8617 |
| Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.8831 |
| Caffeine metabolism_Homo sapiens_hsa00232 | CYP1A2, XDH | 3.3042 |
| Vitamin B6 metabolism_Homo sapiens_hsa00750 | AOX1 | 1.3379 |
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples