Prescription ID | TCMF3960 |
Pinyin Name | Fu Fang Shi Lin Tong Pian |
Chinese Name | 复方石淋通片 |
English Name | Fu Fang Shi Lin Tong Tablets |
Function Description | 石淋, 热淋 |
Indications | Stony stranguria disorder, Heat stranguria disorder, Acute prostatitis, Chronic prostatitis, Salmonella pyelonephritis, Chronic pyelonephritis, Cystitis, Urethritis |
Disease ICD-11 Category |
SA90 [Stony stranguria disorder (TM1), 石淋 (TM1)
]; SA91 [Heat stranguria disorder (TM1), 热淋 (TM1) ]; GA91.Y [Other specified inflammatory and other diseases of prostate, 其他特指的前列腺炎性疾病 ]; GA91.0 [Chronic prostatitis, 慢性前列腺炎 ]; GC2Z [Diseases of the urinary system, unspecified, 泌尿系统疾病,未特指的 ]; GB55.Z [Chronic tubulo-interstitial nephritis, unspecified, 慢性肾小管-间质肾炎,未特指的 ]; GC00 [Cystitis, 膀胱炎 ]; GC02.Y [Other specified urethritis and urethral syndrome, 其他特指的尿道炎和尿道综合征 ]; |
Human Tissues Associated with Indication | Bladder |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH733 | Desmodium styracifolium | 广金钱草 | TCMH733 | ITSAK2600-14 |
TCMH1953 | Pyrrosia lingua | 石韦 | TCMH1953 | GBVQ3369-13 |
TCMH780 | Lygodium japonicum | 海金砂 | TCMH780 | ITSAJ4232-14 |
TCMH933 | Talcum | 滑石 | TCMH933 | |
TCMH1714 | Lonicera japonica | 忍冬藤 | TCMH1714 | ITSAI3881-14 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT187 | AR | Androgen Receptor | Nuclear receptor | P10275 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT2 | MAPT | Microtubule-associated protein tau | Unclassified | P10636 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT236 | ESR2 | Estrogen receptor beta | Nuclear receptor | Q92731 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT254 | CBR1 | Carbonyl reductase [NADPH] 1 | Oxidoreductase | P16152 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT344 | AOX1 | Aldehyde oxidase | Oxidoreductase | Q06278 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT575 | PLA2G2A | Phospholipase A2 group IIA | Hydrolase | P14555 |
TCMT591 | ESRRA | Estrogen-related receptor alpha | Nuclear receptor | P11474 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT613 | NR3C1 | Glucocorticoid receptor | Nuclear receptor | P04150 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT734 | MMP12 | Matrix metalloproteinase 12 | Hydrolase | P39900 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT783 | NR3C2 | Mineralocorticoid receptor | Nuclear receptor | P08235 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
TCMT83 | CD38 | Lymphocyte differentiation antigen CD38 | Unclassified | P28907 |
TCMT87 | CYP2C9 | Cytochrome P450 2C9 | Oxidoreductase | P11712 |
TCMT904 | PGR | Progesterone receptor | Nuclear receptor | P06401 |
TCMT910 | ESRRB | Estrogen-related receptor beta | Nuclear receptor | O95718 |
Target ID | Target Name |
---|---|
TCMT1178 | Actinomyces viscosus |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1189 | Pseudomonas fluorescens |
TCMT1208 | Escherichia coli K12 |
TCMT1210 | Streptococcus sobrinus |
TCMT1211 | Fusobacterium nucleatum |
TCMT1212 | Verticillium dahliae |
TCMT1213 | Neisseria gonorrhoeae |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1218 | Staphylococcus aureus |
TCMT1221 | Human herpesvirus 4 |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1229 | Enterococcus faecalis |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1246 | Escherichia coli |
TCMT1248 | Hepatitis C virus |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1284 | Penicillium expansum |
TCMT1286 | Bacillus cereus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1296 | Influenza A virus H3N2 |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1361 | Neisseria meningitidis |
TCMT1370 | Prevotella melaninogenica |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1393 | Vibrio sp. |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1444 | Fusarium oxysporum |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0043401 | steroid hormone mediated signaling pathway | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC | 9.96404 |
[BP] GO:0009755 | hormone-mediated signaling pathway | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC | 8.94792 |
[BP] GO:0030522 | intracellular receptor signaling pathway | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, PPARA, RORC, SRC | 8.83184 |
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 8.30091 |
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA | 7.98231 |
[BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC | 7.82902 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, APP, AR, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TYR | 7.58014 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 6.97691 |
[BP] GO:0006352 | DNA-templated transcription, initiation | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC | 6.90326 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 6.89854 |
[BP] GO:0010033 | response to organic substance | AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PPARA, RORC, SRC, TYR | 6.84084 |
[BP] GO:0033993 | response to lipid | AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, NR3C1, RORC, SRC, TYR | 6.63412 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 6.36184 |
[BP] GO:0044238 | primary metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 6.26432 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2 | 6.25443 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, APP, AR, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PGR, PIM1, SRC, XDH | 5.98018 |
[BP] GO:0042221 | response to chemical | AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TYR | 5.91567 |
[BP] GO:0014070 | response to organic cyclic compound | APP, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, NR3C1, RORC, SRC, TYR | 5.70842 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, PIM1, PPARA, TYR, XDH | 5.67492 |
[BP] GO:0048513 | animal organ development | ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, SRC, TYR | 5.6421 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR | 5.61996 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 5.55242 |
[BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MMP2, MMP9, PGR, PIM1, PPARA, RORC, SRC, TNKS2, TYR | 5.48458 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, SRC, TNKS, TNKS2, XDH | 5.20054 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, SRC, TNKS, TNKS2, XDH | 5.18232 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 5.18112 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, APP, AR, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, NR3C1, PPARA, SRC | 5.05783 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC | 4.94253 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 4.90999 |
[BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, KDR, MET, PPARA, SRC, TNKS, TNKS2, XDH | 4.89779 |
[BP] GO:0048523 | negative regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 4.68053 |
[BP] GO:0009891 | positive regulation of biosynthetic process | APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2 | 4.65163 |
[BP] GO:0032501 | multicellular organismal process | ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TNKS2, TYR | 4.65163 |
[BP] GO:0030518 | intracellular steroid hormone receptor signaling pathway | AR, ESR1, ESR2, NR3C1, PGR, SRC | 4.65143 |
[BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, MMP9, PGR, PIM1, PPARA, RORC, SRC, TYR | 4.61267 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH | 4.5957 |
[BP] GO:0010557 | positive regulation of macromolecule biosynthetic process | APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2 | 4.48673 |
[BP] GO:0009725 | response to hormone | AKR1B1, AR, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, NR3C1, PPARA, SRC | 4.45875 |
[BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, RORC, SRC | 4.42696 |
[BP] GO:0015701 | bicarbonate transport | CA12, CA14, CA2, CA4, CA7 | 4.42359 |
[BP] GO:0048519 | negative regulation of biological process | ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 4.40748 |
[BP] GO:0031328 | positive regulation of cellular biosynthetic process | APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2 | 4.09072 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 4.08168 |
[BP] GO:0071407 | cellular response to organic cyclic compound | APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, RORC, SRC | 4.04395 |
[BP] GO:0071310 | cellular response to organic substance | AKR1B1, APP, AR, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, RORC, SRC | 4.04395 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH | 3.98196 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APP, AR, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, RORC, SRC | 3.93115 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, XDH | 3.9125 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.89211 |
[BP] GO:0009893 | positive regulation of metabolic process | ADORA1, APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 3.88642 |
[BP] GO:0031325 | positive regulation of cellular metabolic process | ADORA1, APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 3.8552 |
[BP] GO:0010604 | positive regulation of macromolecule metabolic process | ADORA1, APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 3.81964 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC | 3.74521 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC | 3.71064 |
[BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP12, MMP9, SRC, TNKS, TNKS2, XDH | 3.71064 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PPARA | 3.70131 |
[BP] GO:0009967 | positive regulation of signal transduction | ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, SRC, TNKS, TNKS2, XDH | 3.69729 |
[BP] GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2 | 3.68917 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PIM1, SRC, XDH | 3.68508 |
[BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP12, MMP9, SRC, TNKS, TNKS2, XDH | 3.64607 |
[BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, SRC, TNKS, TNKS2, XDH | 3.64607 |
[BP] GO:0044092 | negative regulation of molecular function | ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, SRC, TNKS | 3.59489 |
[BP] GO:0009892 | negative regulation of metabolic process | ADORA1, APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 3.58113 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, SRC | 3.39392 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.32993 |
[BP] GO:0006730 | one-carbon metabolic process | CA12, CA2, CA4, CA7 | 3.27845 |
[BP] GO:0060736 | prostate gland growth | AR, CYP19A1, ESR1 | 3.20623 |
[BP] GO:0007165 | signal transduction | ADORA1, ADORA3, AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2 | 3.10375 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MMP9, PIM1, SRC, XDH | 3.06307 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.98586 |
[BP] GO:0010605 | negative regulation of macromolecule metabolic process | APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MMP12, MMP9, NR3C1, PGR, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 2.9661 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 | 2.95457 |
[BP] GO:0048583 | regulation of response to stimulus | ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, SRC, TNKS, TNKS2, XDH | 2.93667 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 2.93667 |
[BP] GO:0008283 | cell proliferation | ACHE, AR, AURKB, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR | 2.9265 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 | 2.92237 |
[BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.92225 |
[BP] GO:0051130 | positive regulation of cellular component organization | APP, AR, AURKB, AXL, ESR1, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 | 2.89848 |
[BP] GO:0009115 | None | AOX1, XDH | 2.88608 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 | 2.85913 |
[BP] GO:0048511 | rhythmic process | AXL, CSNK2A1, ESR1, PGR, PPARA, RORC, SRC | 2.81601 |
[BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, SRC, XDH | 2.81601 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.81169 |
[BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TYR | 2.80825 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, AXL, CYP1B1, MMP9, SRC | 2.80143 |
[BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.79062 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.79031 |
[BP] GO:0045893 | None | APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS | 2.78864 |
[BP] GO:1903508 | None | APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS | 2.78864 |
[BP] GO:1902680 | None | APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS | 2.78864 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIM1, SRC | 2.78651 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA | 2.74458 |
[BP] GO:0032210 | regulation of telomere maintenance via telomerase | AURKB, SRC, TNKS, TNKS2 | 2.74423 |
[BP] GO:1904355 | positive regulation of telomere capping | AURKB, TNKS, TNKS2 | 2.7385 |
[BP] GO:0019369 | arachidonic acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1 | 2.71836 |
[BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, AR, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 | 2.6664 |
[BP] GO:0030198 | extracellular matrix organization | APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 | 2.64952 |
[BP] GO:0043062 | extracellular structure organization | APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 | 2.64695 |
[BP] GO:0043393 | regulation of protein binding | APP, AURKB, MET, MMP9, PPARA, SRC | 2.63695 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, APP, AR, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, RORC, SRC | 2.61722 |
[BP] GO:0051254 | None | APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TNKS | 2.59333 |
[BP] GO:0034502 | protein localization to chromosome | AURKB, ESR1, TNKS, TNKS2 | 2.59033 |
[BP] GO:0031324 | negative regulation of cellular metabolic process | APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, MET, MMP12, MMP9, NR3C1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 2.57438 |
[BP] GO:1904356 | regulation of telomere maintenance via telomere lengthening | AURKB, SRC, TNKS, TNKS2 | 2.56744 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, HSD17B1, HSD17B2 | 2.54191 |
[BP] GO:0060748 | None | AR, PGR | 2.53171 |
[BP] GO:0046110 | None | AOX1, XDH | 2.53171 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.53171 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 2.50706 |
[BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS | 2.48885 |
[BP] GO:2000573 | positive regulation of DNA biosynthetic process | AURKB, SRC, TNKS, TNKS2 | 2.48287 |
[BP] GO:0030574 | collagen catabolic process | MMP1, MMP12, MMP2, MMP9 | 2.45902 |
[BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC | 2.4587 |
[BP] GO:0030520 | intracellular estrogen receptor signaling pathway | ESR1, ESR2, SRC | 2.4587 |
[BP] GO:0051098 | regulation of binding | APP, AURKB, MET, MMP9, PPARA, SRC, TNKS | 2.41314 |
[BP] GO:0032844 | regulation of homeostatic process | ADORA1, AURKB, CA2, CA7, KDR, SRC, TNKS, TNKS2 | 2.41303 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.40858 |
[BP] GO:0051172 | None | APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, MMP12, MMP9, NR3C1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 2.40858 |
[BP] GO:0010629 | None | APP, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, KDR, MMP12, NR3C1, PGR, PPARA, RORC, SRC, XDH | 2.40858 |
[BP] GO:0022414 | reproductive process | AKR1B1, APP, AR, AXL, CYP19A1, CYP1A1, ESR1, ESRRB, HSD17B2, MMP2, MMP9, PGR, SRC | 2.39255 |
[BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SRC | 2.38717 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.37724 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, FLT3, KDR, MET, SRC, XDH | 2.37158 |
[BP] GO:0071396 | cellular response to lipid | AR, AXL, ESR1, FLT3, NR3C1, RORC, SRC | 2.34815 |
[BP] GO:0019222 | regulation of metabolic process | ACHE, ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 2.32233 |
[BP] GO:0044243 | multicellular organismal catabolic process | MMP1, MMP12, MMP2, MMP9 | 2.31349 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC | 2.31349 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CYP1A1, FABP3, FLT3, PPARA, RORC, SRC | 2.31349 |
[BP] GO:0070213 | None | TNKS, TNKS2 | 2.31349 |
[BP] GO:0006145 | None | AOX1, XDH | 2.31349 |
[BP] GO:0032847 | regulation of cellular pH reduction | CA2, CA7 | 2.31349 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.31349 |
[BP] GO:0071383 | None | AR, FLT3, NR3C1, SRC | 2.31025 |
[BP] GO:0009966 | regulation of signal transduction | ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP12, MMP9, SRC, TNKS, TNKS2, XDH | 2.30986 |
[BP] GO:1904353 | regulation of telomere capping | AURKB, TNKS, TNKS2 | 2.30785 |
[BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC | 2.30106 |
[BP] GO:0006807 | nitrogen compound metabolic process | ACHE, AKR1B1, AKR1B10, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 2.27021 |
[BP] GO:1904357 | None | SRC, TNKS, TNKS2 | 2.26703 |
[BP] GO:0032204 | None | AURKB, SRC, TNKS, TNKS2 | 2.24262 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 | 2.24262 |
[BP] GO:0022617 | extracellular matrix disassembly | MMP1, MMP12, MMP2, MMP9 | 2.22705 |
[BP] GO:0045934 | None | AR, AURKB, ESR1, ESR2, ESRRA, FABP4, MMP12, NR3C1, PPARA, RORC, SRC, TNKS, TNKS2 | 2.22666 |
[BP] GO:0080090 | regulation of primary metabolic process | ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 2.20668 |
[BP] GO:0071495 | cellular response to endogenous stimulus | AKR1B1, APP, AR, ESR1, FLT3, IGF1R, MMP2, NR3C1, SRC | 2.19571 |
[BP] GO:1901655 | None | AKR1B1, AR, NR3C1, SRC | 2.19571 |
[BP] GO:0032963 | collagen metabolic process | MMP1, MMP12, MMP2, MMP9 | 2.19571 |
[BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1 | 2.19263 |
[BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP12, MMP9, PPARA, SRC | 2.18771 |
[BP] GO:0060255 | regulation of macromolecule metabolic process | ACHE, ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 2.18771 |
[BP] GO:0051090 | regulation of DNA binding transcription factor activity | ADORA3, APP, AR, CYP1B1, ESR1, ESR2, PIM1 | 2.18771 |
[BP] GO:0048869 | cellular developmental process | ACHE, APP, AR, AXL, CBR1, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, KDR, MET, MMP2, MMP9, PGR, RORC, SRC | 2.18735 |
[BP] GO:0022900 | electron transport chain | AKR1B1, AOX1, CYP19A1, CYP1A2, XDH | 2.1819 |
[BP] GO:0009987 | cellular process | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 2.1819 |
[BP] GO:0035265 | organ growth | AR, CYP19A1, ESR1 | 2.17182 |
[BP] GO:0048608 | reproductive structure development | AR, AXL, CYP19A1, ESR1, HSD17B2, SRC | 2.15027 |
[BP] GO:0009889 | regulation of biosynthetic process | ADORA3, APP, AR, AURKB, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2 | 2.13262 |
[BP] GO:0044259 | multicellular organismal macromolecule metabolic process | MMP1, MMP12, MMP2, MMP9 | 2.1266 |
[BP] GO:0032228 | regulation of synaptic transmission, GABAergic | ADORA1, CA2, CA7 | 2.10873 |
[BP] GO:0048609 | multicellular organismal reproductive process | AKR1B1, APP, AR, AXL, CYP1A1, ESR1, PGR, SRC | 2.10873 |
[BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, ESR1, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TNKS, TNKS2, TYR, XDH | 2.09975 |
[BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC | 2.09113 |
[BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC | 2.08299 |
[BP] GO:0010907 | None | ESRRB, PPARA, SRC | 2.07864 |
[BP] GO:0035690 | cellular response to drug | AKR1B1, AXL, CYP1B1, KDR, NR3C1, SRC | 2.07664 |
[BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, CYP1B1, MMP9, SRC | 2.07662 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, TYR | 2.06062 |
[BP] GO:0032212 | positive regulation of telomere maintenance via telomerase | AURKB, TNKS, TNKS2 | 2.04714 |
[BP] GO:0045944 | None | APP, AR, ESR1, ESRRA, ESRRB, MET, MMP12, NR3C1, PGR, PPARA, TNKS | 2.04498 |
[BP] GO:0015711 | organic anion transport | CA12, CA14, CA2, CA4, CA7, FABP3, PPARA | 2.04038 |
[BP] GO:1901654 | None | AKR1B1, AR, CSNK2A1, NR3C1, SRC | 2.03973 |
[BP] GO:0046113 | None | AOX1, XDH | 2.03131 |
[BP] GO:0031323 | regulation of cellular metabolic process | ACHE, ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 2.02246 |
[BP] GO:0051171 | regulation of nitrogen compound metabolic process | ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, XDH | 2.02246 |
[BP] GO:0010556 | regulation of macromolecule biosynthetic process | ADORA3, APP, AR, AURKB, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, IGF1R, KDR, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2 | 2.00124 |
[CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, SRC, TNKS, TNKS2, TYR, XDH | 2.02246 |
[CC] GO:0043227 | membrane-bounded organelle | ACHE, ADORA1, AKR1B1, AKR1B10, AOX1, APP, AR, AURKB, AXL, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, IGF1R, KDR, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 1.8606 |
[CC] GO:0005641 | nuclear envelope lumen | ALOX5, APP | 1.8396 |
[CC] GO:0043231 | intracellular membrane-bounded organelle | ACHE, ADORA1, AKR1B1, AKR1B10, APP, AR, AURKB, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, IGF1R, KDR, MMP12, MMP2, NR3C1, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 1.56549 |
[CC] GO:0005829 | cytosol | AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, CA2, CA7, CBR1, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, NR3C1, NR3C2, PGR, PIM1, SRC, TNKS, TNKS2, TYR, XDH | 1.5263 |
[MF] GO:0046914 | transition metal ion binding | ALOX5, AOX1, APP, AR, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, TNKS, TYR, XDH | 18.9077 |
[MF] GO:0003707 | steroid hormone receptor activity | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC | 11.4918 |
[MF] GO:0043167 | ion binding | ACHE, ALOX5, AOX1, APP, AR, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TNKS, TNKS2, TYR, XDH | 10.7102 |
[MF] GO:0005496 | steroid binding | AR, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, NR3C2, PGR, RORC | 10.064 |
[MF] GO:0008270 | zinc ion binding | AR, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, RORC, TNKS | 9.7225 |
[MF] GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding | AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC | 8.94792 |
[MF] GO:0004879 | nuclear receptor activity | AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC | 8.94792 |
[MF] GO:0043169 | cation binding | ACHE, ALOX5, AOX1, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, TNKS, TNKS2, TYR, XDH | 7.44922 |
[MF] GO:0046872 | metal ion binding | ALOX5, AOX1, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, TNKS, TNKS2, TYR, XDH | 6.94232 |
[MF] GO:0004089 | carbonate dehydratase activity | CA12, CA14, CA2, CA4, CA7 | 6.55945 |
[MF] GO:0008289 | lipid binding | AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC | 6.04468 |
[MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC, TNKS, TNKS2, TYR, XDH | 5.79127 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH | 4.84662 |
[MF] GO:0038023 | signaling receptor activity | ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC | 4.83488 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, AOX1, CBR1, HSD17B1, HSD17B2, XDH | 4.60522 |
[MF] GO:0004872 | receptor activity | ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC | 4.18561 |
[MF] GO:0005506 | iron ion binding | ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH | 4.18561 |
[MF] GO:0060089 | molecular transducer activity | ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC | 4.0243 |
[MF] GO:0016836 | hydro-lyase activity | CA12, CA14, CA2, CA4, CA7 | 3.99309 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1 | 3.95116 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.78659 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1 | 3.77588 |
[MF] GO:0004871 | signal transducer activity | ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC | 3.70833 |
[MF] GO:0016835 | carbon-oxygen lyase activity | CA12, CA14, CA2, CA4, CA7 | 3.4477 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.34507 |
[MF] GO:0042562 | hormone binding | ACHE, AR, HSD17B1, IGF1R, NR3C1 | 3.20623 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR | 2.98586 |
[MF] GO:0016903 | None | AKR1B1, AKR1B10, AOX1, XDH | 2.95907 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1 | 2.93667 |
[MF] GO:0044877 | macromolecular complex binding | ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, SRC | 2.90458 |
[MF] GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | ESR1, ESR2 | 2.88608 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.86096 |
[MF] GO:0000978 | None | AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC | 2.86096 |
[MF] GO:0009055 | electron transfer activity | AKR1B1, AOX1, CYP19A1, CYP1A2, XDH | 2.80143 |
[MF] GO:0000987 | None | AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC | 2.77079 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 | 2.64695 |
[MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC | 2.53171 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC | 2.53171 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC | 2.40858 |
[MF] GO:0001012 | None | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, RORC | 2.39615 |
[MF] GO:0000977 | None | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, RORC | 2.39615 |
[MF] GO:0032403 | protein complex binding | ACHE, ADORA1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, SRC | 2.38951 |
[MF] GO:0048037 | cofactor binding | AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, SRC, XDH | 2.38717 |
[MF] GO:0034056 | estrogen response element binding | ESR1, ESR2 | 2.31349 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC | 2.31025 |
[MF] GO:0042802 | identical protein binding | ACHE, AOX1, APP, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, PGR, TYR, XDH | 2.27021 |
[MF] GO:0044212 | None | AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, PGR, PPARA, RORC | 2.24262 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR | 2.24262 |
[MF] GO:0001067 | None | AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, PGR, PPARA, RORC | 2.24069 |
[MF] GO:0043565 | None | AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, NR3C2, PGR, PPARA, RORC | 2.1819 |
[MF] GO:0030284 | estrogen receptor activity | ESR1, ESR2 | 2.1586 |
[MF] GO:0000982 | None | AR, ESR1, ESRRA, NR3C1, PGR, PPARA, RORC | 2.13064 |
[MF] GO:0001077 | None | AR, ESR1, ESRRA, NR3C1, PGR, PPARA | 2.13003 |
[MF] GO:0001047 | None | ESR1, ESR2, ESRRB, MMP12, NR3C1 | 2.1266 |
[MF] GO:0000976 | None | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, RORC | 2.11046 |
[MF] GO:0051879 | Hsp90 protein binding | CSNK2A1, KDR, NR3C1 | 2.10873 |
[MF] GO:0001228 | None | AR, ESR1, ESRRA, ESRRB, NR3C1, PGR, PPARA | 2.08372 |
[MF] GO:0043546 | None | AOX1, XDH | 2.03131 |
[MF] GO:1901363 | heterocyclic compound binding | ADORA1, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, XDH | 2.02246 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R | 8.3836 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 | 6.6031 |
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA2, CA4, CA7, CA14 | 7.5621 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R | 4.706 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, AOX1, CYP1B1 | 4.2068 |
Metabolic pathways_Homo sapiens_hsa01100 | CBR1, AKR1B1, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH | 3.9626 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | SRC, MMP2, MMP9, ESR1, ESR2 | 4.11 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9 | 4.2068 |
Pathways in cancer_Homo sapiens_hsa05200 | AR, FLT3, MMP1, MMP2, MMP9, MET, IGF1R | 3.3157 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | CBR1, CYP1A2, CYP1A1, CYP1B1 | 3.4409 |
Adherens junction_Homo sapiens_hsa04520 | CSNK2A1, SRC, MET, IGF1R | 3.4409 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.474 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | CBR1, CYP1A2, CYP1A1, CYP1B1 | 3.3157 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | SRC, ESR1, ESR2 | 2.257 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP1A2, CYP1A1, AOX1 | 2.3589 |
Focal adhesion_Homo sapiens_hsa04510 | SRC, KDR, MET, IGF1R | 2.0129 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 2.149 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | SRC, KDR, MET, IGF1R | 1.9662 |
Endocytosis_Homo sapiens_hsa04144 | SRC, KDR, MET, IGF1R | 1.7597 |
Oocyte meiosis_Homo sapiens_hsa04114 | AR, PGR, IGF1R | 1.7781 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | PIM1, CYP1B1, MMP9, MET | 1.567 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, ADORA1 | 1.4535 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.4535 |
Ras signaling pathway_Homo sapiens_hsa04014 | KDR, MET, IGF1R | 1.2527 |
VEGF signaling pathway_Homo sapiens_hsa04370 | SRC, KDR | 1.426 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.4393 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | FLT3, MET | 1.376 |
Melanoma_Homo sapiens_hsa05218 | MET, IGF1R | 1.3646 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET | 1.376 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5 | 1.426 |
Tyrosine metabolism_Homo sapiens_hsa00350 | AOX1, TYR | 1.7781 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, PIM1 | 1.1545 |
Prostate cancer_Homo sapiens_hsa05215 | AR, IGF1R | 1.2253 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET | 1.1311 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2 | 1.218 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | PGR, IGF1R | 1.1685 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.8592 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP1A2, AOX1 | 1.376 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | ADORA3, ADORA1, NR3C1 | 1.101 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | SRC, MET | 1.3107 |
Serotonergic synapse_Homo sapiens_hsa04726 | APP, ALOX5 | 1.101 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.0227 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | KDR, MET, IGF1R | 0.9389 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | SRC, ESR1 | 1.0781 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.8236 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.7781 |
Hepatitis B_Homo sapiens_hsa05161 | SRC, MMP9 | 0.9462 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | MMP2, MMP9 | 1.0781 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | ADORA3, ADORA1 | 1.0737 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | ESRRB, IGF1R | 0.9594 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | PIM1, AOX1 | 0.902 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 0.9674 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | ADORA3, ADORA1 | 0.8831 |
cAMP signaling pathway_Homo sapiens_hsa04024 | ADORA1, PPARA | 0.7886 |
ErbB signaling pathway_Homo sapiens_hsa04012 | SRC | 0.5626 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1 | 0.392 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | SRC | 0.3805 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.4232 |
Viral carcinogenesis_Homo sapiens_hsa05203 | SRC | 0.3909 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.4142 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PPARA | 0.465 |
Tuberculosis_Homo sapiens_hsa05152 | SRC | 0.4232 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.5626 |
Platelet activation_Homo sapiens_hsa04611 | SRC | 0.513 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | SRC | 0.453 |
Insulin resistance_Homo sapiens_hsa04931 | PPARA | 0.5394 |
Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.4353 |
TNF signaling pathway_Homo sapiens_hsa04668 | MMP9 | 0.5394 |
Wnt signaling pathway_Homo sapiens_hsa04310 | CSNK2A1 | 0.4829 |
Measles_Homo sapiens_hsa05162 | CSNK2A1 | 0.4944 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | SRC | 0.5589 |
FoxO signaling pathway_Homo sapiens_hsa04068 | IGF1R | 0.4984 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | IGF1R | 0.5619 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | SRC | 0.4142 |
Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.5569 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1 | 0.5626 |
Cholinergic synapse_Homo sapiens_hsa04725 | ACHE | 0.5394 |
Gap junction_Homo sapiens_hsa04540 | SRC | 0.5626 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | IGF1R | 0.5541 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.5626 |
AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.5113 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.5569 |
Hepatitis C_Homo sapiens_hsa05160 | PPARA | 0.4984 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1 | 0.5626 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.5626 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.5068 |
Toxoplasmosis_Homo sapiens_hsa05145 | ALOX5 | 0.521 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1 | 0.5619 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.5619 |
Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.6007 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.5626 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | IGF1R | 0.6293 |
Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.5619 |
Glioma_Homo sapiens_hsa05214 | IGF1R | 0.6293 |
Long-term depression_Homo sapiens_hsa04730 | IGF1R | 0.6306 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.6115 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.6293 |
Renal cell carcinoma_Homo sapiens_hsa05211 | MET | 0.6291 |
Bile secretion_Homo sapiens_hsa04976 | CA2 | 0.6115 |
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | RORC | 0.6293 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.6293 |
Malaria_Homo sapiens_hsa05144 | MET | 0.7064 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.7102 |
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | AOX1 | 0.7082 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | XDH | 0.7124 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | NR3C2 | 0.7734 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.8551 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | CYP1A2 | 0.8684 |
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | AOX1 | 0.8684 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.8837 |
Circadian rhythm_Homo sapiens_hsa04710 | RORC | 0.8617 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.8831 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP1A2, XDH | 3.3042 |
Vitamin B6 metabolism_Homo sapiens_hsa00750 | AOX1 | 1.3379 |