TCM Prescription: Du Tong Pills



Prescription Description
Prescription IDTCMF3822
Pinyin NameDu Tong Wan
Chinese Name肚痛丸
English NameDu Tong Pills
Function Description腹痛
IndicationsAbdominal pain disorder, Dyspepsia, Enteritis
Disease ICD-11 Category SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ];
MD92 [Dyspepsia, 消化不良 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH512 Fructus amomi rotundus 豆蔻 TCMH512
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH158 Piper longum 荜茇 TCMH158 ITSAJ4247-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH2515 Papaver somniferum 罂粟壳 TCMH2515 ITSAD207-14
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH2208 Lindera strychnifolia 乌药 TCMH2208
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT113 OPRD1 Delta opioid receptor GPCR P41143
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT117 OPRK1 Kappa opioid receptor GPCR P41145
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT617 SENP6 Sentrin-specific protease 6 Protease Q9GZR1
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT789 PDE3A Phosphodiesterase 3A Hydrolase Q14432
TCMT790 PDE3B Phosphodiesterase 3B Hydrolase Q13370
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT792 PDE10A Phosphodiesterase 10A Hydrolase Q9Y233
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.9619
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.1027
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, BCL2, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, HSD17B2, IGF1R, MMP2, MMP9, OPRK1, OPRM1, PDE3A, PDE3B, POLB, SRC, TYR 10.6209
[BP] GO:0042221 response to chemical AKR1B1, AXL, BCL2, CA2, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP4, FLT3, HSD17B2, HTR2A, HTR2C, IGF1R, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, POLB, SRC, TYR 9.66057
[BP] GO:0010033 response to organic substance AKR1B1, AXL, BCL2, CA2, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, POLB, SRC, TYR 9.66057
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA3, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, HTR2A, HTR2C, KDR, OPRK1, OPRM1, PDE3A, POLB, SRC 8.58636
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, BCL2, CA3, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, KDR, OPRD1, OPRK1, POLB, SRC 8.34673
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HTR2C, PDE10A, PDE3A, PDE3B, PIM1, TBXAS1, TYR, XDH 7.93356
[BP] GO:0007200 None CHRM2, DRD1, DRD2, ESR1, HTR2A, HTR2C, OPRD1, OPRK1, OPRM1 7.84218
[BP] GO:0014070 response to organic cyclic compound BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FLT3, OPRK1, OPRM1, PDE3A, SRC, TYR 7.79521
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, F2, FABP4, FLT3, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, HTR7, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, POLA1, POLB, SRC, XDH 7.78446
[BP] GO:0033993 response to lipid AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FLT3, HSD17B2, OPRK1, OPRM1, SRC, TYR 6.92514
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 6.51486
[BP] GO:0007187 None CHRM2, CNR1, CNR2, DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 6.42358
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, CA2, CHRM2, CNR1, CNR2, DRD1, DRD2, ESR1, F2, HTR1A, HTR2A, HTR2C, HTR7, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, SIGMAR1, SRC 6.42358
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, OPRK1 6.1548
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD1, DRD2, F2, HTR2A, HTR2C, KDR, SRC 5.9655
[BP] GO:0007188 None CHRM2, CNR1, DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 5.82777
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, F2, FABP4, FLT3, HSD17B2, HTR1A, HTR2A, HTR2C, IGF1R, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, POLA1, POLB, SRC, TYR 5.81995
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CNR1, DRD1, DRD2, F2, HTR2A, HTR2C, KDR, OPRK1, SRC 5.62051
[BP] GO:0032501 multicellular organismal process AKR1B1, ALOX5, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRB, F2, FABP4, HSD17B2, HTR1A, HTR2A, HTR2C, HTR7, IGF1R, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, SRC, TYR 5.56991
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HTR1A, HTR2A, HTR2C, HTR7, IGF1R, KDR, MET, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, POLB, SIGMAR1, SRC 5.53832
[BP] GO:0007193 None CHRM2, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 5.52839
[BP] GO:0038003 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.42501
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FLT3, HSD17B1, HSD17B2, HTR1A, HTR2C, IGF1R, KDR, MET, MMP1, MMP2, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, SENP6, SRC, TBXAS1, TYR, XDH 5.34599
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2 5.29506
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F2, FLT3, HTR1A, HTR2A, HTR2C, IGF1R, KDR, MET, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, SRC, XDH 5.25331
[BP] GO:0009719 response to endogenous stimulus AKR1B1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FLT3, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, SRC 5.24069
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F2, FLT3, HTR1A, HTR2A, HTR2C, IGF1R, KDR, MET, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, SRC, XDH 5.14263
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC 4.9003
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SRC 4.88953
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F2, FLT3, HTR2A, HTR2C, KDR, MET, MMP9, OPRK1, OPRM1, SRC, XDH 4.88518
[BP] GO:0023056 positive regulation of signaling AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F2, FLT3, HTR2A, HTR2C, KDR, MET, MMP9, OPRK1, OPRM1, SRC, XDH 4.86382
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F2, FLT3, HTR2A, HTR2C, IGF1R, KDR, MET, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, SRC, XDH 4.86382
[BP] GO:0042592 homeostatic process AKR1B1, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, ESR1, F2, FABP4, FLT3, HTR2A, HTR2C, MET, POLA1, POLB, SRC 4.78949
[BP] GO:0099536 None CHRM2, CNR1, DRD1, DRD2, HTR2A, HTR2C, HTR7, OPRD1, OPRK1, OPRM1 4.78949
[BP] GO:0099537 None CHRM2, CNR1, DRD1, DRD2, HTR2A, HTR2C, HTR7, OPRD1, OPRK1, OPRM1 4.78949
[BP] GO:0071310 cellular response to organic substance AKR1B1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SRC 4.78599
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, DRD2 4.68839
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.67429
[BP] GO:0043269 regulation of ion transport BCL2, CA2, CA7, CNR1, DRD1, DRD2, F2, HTR1A, HTR2A, MMP9, OPRD1, OPRK1, OPRM1 4.60545
[BP] GO:0008152 metabolic process ACHE, AKR1B1, ALOX5, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FLT3, HSD17B1, HSD17B2, HTR1A, HTR2C, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, SENP6, SRC, TBXAS1, TYR, XDH 4.47673
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, HSD17B1, HSD17B2 4.45358
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.39002
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, DRD1, DRD2, FLT3, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, SRC, TYR 4.3601
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, ESRRA, F2, FLT3, HTR1A, HTR2A, IGF1R, KDR, MMP2, MMP9, OPRM1, PIM1, SRC, XDH 4.31714
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.31714
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2 4.26472
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, POLB, SRC, TYR 4.24526
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, HTR1A, TYR 4.22435
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, ESR1, FABP4, HSD17B1, HSD17B2, MET, PDE3A, TBXAS1 4.15857
[BP] GO:0032502 developmental process ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, HSD17B2, HTR2A, KDR, MET, MMP2, MMP9, PDE3A, PDE3B, PIM1, POLB, SIGMAR1, SRC, TYR 4.08836
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HTR1A, HTR2A, HTR2C, IGF1R, KDR, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, SRC, XDH 4.04663
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, HTR2A, HTR2C, IGF1R, KDR, MET, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, SRC, XDH 4.03189
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, DRD1, DRD2, FLT3, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, SRC, TYR 4.03189
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, ESR1, HTR7, OPRK1, OPRM1, SRC 4.03189
[BP] GO:0051716 cellular response to stimulus AKR1B1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, POLA1, POLB, SRC 4.03189
[BP] GO:0007268 None CHRM2, DRD1, DRD2, HTR2A, HTR2C, HTR7, OPRD1, OPRK1, OPRM1 3.94672
[BP] GO:0098916 None CHRM2, DRD1, DRD2, HTR2A, HTR2C, HTR7, OPRD1, OPRK1, OPRM1 3.94672
[BP] GO:2001023 None CNR1, DRD1, DRD2, HTR2A, MET, OPRK1 3.94672
[BP] GO:0048148 None DRD1, DRD2, HTR2A, OPRK1 3.93205
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DRD2, F2, FLT3, HTR2A, HTR2C, KDR, MET, OPRK1, OPRM1, SRC, XDH 3.92943
[BP] GO:0072523 None AOX1, PDE10A, PDE3A, PDE3B, XDH 3.84494
[BP] GO:0007631 None DRD1, DRD2, HTR2C, OPRD1, OPRK1, OPRM1 3.80112
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, HTR2A, MMP2, OPRD1, OPRK1, OPRM1, POLB, SRC, TYR 3.79768
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 3.769
[BP] GO:0019233 None CNR1, CNR2, OPRD1, OPRK1, OPRM1 3.74647
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, ESR1, FABP4, IGF1R, MET, MMP9, OPRM1, PIM1, SRC 3.72639
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, DRD2, ESR1, F2, FLT3, HTR1A, HTR2A, IGF1R, KDR, MMP2, MMP9, PIM1 3.71882
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 3.71761
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.67065
[BP] GO:0007210 None HTR1A, HTR2A, HTR2C, HTR7 3.67065
[BP] GO:0098664 None HTR1A, HTR2A, HTR2C, HTR7 3.67065
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 3.63044
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, PIM1, POLA1, SRC, TYR 3.59036
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, SIGMAR1, SRC, XDH 3.59036
[BP] GO:0009725 response to hormone AKR1B1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FLT3, OPRK1, PDE3B, SRC 3.56043
[BP] GO:0032879 regulation of localization ACHE, ADORA3, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F2, HTR1A, HTR2A, HTR2C, IGF1R, KDR, MET, MMP9, OPRD1, OPRK1, OPRM1, SRC 3.53486
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, AXL, BCL2, CA2, CHRM2, CNR1, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F2, HTR2A, HTR2C, KDR, MET, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, SRC, XDH 3.46302
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, ESR1, F2, FABP4, HTR2A, HTR2C, MET 3.44015
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, F2, OPRM1 3.43451
[BP] GO:0014059 None CNR1, DRD2, HTR2A, OPRK1 3.43045
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, DRD1, DRD2, HTR2A 3.40997
[BP] GO:0010562 positive regulation of phosphorus metabolic process BCL2, DRD1, DRD2, ESRRB, F2, FLT3, HTR2A, HTR2C, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.39252
[BP] GO:0045937 positive regulation of phosphate metabolic process BCL2, DRD1, DRD2, ESRRB, F2, FLT3, HTR2A, HTR2C, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.39252
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FLT3, HTR1A, HTR2A, HTR2C, IGF1R, KDR, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, SRC, XDH 3.37736
[BP] GO:0002209 None BCL2, DRD1, HTR1A, HTR2C 3.32653
[BP] GO:0001662 None BCL2, DRD1, HTR1A, HTR2C 3.32653
[BP] GO:0009987 cellular process ACHE, ADORA3, AKR1B1, ALOX5, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FLT3, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, HTR7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, SENP6, SIGMAR1, SRC, TBXAS1, TYR, XDH 3.31097
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, AURKB, AXL, BCL2, CA3, CSNK2A1, DRD1, DRD2, FLT3, HTR2C, IGF1R, KDR, MET, PDE10A, PDE3A, PDE3B, PIM1, POLB, SRC, XDH 3.30095
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, CNR2, DRD1, DRD2, ESR1, ESR2, HTR2A, IGF1R, MET, MMP9, OPRK1, OPRM1, PDE3B, SRC, XDH 3.28353
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, CNR2, DRD1, DRD2, ESR1, ESR2, HTR2A, IGF1R, MET, MMP9, OPRK1, OPRM1, PDE3B, SRC, XDH 3.26937
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, AXL, BCL2, CA2, CA3, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, F2, HTR1A, HTR2C, MMP2, MMP9, OPRD1, OPRK1, OPRM1, POLA1, POLB, SRC 3.25212
[BP] GO:0042327 positive regulation of phosphorylation BCL2, DRD2, ESRRB, F2, FLT3, HTR2A, HTR2C, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.25212
[BP] GO:0032496 response to lipopolysaccharide AXL, CNR1, CNR2, CYP1A1, CYP1A2, OPRK1, OPRM1, SRC 3.24599
[BP] GO:0043278 None CNR1, DRD2, OPRK1, OPRM1 3.24288
[BP] GO:0014072 None CNR1, DRD2, OPRK1, OPRM1 3.24288
[BP] GO:0042596 None BCL2, DRD1, HTR1A, HTR2C 3.24288
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, ESRRA, F2, FABP4, FLT3, HTR2A, HTR2C, KDR, MET, MMP2, MMP9, OPRK1, OPRM1, SRC, XDH 3.23595
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.23595
[BP] GO:0048583 regulation of response to stimulus AKR1B1, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, F2, FABP4, FLT3, HTR2A, HTR2C, IGF1R, KDR, MET, MMP2, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, SRC, XDH 3.23595
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, HTR2A, HTR2C, OPRM1 3.23595
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, SIGMAR1, SRC, XDH 3.22121
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.21419
[BP] GO:0007154 None AXL, BCL2, CHRM2, CNR1, DRD1, DRD2, ESR2, HTR2A, HTR2C, HTR7, OPRD1, OPRK1, OPRM1 3.17387
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, F2, FLT3, HSD17B2, KDR, MMP9, PIM1, POLB, SIGMAR1, SRC, TYR 3.17083
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, HTR2A, HTR2C, IGF1R, KDR, MET, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, SRC, XDH 3.1469
[BP] GO:0051952 None CNR1, DRD1, DRD2, HTR2A, OPRK1 3.11805
[BP] GO:0042325 regulation of phosphorylation BCL2, DRD1, DRD2, ESRRB, F2, FABP4, FLT3, HTR2A, HTR2C, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.10351
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MMP9, PDE3A, PIM1, SIGMAR1, SRC, XDH 3.10251
[BP] GO:0002237 response to molecule of bacterial origin AXL, CNR1, CNR2, CYP1A1, CYP1A2, OPRK1, OPRM1, SRC 3.08197
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, OPRK1, PDE3A, PDE3B, SRC 3.07838
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F2, FLT3, HTR2A, HTR2C, KDR, MET, MMP9, OPRK1, OPRM1, SRC, XDH 3.07644
[BP] GO:0007267 None CHRM2, CNR1, DRD1, DRD2, ESR2, HTR2A, HTR2C, HTR7, OPRD1, OPRK1, OPRM1 3.07613
[BP] GO:0006793 phosphorus metabolic process ACHE, AURKB, AXL, BCL2, CA3, CSNK2A1, DRD1, DRD2, FLT3, HTR2C, IGF1R, KDR, MET, PDE10A, PDE3A, PDE3B, PIM1, POLB, SRC, XDH 3.07169
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 3.06133
[BP] GO:0022414 reproductive process AKR1B1, AXL, BCL2, CNR1, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD17B2, MMP2, MMP9, OPRK1, OPRM1, PDE3A, SRC 3.05649
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, CNR1, CNR2, DRD1, DRD2, HTR2A 3.05353
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, CNR1, CNR2, DRD1, DRD2, HTR2A 3.05353
[BP] GO:0030534 None DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1 3.03479
[BP] GO:0001932 regulation of protein phosphorylation BCL2, DRD1, DRD2, F2, FABP4, FLT3, HTR2A, HTR2C, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 2.97473
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, HTR1A, TYR 2.95225
[BP] GO:0003008 None AKR1B1, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PDE3A, SRC, TYR 2.95225
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, OPRK1, OPRM1 2.94071
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, F2 2.90619
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.90619
[BP] GO:0007610 None BCL2, CNR1, DRD1, DRD2, HTR1A, HTR2A, HTR2C, OPRD1, OPRK1, OPRM1 2.87875
[BP] GO:0060359 None CNR1, DRD1, DRD2, OPRK1, OPRM1 2.87875
[BP] GO:0007208 None HTR2A, HTR2C 2.87875
[BP] GO:0031635 None OPRK1, OPRM1 2.87875
[BP] GO:0009115 None AOX1, XDH 2.87875
[BP] GO:0001934 positive regulation of protein phosphorylation BCL2, DRD2, F2, FLT3, HTR2A, HTR2C, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 2.85771
[BP] GO:0006195 None PDE10A, PDE3A, PDE3B, XDH 2.83904
[BP] GO:1903727 positive regulation of phospholipid metabolic process FLT3, HTR2A, HTR2C, SRC 2.83904
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.83904
[BP] GO:0006198 None PDE10A, PDE3A, PDE3B 2.83904
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 2.83904
[BP] GO:0003018 None DRD1, HTR1A, HTR2A, HTR7, PDE3A, SRC 2.83904
[BP] GO:0023052 None CHRM2, CNR1, DRD1, DRD2, ESR2, HTR2A, HTR2C, HTR7, OPRD1, OPRK1, OPRM1 2.7187
[BP] GO:0050433 None CNR1, DRD2, HTR2A, OPRK1 2.70074
[BP] GO:0009056 catabolic process ACHE, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP4, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, SRC, XDH 2.67481
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.67481
[BP] GO:0006939 None DRD1, DRD2, HTR2A, HTR7 2.67076
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, DRD1, ESR1, FLT3, OPRM1, PDE3A, SRC 2.65278
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 2.65278
[BP] GO:0051049 regulation of transport ACHE, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, DRD1, DRD2, F2, HTR1A, HTR2A, HTR2C, MMP9, OPRD1, OPRK1, OPRM1, SRC 2.61249
[BP] GO:0009214 None PDE10A, PDE3A, PDE3B 2.60691
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.59011
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, SRC 2.57908
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, SRC 2.57908
[BP] GO:0019216 regulation of lipid metabolic process CNR1, CYP1A1, F2, FLT3, HTR2A, HTR2C, PDE3B, SRC 2.5678
[BP] GO:0046883 regulation of hormone secretion CNR1, CYP19A1, DRD2, HTR1A, HTR2A, HTR2C, OPRK1 2.56654
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, F2, FLT3, IGF1R, KDR, MET, SENP6, SRC 2.5415
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, PDE3A 2.5356
[BP] GO:0007626 None DRD1, DRD2, HTR2C, OPRD1, OPRK1, OPRM1 2.5356
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.52305
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.52305
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, ESRRB, F2, HTR2A, KDR, MET, MMP9, OPRM1, PDE3A, PIM1, SRC 2.51534
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, HTR2C 2.50934
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD1, DRD2, HTR1A 2.50934
[BP] GO:0040012 regulation of locomotion ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, OPRK1, SRC 2.50152
[BP] GO:0046110 None AOX1, XDH 2.50026
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.50026
[BP] GO:0033602 None CNR1, DRD2 2.50026
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.50026
[BP] GO:0009187 None HTR2C, PDE10A, PDE3A, PDE3B 2.49673
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.47603
[BP] GO:0019220 regulation of phosphate metabolic process BCL2, DRD1, DRD2, ESRRB, F2, FABP4, FLT3, HTR2A, HTR2C, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 2.46386
[BP] GO:0051282 None DRD1, DRD2, F2, HTR2A, HTR2C 2.46386
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.4484
[BP] GO:0072347 None CNR1, DRD2, OPRK1, OPRM1 2.4484
[BP] GO:0051174 regulation of phosphorus metabolic process BCL2, DRD1, DRD2, ESRRB, F2, FABP4, FLT3, HTR2A, HTR2C, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 2.4322
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, OPRM1, SRC 2.43066
[BP] GO:0030334 regulation of cell migration ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, SRC 2.40633
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, DRD1, DRD2, HTR2A 2.40012
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.39488
[BP] GO:0048871 multicellular organismal homeostasis AKR1B1, DRD1, DRD2, HTR2A, MET 2.39383
[BP] GO:0043410 positive regulation of MAPK cascade DRD2, FLT3, HTR2A, HTR2C, KDR, OPRK1, OPRM1, SRC, XDH 2.39383
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, DRD1, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC 2.37961
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, F2, HTR2A, HTR2C 2.37918
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade DRD2, HTR2A, HTR2C, KDR, OPRM1, SRC 2.36988
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, DRD1, DRD2, ESR1, F2, FABP4, KDR, MET, OPRM1 2.36797
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, OPRD1 2.36797
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, MMP2, OPRD1, POLB, SRC 2.36703
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, ESR1, IGF1R, MET, MMP9, PDE3B, SRC, XDH 2.36703
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.36248
[BP] GO:0042391 None BCL2, CNR1, CNR2, DRD1, KDR, OPRD1, OPRM1, SRC 2.35696
[BP] GO:0042698 ovulation cycle AXL, OPRK1, OPRM1 2.35696
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.35696
[BP] GO:0051094 positive regulation of developmental process AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, ESRRB, HTR2A, HTR2C, KDR, OPRM1, PDE3A, PIM1, SRC 2.33236
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FLT3, HTR2A, HTR2C, SRC 2.33236
[BP] GO:0009166 None PDE10A, PDE3A, PDE3B, XDH 2.31922
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2 2.31196
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.30579
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, PDE3A 2.30572
[BP] GO:0003013 None DRD1, HTR1A, HTR2A, HTR7, PDE3A, SRC 2.30399
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, SRC 2.30399
[BP] GO:0050795 None CNR1, DRD2, HTR1A, HTR2A 2.30399
[BP] GO:0051881 regulation of mitochondrial membrane potential BCL2, KDR, OPRD1, SRC 2.30399
[BP] GO:0043207 response to external biotic stimulus AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, F2, OPRK1, OPRM1, SRC 2.28179
[BP] GO:0007198 None HTR1A, HTR7 2.28179
[BP] GO:0006145 None AOX1, XDH 2.28179
[BP] GO:0038171 None CNR1, CNR2 2.28179
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.28179
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, F2, HTR2A, HTR2C 2.27536
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.27178
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, FABP4, MET, PDE3A, TBXAS1 2.26412
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, SRC 2.24915
[BP] GO:0009314 response to radiation AURKB, BCL2, DRD1, DRD2, OPRK1, OPRM1, POLB, TYR 2.2338
[BP] GO:2000145 regulation of cell motility ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, SRC 2.2252
[BP] GO:1903530 regulation of secretion by cell ACHE, CNR1, CYP19A1, DRD2, HTR1A, HTR2A, HTR2C, OPRK1, OPRM1, SRC 2.21861
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, DRD1, ESR1, FLT3, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC 2.2149
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, AXL, CNR1, CYP1A1, DRD1, ESR1, OPRK1, OPRM1, SRC 2.21318
[BP] GO:1901292 None PDE10A, PDE3A, PDE3B, XDH 2.20593
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, DRD1, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC 2.20355
[BP] GO:0048585 negative regulation of response to stimulus BCL2, CNR1, CNR2, CYP19A1, DRD1, DRD2, ESR1, ESR2, F2, IGF1R, MET, MMP9, PDE3B, SRC, XDH 2.2021
[BP] GO:0031644 None HTR2C, OPRD1, OPRK1, OPRM1 2.18838
[BP] GO:0001975 None CNR2, DRD1, DRD2 2.18838
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9 2.18196
[BP] GO:0009607 response to biotic stimulus AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, F2, OPRK1, OPRM1, SRC 2.1533
[BP] GO:0009966 regulation of signal transduction AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, F2, FLT3, HTR2A, HTR2C, IGF1R, KDR, MET, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, SRC, XDH 2.14906
[BP] GO:1903725 regulation of phospholipid metabolic process FLT3, HTR2A, HTR2C, SRC 2.14873
[BP] GO:0034762 None BCL2, CA2, DRD1, DRD2, F2, MMP9, OPRK1, OPRM1 2.14213
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, DRD1, DRD2, ESR1, F2, HTR2A, HTR2C 2.13366
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, DRD2, HTR2A, MMP9 2.11431
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PDE3A, PIM1, SRC 2.11018
[BP] GO:0042755 None OPRD1, OPRK1, OPRM1 2.11018
[BP] GO:0021853 None DRD1, DRD2 2.11018
[BP] GO:1904936 None DRD1, DRD2 2.11018
[BP] GO:0010513 None HTR2A, HTR2C 2.11018
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AOX1, AURKB, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, ESR1, F2, FLT3, HTR1A, HTR2C, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, POLB, SENP6, SRC, TYR, XDH 2.11018
[BP] GO:0032845 None BCL2, DRD2, HTR2A, HTR2C, SRC 2.08351
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, POLB 2.08351
[BP] GO:0043408 regulation of MAPK cascade DRD2, FLT3, HTR2A, HTR2C, IGF1R, KDR, OPRK1, OPRM1, SRC, XDH 2.07477
[BP] GO:0042310 None HTR1A, HTR2A, HTR7 2.0722
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, DRD1, DRD2, ESR1, F2, HTR2A, HTR2C 2.0722
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, PDE10A, PDE3A, PDE3B, XDH 2.06305
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.05963
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.03382
[BP] GO:0009154 None PDE10A, PDE3A, PDE3B 2.03382
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CA3, CYP1B1, MMP9, SRC 2.02193
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.02193
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process AURKB, BCL2, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HTR2A, HTR2C, IGF1R, KDR, MET, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 2.01818
[BP] GO:0001763 morphogenesis of a branching structure BCL2, DRD2, ESR1, MET, SRC 2.01647
[BP] GO:0051046 None ACHE, CNR1, CYP19A1, DRD2, HTR1A, HTR2A, HTR2C, OPRK1, OPRM1, SRC 2.01195
[BP] GO:0031401 positive regulation of protein modification process BCL2, DRD2, F2, FLT3, HTR2A, HTR2C, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 2.0077
[BP] GO:0042220 None CNR1, DRD2, OPRM1 2.00438
[BP] GO:0009261 None PDE10A, PDE3A, PDE3B 2.00438
[BP] GO:0001659 None DRD1, DRD2, HTR2A 2.00438
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.00438
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, AXL, CA4, CHRM2, CNR1, CNR2, DRD1, DRD2, FLT3, HTR1A, HTR2A, HTR2C, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 4.9433
[CC] GO:0005887 integral component of plasma membrane ADORA3, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, FLT3, HTR1A, HTR2A, HTR2C, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 4.60545
[CC] GO:0044459 plasma membrane part ADORA3, AXL, CA2, CA4, CA9, CHRM2, CNR1, CNR2, DRD1, DRD2, F2, FLT3, HTR1A, HTR2A, HTR2C, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC 3.44015
[CC] GO:0098590 plasma membrane region CA2, CA4, CA9, CHRM2, CNR1, DRD1, DRD2, HTR2A, MET, OPRD1, OPRM1, SIGMAR1, SRC 2.72585
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX5, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, F2, FLT3, HSD17B2, HTR1A, HTR2A, HTR2C, HTR7, IGF1R, KDR, MET, MMP2, OPRD1, OPRK1, OPRM1, PDE10A, PDE3B, PIM1, SIGMAR1, SRC, TBXAS1, TYR 2.7187
[CC] GO:0044425 membrane part ACHE, ADORA3, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, F2, FLT3, HSD17B2, HTR1A, HTR2A, HTR2C, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SIGMAR1, SRC, TBXAS1, TYR 2.70625
[CC] GO:0005886 plasma membrane ACHE, ADORA3, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, DRD1, DRD2, ESR1, F2, FLT3, HTR1A, HTR2A, HTR2C, HTR7, IGF1R, KDR, MET, MMP2, OPRD1, OPRK1, OPRM1, PIM1, SRC 2.50589
[CC] GO:0043679 None CHRM2, DRD2, OPRD1, OPRK1 2.49673
[CC] GO:0044463 None AKR1B1, CA4, CA9, CHRM2, CNR1, DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC 2.46386
[CC] GO:0120038 None AKR1B1, CA4, CA9, CHRM2, CNR1, DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC 2.46386
[CC] GO:0043204 None CNR2, DRD2, OPRK1, OPRM1, PDE10A 2.43291
[CC] GO:0031253 None CA4, CA9, DRD1, DRD2, OPRD1, OPRM1, SRC 2.20593
[CC] GO:0044306 None CHRM2, DRD2, OPRD1, OPRK1 2.18838
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 20.2026
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, TBXAS1, TYR, XDH 14.0701
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 13.148
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.0818
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2C, HTR7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, SRC, TBXAS1, TYR, XDH 11.8707
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, HTR1A, HTR2A, HTR2C, HTR7, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, TBXAS1, TYR, XDH 10.6216
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 8.82213
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HTR1A, HTR2A, HTR2C, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 8.25702
[MF] GO:0004872 receptor activity ADORA3, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HTR1A, HTR2A, HTR2C, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 7.26974
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HTR1A, HTR2A, HTR2C, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 7.00523
[MF] GO:0004871 signal transducer activity ADORA3, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HTR1A, HTR2A, HTR2C, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 6.47037
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, F2, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, SENP6, SRC, TBXAS1, TYR, XDH 6.42358
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9 6.23808
[MF] GO:0046872 metal ion binding ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, TBXAS1, TYR, XDH 6.09611
[MF] GO:0099528 None CHRM2, HTR1A, HTR2A, HTR2C, HTR7, OPRM1 5.79374
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, FLT3, HTR2A, HTR2C, IGF1R, KDR, MET, PDE10A, PIM1, SIGMAR1, SRC 5.79374
[MF] GO:0030594 None CHRM2, DRD1, DRD2, HTR1A, HTR2A, HTR2C, HTR7, OPRM1 5.79374
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, XDH 5.79374
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR2A, HTR2C, HTR7 5.62051
[MF] GO:0004985 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.42501
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.29506
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, FLT3, HTR1A, HTR2A, HTR2C, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 5.25331
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, FLT3, HTR1A, HTR2A, HTR2C, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 5.25331
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.05943
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, TYR 4.95521
[MF] GO:0008227 None CHRM2, DRD2, HTR1A, HTR2A, HTR2C, HTR7 4.89816
[MF] GO:0043176 None HTR1A, HTR2A, HTR2C, HTR7 4.88953
[MF] GO:0051378 None HTR1A, HTR2A, HTR2C, HTR7 4.88953
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC, TBXAS1 4.2308
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC, TBXAS1 4.03434
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.03189
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, POLA1, SRC, TBXAS1, XDH 3.94672
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 3.84494
[MF] GO:0004930 None ADORA3, CHRM2, CNR1, CNR2, DRD1, DRD2, HTR1A, HTR2A, HTR2C, HTR7, OPRD1, OPRK1, OPRM1, SIGMAR1 3.77623
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2C, HTR7 3.77623
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, TYR 3.77623
[MF] GO:0004993 None HTR1A, HTR2A, HTR2C, HTR7 3.67065
[MF] GO:0099589 None HTR1A, HTR2A, HTR2C, HTR7 3.67065
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.46127
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.06034
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1 2.90619
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.87875
[MF] GO:0004119 None PDE3A, PDE3B 2.87875
[MF] GO:0071886 None HTR2A, HTR2C 2.87875
[MF] GO:0047555 None PDE10A, PDE3A, PDE3B 2.83904
[MF] GO:0004115 None PDE10A, PDE3A, PDE3B 2.748
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 2.64367
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 2.64367
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.52305
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.51671
[MF] GO:0004949 None CNR1, CNR2 2.50026
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB 2.40012
[MF] GO:0042923 None OPRD1, OPRK1, OPRM1 2.35696
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.28179
[MF] GO:0004114 None PDE10A, PDE3A, PDE3B 2.27178
[MF] GO:0004112 None PDE10A, PDE3A, PDE3B 2.2252
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AOX1, HSD17B1, HSD17B2, XDH 2.17943
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.11018


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 21.6544
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 OPRD1, CHRM2, HTR1A, OPRK1, HTR2C, OPRM1, HTR2A, F2, HTR7, CNR2, CNR1, ADORA3, DRD1, DRD2 10.9551
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.0384
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.0278
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, OPRM1, MMP9, ESR1, ESR2 4.7268
Serotonergic synapse_Homo sapiens_hsa04726 HTR7, CYP2D6, ALOX5, HTR1A, HTR2C, HTR2A 4.4905
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.1673
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9423
Morphine addiction_Homo sapiens_hsa05032 PDE10A, PDE3B, PDE3A, OPRM1, DRD1 3.9122
Gap junction_Homo sapiens_hsa04540 SRC, HTR2C, HTR2A, DRD1, DRD2 3.9423
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9423
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, PDE3B, PDE3A, HTR1A, DRD1, DRD2 3.3616
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, DRD2, MET, IGF1R 3.2548
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 2.7392
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2D6, CYP1A2, CYP1A1, CYP1B1 3.1119
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.1119
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR7, HTR2C, HTR2A, DRD1 2.7392
Purine metabolism_Homo sapiens_hsa00230 POLA1, PDE10A, PDE3B, PDE3A, XDH 2.7392
Metabolic pathways_Homo sapiens_hsa01100 POLA1, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, AKR1B1, TYR, CYP19A1, XDH 2.5311
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.5318
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 OPRD1, ADORA3, PDE3B, PDE3A 1.9961
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0812
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET 1.9427
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1718
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, AOX1 2.1161
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, KDR, BCL2, MET, IGF1R 1.7373
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.7747
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2C, HTR2A 1.7972
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9427
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.6874
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.6668
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 1.9543
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4931
Sphingolipid signaling pathway_Homo sapiens_hsa04071 OPRD1, ADORA3, BCL2 1.6317
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.4344
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.369
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, F2 1.1245
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PDE3B 1.369
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3233
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.369
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9488
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.1085
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0989
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PDE3B, IGF1R 1.0562
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2851
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2648
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0248
Renin secretion_Homo sapiens_hsa04924 PDE3B, PDE3A 1.3036
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9303
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2822
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1974
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9488
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.451
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0896
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.3199
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9488
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9488
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.8945
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8425
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8425
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.845
PPAR signaling pathway_Homo sapiens_hsa03320 FABP4, MMP1 1.2793
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6602
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.734
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.734
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.6602
HTLV-I infection_Homo sapiens_hsa05166 POLB 0.248
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6861
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.341
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3666
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.341
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4156
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3854
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4038
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4182
Insulin signaling pathway_Homo sapiens_hsa04910 PDE3B 0.4156
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4144
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4222
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4432
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4393
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4393
Axon guidance_Homo sapiens_hsa04360 MET 0.4346
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4706
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4938
Glucagon signaling pathway_Homo sapiens_hsa04922 PDE3B 0.4938
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5119
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5003
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.5161
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4836
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5003
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.4938
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5003
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5119
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5119
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5119
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5119
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5119
Peroxisome_Homo sapiens_hsa04146 XDH 0.5161
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5462
Complement and coagulation cascades_Homo sapiens_hsa04610 F2 0.5258
Bile secretion_Homo sapiens_hsa04976 CA2 0.5575
Glioma_Homo sapiens_hsa05214 IGF1R 0.5776
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5776
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5764
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5754
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9465
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5891
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5812
Shigellosis_Homo sapiens_hsa05131 SRC 0.5776
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.5906
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6432
Malaria_Homo sapiens_hsa05144 MET 0.654
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6602
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.657
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6602
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.7857
DNA replication_Homo sapiens_hsa03030 POLA1 0.7347
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7652
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7934
Base excision repair_Homo sapiens_hsa03410 POLB 0.7585
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7347
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7934
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8102
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1064
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.286


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)