Prescription Description
| Prescription ID | TCMF3822 |
| Pinyin Name | Du Tong Wan |
| Chinese Name | 肚痛丸 |
| English Name | Du Tong Pills |
| Function Description | 腹痛 |
| Indications | Abdominal pain disorder, Dyspepsia, Enteritis |
| Disease ICD-11 Category |
SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1)
]; MD92 [Dyspepsia, 消化不良 ]; 1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ]; |
| Human Tissues Associated with Indication | Intestine, Stomach |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH512 | Fructus amomi rotundus | 豆蔻 | TCMH512 | |
| TCMH1059 | Glycine max | 姜 | TCMH1059 | ITSAJ4675-14 |
| TCMH1803 | Amomum villosum | 砂仁 | TCMH1803 | ITSAD521-14 |
| TCMH158 | Piper longum | 荜茇 | TCMH158 | ITSAJ4247-14 |
| TCMH890 | Cortex magnoliae officinalis | 厚朴 | TCMH890 | ITSAM1591-14 |
| TCMH2515 | Papaver somniferum | 罂粟壳 | TCMH2515 | ITSAD207-14 |
| TCMH1742 | Cinnamomum cassia | 肉桂 | TCMH1742 | GQ255631 |
| TCMH2630 | Citrus aurantium | 枳实 | TCMH2630 | ITSAA1279-14 |
| TCMH1533 | Saussurea lappa | 木香 | TCMH1533 | |
| TCMH2208 | Lindera strychnifolia | 乌药 | TCMH2208 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT113 | OPRD1 | Delta opioid receptor | GPCR | P41143 |
| TCMT114 | CNR2 | Cannabinoid CB2 receptor | GPCR | P34972 |
| TCMT115 | CNR1 | Cannabinoid CB1 receptor | GPCR | P21554 |
| TCMT116 | OPRM1 | Mu opioid receptor | GPCR | P35372 |
| TCMT117 | OPRK1 | Kappa opioid receptor | GPCR | P41145 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
Showing 1 to 10 of 88 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1175 | Human immunodeficiency virus |
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1183 | Candida albicans SC5314 |
| TCMT1201 | Staphylococcus epidermidis ATCC 12228 |
| TCMT1208 | Escherichia coli K12 |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1212 | Verticillium dahliae |
| TCMT1218 | Staphylococcus aureus |
| TCMT1219 | Enterococcus |
Showing 1 to 10 of 47 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC | 2.59011 |
| [BP] GO:0001659 | None | DRD1, DRD2, HTR2A | 2.00438 |
| [BP] GO:0001662 | None | BCL2, DRD1, HTR1A, HTR2C | 3.32653 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 | 2.65278 |
| [BP] GO:0001763 | morphogenesis of a branching structure | BCL2, DRD2, ESR1, MET, SRC | 2.01647 |
| [BP] GO:0001932 | regulation of protein phosphorylation | BCL2, DRD1, DRD2, F2, FABP4, FLT3, HTR2A, HTR2C, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH | 2.97473 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | BCL2, DRD2, F2, FLT3, HTR2A, HTR2C, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH | 2.85771 |
| [BP] GO:0001975 | None | CNR2, DRD1, DRD2 | 2.18838 |
| [BP] GO:0002209 | None | BCL2, DRD1, HTR1A, HTR2C | 3.32653 |
| [BP] GO:0002237 | response to molecule of bacterial origin | AXL, CNR1, CNR2, CYP1A1, CYP1A2, OPRK1, OPRM1, SRC | 3.08197 |
Showing 1 to 10 of 321 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.369 |
| Adherens junction_Homo sapiens_hsa04520 | CSNK2A1, SRC, MET, IGF1R | 3.1119 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.4038 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, BCL2, PIM1 | 1.7747 |
| Alcoholism_Homo sapiens_hsa05034 | DRD1, DRD2 | 0.734 |
| Amphetamine addiction_Homo sapiens_hsa05031 | DRD1 | 0.5754 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.4393 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.6432 |
| Apoptosis_Homo sapiens_hsa04210 | BCL2 | 0.4156 |
| Arachidonic acid metabolism_Homo sapiens_hsa00590 | ALOX5, TBXAS1 | 1.3199 |
Showing 1 to 10 of 125 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples