TCM Prescription: Xin Nao Ning Capsule



Prescription Description
Prescription IDTCMF376
Pinyin NameXin Nao Ning Jiao Nang 
Chinese Name心脑宁胶囊
English NameXin Nao Ning Capsule
Function Description胸痹, 头痛, 眩晕, 症见：胸闷刺痛, 心悸不宁, 头晕目眩等, 以及冠心病, 脑动脉硬化见上述症状者
IndicationsVertigo disorder, Cerebral atherosclerosis, Coronary heart disease
Disease ICD-11 Category SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
BD55 [Asymptomatic stenosis of intracranial or extracranial artery, 颅内或颅外动脉无症状狭窄 ];
BA80.Z [Coronary atherosclerosis, unspecified site, 冠状动脉粥样硬化,未特指部位 ];
Human Tissues Associated with IndicationBrain, Heart
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2506 Ginkgo biloba 银杏叶 TCMH2506 ITSAJ4779-14
TCMH2306 Buxus microphylla 小叶黄杨 TCMH2306 GBVX1854-13
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH359 Litsea lancilimba merr. 大果木姜子 TCMH359
TCMH2309 Allium macrostemon 薤白 TCMH2309 ITSAL4510-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT340 GLRA1 Glycine receptor subunit alpha-1 Ion channel P23415
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT578 GLRA2 Glycine receptor subunit alpha-2 Ion channel P23416
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, APEX1, AXL, CA2, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GLRA1, GSK3B, HSD17B2, IGF1R, KCNH2, KDR, MMP2, MMP9, PPARA, PPARD, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 8.67805
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, FABP3, FABP4, HSD17B1, HSD17B2, MET, MIF, PPARA, PPARD 8.02101
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, GLRA1, GSK3B, HSD17B2, IGF1R, MMP2, MMP9, PPARA, PPARD, RORC, SLC6A4, SRC, TYR 7.63287
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, HSD17B1, HSD17B2, PPARD 7.63287
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GSK3B, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 7.47631
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GSK3B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PPARD, PTPN1, SRC, TERT, TOP2A, XDH 7.44255
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GSK3B, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TYR, XDH 7.44255
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, APEX1, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GLRA1, GSK3B, HSD17B2, IGF1R, KDR, MMP2, PPARA, PPARD, RORC, SLC6A4, SRC, TYR 7.36934
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLRA1, GSK3B, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 7.36934
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GSK3B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARD, PTPN1, SRC, TERT, TOP2A, XDH 7.35058
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, MIF, PIM1, PPARA, PPARD, TYR, XDH 7.19825
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PPARD, SLC6A4, SRC, TERT, XDH 6.84967
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, GLRA1, GSK3B, HSD17B1, HSD17B2, KCNH2, KDR, MET, MIF, PPARA, PPARD, SLC6A2, SLC6A4, SRC, TERT, XDH 6.84967
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GLRA1, GSK3B, IGF1R, KCNH2, KDR, MMP2, MMP9, PPARD, RORC, SLC6A4, SRC, TERT 6.83409
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GSK3B, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP2, PIM1, PPARA, PPARD, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TYR, XDH 6.83409
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GLRA1, GSK3B, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 6.7822
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GSK3B, IGF1R, KDR, MIF, MMP9, PIM1, PPARD, PTPN1, SRC, TERT, TOP2A, XDH 6.77304
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, GSK3B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PPARD, PTPN1, SRC, TERT 6.69941
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, GSK3B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARD, PTPN1, SRC, TERT 6.40379
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CA2, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GLRA1, GSK3B, HSD17B2, IGF1R, KCNH2, KDR, MIF, MMP12, MMP2, MMP9, PPARA, PPARD, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TYR 6.19753
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, GLRA1, KDR, MMP9, SRC, TERT 6.13058
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MIF, PPARA, PPARD 6.04523
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, APEX1, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GLRA1, GSK3B, IGF1R, KCNH2, KDR, MIF, MMP2, MMP9, PPARD, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A 5.83702
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, PPARD, RORC, SRC 5.75565
[BP] GO:0033993 response to lipid AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, PPARD, RORC, SLC6A4, SRC, TYR 5.75565
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, APEX1, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GLRA1, GSK3B, IGF1R, MMP2, PPARA, SLC6A4, SRC 5.69282
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, GSK3B, IGF1R, KDR, MIF, MMP9, PIM1, PPARD, PTPN1, SRC, TERT 5.68723
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GLRA1, GSK3B, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 5.68216
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, GLO1, GSK3B, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, PPARD, RORC, SLC6A4, SRC, TERT, TOP2A, TYR 5.67155
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.66901
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC, SRC 5.53466
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, GSK3B, HSD17B1, HSD17B2, PPARD, TYR, XDH 5.46084
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, KDR, MET, MIF, MMP12, MMP9, PPARD, PTPN1, SRC, TERT, XDH 5.46084
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, KDR, MET, MIF, MMP12, MMP9, PPARD, PTPN1, SRC, TERT, XDH 5.43793
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, GSK3B, MMP1, MMP12, MMP2, MMP9, PPARD, SRC, XDH 5.41234
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.32873
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GLRA1, GSK3B, IGF1R, KDR, MMP2, PPARD, RORC, SLC6A4, SRC 5.25521
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.15853
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF 5.12709
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, MIF, PPARA, PPARD 5.12309
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, MET, MIF, PPARA, PPARD 5.09777
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GSK3B, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 4.9959
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF 4.96457
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.86395
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC, SRC 4.84295
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, GLRA1, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, RORC, SLC6A2, SLC6A4, SRC, TYR 4.83026
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, ESR1, GLRA1, GSK3B, IGF1R, MMP2, MMP9, PPARD, RORC, SLC6A4, SRC 4.81104
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PPARD, TERT 4.81104
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, RORC 4.73618
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, PPARD, SRC, TYR 4.73618
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GSK3B, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, SLC6A4, SRC, TERT 4.71891
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PPARD, SRC, TERT 4.71007
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, APEX1, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, PPARA, SLC6A4, SRC 4.6363
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.61286
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.57643
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GLRA1, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARD, PTPN1, SLC6A4, SRC, TERT, XDH 4.48274
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PPARD, SRC, TERT 4.41116
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, PIM1, SRC 4.40072
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GLRA1, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARD, PTPN1, SLC6A4, SRC, TERT, XDH 4.38581
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ESR1, ESR2, GLRA1, GSK3B, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 4.31771
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ESR1, ESR2, GLRA1, GSK3B, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 4.30396
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, GSK3B, PPARA, RORC, SLC6A4, SRC, TOP2A 4.29369
[BP] GO:0014070 response to organic cyclic compound APEX1, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, RORC, SLC6A4, SRC, TYR 4.22334
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, MIF, PIM1, PPARA, PPARD, TYR 4.22334
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GSK3B, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 4.18716
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 4.17575
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 4.16465
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, KDR, MET, MIF, MMP12, MMP9, PPARD, PTPN1, SRC, TERT, XDH 4.079
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, PPARD 4.079
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CES1, CYP1A1, CYP1B1, GLRA1, KDR, SLC6A4, SRC 4.07839
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PPARD, SRC, TERT 4.0763
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PPARD, SRC, TERT 4.06344
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MIF 3.98927
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.98927
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 3.96434
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 3.90707
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, MIF, PIM1, PPARA, PPARD, TYR 3.78871
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.76499
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, GSK3B, KDR, MET, MIF, MMP12, MMP2, MMP9, PPARD, PTPN1, SRC, TERT, XDH 3.74838
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PPARD 3.72522
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CYP19A1, GSK3B, KCNH2, MIF, MMP12, PPARD, SLC6A4, SRC, TERT 3.72465
[BP] GO:0006082 organic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, MIF, PIM1, PPARA, PPARD, TYR 3.71811
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.71389
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 3.69853
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CYP19A1, ESR1, FABP4, GSK3B, IGF1R, MET, MIF, MMP12, MMP2, PPARA, PPARD, PTPN1, SRC, TERT, XDH 3.66539
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PPARD, SLC6A4, SRC, TERT 3.64598
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, CYP19A1, ESR1, ESR2, GSK3B, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, SRC, TERT, XDH 3.58331
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PPARD, SLC6A4, SRC, TERT 3.55863
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, PPARD 3.52654
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GSK3B, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.52654
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, GLRA1, KDR 3.48826
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, FABP3, GLRA1, KCNH2, KDR, SLC6A2, SLC6A4, SRC 3.46105
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APEX1, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, KCNH2, MET, SRC, TERT 3.41432
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, GLRA1, KCNH2, KDR, SRC 3.40392
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PPARD 3.39935
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, FABP3, FLT3, GLRA1, GSK3B, IGF1R, MMP2, PPARA, SLC6A4, SRC, TYR 3.33248
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PPARD, SLC6A4, SRC, TERT 3.32036
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 3.29955
[BP] GO:0043393 regulation of protein binding AURKB, GSK3B, MET, MMP9, PPARA, SRC, TERT 3.29955
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, ESR1, FLT3, MET, MIF, PIM1, PPARD, SRC, TYR 3.18202
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, PPARD 3.12583
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MIF, MMP9, PPARD, PTPN1, SRC, XDH 3.11321
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, AXL, CA2, CYP1B1, ESR1, ESRRA, ESRRB, GLRA1, GSK3B, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARD, SLC6A4, SRC, TERT, XDH 3.0956
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, GLRA1, PPARA, PPARD 3.07145
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, GLRA1, HSD17B2, KDR, MMP2, SLC6A4, SRC 3.04246
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, FABP3, FLT3, GLRA1, GSK3B, IGF1R, MMP2, PPARA, SLC6A4, SRC, TYR 3.04218
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, ESR1, FLT3, GLRA1, GSK3B, IGF1R, MMP2, SLC6A4, SRC 3.03144
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CES1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, MIF, PPARD 3.03134
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AXL, CYP1B1, FLT3, KDR, MET, MIF, PPARD, PTPN1, SRC, XDH 3.02563
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CA7, CYP19A1, GSK3B, KCNH2, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, SLC6A4, SRC, TERT 3.01185
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GLRA1, GSK3B, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TYR, XDH 3.0013
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, XDH 2.96215
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.94997
[BP] GO:0009115 None AOX1, XDH 2.87855
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.86071
[BP] GO:0022414 reproductive process AKR1B1, AXL, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, GLRA1, HSD17B2, MMP2, MMP9, PPARD, SLC6A4, SRC, TOP2A 2.84925
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GSK3B, HSD17B2, KDR, MMP9, PIM1, PPARA, PPARD, RORC, SRC, TYR 2.83972
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, CYP1A1, CYP1B1, ESR1, FLT3, RORC, SLC6A4, SRC 2.82232
[BP] GO:0010906 None ESRRB, GSK3B, PPARA, RORC, SRC 2.81725
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, PPARA, RORC, SRC 2.72217
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, MIF, PTPN1, SRC 2.7081
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.70318
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.70194
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, MIF, PPARD 2.68144
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, MIF, SLC6A4, SRC, TERT 2.67
[BP] GO:0048869 cellular developmental process ACHE, AXL, CDC25B, CES1, CYP1A1, ESR1, ESRRB, FABP4, FLT3, GLO1, GSK3B, KDR, MET, MIF, MMP2, MMP9, PPARD, RORC, SRC, TERT, TOP2A 2.6234
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.60843
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, PPARA, PPARD, PTPN1, SRC, TERT, XDH 2.60277
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.60277
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, MIF, MMP12, PPARD, SLC6A4, SRC 2.59686
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GSK3B, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, XDH 2.59576
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.56632
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, MET, PIM1, SRC 2.56464
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.56464
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, MIF, PPARD 2.56315
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.53943
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, GLRA1, GSK3B, IGF1R, MMP2, SLC6A4, SRC 2.51261
[BP] GO:0046110 None AOX1, XDH 2.48991
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.48991
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.48991
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, GSK3B, MIF, MMP2, MMP9, PPARA, PPARD, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TOP2A 2.44046
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, MIF, PPARD 2.43258
[BP] GO:0010675 None ESRRB, GSK3B, PPARA, RORC, SRC 2.40813
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1B1, PPARD, TYR 2.39094
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.38936
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.38936
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.3478
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.3478
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD17B1, HSD17B2 2.33737
[BP] GO:0040013 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, MIF, PPARD 2.32315
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, MMP2, PPARA, PPARD, SLC6A4, SRC, TERT, TYR 2.32189
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, GSK3B, PPARD, SRC, XDH 2.32161
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PPARD, TERT 2.31346
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, GLRA1, GSK3B, IGF1R, MMP2, SLC6A4, SRC 2.31107
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.30344
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.3023
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, ESR1, ESR2, GSK3B, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.29011
[BP] GO:0010038 response to metal ion CA2, CYP1A1, CYP1A2, FABP4, GLRA1, MMP9, TERT 2.26615
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 2.26541
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, PPARD, SRC, TERT 2.26334
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.26334
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, MET, PIM1, PPARD, PTPN1, SRC, XDH 2.2588
[BP] GO:0006145 None AOX1, XDH 2.25557
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.25557
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25557
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.23121
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GLRA1, GSK3B, IGF1R, KCNH2, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC 2.20925
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AURKB, CDC25B, CSNK2A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, GLO1, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 2.17024
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, AOX1, CYP19A1, CYP1A2, GSK3B, PPARD, XDH 2.15677
[BP] GO:0050730 None ADORA1, ADRA2A, FLT3, MIF, PTPN1, SRC 2.15084
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.15084
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, PPARA, PPARD, RORC, SRC, TERT, TOP2A 2.14527
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, IGF1R, MIF, PTPN1, SRC 2.13616
[BP] GO:0051098 regulation of binding AURKB, GSK3B, MET, MMP9, PPARA, SRC, TERT 2.1142
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GSK3B, IGF1R, KDR, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, XDH 2.10774
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, TERT 2.09569
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, GLRA1, MMP9 2.08407
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, GSK3B, IGF1R, PPARA, SRC 2.0784
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, KDR, MIF, SRC 2.06822
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, ESR2, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARD, PTPN1, SRC, TERT, XDH 2.06545
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, MET, PIM1, PPARD, PTPN1, SRC, XDH 2.06502
[BP] GO:0051172 None ADRA2A, APEX1, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, XDH 2.04658
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.04658
[BP] GO:1903532 None ACHE, CYP19A1, MIF, MMP12, PPARD, SLC6A4, SRC 2.03923
[BP] GO:0071396 cellular response to lipid AXL, ESR1, FLT3, PPARD, RORC, SLC6A4, SRC 2.03923
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, PPARA, PPARD, RORC, SRC, TERT, TOP2A 2.02664
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, CDC25B, ESRRB, FABP3, FLT3, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.02664
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, CDC25B, ESRRB, FABP3, FLT3, KDR, MIF, MMP9, PTPN1, SRC, XDH 2.02664
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.01497
[BP] GO:0003018 None ADORA1, ADRA2A, PPARD, SLC6A4, SRC 2.01467
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF 2.00121
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, CA1, CA2, CA4, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, GLRA1, GSK3B, HSD17B1, HSD17B2, KCNH2, KDR, MIF, MMP2, MMP9, PIM1, PTPN1, SLC6A4, SRC, TERT, TOP2A, TYR, XDH 2.17024
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, AOX1, APEX1, AURKB, AXL, CA1, CA2, CA4, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GLRA1, GSK3B, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 2.00121
[CC] GO:0005783 None ADORA1, APEX1, CA4, CES1, CES2, CYP19A1, FLT3, GLRA1, KDR, PTPN1, XDH 1.9986
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.96193
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, AURKB, CA4, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, GLO1, GLRA1, GSK3B, IGF1R, KDR, MMP12, MMP2, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 1.75574
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, GLO1, GLRA1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, TYR, XDH 16.1736
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GLRA1, GSK3B, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TYR, XDH 10.2318
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FLT3, GLO1, GSK3B, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, TYR, XDH 8.42731
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, GLO1, GLRA1, MMP1, MMP12, MMP2, MMP9, PPARA, PPARD, PTPN1, RORC 8.13651
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.02101
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, GLO1, GLRA1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TOP2A, TYR, XDH 7.48832
[MF] GO:0046872 metal ion binding ALOX5, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, GLO1, GLRA1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TOP2A, TYR, XDH 7.24033
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 6.84967
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 6.84967
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 6.40379
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7 5.75565
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FLT3, GLRA1, GSK3B, IGF1R, KDR, MET, PIM1, PPARA, PPARD, SLC6A4, SRC, TOP2A 5.15853
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.15853
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 4.97078
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH 4.96457
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B1, HSD17B2, TYR, XDH 4.96457
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 4.58862
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, GLO1 4.58862
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 4.19476
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.1905
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 3.98927
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GLRA1, IGF1R, KCNH2, KDR, MET, PPARA, PPARD, RORC 3.98927
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.83449
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MIF, MMP9, SLC6A4, TERT, TOP2A, TYR, XDH 3.70611
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.65577
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.60866
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GLRA1, IGF1R, KCNH2, KDR, MET, PPARA, PPARD, RORC 3.36157
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 3.34648
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, HSD17B2, XDH 3.21091
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GLRA1, IGF1R, KCNH2, KDR, MET, PPARA, PPARD, RORC 3.19868
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, MET, PIM1, SRC 3.18426
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 3.18426
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.15856
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, PPARA, PPARD, RORC 3.06453
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 2.9466
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GLRA1, IGF1R, KCNH2, KDR, MET, PPARA, PPARD, RORC 2.87855
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.87855
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.85876
[MF] GO:0008134 transcription factor binding APEX1, ESR1, ESRRB, FLT3, GSK3B, PIM1, PPARA, PPARD, SRC, TERT 2.82633
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B1, SRC, XDH 2.70318
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.61537
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.60277
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, MET, PIM1, SRC 2.56464
[MF] GO:0005330 None SLC6A2, SLC6A4 2.48991
[MF] GO:0047374 None CES1, CES2 2.48991
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.45824
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, MET, PIM1, SRC, TERT 2.30149
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KCNH2, KDR, MET, PIM1, SRC 2.27582
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.25557
[MF] GO:0032795 None ADORA1, ADRA2A 2.25557
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2C19, ESR1, ESR2, ESRRB, GSK3B, KCNH2, MET, MIF, PPARA, PTPN1, SLC6A4, SRC, TOP2A 2.23194
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, GLRA1, GSK3B, HSD17B1, IGF1R, KDR, MET, PIM1, PPARD, SRC, TOP2A, XDH 2.15825
[MF] GO:0052689 carboxylic ester hydrolase activity ACHE, CA1, CA2, CES1, CES2 2.15084
[MF] GO:0005504 None FABP3, FABP4, PPARD 2.14214
[MF] GO:0051059 None APEX1, GSK3B, PPARD 2.10145
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, AOX1, AXL, FLT3, KCNH2, PPARD, SLC6A4, TERT, TOP2A, TYR, XDH 2.08623
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.07505
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.00121


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.1082
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.1059
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.1089
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.2576
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.2576
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA, PPARD 4.2576
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9914
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, FLT3, MMP1, MMP2, MMP9, MET, IGF1R, PPARD 3.5797
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.8108
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9914
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP2C19, CYP19A1, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, CES1 3.2197
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC, ESR1, ESR2 3.1902
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, MET, IGF1R 2.594
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP2C19 3.0362
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1, PPARD 2.3438
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.8952
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 1.9763
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.594
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2006
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP2C19 2.1475
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.0978
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9614
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.7765
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PPARA 1.7423
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, CYP2C19, SLC6A4 1.724
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5563
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC, ESR1 1.6889
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GLRA1, ADORA3, ADORA1, ADRA2A 1.4936
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1, PPARD 1.5063
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, ESRRB, IGF1R 1.5063
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA2A 1.363
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, KDR, MET, IGF1R 1.2879
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.1287
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3856
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3486
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2925
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.363
Prostate cancer_Homo sapiens_hsa05215 GSK3B, IGF1R 1.1291
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.0706
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 1.1384
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9952
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0781
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2846
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1287
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2914
Melanogenesis_Homo sapiens_hsa04916 GSK3B, TYR 1.0706
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, CYP2C19 1.3459
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2174
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9662
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9662
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1 0.8993
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.7765
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA 0.9094
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8658
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDC25B 0.9485
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.9374
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA 0.8471
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7765
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B 0.8965
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.8262
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8965
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1 0.6899
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.7275
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.6946
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7423
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6889
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, TERT 0.5981
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2745
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9551
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3241
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3342
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3732
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3638
Influenza A_Homo sapiens_hsa05164 GSK3B 0.3732
Tuberculosis_Homo sapiens_hsa05152 SRC 0.373
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B 0.3817
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.4064
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3989
Platelet activation_Homo sapiens_hsa04611 SRC 0.4694
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4517
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4905
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B 0.4698
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4694
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4694
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4905
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.4589
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5068
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4721
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5096
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5168
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.5068
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5204
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5239
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5239
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5239
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5239
Gap junction_Homo sapiens_hsa04540 SRC 0.5239
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5204
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5204
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5204
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5239
Peroxisome_Homo sapiens_hsa04146 XDH 0.5324
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.5728
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5722
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5981
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5797
Glioma_Homo sapiens_hsa05214 IGF1R 0.5981
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5981
Bile secretion_Homo sapiens_hsa04976 CA2 0.5789
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5981
Colorectal cancer_Homo sapiens_hsa05210 GSK3B 0.5981
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5981
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5981
Shigellosis_Homo sapiens_hsa05131 SRC 0.5981
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.6419
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6247
Malaria_Homo sapiens_hsa05144 MET 0.6548
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6603
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6521
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6576
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7086
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7757
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.817
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8091
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8339
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.077
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9662
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2914


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)