TCM Prescription: Fu Fang Huang Qin Tablets



Prescription Description
Prescription IDTCMF3593
Pinyin NameFu Fang Huang Qin Pian
Chinese Name复方黄芩片
English NameFu Fang Huang Qin Tablets
Function Description喉痹, 口疮, 发热, 腹泻, 热淋, 疮疡
IndicationsHeat stranguria disorder, Common cold, Fever, Aphtha
Disease ICD-11 Category SA91 [Heat stranguria disorder (TM1), 热淋 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
MG26 [Fever of other or unknown origin, 其他或不明原因的发热 ];
DA01.10 [Oral aphthae or aphtha-like ulceration, 口腔阿弗他溃疡或阿弗他样溃疡 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH921 Polygonum cuspidatum 虎杖 TCMH921 ITSAI2369-14
TCMH298 Andrographis paniculata 穿心莲 TCMH298 ITSAO3492-14
TCMH686 Caulis mahoniae 功劳木 TCMH686
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 10.2389
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, ALOX15, AURKB, AXL, BCHE, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TNKS, TNKS2, XDH 8.29787
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCHE, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SRC, TYR 7.88228
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, PPARA, PTGS2, SRC, TYR 7.78007
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SRC, TYR 7.46192
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 7.44412
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 7.25116
[BP] GO:0033993 response to lipid ALPL, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, PTGS2, SRC, TYR 7.18079
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TNKS, TNKS2, XDH 7.03165
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TNKS, TNKS2, XDH 7.0258
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.01368
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.85806
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCHE, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 6.75774
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.67846
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 6.67846
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.47494
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCHE, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 6.47494
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCHE, BCL2, CA2, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, SRC, TNKS2, TYR 6.14791
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.09061
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, PPARA, PTGS2, SRC 5.92246
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.81109
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, AURKB, AXL, BCHE, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, SRC, TNKS, TNKS2, XDH 5.61789
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, XDH 5.61789
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC 5.58782
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, AURKB, AXL, BCHE, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, SRC, TNKS, TNKS2, XDH 5.52731
[BP] GO:0014070 response to organic cyclic compound ALPL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, PTGS2, SRC, TYR 5.47741
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 5.42693
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, XDH 5.39867
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, KDR, PIK3CA, PPARA, PTPRS, SRC, TYR 5.37147
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.31527
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.28053
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.05819
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2 4.99761
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.97271
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, BCHE, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TNKS2, TYR 4.84439
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, SRC 4.84439
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.80109
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, XDH 4.77475
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TNKS, TNKS2, XDH 4.74453
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.72052
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, HCAR2, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 4.70886
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TNKS, TNKS2, XDH 4.58721
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PIK3CA, PTGS2, SRC 4.54681
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.52834
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TNKS, TNKS2, XDH 4.489
[BP] GO:0042127 regulation of cell proliferation AKR1B1, BCHE, BCL2, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 4.33306
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR 4.33034
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC 4.27902
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 4.26432
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPRS, SRC, TNKS, XDH 3.93066
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TNKS, TNKS2, XDH 3.93066
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, SRC 3.93066
[BP] GO:0050896 response to stimulus ABCB1, ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TYR 3.90668
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCHE, BCL2, CA9, CYP1A1, CYP1B1, FABP3, KDR, PTGS2, SRC 3.86224
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.83501
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 3.82213
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.75606
[BP] GO:0006805 xenobiotic metabolic process BCHE, CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1 3.75606
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SRC, TYR 3.73009
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.73009
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPRS, SRC, TNKS, XDH 3.71141
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 3.71141
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPRS, SRC, TNKS, TNKS2, XDH 3.63035
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.62468
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, AXL, BCL2, CYP1B1, FLT3, KDR, MET, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.45577
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.44002
[BP] GO:0015711 organic anion transport ABCB1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.4086
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, SRC 3.37377
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 3.34559
[BP] GO:0048545 response to steroid hormone ALPL, BCHE, BCL2, CA2, FLT3, PTGS2, SRC 3.33797
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCHE, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 3.32881
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.31883
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, SRC 3.30606
[BP] GO:0001101 response to acid chemical AKR1B1, BCHE, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 3.30606
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.30606
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.30606
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.2983
[BP] GO:0033273 response to vitamin ALPL, BCHE, CYP1A1, PTGS2, TYR 3.22498
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.21753
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 3.20582
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.19915
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 3.19037
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 3.14277
[BP] GO:0031960 response to corticosteroid ALPL, BCHE, BCL2, FLT3, PTGS2, SRC 3.12659
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP1A1, CYP1A2, ESR1, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 2.99951
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.98251
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC, TNKS 2.95669
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, SRC, TNKS, TNKS2, XDH 2.9517
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 2.91608
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.90587
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.90541
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.88583
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, SRC 2.87293
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 2.86753
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B1, HSD17B2 2.86401
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 2.83148
[BP] GO:0044092 negative regulation of molecular function AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TNKS 2.78203
[BP] GO:0042592 homeostatic process AKR1B1, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC 2.78032
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, ESR1, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.78032
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.78032
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.78032
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.78032
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.77456
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.77456
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.77456
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 2.77118
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.75705
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.75061
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.75061
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.72914
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.72691
[BP] GO:0006820 anion transport ABCB1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.70163
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.69205
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, TYR 2.69205
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.60018
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.58565
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCHE, BCL2, CYP1A1, PTGS2, SRC, TYR 2.57344
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.56689
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.5543
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.54343
[BP] GO:0051896 regulation of protein kinase B signaling AXL, MET, PIK3CA, PIK3CB, SRC, XDH 2.53705
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.53705
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.53705
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.53133
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, ALOX15, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SRC, TNKS, TNKS2, XDH 2.52365
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.50305
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.50305
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.45909
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, SRC 2.4376
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.4376
[BP] GO:0010243 response to organonitrogen compound AKR1B1, BCHE, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.40626
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.39594
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.39594
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, KDR, MET, MMP9, SRC, TNKS, TNKS2 2.354
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TNKS 2.35278
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.35278
[BP] GO:0051384 response to glucocorticoid ALPL, BCHE, BCL2, FLT3, PTGS2 2.3517
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.35137
[BP] GO:0009987 cellular process ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCHE, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 2.31532
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, SRC 2.30158
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.29131
[BP] GO:0070213 None TNKS, TNKS2 2.29131
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.29131
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.27567
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.26603
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SRC, TNKS, TNKS2, XDH 2.2651
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.2389
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, SRC 2.23061
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.22735
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.22552
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, MET, PIK3CA, PIK3CB, SRC 2.20675
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, PIK3CB 2.18801
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.18801
[BP] GO:1901698 response to nitrogen compound AKR1B1, BCHE, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.18601
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.17079
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2 2.15885
[BP] GO:1901570 None ALOX15, ALOX5, PTGS1, PTGS2 2.15475
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGS1, PTGS2 2.15475
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.15475
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.1465
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MMP9, PTGS2, SRC, XDH 2.1465
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.1465
[BP] GO:0016477 cell migration AXL, CYP1B1, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.1465
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, PIK3CB 2.1291
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.12483
[BP] GO:0040011 locomotion AXL, CYP1B1, FUT7, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.1145
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.1145
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, BCHE, CBR1, CYP1A1, CYP1A2, CYP1B1 2.09811
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, AXL, BCL2, CA2, CA7, CYP19A1, HCAR2, MMP12, MMP9, PIK3CB, PPARA, PTGS2, SRC 2.09811
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling IGF1R, PIK3CA, PIK3CB 2.09405
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.09405
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, SRC 2.0774
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.0774
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.07698
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, PTGS2, SRC 2.02026
[BP] GO:0031667 response to nutrient levels ALPL, BCHE, BCL2, CYP1A1, PTGS2, SRC, TYR 2.00804
[BP] GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SRC 2.00804
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, SRC, TNKS 2.00804
[BP] GO:0080134 regulation of response to stress ABCB1, CYP19A1, ESR1, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPRS, SRC, XDH 2.00804
[CC] GO:0016020 membrane ABCB1, ACHE, ALOX15, ALOX5, ALPL, AXL, BCHE, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, HCAR2, HSD17B2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TNKS, TNKS2, TYR 2.75061
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, AURKB, BCHE, BCL2, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 1.90912
[CC] GO:0005641 nuclear envelope lumen ALOX5, BCHE 1.81323
[CC] GO:0044421 None ABCB1, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCHE, CA2, CA4, CBR1, FABP3, FABP4, MMP1, MMP12, MMP2, MMP9, NQO2, PTGS1, PTPRS, SRC, TUBB3, XDH 1.71211
[CC] GO:0044425 membrane part ABCB1, ACHE, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, HCAR2, HSD17B2, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPRS, SRC, TYR 1.40439
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCHE, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 12.9256
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AURKB, AXL, BCHE, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 11.408
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, TNKS, TYR, XDH 10.2389
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 8.29787
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.14447
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 5.33645
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AURKB, BCHE, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, TNKS, TNKS2, TYR, XDH 4.95908
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC 4.67902
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.67353
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 4.67353
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 4.489
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, TNKS 4.23297
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 4.18766
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 4.10064
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, TNKS, TNKS2, TYR, XDH 4.03595
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.90091
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 3.79515
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.73009
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.73009
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.37377
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.2983
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.19915
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.95514
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.9193
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.91198
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.88583
[MF] GO:0003990 acetylcholinesterase activity ACHE, BCHE 2.88583
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 2.84416
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.81102
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 2.78032
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.77456
[MF] GO:0043168 anion binding ABCB1, ALOX15, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TUBB3, XDH 2.72914
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.67688
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.60945
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.53705
[MF] GO:0004104 cholinesterase activity ACHE, BCHE 2.53705
[MF] GO:0036094 small molecule binding ABCB1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TUBB3, XDH 2.34098
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.26603
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.22735
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.1465
[MF] GO:0042802 identical protein binding ACHE, BCHE, BCL2, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, TYR, XDH 2.11773
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, NQO2 2.08677
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TUBB3, XDH 2.07851
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TUBB3, XDH 2.07804
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, PTGS1, PTGS2 2.00804


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.0822
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.945
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 9.7084
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.8239
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 5.8256
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.53
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 5.3659
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 5.2262
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.0993
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, PTGS1 5.0993
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.967
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET 4.967
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB 4.2208
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.6052
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.8395
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.8938
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.4135
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.6245
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.6653
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.6245
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.6245
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.6383
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.6196
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.6245
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 3.3723
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.5474
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.4147
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 3.0202
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 3.059
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 3.1432
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 3.0603
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, PTGS2, PTGS1 3.0573
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.9598
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 3.0202
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.9763
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 3.0202
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 3.0202
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.6256
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.6256
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.4249
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 2.2924
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, PIK3CB, PPARA 2.2924
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.6635
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.6728
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.7027
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.345
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 2.2571
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.6544
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.1432
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, IGF1R 2.2571
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.2924
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.9923
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.2924
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB, PPARA 2.1494
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 2.0539
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, BCL2, PIK3CB 2.0539
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 2.0283
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.9215
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.9706
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.95
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.9706
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.9112
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.8739
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.862
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.647
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.58
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.5358
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4161
Purine metabolism_Homo sapiens_hsa00230 XDH 0.43
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4409
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.3427
Phagosome_Homo sapiens_hsa04145 TUBB3 0.4704
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4962
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.7655
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 1.0035
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.1724
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, PIK3CB 1.1583
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 1.1352
Axon guidance_Homo sapiens_hsa04360 MET 0.5336
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.1856
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5423
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, PIK3CB 1.0347
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.9987
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.1583
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.3452
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.3702
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.356
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.3736
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.4352
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.4225
Melanogenesis_Homo sapiens_hsa04916 TYR 0.613
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.613
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.356
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.385
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.6232
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.613
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.6225
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.6405
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.6424
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.6424
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3 1.4575
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.6415
Peroxisome_Homo sapiens_hsa04146 XDH 0.6584
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.5952
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.5952
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.633
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.7018
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6998
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.647
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.6078
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.7149
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.7095
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.6078
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.6486
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.633
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.7169
Shigellosis_Homo sapiens_hsa05131 SRC 0.7371
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.7655
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.7557
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.7178
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.8119
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.7932
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.8202
Malaria_Homo sapiens_hsa05144 MET 0.8327
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.8674
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.9097
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.8459
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.9923
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.8508
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.8652
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.1592
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 2.1806
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 2.1189
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 2.0398
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.9559
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9987
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.3226
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 1.0558
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 1.0441
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.2925
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.4464


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)