TCM Prescription: Fu Fang Ge Qing Tablets



Prescription Description
Prescription IDTCMF3540
Pinyin NameFu Fang Ge Qing Pian
Chinese Name复方蛤青片
English NameFu Fang Ge Qing Tablets
Function Description咳嗽, 喘病, 肺胀
IndicationsLung distension disorder, Dyspnea
Disease ICD-11 Category SA82 [Lung distension disorder (TM1), 肺胀 (TM1) ];
MD11.5 [Dyspnoea, 呼吸困难 ];
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH641 Bufo melanostictus 干蟾 TCMH641 GBAP0011-06
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH60 Ginkgo biloba 白果 TCMH60 ITSAJ4779-14
TCMH2728 Aster tataricus 紫菀 TCMH2728 ITSAI2445-14
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH1656 Angelica decursiva 前胡 TCMH1656 ITSAN4164-14
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH907 Piper nigrum 胡椒 TCMH907 ITSAA3189-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT241 CHRNA7 Neuronal acetylcholine receptor protein alpha-7 subunit Ion channel P36544
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT340 GLRA1 Glycine receptor subunit alpha-1 Ion channel P23415
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT552 CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 Ion channel P32297
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT559 ADRB2 Beta-2 adrenergic receptor GPCR P07550
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT578 GLRA2 Glycine receptor subunit alpha-2 Ion channel P23416
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT629 ABCC1 Multidrug resistance-associated protein 1 Transporter P33527
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT642 ADRA1D Alpha-1d adrenergic receptor GPCR P25100
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT650 ADRA1B Alpha-1b adrenergic receptor GPCR P35368
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.6993
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.6993
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CHRNA3, CHRNA7, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD3, FABP3, FABP4, FLT3, GLRA1, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KCNH2, KDR, MET, PPARA, PPARD, PTGS2, SRC, TERT, TRPV1, XDH 16.2931
[BP] GO:0042221 response to chemical ABCB1, ADRA1A, ADRB2, AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, FABP3, FABP4, FLT3, GLRA1, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PPARA, PPARD, PTGS2, SRC, TERT, TRPV1, TYR 15.1843
[BP] GO:0097756 None ADORA1, ADRA1A, ADRA1B, ADRA1D, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 14.3399
[BP] GO:1901700 response to oxygen-containing compound ADRB2, AKR1B1, APEX1, APP, AXL, CA9, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, FABP3, GLRA1, HSD17B2, HTR1B, HTR5A, IDO1, IGF1R, MMP2, MMP9, NR3C1, PPARA, PPARD, PTGS2, SRC, TRPV1, TYR 12.3766
[BP] GO:0042493 response to drug ABCB1, ADRA1A, AKR1B1, APEX1, AXL, CA9, CHRNA3, CHRNA7, CNR2, CYP1A1, CYP1B1, DRD3, FABP3, GLRA1, HTR1B, HTR2A, HTR2B, HTR2C, KCNH2, KDR, NR3C1, PTGS2, SRC, TRPV1 12.2631
[BP] GO:0007187 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, CNR2, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 12.2631
[BP] GO:0003018 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2, SRC 11.8856
[BP] GO:0042310 None ADRA1A, ADRA1B, ADRA1D, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 11.8742
[BP] GO:0097746 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 11.7452
[BP] GO:0035296 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 11.7452
[BP] GO:0010033 response to organic substance ADRA1A, ADRB2, AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, FABP3, FABP4, FLT3, GLRA1, HSD17B2, HTR1B, HTR5A, IDO1, IGF1R, KDR, MMP2, NR3C1, PPARA, PPARD, PTGS2, SRC, TRPV1, TYR 11.5983
[BP] GO:0050880 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 11.4327
[BP] GO:0035150 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 11.4041
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, PPARD, PTGS2, TRPV1 11.3726
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AXL, CHRNA3, CHRNA7, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD3, FABP4, GLRA1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IDO1, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTGS2, SRC, TRPV1, TYR 11.0475
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, GLO1, HTR2B, HTR2C, IDO1, PIM1, PPARA, PPARD, PTGS2, TYR, XDH 10.9958
[BP] GO:0003013 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2, SRC 10.3692
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 10.0906
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 9.76044
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 9.43682
[BP] GO:0007188 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 9.24555
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, ADRA1D, AKR1B1, ALOX12, APP, CHRNA7, CSNK2A1, CYP1B1, DRD3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARD, PTGS2, SRC, TERT, XDH 9.1293
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PPARD, PTGS2, SRC, TERT, XDH 9.0595
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PPARD, PTGS2, SRC, TERT, XDH 9.03175
[BP] GO:0009719 response to endogenous stimulus ADRA1A, ADRB2, AKR1B1, APEX1, APP, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, FABP3, FLT3, GLRA1, HTR1B, HTR5A, IGF1R, MMP2, NR3C1, PPARA, PTGS2, SRC, TRPV1 8.9466
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, IDO1, PPARD, PTGS2, TYR, XDH 8.85355
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 8.85355
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, FABP3, FABP4, FLT3, GLRA1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 8.59911
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, ALOX12, APEX1, APP, AXL, CA12, CA2, CA7, CHRNA7, DRD3, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, KCNH2, MET, SRC, TERT, TRPV1 8.59111
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRB2, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, FABP3, FABP4, FLT3, GLRA1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, KCNH2, KDR, MMP12, MMP2, MMP9, NR3C1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, TYR 8.41498
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARD, PTGS2 8.41498
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, ADRB2, APP, CA2, CA7, CHRNA3, CHRNA7, CNR2, DRD3, HTR1B, HTR2A, PTGS2 8.33225
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, ADRB2, APP, CA2, CA7, CHRNA3, CHRNA7, CNR2, DRD3, HTR1B, HTR2A, PTGS2 8.33225
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PPARD 8.24731
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.07493
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 8.0479
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, GLRA1, KDR, MMP9, PTGS2, SRC, TERT 7.97293
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, IDO1, PPARA, PPARD, PTGS2 7.75328
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ADRB2, ALOX12, ALOX15, APEX1, APP, AXL, CA2, CA7, CHRNA3, CSNK2A1, CYP19A1, CYP1B1, DRD3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PPARA, PPARD, PTGS2, SRC, TERT, TRPV1 7.68289
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, ALOX15, APP, AXL, CHRNA7, CSNK2A1, CYP1B1, DRD3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PPARD, PTGS2, SRC, TERT, XDH 7.65337
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, APEX1, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, FABP3, FLT3, HTR1B, HTR5A, NR3C1, PPARA, PTGS2, SRC, TRPV1 7.60587
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, ALOX15, APP, AXL, CHRNA7, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, PPARD, PTGS2, SRC, XDH 7.38337
[BP] GO:0008284 positive regulation of cell proliferation ADRA1D, AKR1B1, ALOX12, CHRNA7, CSNK2A1, DRD3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARD, PTGS2, TERT 7.28741
[BP] GO:0090066 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, ALOX15, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 7.25694
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 7.19413
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.18047
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CNR2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, HTR1B, HTR5A, IDO1, NR3C1, PPARD, PTGS2, SRC, TYR 7.028
[BP] GO:1901698 response to nitrogen compound ADRB2, AKR1B1, APEX1, APP, CHRNA3, CHRNA7, CNR2, DRD3, FABP3, FLT3, GLRA1, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR 7.00184
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CHRNA7, CSNK2A1, CYP1B1, FLT3, GLO1, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 6.97129
[BP] GO:0003008 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, APP, CHRNA7, CNR2, CYP1B1, DRD3, GLRA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, KCNH2, PPARD, PTGS2, SRC, TRPV1, TYR 6.96617
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.96617
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, APP, CA2, CNR2, DRD3, GLRA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, SRC 6.82075
[BP] GO:0007193 None ADORA1, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 6.77317
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, FLT3, GLRA1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PPARD, PTGS2, SRC, TERT, XDH 6.7674
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, MET, PPARA, PPARD, PTGS2 6.71246
[BP] GO:0010243 response to organonitrogen compound ADRB2, AKR1B1, APEX1, APP, CHRNA7, CNR2, DRD3, FABP3, FLT3, GLRA1, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR 6.70522
[BP] GO:0007154 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRNA3, DRD3, GLRA1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2, TRPV1 6.6419
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, FLT3, GLRA1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PPARD, PTGS2, SRC, TERT, XDH 6.6353
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, GLRA1, HTR1B, KCNH2, KDR, NR3C1, PTGS2, SRC, TRPV1 6.56131
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CHRNA3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, PPARD 6.51662
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB2, AKR1B1, APP, AURKB, CA2, CHRNA7, CYP1A1, DRD3, HTR1B, HTR2A, HTR2B, MMP2, PPARA, PPARD, PTGS2, SRC, TERT, TRPV1, TYR 6.44865
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, ALOX15, APP, AXL, CHRNA7, CSNK2A1, CYP1B1, DRD3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IDO1, KDR, MET, MMP12, MMP2, MMP9, PPARD, PTGS2, SRC, TERT, XDH 6.44794
[BP] GO:0070887 cellular response to chemical stimulus ADRB2, AKR1B1, ALOX15, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GLRA1, HTR1B, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PPARD, PTGS2, SRC, TERT, TRPV1 6.43585
[BP] GO:0023052 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRNA3, DRD3, GLRA1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, KCNH2 6.43197
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRB2, AKR1B1, ALOX12, APEX1, APP, AURKB, AXL, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, FABP3, FABP4, GLO1, GLRA1, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 6.33284
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 6.25235
[BP] GO:0007267 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRNA3, DRD3, GLRA1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 6.24073
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, CNR2, HTR1B 6.24073
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, FLT3, HTR1B, HTR5A, NR3C1, PTGS2, SRC, TRPV1, TYR 6.20952
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, ALOX15, APP, AURKB, AXL, CHRNA7, CSNK2A1, CYP1B1, DRD3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP9, PPARD, PTGS2, SRC, XDH 6.13085
[BP] GO:0048878 chemical homeostasis ADRA1A, ADRA1B, ADRA1D, AKR1B1, ALOX12, APP, CA12, CA2, CA7, CHRNA7, DRD3, FABP3, FABP4, HTR2A, HTR2B, HTR2C, KCNH2, MET, TRPV1 6.12179
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARD, PTGS2, SRC, TERT 6.07744
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, IDO1, PIM1, PPARA, PPARD, PTGS2, TYR 5.9649
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADRB2, ALOX15, APP, AXL, CA2, CA7, CHRNA3, CYP19A1, DRD3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, KCNH2, MMP12, MMP9, PPARA, PPARD, PTGS2, SRC, TERT, TRPV1 5.95695
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.9496
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CHRNA7, CNR2, CYP1A1, CYP1B1, DRD3, GLRA1, HTR1B, HTR1D, KDR, SRC 5.92557
[BP] GO:0050795 None ADORA1, DRD3, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.92557
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARD, PTGS2, SRC, TERT 5.9059
[BP] GO:0006940 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRNA3, PTGS2 5.88495
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD3, HTR1A, PPARD, TYR 5.78693
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD3, HTR2A, HTR2B, HTR2C, KDR, SRC, TRPV1 5.74457
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD3, FABP3, PPARA, PPARD, TRPV1 5.74457
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRB2, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, FABP3, FABP4, GLO1, GLRA1, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 5.73633
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, HTR2B, IDO1, IGF1R, KDR, MMP9, PIM1, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 5.69264
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, CHRNA7, FLT3, HTR2A, HTR2B, HTR2C, KDR, SRC, XDH 5.65626
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRNA3, DRD3, GLRA1, HTR2A, HTR2C, KCNH2, PTGS2, TRPV1 5.57486
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, ADRA1B, ADRA1D, ADRB2, ALOX12, APP, AXL, CA2, CHRNA7, CYP1B1, DRD3, HTR2A, HTR2B, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TERT, TRPV1 5.54778
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.53336
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 5.51779
[BP] GO:0007268 None CHRNA3, DRD3, GLRA1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.44292
[BP] GO:0098916 None CHRNA3, DRD3, GLRA1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.44292
[BP] GO:0006811 None ABCB1, ADRA1A, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRNA3, CHRNA7, DRD3, FABP3, GLRA1, HTR2A, HTR2B, HTR2C, KCNH2, PPARA, PPARD, TRPV1 5.40808
[BP] GO:0007610 None APP, CHRNA3, CHRNA7, DRD3, GLRA1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IDO1, PPARA, PTGS2, TRPV1 5.38593
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, IDO1, PIM1, PPARA, PPARD, PTGS2, TYR 5.3796
[BP] GO:0099536 None CHRNA3, DRD3, GLRA1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.35893
[BP] GO:0099537 None CHRNA3, DRD3, GLRA1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.35893
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, ADRB2, APP, CA2, CA7, CHRNA7, PTGS2 5.35893
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD3, FABP3, GLRA1, PPARA, PPARD, TRPV1 5.35198
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.3432
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CBR1, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GLO1, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TYR 5.33831
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SRC 5.31553
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, IDO1, PIM1, PPARA, PPARD, PTGS2, TYR 5.28728
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, HTR2B, IDO1, IGF1R, KDR, MMP9, PIM1, PPARD, PTGS2, SRC, TERT 5.28585
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, APP, AXL, CA1, CA2, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP1B1, DRD3, FLT3, GLRA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARD, SRC, TRPV1 5.28585
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, CHRNA3, CHRNA7, DRD3, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PPARA, PTGS2, SRC, XDH 5.27999
[BP] GO:0006939 None ADRA1A, HTR1D, HTR2A, HTR2B, HTR7, TRPV1 5.27796
[BP] GO:0071310 cellular response to organic substance ADRB2, AKR1B1, ALOX15, APEX1, APP, AXL, CYP1A1, CYP1B1, FABP4, FLT3, GLRA1, HTR1B, IGF1R, KDR, MMP2, NR3C1, PPARD, PTGS2, SRC, TRPV1 5.22279
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, CHRNA3, CHRNA7, DRD3, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PPARA, PTGS2, SRC, XDH 5.22223
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PPARD, PTGS2, SRC, TERT, XDH 5.18027
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, ALOX12, APP, AXL, CA2, CHRNA3, CHRNA7, CYP1B1, DRD3, GLRA1, HTR2A, HTR2B, HTR2C, IDO1, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARD, PTGS2, SRC, TERT, TRPV1, XDH 5.1416
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 5.13289
[BP] GO:0050801 ion homeostasis ADRA1A, ADRA1B, ADRA1D, APP, CA12, CA2, CA7, CHRNA7, DRD3, FABP3, HTR2A, HTR2B, HTR2C, KCNH2, TRPV1 5.13119
[BP] GO:0042391 None ADORA1, ADRA1A, ADRB2, APP, CHRNA3, CHRNA7, CNR2, GLRA1, KCNH2, KDR, SRC, TRPV1 5.09174
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, DRD3, HTR1D, IGF1R, KDR, MET, MMP9, PPARD, PTGS2, SRC, TERT 5.06507
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, APP, CHRNA7, HTR2A, HTR2B, HTR2C, KDR, SRC 4.9208
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, ADRB2, APP, CA2, CA7, CHRNA3, DRD3, HTR1A, HTR1B, HTR2A, KCNH2, MMP9, PTGS2 4.82519
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, CHRNA7, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, SRC, XDH 4.75992
[BP] GO:1901652 response to peptide ADRB2, AKR1B1, APEX1, APP, CHRNA7, FABP3, IGF1R, PPARA, PTGS2, SRC, TRPV1 4.75657
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, CHRNA3, CHRNA7, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PTGS2, SRC, XDH 4.70772
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.69593
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADRB2, APP, AXL, CA2, CYP19A1, DRD3, HTR2B, KCNH2, MMP12, PPARD, PTGS2, SRC, TERT, TRPV1 4.60682
[BP] GO:0045907 None ADRA1A, ADRA1B, ADRA1D, HTR2A, PTGS2 4.60682
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SRC 4.60084
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, HTR1B, HTR2A, PTGS2 4.5825
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, ADRA1B, ADRA1D, APP, CA12, CA2, CA7, CHRNA7, DRD3, HTR2A, HTR2B, HTR2C, KCNH2, TRPV1 4.56339
[BP] GO:0001994 None ADRA1A, ADRA1B, ADRA1D 4.52184
[BP] GO:1901701 cellular response to oxygen-containing compound ADRB2, AKR1B1, APEX1, APP, AXL, CYP1B1, GLRA1, IGF1R, MMP2, MMP9, NR3C1, PPARD, PTGS2, SRC, TRPV1 4.52184
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.52184
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, CHRNA3, CHRNA7, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PTGS2, SRC, XDH 4.52184
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, CHRNA3, CHRNA7, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PTGS2, SRC, XDH 4.52184
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PPARD, PTGS2 4.5014
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, FABP3, FABP4, FLT3, GLO1, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, TYR, XDH 4.4881
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, CHRNA3, CHRNA7, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PTGS2, SRC, XDH 4.47499
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARD, PTGS2, SRC, TERT 4.39698
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD3, HTR2A, HTR2B, HTR2C, KDR, PTGS2, SRC, TRPV1 4.35933
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.3192
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.3192
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 4.31342
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB2, AKR1B1, ALOX12, HTR2A, MET, TRPV1 4.28706
[BP] GO:0051716 cellular response to stimulus ADRB2, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GLRA1, HTR1B, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1 4.2864
[BP] GO:0071417 cellular response to organonitrogen compound ADRB2, AKR1B1, APEX1, APP, GLRA1, HTR1B, IGF1R, MMP2, PTGS2, SRC, TRPV1 4.2864
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, FABP4, GLRA1, MMP9, PTGS2, TERT 4.2126
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2, TERT 4.18671
[BP] GO:0071502 None HTR1B, HTR2B, TRPV1 4.16989
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.16989
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, FABP3, FABP4, FLT3, GLO1, GLRA1, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 4.13333
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARD, PTGS2, SRC, TERT 4.08287
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PPARD, PTGS2, TERT 4.06968
[BP] GO:0001666 response to hypoxia ADORA1, CHRNA7, CYP1A1, MMP2, PPARA, PPARD, PTGS2, SRC, TERT 4.01444
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CES2, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, FABP3, FABP4, FLT3, GLO1, GLRA1, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, TYR, XDH 4.00428
[BP] GO:1901699 cellular response to nitrogen compound ADRB2, AKR1B1, APEX1, APP, GLRA1, HTR1B, IGF1R, MMP2, PTGS2, SRC, TRPV1 3.96806
[BP] GO:0003012 None ADORA1, ADRA1A, GLRA1, HTR1D, HTR2A, HTR2B, HTR7, KCNH2, TRPV1 3.95191
[BP] GO:0051046 None ACHE, ADORA1, CHRNA3, CYP19A1, DRD3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, PPARD, SRC, TRPV1 3.94147
[BP] GO:0071880 None ADRA1A, ADRA1B, ADRA1D, ADRB2 3.94147
[BP] GO:0055080 cation homeostasis ADRA1A, ADRA1B, ADRA1D, APP, CA2, CA7, CHRNA7, DRD3, HTR2A, HTR2B, HTR2C, KCNH2, TRPV1 3.93146
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CHRNA7, CYP1A1, MMP2, PPARA, PPARD, PTGS2, SRC, TERT 3.92179
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, AURKB, CHRNA3, CHRNA7, CSNK2A1, DRD3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 3.90854
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.90846
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.90846
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, CHRNA3, CHRNA7, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PPARA, PTGS2, SRC, XDH 3.90509
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, PPARD 3.89597
[BP] GO:0007200 None ADRA1A, ADRA1B, ADRA1D, HTR2A, HTR2B, HTR2C 3.88908
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, APP, CHRNA7, HTR2A, HTR2B, HTR2C, KDR, SRC 3.84918
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, CHRNA3, CHRNA7, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PTGS2, SRC, XDH 3.84661
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD3, HTR1B, HTR2A, KCNH2, MMP9, PTGS2 3.83032
[BP] GO:0043393 regulation of protein binding ADRB2, APP, AURKB, MET, MMP9, PPARA, SRC, TERT 3.80842
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 3.79978
[BP] GO:0019933 None ADRA1A, ADRA1B, ADRA1D, ADRB2, DRD3, HTR5A 3.78584
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, IDO1, MMP1, MMP12, MMP2, MMP9, PPARD, SRC, XDH 3.77576
[BP] GO:0008283 cell proliferation ABCB1, ACHE, ADRA1B, ADRA1D, AURKB, CYP1A1, FLT3, HTR1A, MET, PIM1, PPARD, SRC, TYR 3.77441
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, GLRA1, MMP9, PTGS2 3.7012
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARD, PTGS2, SRC, TERT 3.70002
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.70002
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.70002
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.70002
[BP] GO:0006936 None ADRA1A, GLRA1, HTR1D, HTR2A, HTR2B, HTR7, KCNH2, TRPV1 3.68825
[BP] GO:0009266 None ADORA1, ADRB2, HTR1B, HTR2A, HTR2B, PTGS2, TRPV1 3.67368
[BP] GO:0070482 response to oxygen levels ADORA1, CHRNA7, CYP1A1, MMP2, PPARA, PPARD, PTGS2, SRC, TERT 3.66496
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.66496
[BP] GO:0071875 None ADRA1A, ADRA1B, ADRA1D, ADRB2 3.66496
[BP] GO:0030003 cellular cation homeostasis ADRA1A, ADRA1B, ADRA1D, APP, CA2, CA7, CHRNA7, DRD3, HTR2A, HTR2B, HTR2C, TRPV1 3.66329
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, ADRA1B, ADRA1D, APP, CHRNA7, DRD3, HTR2A, HTR2B, HTR2C, TRPV1 3.61182
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CHRNA3, CYP19A1, DRD3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, PPARD, SRC 3.6022
[BP] GO:0071495 cellular response to endogenous stimulus ADRB2, AKR1B1, APEX1, APP, FLT3, GLRA1, HTR1B, IGF1R, MMP2, NR3C1, PTGS2, SRC, TRPV1 3.59704
[BP] GO:0044237 cellular metabolic process ACHE, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TYR, XDH 3.58858
[BP] GO:0019935 None ADRA1A, ADRA1B, ADRA1D, ADRB2, DRD3, HTR5A 3.583
[BP] GO:0006873 cellular ion homeostasis ADRA1A, ADRA1B, ADRA1D, APP, CA2, CA7, CHRNA7, DRD3, HTR2A, HTR2B, HTR2C, TRPV1 3.56863
[BP] GO:0055074 calcium ion homeostasis ADRA1A, ADRA1B, ADRA1D, APP, CHRNA7, DRD3, HTR2A, HTR2B, HTR2C, TRPV1 3.5029
[BP] GO:0006937 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRNA3, PTGS2 3.49488
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, ADRA1B, ADRA1D, APP, CHRNA7, DRD3, HTR2A, HTR2B, HTR2C, TRPV1 3.4578
[BP] GO:0019229 None ADRA1A, ADRA1B, ADRA1D, HTR2A, PTGS2 3.44786
[BP] GO:0044236 multicellular organism metabolic process ADRB2, MMP1, MMP12, MMP2, MMP9, TRPV1 3.44614
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PPARD 3.42465
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, AURKB, CHRNA3, CHRNA7, DRD3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 3.42465
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, ADRA1B, ADRA1D, ADRB2, DRD3, HTR2B, HTR5A, KDR 3.42465
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, CHRNA3, CHRNA7, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PTGS2, SRC, XDH 3.42361
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, AURKB, CHRNA3, CHRNA7, CSNK2A1, DRD3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 3.41215
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.40933
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, GLRA1, MMP9, PTGS2 3.32887
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.32887
[BP] GO:0060402 None ADRA1A, HTR2A, HTR2B, HTR2C, TRPV1 3.32887
[BP] GO:1904645 response to amyloid-beta ADRB2, APP, CHRNA7, IGF1R 3.30695
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, ADRA1B, ADRA1D, APP, CHRNA7, DRD3, HTR2A, HTR2B, HTR2C, TRPV1 3.29573
[BP] GO:0006805 xenobiotic metabolic process CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 3.28678
[BP] GO:0001659 None ADORA1, ADRB2, HTR2A, TRPV1 3.25323
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.23181
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.23181
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB2, AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CHRNA7, CNR2, CYP1A1, CYP1A2, CYP1B1, HTR1A, HTR2C, IDO1, MMP2, MMP9, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1 3.21629
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD3, IDO1 3.21481
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, IDO1 3.18511
[BP] GO:0060079 None ADORA1, CHRNA3, CHRNA7, GLRA1, TRPV1 3.18511
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, GLRA1, KDR 3.17299
[BP] GO:1903524 None ADRA1A, ADRA1B, ADRA1D, HTR2A, PTGS2 3.15789
[BP] GO:0006775 fat-soluble vitamin metabolic process CBR1, CYP1A1, CYP3A4, PPARD 3.15789
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, ADRB2, CNR2, DRD3, GLRA1, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, SRC, TERT, XDH 3.11564
[BP] GO:0002031 None DRD3, HTR1B, HTR2B 3.11235
[BP] GO:0045987 None ADRA1A, ADRA1B, ADRA1D, PTGS2 3.11114
[BP] GO:0007189 None ADRA1A, ADRA1B, ADRA1D, ADRB2, DRD3 3.10729
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, ADRA1B, ADRA1D, APP, CA2, CA7, CHRNA7, DRD3, HTR2A, HTR2B, HTR2C, TRPV1 3.10729
[BP] GO:0055065 metal ion homeostasis ADRA1A, ADRA1B, ADRA1D, APP, CHRNA7, DRD3, HTR2A, HTR2B, HTR2C, KCNH2, TRPV1 3.10729
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, ADRB2, CNR2, DRD3, GLRA1, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, SRC, TERT, XDH 3.10729
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, ADRA1A, ADRB2, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRNA3, CHRNA7, DRD3, FABP3, GLRA1, HTR1B, HTR2A, HTR2B, HTR2C, KCNH2, MMP12, MMP9, PPARA, PPARD, SRC, TERT, TRPV1, XDH 3.10248
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PPARD 3.09136
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, APP, CYP1A1, CYP1B1, FLT3, NR3C1, PTGS2, SRC, TRPV1 3.09136
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, AURKB, CHRNA3, CHRNA7, CSNK2A1, DRD3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, XDH 3.07854
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.0747
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRB2, APP, AURKB, CNR2, CSNK2A1, CYP1B1, DRD3, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC 3.0385
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CNR2, CYP19A1, DRD3, FABP4, IDO1, KDR, MET, MMP12, PPARA, PPARD, PTGS2 3.03158
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, ADRA1B, ADRB2, AKR1B1, ALOX15, APP, AURKB, AXL, CHRNA7, CSNK2A1, CYP1B1, DRD3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PPARD, PTGS2, SRC, TERT, XDH 3.03146
[BP] GO:0019725 cellular homeostasis ADRA1A, ADRA1B, ADRA1D, APEX1, APP, CA2, CA7, CHRNA7, DRD3, HTR2A, HTR2B, HTR2C, TRPV1 3.01699
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.01699
[BP] GO:0051952 None ADORA1, CHRNA3, DRD3, HTR1B, HTR2A 3.01699
[BP] GO:0060401 None ADRA1A, HTR2A, HTR2B, HTR2C, TRPV1 3.01699
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.01655
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ALOX12, APP, CNR2, CYP19A1, FABP4, IDO1, IGF1R, MET, MMP12, MMP2, PPARA, PPARD, PTGS2, SRC, TERT, XDH 2.9991
[BP] GO:0060078 None ADORA1, CHRNA3, CHRNA7, GLRA1, TRPV1 2.99461
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGS2 2.99461
[BP] GO:0032496 response to lipopolysaccharide AXL, CNR2, CYP1A1, CYP1A2, IDO1, PPARD, PTGS2, SRC 2.9806
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD11B1, HSD17B2, KDR, PPARA, PPARD, SRC, TYR 2.96607
[BP] GO:0007566 embryo implantation MMP2, MMP9, PPARD, PTGS2 2.95791
[BP] GO:0007208 None HTR2A, HTR2C 2.95791
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.95791
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.95791
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.95791
[BP] GO:0006810 None ABCB1, ACHE, ADORA1, ADRA1A, ADRB2, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRNA3, CHRNA7, DRD3, FABP3, GLRA1, HTR1B, HTR2A, HTR2B, HTR2C, KCNH2, MMP12, MMP9, PPARA, PPARD, SRC, TRPV1, XDH 2.93963
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.93041
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.93041
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ADRB2, ALOX12, ALOX15, CNR2, CYP19A1, DRD3, IGF1R, MET, MMP12, MMP9, PPARA, PPARD, PTGS2, SRC, TERT, XDH 2.92755
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 2.92449
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, HTR2A, KCNH2, PTGS2 2.91398
[BP] GO:0009891 positive regulation of biosynthetic process ADRB2, APP, AURKB, DRD3, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, NR3C1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1 2.87131
[BP] GO:0030534 None APP, CHRNA3, DRD3, GLRA1, HTR2A, PPARA 2.85988
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD3, HTR2B, MMP12, PPARD, SRC, TRPV1 2.8501
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.8365
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, ADRA1B, ADRA1D, APP, CHRNA7, DRD3, HTR2A, HTR2B, HTR2C, TRPV1 2.82574
[BP] GO:0002237 response to molecule of bacterial origin AXL, CNR2, CYP1A1, CYP1A2, IDO1, PPARD, PTGS2, SRC 2.80548
[BP] GO:0045776 None ADORA1, ADRB2, DRD3, PPARA 2.80548
[BP] GO:0032845 None ADORA1, HTR2A, HTR2B, HTR2C, SRC, TRPV1 2.79871
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, FABP3, FABP4, FLT3, GLO1, GLRA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 2.77196
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.75021
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.75021
[BP] GO:2001023 None CHRNA3, DRD3, HTR1B, HTR2A, MET 2.72885
[BP] GO:0008217 None ADORA1, ADRA1A, ADRB2, DRD3, PPARA, PTGS2 2.72167
[BP] GO:0051588 None CHRNA3, DRD3, HTR1A, HTR1B, HTR2C 2.70932
[BP] GO:0051209 None HTR2A, HTR2B, HTR2C, TRPV1 2.69839
[BP] GO:0051283 None HTR2A, HTR2B, HTR2C, TRPV1 2.69839
[BP] GO:0051094 positive regulation of developmental process ADRB2, ALOX12, APP, AXL, CA2, CHRNA7, CYP1B1, HTR2A, HTR2C, IDO1, KDR, PIM1, PPARD, PTGS2, SRC, TERT 2.68101
[BP] GO:0045986 None ADORA1, ADRB2, PTGS2 2.67304
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CHRNA7, CYP1B1, KDR, PTGS2, TERT 2.65293
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, FABP3, FABP4, FLT3, GLO1, GLRA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 2.65293
[BP] GO:0090257 None ADORA1, ADRA1A, ADRA1B, ADRA1D, ADRB2, CHRNA3, PTGS2 2.65293
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, ADRA1B, ADRA1D, AKR1B1, ALOX15, APP, AXL, CA2, CHRNA3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD11B1, HSD17B2, HTR5A, KDR, MMP9, PIM1, PPARA, PPARD, PTGS2, SRC, TYR 2.62797
[BP] GO:0098657 import into cell ACHE, ADORA1, ADRB2, ALOX15, APP, AXL, DRD3, HTR1B, HTR2B, TRPV1 2.62328
[BP] GO:0007568 aging ADRA1A, APEX1, AURKB, CYP1A1, HTR2A, PTGS2, TERT 2.6206
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, ADRA1A, ADRB2, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRNA3, CHRNA7, DRD3, FABP3, GLRA1, HTR1B, HTR2A, HTR2B, HTR2C, KCNH2, MMP12, MMP9, PPARA, PPARD, SRC, TERT, TRPV1, XDH 2.58773
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, GLRA1, HSD17B2, KDR, MMP2, PTGS2, SRC 2.57784
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.54341
[BP] GO:0045933 None ADRA1A, ADRA1B, ADRA1D, PTGS2 2.54322
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.54322
[BP] GO:1905144 None CHRNA3, CHRNA7 2.54322
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CBR1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, FABP3, FABP4, FLT3, GLO1, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, TYR, XDH 2.54216
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, CHRNA3, CHRNA7, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PTGS2, SRC, XDH 2.51238
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, CHRNA3, CHRNA7, CSNK2A1, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PTGS2, SRC, XDH 2.49148
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB2, APP, AURKB, DRD3, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, MET, MMP12, NR3C1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1 2.48483
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.47092
[BP] GO:0060004 None ADRA1A, DRD3, GLRA1 2.47092
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, ADRA1B, ADRA1D, HTR2A, HTR2B, HTR2C, TRPV1 2.45118
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, IDO1, PTGS2 2.43717
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, MMP12, PPARA, PPARD 2.43206
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.41683
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, MMP9, PTGS2, SRC 2.40922
[BP] GO:0051098 regulation of binding ADRB2, APP, AURKB, MET, MMP9, PPARA, SRC, TERT 2.40922
[BP] GO:0031623 None ACHE, DRD3, HTR1B, HTR2B 2.39736
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.39723
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CHRNA3, CYP1B1, DRD3, HTR1A, PTGS2, TRPV1 2.38578
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CHRNA7, CYP1B1, KDR, PTGS2, TERT 2.38577
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.38338
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.35232
[BP] GO:0097553 None HTR2A, HTR2B, HTR2C, TRPV1 2.34442
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, PPARA, PPARD 2.33841
[BP] GO:0007626 None APP, CHRNA3, DRD3, GLRA1, HTR2C, IDO1 2.33841
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.31501
[BP] GO:0046883 regulation of hormone secretion ADORA1, CHRNA3, CYP19A1, HTR1A, HTR2A, HTR2C, PPARD 2.31327
[BP] GO:0006897 endocytosis ACHE, ADORA1, ADRB2, ALOX15, APP, AXL, DRD3, HTR1B, HTR2B 2.3112
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD3, HTR1A 2.30426
[BP] GO:0045600 positive regulation of fat cell differentiation HTR2A, HTR2C, PPARD, PTGS2 2.29685
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, HTR1B, HTR2A, PTGS2 2.29685
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.29685
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ADRA1B, ADRB2, ALOX15, APP, CHRNA3, CHRNA7, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PTGS2, SRC, XDH 2.29005
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.28615
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.28615
[BP] GO:0014827 None HTR1D, HTR2B 2.28615
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PPARD 2.27532
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRB2, ALOX15, APEX1, APP, AURKB, CA9, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 2.27402
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.26561
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.25399
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.25219
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, APP, CYP1B1, FABP3, IDO1, PPARD, PTGS2, TERT, XDH 2.24608
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.24489
[BP] GO:0051241 negative regulation of multicellular organismal process ADORA1, ADRA1A, ADRB2, ALOX12, APP, AXL, CHRNA7, DRD3, GLRA1, IDO1, PPARD, PTGS2, TERT, XDH 2.23916
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.23396
[BP] GO:0009605 response to external stimulus ADORA1, ADRA1A, AXL, CNR2, CYP1A1, CYP1A2, DRD3, GLRA1, HTR2A, IDO1, MMP12, PPARD, PTGS2, SRC, TRPV1, TYR 2.22654
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.20802
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.20802
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.20802
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CNR2, CYP19A1, DRD3, PPARA, PPARD 2.18226
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.17931
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, ADRA1B, ADRB2, ALOX15, APEX1, APP, AURKB, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1B1, DRD3, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 2.17005
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.15903
[BP] GO:0045932 None ADORA1, ADRB2, PTGS2 2.15903
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.14283
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, ADRA1D, ADRB2, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CBR1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, FLT3, GLO1, HSD11B1, HSD17B1, HSD17B2, HTR2B, HTR2C, IDO1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, TYR, XDH 2.14283
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD3, HTR7, PPARA, SRC, TOP2A 2.14192
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, ADRA1B, ADRA1D, HTR2A, HTR2B, HTR2C, TRPV1 2.13354
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.12917
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, PPARD, SRC, TERT 2.11537
[BP] GO:0015908 None DRD3, FABP3, PPARA, PPARD 2.11537
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.11537
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR2, CYP19A1, FABP4, IDO1, PPARA, PPARD, PTGS2 2.09831
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.09831
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.09831
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, CHRNA7, CNR2, CSNK2A1, DRD3, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PPARD, PTGS2, SRC, TERT, TRPV1, XDH 2.09801
[BP] GO:1904646 cellular response to amyloid-beta ADRB2, APP, IGF1R 2.07364
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTGS2, TRPV1, TYR 2.06165
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.0527
[BP] GO:1901653 cellular response to peptide ADRB2, AKR1B1, APEX1, APP, IGF1R, SRC 2.03782
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA1A, ADRA1B, ADRB2, ALOX15, APEX1, APP, AURKB, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1B1, DRD3, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 2.03782
[BP] GO:1900543 None DRD3, HTR1B, HTR1E, PPARA 2.03369
[BP] GO:0050873 None ADRB2, FABP4, PTGS2 2.03369
[BP] GO:0014059 None DRD3, HTR1B, HTR2A 2.03369
[BP] GO:0045980 None DRD3, HTR1B, HTR1E, PPARA 2.0133
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KCNH2, KDR, MET, PIM1, PPARD, PTGS2, SRC, XDH 2.01137
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, ALOX15, APP, AXL, CA2, CA4, CA9, CHRNA3, CHRNA7, CNR2, DRD3, FLT3, GLRA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PTGS2, SRC, TRPV1 9.52075
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, APP, AXL, CA4, CNR2, DRD3, FLT3, GLRA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, TRPV1 9.42164
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, APP, AXL, CNR2, DRD3, FLT3, GLRA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, TRPV1 9.05405
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, ALOX12, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRNA3, CHRNA7, CNR2, CSNK2A1, DRD3, FLT3, GLO1, GLRA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, SRC, TERT, TRPV1 8.23596
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, ALOX12, ALOX15, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRNA3, CHRNA7, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, FLT3, GLO1, GLRA1, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTGS2, SRC, TERT, TRPV1, TYR 6.24073
[CC] GO:0044853 plasma membrane raft ADRA1A, ADRA1B, CHRNA3, CHRNA7, HTR2A, PTGS2, SRC 4.98859
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRNA3, CHRNA7, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, FLT3, GLRA1, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PTGS2, SRC, TRPV1, TYR 4.9197
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, ADRA1A, ADRA1B, ADRB2, CA2, CA4, CA9, CHRNA3, CHRNA7, GLRA1, HTR2A, MET, PTGS2, SRC, TRPV1 3.89079
[CC] GO:0045121 membrane raft ADRA1A, ADRA1B, APP, CHRNA3, CHRNA7, HTR2A, KDR, PTGS2, SRC 3.64593
[CC] GO:0098857 membrane microdomain ADRA1A, ADRA1B, APP, CHRNA3, CHRNA7, HTR2A, KDR, PTGS2, SRC 3.62356
[CC] GO:0005901 caveola ADRA1A, ADRA1B, HTR2A, PTGS2, SRC 3.13027
[CC] GO:0098589 membrane region ADRA1A, ADRA1B, APP, CHRNA3, CHRNA7, HTR2A, KDR, PTGS2, SRC 3.06641
[CC] GO:0031224 None ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, APP, AXL, CA12, CA14, CA4, CA9, CHRNA3, CHRNA7, CNR2, CYP3A4, DRD3, FLT3, GLRA1, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, TRPV1, TYR 3.01699
[CC] GO:0016021 None ABCB1, ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, APP, AXL, CA12, CA14, CA9, CHRNA3, CHRNA7, CNR2, CYP3A4, DRD3, FLT3, GLRA1, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, TRPV1, TYR 2.5974
[MF] GO:0008227 None ADRA1A, ADRA1B, ADRA1D, ADRB2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 18.9959
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.6993
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.6993
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.5745
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.5745
[MF] GO:0042165 neurotransmitter binding ACHE, CHRNA3, CHRNA7, GLRA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.4713
[MF] GO:0030594 None CHRNA3, CHRNA7, DRD3, GLRA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.4011
[MF] GO:0070405 ammonium ion binding ACHE, CHRNA3, CHRNA7, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 14.5425
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.4502
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX12, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, FABP3, FABP4, FLT3, GLO1, GLRA1, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, TYR, XDH 13.7366
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, GLO1, GLRA1, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARD, TYR, XDH 13.4471
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRNA3, CHRNA7, CNR2, DRD3, FLT3, GLRA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PPARD, TRPV1 13.4465
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, GLO1, GLRA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARD, PTGS2, TERT, TOP2A, TRPV1, TYR, XDH 12.2631
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRNA3, CHRNA7, CNR2, DRD3, FLT3, GLRA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PPARD, TRPV1 12.0388
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRNA3, CHRNA7, CNR2, DRD3, FLT3, GLRA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PPARD, TRPV1 11.7367
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRNA3, CHRNA7, CNR2, DRD3, FLT3, GLRA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PPARD, TRPV1 11.0112
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.3383
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRNA3, CHRNA7, CNR2, DRD3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, TRPV1 10.1451
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, AXL, CHRNA3, CHRNA7, CNR2, DRD3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, TRPV1 10.1451
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 9.53663
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD3, FLT3, GLRA1, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, PIM1, PPARA, PPARD, SRC, TOP2A, TRPV1 8.60733
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.53579
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 7.91139
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, PTGS2, SRC 7.57789
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, PTGS2, SRC 7.27131
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 7.05626
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.81501
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRB2, CNR2, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 6.6349
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.334
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FLT3, GLO1, HSD11B1, HSD17B1, HSD17B2, IDO1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, SRC, TERT, TOP2A, TYR, XDH 6.24073
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 6.09305
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS2, TYR 5.70444
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.40808
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.14742
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, IDO1, PTGS2 5.11428
[MF] GO:0004937 None ADRA1A, ADRA1B, ADRA1D 5.07049
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, IDO1, PTGS2 5.03782
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, GLO1, GLRA1, IDO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARD, PTGS2, TERT, TOP2A, TRPV1, TYR, XDH 4.62848
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.54925
[MF] GO:0004935 None ADRA1A, ADRA1B, ADRA1D, ADRB2 4.3192
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, IDO1, PTGS2, SRC, XDH 4.29393
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, GLRA1, MMP1, MMP12, MMP2, MMP9, NR3C1, PPARA, PPARD 4.15856
[MF] GO:0042562 hormone binding ACHE, CHRNA3, CHRNA7, HSD17B1, IGF1R, NR3C1 3.9283
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 3.91336
[MF] GO:0004936 None ADRA1A, ADRA1B, ADRA1D 3.90846
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.39069
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.37051
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 3.18908
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.95791
[MF] GO:0008389 None CYP2A13, CYP2A6 2.95791
[MF] GO:0071886 None HTR2A, HTR2C 2.95791
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.95618
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, IDO1, PTGS2 2.70932
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRB2, APEX1, CSNK2A1, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, SRC 2.68038
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, ADRB2, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, FLT3, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, MET, MMP12, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 2.61628
[MF] GO:0005231 None CHRNA3, CHRNA7, GLRA1, TRPV1 2.60141
[MF] GO:0042166 None ACHE, CHRNA3, CHRNA7 2.60141
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.54322
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.54322
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.54322
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.54322
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRB2, APEX1, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PPARA, SRC 2.39736
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.38338
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.31405
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.28615
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.28615
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA1A, ADRA1B, ADRB2, AXL, CHRNA7, FLT3, KCNH2, PPARD, PTGS2, TERT, TOP2A, TYR, XDH 2.20802
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.09831
[MF] GO:0005504 None FABP3, FABP4, PPARD 2.07364
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.07364
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FLT3, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, MET, MMP12, NR3C1, PIM1, PPARA, PPARD, PTGS2, SRC, TERT, TOP2A, TRPV1, XDH 2.03782
[MF] GO:0042802 identical protein binding ACHE, ADRB2, APP, CHRNA7, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, PTGS2, TERT, TOP2A, TRPV1, TYR, XDH 2.02461


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRNA3, HTR1E, CHRNA7, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, ADRA1D, TRPV1, HTR2A, ADRB2, NR3C1, HTR5A, ADRA1B, HTR4, ADRA1A, GLRA1, HTR6, HTR7, CNR2, ADORA3, ADORA1, DRD3 23.5091
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, ALOX12, HTR2A, PTGS2, HTR5A, HTR4, HTR6, HTR7, ALOX5 18.721
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, CHRNA7, HTR2B, HTR2C, ADRA1D, HTR2A, ADRB2, HTR5A, ADRA1B, HTR4, ADRA1A 9.9846
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CHRNA7, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 10.6975
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.5042
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.1456
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.0291
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 8.2612
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, HTR1E, HTR1D, ADORA1, HTR1A, HTR1B, ADRB2, PPARA, HTR4 6.0192
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, CYP19A1, HSD11B1, CYP2A6, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH, IDO1 5.0639
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2C, ALOX12, TRPV1, HTR2A 4.6731
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12, PTGS2 4.4281
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA, PPARD 4.2297
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA1D, ADRB2, ADRA1B, ADRA1A 3.5229
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, PTGS2, MMP9, MET, IGF1R, PPARD 3.1077
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.1216
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 3.8742
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8589
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB2, PTGS2 3.3929
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH, CES2 3.6842
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.1609
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.8468
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.0211
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIM1, CYP1B1, PTGS2, MMP9, MET 2.3684
Salivary secretion_Homo sapiens_hsa04970 ADRA1D, ADRB2, ADRA1B, ADRA1A 2.7645
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, HTR2A 2.7667
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB2, MET, IGF1R 1.9412
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRA1D, ADRB2, ADRA1B, ADRA1A 2.0246
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1, PPARD 2.2425
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.1721
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.765
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, CYP3A4 2.0328
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.6364
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.6836
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.5983
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, CYP3A4 2.0246
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, CHRNA3, CHRNA7 1.5983
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.5146
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1D, ADRA1B, ADRA1A 1.5164
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.0211
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 0.8908
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9547
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7744
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.8339
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.1335
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1622
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 0.9462
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.7838
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7889
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.6836
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A, IGF1R 0.7744
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PPARD 0.6966
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0673
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB2 1.19
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1593
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.6451
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7051
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.6071
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2466
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.1988
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2541
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2451
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2537
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2803
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.273
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2803
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3056
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2903
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3161
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.273
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4029
Platelet activation_Homo sapiens_hsa04611 SRC 0.3554
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.332
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3423
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.3979
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3456
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.3799
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4029
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3554
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.361
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3456
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3979
Axon guidance_Homo sapiens_hsa04360 MET 0.3487
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.3979
Dopaminergic synapse_Homo sapiens_hsa04728 DRD3 0.3477
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3979
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.4029
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4029
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.3954
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.361
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4029
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4029
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3979
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4029
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4029
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.3979
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.4336
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3979
Peroxisome_Homo sapiens_hsa04146 XDH 0.4029
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4336
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4336
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4382
Glioma_Homo sapiens_hsa05214 IGF1R 0.4551
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4551
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4549
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.4684
Shigellosis_Homo sapiens_hsa05131 SRC 0.4551
Malaria_Homo sapiens_hsa05144 MET 0.5415
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7156
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5782
Nicotine addiction_Homo sapiens_hsa05033 CHRNA7 0.6071
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6057
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6836
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.6451
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6071
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.6451
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6492
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9194
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7051
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1839


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)