TCM Prescription: Chuan Xi Ling Capsules



Prescription Description
Prescription IDTCMF3497
Pinyin NameChuan Xi Ling Jiao Nang
Chinese Name喘息灵胶囊
English NameChuan Xi Ling Capsules
Function Description咳嗽, 哮喘
IndicationsAsthma
Disease ICD-11 Category CA23 [Asthma, 哮喘 ];
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1397 Aristolochia debilis 马兜铃 TCMH1397 GBVE1975-11
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH2392 NA 盐酸克仑特罗 TCMH2392
TCMH1403 NA 马来酸氯苯那敏 TCMH1403
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, TRPV1 11.8056
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 10.5862
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, F3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MAOB, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC, TNKS, TNKS2, TRPV1, XDH 9.71553
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, NQO2, PTGS1, PTGS2, TYR, XDH 9.71553
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FLT3, HSD11B2, HSD17B2, MAOB, NR3C1, PTGS2, SRC, TYR 9.34821
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.07199
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FUT7, GBA2, PDE5A, PIK3CA, PIM1, PTGS1, PTGS2, TYR, XDH 8.79908
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 8.48263
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, MAOB, NR3C1, PTGS2, SRC, TRPV1, TYR 8.35459
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MAOB, NR3C1, PIK3CA, PTGS2, SRC, TRPV1, TYR 8.25465
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 8.10446
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.97645
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, HSD17B2, IGF1R, MAOB, NR3C1, PIK3CA, PTGS2, SRC, TRPV1, TYR 7.97645
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.18313
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FLT3, HSD11B2, MAOB, NR3C1, PTGS2, SRC, TRPV1 7.07787
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HCAR2, KDR, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.81469
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HCAR2, KDR, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.80703
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.80703
[BP] GO:0043067 regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TRPV1, XDH 6.7071
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.67472
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP4, FUT7, GBA2, MET, PIK3CA, PIK3CB, PTGS1, PTGS2 6.64658
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 6.44688
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.44688
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MAOB, NR3C1, PIK3CA, PTGS2, SRC, TRPV1, TYR 6.42988
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.38727
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.24085
[BP] GO:0010941 regulation of cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TRPV1, XDH 6.2229
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MAOB, PTGS2, SRC 6.219
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.19832
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 6.15503
[BP] GO:0042981 regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TRPV1, XDH 6.13667
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CDK6, HCAR2, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2, TRPV1 6.12669
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FLT3, HSD11B2, IGF1R, MAOB, NR3C1, PTGS2, SRC, TRPV1 5.77783
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, GBA2, MAOB, TYR 5.7667
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 5.56944
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 5.48813
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, SRC, TYR 5.46347
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 5.46347
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, NR3C1, PIK3CA, PTGS2, SRC, TRPV1 5.31433
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, MAOB, MET, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TNKS2, TYR 5.15759
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, MAOB, NR3C1, PTGS2, SRC 5.12039
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.10263
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, MAOB, NR3C1, PTGS2, SRC 5.10263
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.10263
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, AXL, BCL2, CYP1B1, F3, FLT3, KDR, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.08973
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 5.02417
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, HSD11B2, KDR, MAOB, NR3C1, PTGS2, SRC, TRPV1 4.95489
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.92798
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, NR3C1, PIK3CA, PTGS2, SRC, TRPV1 4.84355
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, KDR, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.7163
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 4.70398
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 4.56306
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.5056
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.5056
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MAOB, MET, NR3C1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 4.5056
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.5056
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.41667
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.4024
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MAOB, PIK3CA, PIM1, PTGS2, SRC, TYR 4.34042
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, NR3C1, PTGS2, SRC, TRPV1 4.33039
[BP] GO:0042127 regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FLT3, IGF1R, KDR, PDE5A, PIM1, PTGS1, PTGS2, SRC, XDH 4.27525
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.26033
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, MAOB, NR3C1, PTGS2 4.26033
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, PIK3CA, PIM1, PTGS2, PTPN1, SRC 4.18807
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 3.99677
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.89042
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 3.8432
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC, TNKS 3.82318
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, MAOB 3.80819
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IGF1R, MET, PDE5A, PIK3CA, PIM1, PTGS2, SRC, TNKS2, TRPV1, TYR 3.75855
[BP] GO:0060548 negative regulation of cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, PIK3CA, PIM1, PTGS2, PTPN1, SRC 3.75464
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.75189
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.75189
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, KDR, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.73541
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MAOB, MET, NR3C1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 3.66943
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, SRC 3.66239
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, SRC, TRPV1 3.63503
[BP] GO:0009893 positive regulation of metabolic process ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MAOB, MET, NR3C1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 3.63503
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, NR3C1, PIK3CA, PTGS2, PTPN1, SRC, TRPV1 3.62234
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, NQO2, PTGS1 3.58712
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 3.5727
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, PIK3CA, PIM1, PTGS2, PTPN1, SRC 3.55857
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.54301
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGS1, PTGS2 3.48818
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, PIM1, PTGS2 3.42243
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.41145
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.32809
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, SRC 3.31433
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.26904
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.26081
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, MAOB, SRC 3.24365
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F3, MET, PIK3CA, PIK3CB, SRC, XDH 3.2235
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR 3.18202
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, NR3C1, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.15829
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, HCAR2, IGF1R, KDR, MAOB, MET, NR3C1, PDE5A, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 3.14441
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 3.14441
[BP] GO:0032879 regulation of localization ACHE, ALOX12, ALOX15, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, HCAR2, IGF1R, KDR, MAOB, MET, PIK3CB, PTGS2, PTPN1, SRC, TRPV1 3.12463
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP4, FUT7, GBA2, MAOB, PDE5A, PIK3CB, SRC, XDH 3.07881
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MAOB, PTGS2 3.07847
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MAOB, NR3C1, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TRPV1, TYR 3.04172
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HSD11B2, PTGS2, SRC, TRPV1, TYR 3.03838
[BP] GO:0048583 regulation of response to stimulus AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IGF1R, KDR, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.01769
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, PTGS1, PTGS2 2.99237
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F3, MET, PIK3CA, PIK3CB, SRC 2.99237
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, BCL2, CDC25B, ESRRB, FLT3, KDR, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.97856
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.95644
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, ALOX12, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, IGF1R, KDR, MAOB, MET, NR3C1, PDE5A, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 2.95644
[BP] GO:0009115 None AOX1, XDH 2.9064
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.9064
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.9064
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.9064
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.88838
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.88138
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP4, GBA2, MAOB, PDE5A, PIK3CB, SRC, XDH 2.87869
[BP] GO:0042592 homeostatic process AKR1B1, ALOX12, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC, TRPV1 2.86653
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, SRC 2.81392
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, IGF1R, KDR, MAOB, MET, PDE5A, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.80603
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, PTGS2, SRC 2.79773
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, GBA2, PTGS1, PTGS2 2.75431
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.7292
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.7292
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, ESR1, IGF1R, NR3C1, PIK3CA, PTGS2, SRC, TRPV1 2.72199
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.71518
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, MAOB, NR3C1, SRC 2.68173
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP4, GBA2 2.66467
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.66378
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.66378
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.6518
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTPN1, SRC 2.64794
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.63695
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.62094
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, MAOB, PTGS2, SRC 2.61692
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.60851
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.60452
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, BCL2, CDC25B, ESRRB, FLT3, KDR, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.59177
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, BCL2, CDC25B, ESRRB, FLT3, KDR, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.59177
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, PIK3CB, SRC 2.58512
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.57475
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, BCL2, CA12, CA2, CA7, ESR1, FABP4, MET, PIK3CA, PIK3CB, TRPV1 2.57475
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, BCL2, CDC25B, FLT3, KDR, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.56793
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.55283
[BP] GO:0046110 None AOX1, XDH 2.53506
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.53506
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MAOB 2.50414
[BP] GO:0048871 multicellular organismal homeostasis AKR1B1, ALOX12, MET, PIK3CA, TRPV1 2.50006
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, HSD11B2, PTGS2, SRC, TRPV1, TYR 2.49804
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.48476
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, BCL2, CDK6, CYP1B1, KDR, PDE5A, PIK3CA, PIK3CB, SRC 2.48476
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, MAOB, PTGS2, SRC 2.48476
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.46291
[BP] GO:0042325 regulation of phosphorylation ALOX15, BCL2, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.46125
[BP] GO:2000145 regulation of cell motility ALOX12, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, PTGS2, SRC 2.45918
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.45918
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.45918
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, TRPV1 2.42106
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.40435
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.40242
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, KDR, SRC, TRPV1 2.39756
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HCAR2, KDR, MET, PDE5A, PIM1, PTGS2, SRC, TRPV1 2.37783
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.37185
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.35435
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35435
[BP] GO:1901575 None ACHE, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP4, FUT7, GBA2, MAOB, PDE5A, XDH 2.32458
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, GBA2, PIM1, PTGS1, PTGS2, TYR 2.31476
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.29788
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.29788
[BP] GO:0070213 None TNKS, TNKS2 2.29788
[BP] GO:0006145 None AOX1, XDH 2.29788
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.29788
[BP] GO:0030335 positive regulation of cell migration ALOX12, BCL2, F3, IGF1R, KDR, MET, PTGS2, SRC 2.28826
[BP] GO:0051239 regulation of multicellular organismal process ALOX12, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, HCAR2, KDR, MET, PDE5A, PIK3CA, PIM1, PTGS2, SRC, TNKS2, TRPV1, XDH 2.24145
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.22013
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.22013
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP3A4, MAOB, PDE5A, XDH 2.21581
[BP] GO:0040012 regulation of locomotion ALOX12, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, PTGS2, SRC 2.19959
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 2.19959
[BP] GO:2000147 positive regulation of cell motility ALOX12, BCL2, F3, IGF1R, KDR, MET, PTGS2, SRC 2.19453
[BP] GO:0051270 regulation of cellular component movement ALOX12, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, PTGS2, SRC 2.19174
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.18081
[BP] GO:0050793 regulation of developmental process ALOX12, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, KDR, PDE5A, PIK3CA, PIM1, PTGS2, SRC, TNKS2, TRPV1, XDH 2.18081
[BP] GO:0032845 None BCL2, SRC, TNKS, TNKS2, TRPV1 2.17082
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, KDR, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.16481
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, PTGS1, PTGS2, SRC 2.15748
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, PIK3CB 2.14437
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.14437
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, BCL2, F3, IGF1R, KDR, MET, PTGS2, SRC 2.12815
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, HCAR2, PIK3CB, PTGS2, SRC, TRPV1, XDH 2.12815
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX12, ALOX15, CYP1A1, PTGS1, PTGS2 2.12815
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, PTGS2 2.12815
[BP] GO:0043696 None CDK6, ESRRB 2.12702
[BP] GO:0043697 None CDK6, ESRRB 2.12702
[BP] GO:0010641 None F3, SRC 2.12702
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.12702
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.12702
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.11786
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.11751
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway ESR1, ESR2, NR3C1, SRC 2.11751
[BP] GO:0018958 None AKR1B1, BCL2, MAOB, TYR 2.11751
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, HCAR2, PIK3CB, PTGS2, SRC, TRPV1, XDH 2.11739
[BP] GO:0030258 lipid modification ALOX12, CYP1A1, CYP3A4, MET, PIK3CA, PIK3CB 2.11364
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, PTGS2, SRC, TRPV1 2.11068
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.08587
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, MAOB 2.08587
[BP] GO:0030334 regulation of cell migration ALOX12, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, PTGS2, SRC 2.07593
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CYP1B1, F3, KDR, PTGS2 2.07593
[BP] GO:0040017 positive regulation of locomotion ALOX12, BCL2, F3, IGF1R, KDR, MET, PTGS2, SRC 2.05638
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling IGF1R, PIK3CA, PIK3CB 2.05332
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.05332
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, PIK3CB 2.05332
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PTGS2, TYR 2.05332
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, GBA2, PIM1, PTGS1, PTGS2, TYR 2.02216
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1 2.0118
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MAOB, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 4.12204
[CC] GO:0016020 membrane ACHE, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MAOB, MET, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR 3.48818
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2 2.66216
[CC] GO:0005829 cytosol AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA7, CDC25B, CDK6, CSNK2A1, FABP4, FLT3, HSD17B1, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 2.54214
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1 2.54214
[CC] GO:0044425 membrane part ACHE, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MAOB, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TRPV1, TYR 2.35676
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 12.9177
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, NQO2, NR3C1, PIM1, PTPN1, TNKS, TYR, XDH 12.9177
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 11.5217
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, NQO2, PTGS1, PTGS2, TYR, XDH 11.2307
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.4724
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 7.23503
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B2, HSD17B1, MAOB, NQO2, PTGS1, PTGS2, SRC, XDH 6.83651
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1 6.76725
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.64658
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, NQO2, NR3C1, PDE5A, PIM1, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 6.46995
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, NQO2, NR3C1, PDE5A, PIM1, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 6.14823
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.84303
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, SRC 5.63685
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.49416
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.46407
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, SRC 5.43887
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.26406
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, TYR 5.10263
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 4.91187
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TRPV1 4.56306
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, HSD11B2, HSD17B1, NR3C1, TRPV1 4.53264
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, NQO2, NR3C1, PTPN1, TNKS 4.5056
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.20072
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.9723
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1 3.66943
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.63503
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.58882
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.58712
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.58712
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.55857
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.50202
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.48818
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CDK6, CSNK2A1, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, TRPV1, XDH 3.42243
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CDK6, CSNK2A1, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, TRPV1, XDH 3.42243
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.40087
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 3.21427
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 3.18506
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.15856
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.14998
[MF] GO:0036094 small molecule binding AOX1, AURKB, AXL, CDK6, CSNK2A1, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, TRPV1, XDH 3.09518
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, NQO2, NR3C1 3.03615
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.93476
[MF] GO:0043168 anion binding ALOX15, AOX1, AURKB, AXL, CDK6, CSNK2A1, F3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, SRC, TRPV1, XDH 2.92886
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.9064
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.9064
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.9064
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.9064
[MF] GO:0003845 None HSD11B1, HSD11B2 2.9064
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.88626
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 2.72623
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 2.72623
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.65273
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCL2, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, MAOB, MET, NQO2, PTGS2, TRPV1, TYR, XDH 2.62163
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.53506
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.53506
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.53506
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.53506
[MF] GO:1901363 heterocyclic compound binding AOX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MAOB, MET, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TRPV1, XDH 2.48476
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.35002
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.29788
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.29788
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.29788
[MF] GO:0097159 organic cyclic compound binding AOX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MAOB, MET, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TRPV1, XDH 2.28463
[MF] GO:0050660 flavin adenine dinucleotide binding AOX1, MAOB, NQO2, XDH 2.17345
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.12702
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.12702
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.05332
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.01631


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.0602
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 11.1866
Metabolic pathways_Homo sapiens_hsa01100 MAOB, ALOX15, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, GBA2, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 9.1266
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.4077
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1 5.4566
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 4.8545
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 5.419
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.7862
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 4.7862
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 4.7862
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, KDR, PIK3CB, MET, ESR1, IGF1R 4.6325
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.6325
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 4.6325
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.6325
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MET, CDC25B 4.6325
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.6325
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.6325
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, ALOX12, PIK3CB, TRPV1 4.08
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, BCL2, PIM1, PIK3CB, F3 4.0588
Pathways in cancer_Homo sapiens_hsa05200 CDK6, PIK3CA, FLT3, BCL2, PIK3CB, PTGS2, MET, IGF1R 3.8447
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 4.334
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.08
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.6354
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 3.4799
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, IGF1R 3.6236
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.7967
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, SRC, BCL2, PIK3CB 3.4438
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 3.3361
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.588
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.6236
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2, AOX1, CYP3A4 3.5535
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 3.2185
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.4041
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 3.0811
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.9076
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 3.021
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.7199
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.7833
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.828
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.828
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.6349
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.5834
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.4459
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 2.1046
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 2.0891
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.2196
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.1395
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB 2.6868
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.4224
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7991
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.5325
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.5541
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.5834
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB 1.9948
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2 1.9905
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.145
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.9055
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.5325
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.7991
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, BCL2, PIK3CB 1.9055
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.7647
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.8726
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.7647
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.7109
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, PDE5A, PIK3CB 1.5865
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.511
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 3.0799
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.4885
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.3611
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, PIK3CB 1.4379
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2745
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1686
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3713
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3956
Alcoholism_Homo sapiens_hsa05034 MAOB 0.3792
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4525
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.6755
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 TRPV1, NR3C1 0.6484
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB 0.9876
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 1.0154
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.8972
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.2049
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.065
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.2292
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0381
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.0562
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.8979
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.2153
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB 1.0635
Axon guidance_Homo sapiens_hsa04360 MET 0.4861
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.2324
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.2806
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4947
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8928
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB 0.4835
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.2153
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.2437
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, PIK3CB 1.1344
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 1.1089
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, AOX1, TYR 3.1978
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5648
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.4041
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5642
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5781
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5771
GnRH signaling pathway_Homo sapiens_hsa04912 SRC 0.5913
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5977
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5977
Gap junction_Homo sapiens_hsa04540 SRC 0.5977
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4935
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5965
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.4612
Peroxisome_Homo sapiens_hsa04146 XDH 0.6107
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.6265
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6484
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.4789
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6484
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4935
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.4789
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5804
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.6661
PPAR signaling pathway_Homo sapiens_hsa03320 FABP4 0.6661
Amphetamine addiction_Homo sapiens_hsa05031 MAOB 0.671
Shigellosis_Homo sapiens_hsa05131 SRC 0.6761
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5865
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.7044
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.6824
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.768
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.766
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.7378
Malaria_Homo sapiens_hsa05144 MET 0.7752
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.7706
Cocaine addiction_Homo sapiens_hsa05030 MAOB 0.7752
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7812
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7762
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.7647
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.7812
Bladder cancer_Homo sapiens_hsa05219 SRC 0.8294
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.0458
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.8359
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9978
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.9179
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9259
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2297
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.95
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9876
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9759
Histidine metabolism_Homo sapiens_hsa00340 MAOB 1.0131
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 1.1251
Other glycan degradation_Homo sapiens_hsa00511 GBA2 1.1089
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1943
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.4041
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4896


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)