TCM Prescription: Niu Huang Jiang Ya Tablet



Prescription Description
Prescription IDTCMF341
Pinyin NameNiu Huang Jiang Ya Pian 
Chinese Name牛黄降压片
English NameNiu Huang Jiang Ya Tablet
Function Description头晕目眩, 头痛失眠, 烦躁不安; 高血压病见上述证候者
IndicationsHypertension
Disease ICD-11 Category BA2Z [Hypotension, unspecified, 低血压，未特指的 ];
Human Tissues Associated with IndicationBrain, Heart, Blood
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1294 Cornu saigae tataricae 羚羊角 TCMH1294
TCMH1999 Bubalus bubalis 水牛角浓缩粉 TCMH1999 GBMA0080-06
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH1199 Cassia tora 决明子 TCMH1199 GENG109-13
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH2605 Margarita 珍珠 TCMH2605
TCMH1716 Calculus bovis artificiosus 人工牛黄 TCMH1716
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH658 Nardostachys chinensis 甘松 TCMH658 GBVF2376-11
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT796 PCNA Proliferating cell nuclear antigen Unclassified P12004
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT864 THRA Thyroid hormone receptor alpha Nuclear receptor P10827
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EPHX2, F10, F3, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, HSD17B3, KDR, MAOA, MET, NR1H4, PPARA, SRC, THRA, THRB, TNKS, TNKS2, XDH 10.4985
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, KDR, MAP2K1, MAP3K7, MET, MMP9, NR1H4, RELA, SRC, TNKS, TNKS2, XDH 9.26482
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, KDR, MAP2K1, MAP3K7, MET, MMP9, NR1H4, RELA, SRC, TNKS, TNKS2, XDH 9.26482
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FDPS, FUT7, HSD17B1, HSD17B2, HSD17B3, MET, NR1H4, PPARA, PTGES 8.78854
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EPHX2, FABP3, FDPS, FUT7, GLO1, HSD17B3, NR1H4, PIM1, PPARA, PTGES, TYR, XDH 8.11898
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGES, RELA, SRC 7.13551
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, NR1H4, PIM1, PPARA, RELA, SRC, THRA, TOP2A, XDH 7.00694
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, F10, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, MMP9, NR1H4, RELA, SRC, TNKS, TNKS2, XDH 6.93679
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, NR1H4, PIM1, RELA, SRC, THRA, TOP2A, XDH 6.93598
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR1H4, PTPRS, RELA, SRC, THRA, TNKS, TNKS2, XDH 6.31293
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, CYP1B1, F10, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, RELA, SRC, XDH 6.28645
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MAP2K1, MMP9, NR1H4, PIM1, RELA, SRC, THRA, TOP2A, XDH 6.28645
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EPHX2, F10, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR1H4, PIM1, PPARA, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 6.27762
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR1H4, PTPRS, RELA, SRC, THRA, TNKS, TNKS2, XDH 6.27762
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, F10, F3, FABP3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR1H4, PIM1, PPARA, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 6.17928
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, PTGES 6.1766
[BP] GO:0008202 steroid metabolic process AKR1B1, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FDPS, HSD17B1, HSD17B2, HSD17B3, NR1H4 6.14445
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EPHX2, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR1H4, PIM1, PPARA, PTGES, PTPRS, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 5.90242
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, PTGES 5.90242
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, HSD17B3, KDR, MAP2K1, PPARA, PTPRS, RELA, SRC, THRA, TYR 5.90242
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD17B1, HSD17B2, HSD17B3, NR1H4 5.90242
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AR, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, F10, F3, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, NR1H4, PPARA, SRC, THRA 5.80489
[BP] GO:0042221 response to chemical ABCB1, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR1H4, PPARA, PTGES, RELA, SRC, TYR 5.74708
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, PTGES 5.74708
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, F10, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR1H4, RELA, SRC, XDH 5.71748
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX15, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EPHX2, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, NR1H4, PIM1, PPARA, PTGES, PTPRS, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 5.67625
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, NR1H4, PPARA, PTGES, RELA, SRC, TYR 5.67514
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, EPHX2, FABP3, FDPS, FLT3, HCAR2, NR1H4, PPARA, SRC, THRA 5.67514
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, F10, F3, FABP4, FLT3, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, NR1H4, RELA, SRC, TNKS, TNKS2, XDH 5.64154
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, NR1H4, PPARA, PTGES, RELA, SRC, TYR 5.48773
[BP] GO:0030522 intracellular receptor signaling pathway AR, MAP3K7, NR1H4, PIM1, PPARA, RELA, SRC, THRA, THRB 5.34783
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.34783
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, DAO, FDPS, HSD17B3, MAOA, NR1H4, TYR 5.12158
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, GLO1, HSD17B2, HSD17B3, KDR, MAP2K1, MET, MMP2, MMP9, PIM1, PPARA, PTPRS, RELA, SRC, THRA, THRB, TNKS2, TOP2A, TYR 4.98055
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 4.7128
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, PTGES 4.63572
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, PTGES 4.59743
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, ALOX5, APP, AR, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, EPHX2, F10, F3, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RELA, SRC, THRA, THRB, TNKS2, TYR 4.59743
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, CSNK2A1, CYP1B1, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MMP2, MMP9, PIM1, PTGES, RELA, SRC, XDH 4.58117
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, PPARA, PTGES 4.57787
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, CACNA1C, HCAR2, KDR, NR1H4, SRC, TNKS, TNKS2 4.57116
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, NR1H4, PPARA, PTGES 4.53993
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2, HSD17B3 4.48161
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, RELA, SRC 4.48161
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, PPARA, RELA, SRC 4.45321
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FDPS, FUT7, MET, PPARA, PTGES 4.38028
[BP] GO:0033993 response to lipid AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, NR1H4, PTGES, RELA, SRC, TYR 4.36463
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.3049
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, FLT3, KDR, MAP2K1, MAP3K7, SRC, XDH 4.3049
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, APEX1, APP, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, MMP2, NR1H4, PPARA, RELA, SRC 4.29392
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, EPHX2, FABP3, GLO1, NR1H4, PIM1, PPARA, PTGES, TYR 4.27349
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, NR1H4, PPARA, PTPRS, RELA, SRC, THRA, TNKS, TNKS2, XDH 4.22235
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, RELA, SRC 4.22235
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2, HSD17B3 4.15065
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, APP, CACNA1C, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.0878
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, IGF1R, KDR, MAP2K1, MET, MMP9, NR1H4, PIM1, PPARA, PTGES, PTPRS, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 4.0878
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, APP, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.07068
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, NR1H4, PIM1, PPARA, PTGES, PTPRS, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 4.05257
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, F10, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR1H4, PTPRS, RELA, SRC, THRA, TNKS, TNKS2, XDH 4.05257
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, APEX1, APP, AR, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EPHX2, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR1H4, PIM1, PPARA, PTGES, PTPRS, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 4.03475
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR1H4, RELA, SRC 4.01399
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, APEX1, APP, AR, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EPHX2, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR1H4, PIM1, PPARA, PTGES, PTPRS, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 3.96564
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AXL, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, NR1H4, RELA, SRC 3.86614
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, F10, F3, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MAP2K1, MAP3K7, MMP2, MMP9, NR1H4, PPARA, PTGES, RELA, SRC, THRA, TOP2A, TYR 3.85517
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, EPHX2, FABP3, GLO1, NR1H4, PIM1, PPARA, PTGES, TYR 3.81379
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, APP, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 3.7894
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, EPHX2, FABP3, GLO1, NR1H4, PIM1, PPARA, PTGES, TYR 3.73821
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, EPHX2 3.72859
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, SRC, XDH 3.69297
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, TYR 3.67218
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, PTGES, RELA, SRC, TYR 3.64928
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA, THRA 3.63952
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MMP9, NR1H4, PIM1, RELA, SRC 3.63911
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, CSNK2A1, EPHX2, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR1H4, PPARA, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 3.63063
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AXL, CA2, CACNA1C, CYP1B1, F3, HCAR2, KDR, MAP2K1, MAP3K7, MET, MMP9, NR1H4, PIM1, PTPRS, RELA, SRC, THRA, THRB, TNKS2, XDH 3.62835
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, CSNK2A1, EPHX2, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR1H4, PPARA, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 3.57627
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.5369
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, F10, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, NR1H4, SRC, TNKS, TOP2A 3.5369
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADRA2A, APP, CYP19A1, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, MMP2, NR1H4, PPARA, PTPRS, RELA, SRC, XDH 3.5369
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, DAO, FDPS, HSD17B3, TYR 3.5325
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, NR1H4, PTGES, RELA, SRC 3.50276
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, FABP3, NR1H4, PPARA 3.50147
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, APP, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 3.48747
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, CSNK2A1, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR1H4, PPARA, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 3.47907
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA, SRC 3.41892
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA 3.38001
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2, HSD17B3 3.38001
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, APEX1, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, RELA, SRC 3.37698
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, RELA, SRC 3.3764
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, CACNA1C, EPHX2, FABP3, FABP4, FLT3, MET, NR1H4, SRC 3.36382
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, FDPS, HSD17B1, HSD17B2, HSD17B3, PTGES 3.32166
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, APP, AR, AXL, CA2, CYP1B1, F3, HCAR2, KDR, MAP2K1, MAP3K7, MET, MMP9, NR1H4, PIM1, RELA, SRC 3.31311
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B2, HSD17B3, KDR, MAP2K1, MMP9, PIM1, PPARA, PTPRS, RELA, SRC, THRA, TYR 3.31172
[BP] GO:0007176 None ADORA1, ADRA2A, ADRA2C, APP 3.288
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP2, MMP9, NR1H4, RELA, SRC, TOP2A 3.26402
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR1H4, PPARA, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 3.2377
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.22554
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, RELA 3.2172
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, FABP3, FLT3, KDR, MAP2K1, MAP3K7, MMP9, NR1H4, SRC, XDH 3.20297
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, FABP3, FLT3, KDR, MAP2K1, MAP3K7, MMP9, NR1H4, SRC, XDH 3.20297
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.19371
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, RELA, SRC 3.12233
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.11856
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.11856
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HSD17B1, HSD17B2, HSD17B3 3.11856
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.10656
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, EPHX2, FDPS, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PTPRS, SRC, TNKS, XDH 3.07106
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR1H4, PPARA, SRC, THRA, THRB 3.05338
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, FABP4, IGF1R, MET, MMP9, NR1H4, PIM1, PPARA, SRC, TNKS 2.93824
[BP] GO:0045742 None ADORA1, ADRA2A, ADRA2C, MMP9 2.9213
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EPHX2, FABP3, FABP4, FUT7, MAOA, MMP1, MMP2, MMP9, SRC, XDH 2.91795
[BP] GO:0045741 None ADORA1, ADRA2A, ADRA2C 2.89228
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CYP1B1, IGF1R, MMP2, MMP9, NR1H4, RELA, SRC 2.89228
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, EPHX2, KDR, RELA, SRC 2.87221
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, FABP3, FLT3, IGF1R, MMP2, NR1H4, PPARA, RELA, SRC, TYR 2.85803
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AXL, CA2, CA7, CACNA1C, CYP19A1, HCAR2, MAP2K1, MMP9, NR1H4, PPARA, SRC, THRA 2.8519
[BP] GO:1901186 None ADORA1, ADRA2A, ADRA2C, MMP9 2.84987
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, DAO, F10, F3, FLT3, FUT7, GLO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR1H4, PIM1, PPARA, PTPRS, RELA, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.83159
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, APP, AR, AXL, CYP19A1, CYP1A1, HSD17B2, HSD17B3, MAP2K1, MMP2, MMP9, SRC, THRA, THRB, TOP2A 2.83159
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, EPHX2, FDPS, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PTPRS, SRC, TNKS, XDH 2.8204
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.80854
[BP] GO:0042058 None ADORA1, ADRA2A, ADRA2C, APP, MMP9 2.78782
[BP] GO:0008050 None THRA, THRB 2.78128
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, HCAR2, NR1H4, TNKS, TNKS2 2.77671
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, NR1H4, PIM1, PPARA, PTGES, RELA, SRC, THRA, THRB, TNKS, TNKS2 2.77671
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EPHX2, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HCAR2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR1H4, PIM1, PPARA, PTGES, PTPRS, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.77503
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, CYP1A1, FLT3, MAP2K1, MET, PIM1, SRC, TYR 2.76946
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGES 2.76081
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, NR1H4, SRC 2.72658
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, NR1H4, PPARA, SRC, XDH 2.71411
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 2.71315
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, FABP3, NR1H4, PPARA 2.70027
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, NR1H4, PPARA, SRC, XDH 2.67459
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, FLT3, KDR, MAP2K1, MAP3K7, MMP9, SRC, XDH 2.67231
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, MAP2K1, RELA, THRA, TYR 2.63073
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, APP, AR, FLT3, IGF1R, MMP2, NR1H4, RELA, SRC 2.63073
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.63073
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, FABP3, FLT3, IGF1R, MMP2, NR1H4, PPARA, RELA, SRC, TYR 2.60976
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, MMP9, RELA, SRC 2.57319
[BP] GO:1901184 None ADORA1, ADRA2A, ADRA2C, APP, MMP9 2.55954
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EPHX2, MAP2K1, MAP3K7, MMP2, MMP9, NR1H4, PPARA, PTGES, RELA, SRC, THRA, TOP2A 2.55869
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR1H4, PPARA, SRC, THRA, THRB 2.55869
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, PPARA, RELA, SRC 2.53161
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.52886
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.52114
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, FLT3, KDR, MAP2K1, MAP3K7, MMP9, SRC, XDH 2.50972
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.44082
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, F10, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HCAR2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR1H4, PIM1, PPARA, PTGES, PTPRS, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 2.43749
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADRA2A, ADRA2C, CACNA1C, CYP19A1, HCAR2, NR1H4 2.43171
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.42514
[BP] GO:1900673 olefin metabolic process CYP1A1, EPHX2 2.40222
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.40222
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, IGF1R, KDR, MAP2K1, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.40222
[BP] GO:0007617 None APP, THRA, THRB 2.39477
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PPARA, SRC, XDH 2.39477
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, HSD17B2, HSD17B3, MAP2K1, SRC 2.38194
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.35067
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, CSNK2A1, F3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, RELA 2.34705
[BP] GO:0032496 response to lipopolysaccharide AXL, CYP1A1, CYP1A2, NR1H4, PTGES, RELA, SRC 2.32022
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, RELA, SRC 2.2754
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, SRC, XDH 2.2601
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, MAP3K7, NR1H4, PIM1, RELA 2.2601
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, ADRA2C, CACNA1C, THRA, THRB 2.2558
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.2558
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.23182
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, F3, FLT3, MAP2K1, MAP3K7, MET, MMP9, RELA, SRC, TNKS, XDH 2.22079
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, IGF1R, MMP2, NR1H4, RELA, SRC 2.22079
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, NR1H4, PPARA, SRC 2.18759
[BP] GO:0051953 None ADORA1, ADRA2A, ADRA2C 2.18467
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.18467
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, CSNK2A1, CYP1B1, F3, FABP4, FLT3, IGF1R, MAP2K1, MAP3K7, MET, MMP9, NR1H4, PIM1, PPARA, RELA, SRC, TNKS, XDH 2.18467
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, F3, FABP4, KDR, MAP2K1, MET, NR1H4, PPARA, PTPRS, RELA 2.18467
[BP] GO:0002237 response to molecule of bacterial origin AXL, CYP1A1, CYP1A2, NR1H4, PTGES, RELA, SRC 2.17927
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.17927
[BP] GO:0035625 None ADRA2A, ADRA2C 2.17927
[BP] GO:0032811 None ADRA2A, ADRA2C 2.17927
[BP] GO:0070213 None TNKS, TNKS2 2.17927
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.17927
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.17927
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.1666
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.15513
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, EPHX2, MAOA 2.15446
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, APP, CA12, CA2, CA7, CACNA1C, EPHX2, FABP3, FABP4, MET, NR1H4 2.14678
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AR, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR1H4, PIM1, PPARA, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 2.14678
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, RELA, SRC 2.14678
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, KDR, SRC 2.14678
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, F3, FLT3, IGF1R, KDR, MAP3K7, MET, MMP2, MMP9, NR1H4, RELA, SRC, TNKS, TNKS2 2.14614
[BP] GO:0051094 positive regulation of developmental process ADRA2C, APP, AR, AXL, CA2, CYP1B1, F3, KDR, MAP2K1, NR1H4, PIM1, RELA, SRC, THRA 2.14614
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, APP, AR, AURKB, CSNK2A1, FABP4, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, NR1H4, PPARA, RELA, SRC, THRA, THRB, TNKS, TNKS2, XDH 2.14203
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, F3, MET, SRC, XDH 2.12162
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, CSNK2A1, F3, FLT3, KDR, MAP2K1, MAP3K7, MMP9, RELA, SRC, XDH 2.1098
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, ADRA2C, APP, CA2, CACNA1C, HCAR2, NR1H4, SRC, THRA 2.09325
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, FABP3, IGF1R, KDR, MAP2K1, MET, NR1H4, PPARA, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A 2.09244
[BP] GO:0042180 None AKR1B1, CYP19A1, GLO1, HSD17B3 2.09244
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AR, AURKB, CSNK2A1, CYP1A1, CYP1B1, EPHX2, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR1H4, PIM1, PPARA, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 2.09167
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.08325
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, IGF1R, MMP2, NR1H4, RELA, SRC 2.04981
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.0384
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, NR1H4, SRC 2.03072
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, EPHX2, NR1H4, PTGES, RELA 2.01758
[BP] GO:0035624 None ADRA2A, ADRA2C 2.01758
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.01758
[BP] GO:0010641 None F3, SRC 2.01758
[BP] GO:0007598 None F10, F3 2.01758
[BP] GO:0060509 None THRA, THRB 2.01758
[BP] GO:0014060 None ADRA2A, ADRA2C 2.01758
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, IGF1R, KDR, MAP2K1, MET, NR1H4, PPARA, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A 2.01182
[BP] GO:0061097 None ADORA1, ADRA2A, ADRA2C, APP 2.00131
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.3764
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA2C, AKR1B1, ALOX15, ALOX5, APEX1, APP, AR, AURKB, CA1, CA2, CA4, CA7, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EPHX2, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, KDR, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PTGES, PTPRS, RELA, SRC, THRA, TNKS, TNKS2, TOP2A, TYR, XDH 2.8204
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, F10, F3, FLT3, FUT7, GLO1, HCAR2, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTGES, PTPRS, SRC, TNKS, TNKS2, TYR 2.56661
[CC] GO:0031233 None CA4, F10, F3 2.33892
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AR, AXL, CA12, CA14, CA2, CA4, CACNA1C, CSNK2A1, F10, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTPRS, SRC 2.29186
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, ADRA2C, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA1, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EPHX2, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PPARA, PTPRS, RELA, SHBG, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.22079
[CC] GO:0044454 None APEX1, AR, AURKB, CSNK2A1, NR1H4, RELA, THRB, TNKS, TNKS2 2.14614
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EPHX2, F10, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR1H4, PIM1, PPARA, PTGES, PTPRS, RELA, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 11.8516
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP2, MMP9, NR1H4, PIM1, PPARA, THRA, THRB, TNKS, TYR, XDH 10.4985
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EPHX2, F10, F3, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PTGES, PTPRS, SRC, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 10.3743
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 7.82677
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 5.75987
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, F10, FDPS, GLO1, MAP3K7, MMP1, MMP2, MMP9, NR1H4, PIM1, PPARA, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 5.41869
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7 5.41869
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, F10, FDPS, GLO1, MAP3K7, MMP1, MMP2, MMP9, NR1H4, PIM1, PPARA, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 5.09637
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, SHBG, THRA, THRB 5.08973
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.79945
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, GLO1, MMP1, MMP2, MMP9, NR1H4, PPARA, THRA, THRB, TNKS 4.52193
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, DAO, F10, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, NR1H4, PIM1, PTGES, PTPRS, RELA, SRC, TOP2A, TUBB3, XDH 4.47235
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, GLO1 4.16216
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, NR1H4, PPARA, THRA, THRB 3.73953
[MF] GO:0004879 nuclear receptor activity AR, NR1H4, PPARA, THRA, THRB 3.73953
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.60066
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.54692
[MF] GO:0004887 None NR1H4, THRA, THRB 3.5325
[MF] GO:0003707 steroid hormone receptor activity AR, NR1H4, PPARA, THRA, THRB 3.43611
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.43454
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.36382
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.288
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PPARA, SRC, TOP2A 3.23888
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, RELA, SRC, THRA 3.07868
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, CBR1, HSD17B1, HSD17B2, HSD17B3, XDH 2.94372
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.92628
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR1H4, PPARA, THRA, THRB 2.78128
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, NR1H4, PPARA, THRA, THRB 2.77888
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.7729
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, FLT3, IGF1R, KDR, MMP9, PPARA, RELA, SRC, THRA 2.72658
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.66287
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, F10, F3, FABP3, FABP4, HSD17B1, NR1H4, PPARA, SHBG 2.66252
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.63073
[MF] GO:0004938 None ADRA2A, ADRA2C 2.40222
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, DAO, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, NR1H4, PIM1, SRC, TOP2A, TUBB3, XDH 2.38477
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, HSD17B1, PTGES, SRC, XDH 2.38194
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR1H4, PPARA, THRA, THRB 2.25962
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, CBR1, HSD17B1, HSD17B2, HSD17B3 2.24567
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.18171
[MF] GO:0032795 None ADORA1, ADRA2A 2.17927
[MF] GO:0005497 None AR, SHBG 2.17927
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR1H4, PPARA, THRA, THRB 2.14707
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.14678
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ADRA2C, APP, CSNK2A1, EPHX2, FLT3, IGF1R, KDR, MAP3K7, MET, MMP9, RELA, TOP2A, TYR, XDH 2.09244
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD17B1, HSD17B2, HSD17B3 2.0384
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.02595


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.6297
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 8.677
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 7.3362
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, MAOA, EPHX2, ALOX15, HSD17B3, AKR1B1, TYR, CYP19A1, FUT7, DAO, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH, PTGES 5.5661
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 5.1056
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, EPHX2, ALOX15, PTGES 4.3387
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX5, ALOX15, CACNA1C 4.3387
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, FLT3, MMP1, MMP2, MMP9, MET, RELA, IGF1R 3.9923
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, IGF1R 4.0496
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MAP3K7, MET, IGF1R 4.0496
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, CACNA1C, ADRA2C, ADRA2A 3.5768
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.8523
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, MAP2K1, ADORA1, CACNA1C, PPARA, RELA 3.2162
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.3074
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 2.9747
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, RELA, IGF1R 2.7156
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0423
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.7007
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 THRB, THRA, ADORA3, ADORA1, ADRA2C, ADRA2A 2.6212
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3, RELA 2.6066
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9 2.6212
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 2.8294
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, ABCB1, PIM1, CYP1B1, MMP9, MET 2.5229
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.6212
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, MET, IGF1R 2.4641
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MMP9, MAP3K7, RELA 2.5005
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, KDR, MET, IGF1R 2.4202
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, KDR, MET, RELA, IGF1R 2.2958
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, THRB, THRA, SRC 2.4202
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, ADORA1, RELA 2.4202
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SRC, MMP9, RELA 2.148
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.2397
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET 2.148
Melanoma_Homo sapiens_hsa05218 MAP2K1, MET, IGF1R 2.1121
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, RELA 2.1062
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, KDR, MET, RELA, IGF1R 1.7111
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.142
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, NR1H4 2.1121
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, CACNA1C 1.6828
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, RELA, IGF1R 1.7293
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.714
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC, TUBB3 1.8908
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.7275
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, MAP3K7, RELA 1.8336
Peroxisome_Homo sapiens_hsa04146 DAO, EPHX2, XDH 1.9519
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA 1.4981
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, MAP3K7, RELA 1.6212
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4909
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.5889
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.5136
Measles_Homo sapiens_hsa05162 CSNK2A1, MAP3K7, RELA 1.4944
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C 1.3649
Influenza A_Homo sapiens_hsa05164 FDPS, MAP2K1, RELA 1.3079
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.2799
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.2799
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, MAP3K7, RELA 1.2157
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9638
Glioma_Homo sapiens_hsa05214 MAP2K1, IGF1R 1.3079
Insulin resistance_Homo sapiens_hsa04931 PPARA, RELA 1.0093
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3697
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, IGF1R 1.0822
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, RELA 0.9594
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 1.0713
Apoptosis_Homo sapiens_hsa04210 MAP2K1, RELA 0.8788
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.3344
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, IGF1R 0.9041
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, IGF1R 0.9389
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.3079
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9626
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 0.9136
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 1.1099
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8798
Hepatitis C_Homo sapiens_hsa05160 PPARA, RELA 0.9041
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, IGF1R 0.8768
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.3079
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.9594
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.8768
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3515
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, RELA 1.3079
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC 1.1608
Calcium signaling pathway_Homo sapiens_hsa04020 CACNA1C 0.3469
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA, RELA 0.8477
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3079
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.3079
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC 0.6649
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.2799
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3842
Viral carcinogenesis_Homo sapiens_hsa05203 SRC, RELA 0.6863
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3902
Tuberculosis_Homo sapiens_hsa05152 SRC, RELA 0.7635
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.7632
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.7937
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 CACNA1C 0.4009
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, RELA 1.2799
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1569
HTLV-I infection_Homo sapiens_hsa05166 FDPS, RELA 0.5764
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.3031
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1 0.4076
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3649
Insulin signaling pathway_Homo sapiens_hsa04910 MAP2K1 0.417
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.2855
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.4245
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.3079
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.232
Axon guidance_Homo sapiens_hsa04360 MET 0.443
Platelet activation_Homo sapiens_hsa04611 SRC 0.4544
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2 1.2855
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.2799
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.2272
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.2855
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.476
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.5064
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.5144
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5144
Amoebiasis_Homo sapiens_hsa05146 RELA 0.5144
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.4655
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.5224
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5144
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO, MAOA 1.4562
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5203
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5193
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5203
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.5144
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5277
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5289
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5289
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.5384
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.5289
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5342
Salmonella infection_Homo sapiens_hsa05132 RELA 0.5342
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5289
Small cell lung cancer_Homo sapiens_hsa05222 RELA 0.5342
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5415
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5384
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5527
Pertussis_Homo sapiens_hsa05133 RELA 0.5646
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5666
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.5896
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5666
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6066
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO, MAOA 1.5889
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.6066
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1 0.6124
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RELA 0.604
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.7865
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6286
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.6828
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1 0.6459
Legionellosis_Homo sapiens_hsa05134 RELA 0.6496
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1 0.6649
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6496
Malaria_Homo sapiens_hsa05144 MET 0.6817
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6863
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9519
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6964
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7106
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7852
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7457
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8292
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8392
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.8608
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8196
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8016
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8105
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7773
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8681
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8608
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8801
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9698
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.9041
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9788


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)