TCM Prescription: Fu Fang Yin Chen Syrup



Prescription Description
Prescription IDTCMF3319
Pinyin NameFu Fang Yin Chen Tang Jiang
Chinese Name复方茵陈蒿糖浆
English NameFu Fang Yin Chen Syrup
Function Description胁痛, 黄疸
IndicationsHypochondrium pain disorder, Jaundice disorder, Jaundice
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
SA01 [Jaundice disorder (TM1), 黄疸 (TM1) ];
ME10.1 [Unspecified jaundice, 未特指的黄疸 ];
Human Tissues Associated with IndicationLiver
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1317 Gentiana scabra 龙胆 TCMH1317 ITSAP4208-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH381 Isatis indigotica 大青叶 TCMH381 KJ765825
TCMH240 Plantago depressa 车前草 TCMH240 ITSAM917-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT242 HRH3 Histamine H3 receptor GPCR Q9Y5N1
TCMT245 HRH2 Histamine H2 receptor GPCR P25021
TCMT246 HRH4 Histamine H4 receptor GPCR Q9H3N8
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, AKR1C3, APP, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MMP2, MMP9, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 13.6992
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, AKR1C3, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MMP2, PPARA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TYR 12.5175
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APP, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FLT3, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 12.3544
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, FABP3, GSK3B, HSD17B2, IDO1, IGF1R, INSR, MMP2, MMP9, PPARA, PTGS2, RORC, SLC6A4, SRC, TEK, TYR 11.3778
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DHFR, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GSK3B, HRH3, HRH4, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, KIT, MET, PPARA, PTGS2, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.7853
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, AKR1C3, APP, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GSK3B, IGF1R, INSR, KIT, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK 10.2856
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPR35, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.1301
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, GSK3B, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.88156
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, GSK3B, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.87218
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPR35, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 9.68472
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ESR1, FABP3, FABP4, HSD17B1, HSD17B2, KIT, MET, PPARA, PTGS2 9.53217
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GSK3B, HRH3, HRH4, HSPA1A, IDO1, IGF1R, KCNH2, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 9.41593
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, AKR1C3, APP, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KCNH2, KDR, KIT, MMP2, MMP9, PTGS2, RORC, SLC6A4, SMAD3, SRC, TERT 9.34687
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HRH4, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PPARA, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 9.15818
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GSK3B, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.96443
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, AKR1C3, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, KIT, PPARA, PTGS2, SLC6A4, SRC, TEK 8.96443
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GSK3B, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.81245
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, GSK3B, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 8.72434
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, GSK3B, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 8.57714
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GSK3B, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.51069
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, HSD17B1, HSD17B2 8.49768
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, GSK3B, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.49467
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, FABP4, HRH3, HSD17B2, IDO1, IGF1R, INSR, KCNH2, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TYR 8.49467
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GSK3B, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.47397
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 8.47236
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 8.47236
[BP] GO:0033993 response to lipid AKR1C3, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, IDO1, PTGS2, RORC, SLC6A4, SRC, TYR 8.47236
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 8.44736
[BP] GO:0014070 response to organic cyclic compound AKR1C3, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, FLT3, PTGS2, RORC, SLC6A4, SRC, TEK, TYR 8.44736
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH 8.43389
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KCNH2, KDR, KIT, MMP2, MMP9, NUAK1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT 8.30555
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, CA12, CA2, CA4, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, FABP3, HSPA1A, IDO1, PIM1, PPARA, PTGS2, TYR, XDH 8.25107
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GSK3B, HRH3, HRH4, HSPA1A, IDO1, IGF1R, KCNH2, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 8.22157
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AXL, CSNK2A1, CYP1B1, EGFR, ESRRA, FABP4, FLT3, GPR35, GSK3B, HSPA1A, IDO1, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.20032
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 8.16635
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, APP, CYP19A1, DHFR, DUSP3, EGFR, ESR1, FABP4, GSK3B, HSPA1A, IDO1, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.16635
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, FLT3, GPR35, GSK3B, HRH4, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.91034
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, GSK3B, HRH3, HSPA1A, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT 7.62301
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, KIT, PPARA, SMAD3, SRC, TEK, TYR 7.4685
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.36223
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AXL, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, PTGS2, PTPN1, SRC, TEK, XDH 7.28862
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, AKR1C3, APP, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MMP2, PTGS2, RORC, SLC6A4, SMAD3, SRC 7.28862
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.18443
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AKR1C3, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT 7.15116
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.15116
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA9, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, GSK3B, HSD17B2, INSR, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 7.03113
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, GSK3B, HRH3, HRH4, HSPA1A, IGF1R, INSR, KIT, MET, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.98273
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, APP, AURKB, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GSK3B, HRH3, HRH4, HSPA1A, IGF1R, INSR, KIT, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.97403
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, GSK3B, HRH3, HRH4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 6.83482
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.79558
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.78276
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HRH3, HRH4, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.72316
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, TYR 6.70306
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, GSK3B, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.67128
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HRH3, HRH4, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.67128
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.63247
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, AKR1C3, APP, AURKB, CDC25B, CSNK2A1, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 6.62668
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.50147
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.45498
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.39723
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.35604
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.33962
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.33962
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, GSK3B, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 6.33535
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, AKR1C3, APP, EGFR, ESR1, FLT3, GSK3B, IGF1R, INSR, KIT, MMP2, PTGS2, SLC6A4, SMAD3, SRC 6.31539
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GSK3B, HSD17B2, INSR, KDR, KIT, MMP9, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 6.29211
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS2 6.2674
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, DUSP3, EGFR, ESR1, ESR2, GPR35, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 6.24866
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, DUSP3, EGFR, ESR1, ESR2, GPR35, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 6.2299
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 6.14679
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9, DHFR 6.11235
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 6.08378
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS2 6.06185
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.94105
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, GSK3B, HRH4, HSPA1A, IDO1, KIT, MMP2, MMP9, NUAK1, PPARA, PTGS2, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 5.9349
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, FABP3, FABP4, KIT, MET, PPARA, PTGS2 5.90853
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, AKR1C3, CYP1A1, FABP3, FLT3, KIT, PPARA, PTGS2, RORC, SRC, TEK 5.88464
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APP, AXL, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HRH4, INSR, KCNH2, MET, SMAD3, SRC, TERT 5.85966
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 5.82839
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AXL, CYP1B1, EGFR, ESR1, GSK3B, IGF1R, INSR, MMP2, MMP9, PTGS2, RORC, SLC6A4, SRC 5.79054
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PPARA, PTGS2 5.76734
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, EGFR, FABP3, FLT3, GSK3B, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A4, SRC, TEK, TYR 5.74751
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, GSK3B, HSPA1A, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 5.71556
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, HSPA1A, KIT, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 5.68235
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, AKR1C3, APP, AURKB, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 5.68139
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, APP, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GPR35, GSK3B, HSPA1A, IDO1, INSR, KCNH2, KDR, KIT, MET, MMP12, MMP9, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 5.67408
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.6472
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, APP, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 5.6431
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, CA2, CA7, CYP19A1, EGFR, GPR35, GSK3B, HRH3, HSPA1A, INSR, KCNH2, MMP12, MMP9, PPARA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT 5.63485
[BP] GO:0006793 phosphorus metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 5.49377
[BP] GO:0010038 response to metal ion AKR1C3, APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGS2, TERT 5.49079
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AKR1C3, APP, AURKB, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, HRH3, HRH4, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH 5.4889
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, APP, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 5.47192
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 5.46829
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, DHFR, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SLC6A4, SRC 5.46829
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.44871
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TEK 5.43279
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DHFR, EGFR, HRH3, INSR, PTGS2, SLC6A2, SLC6A4, SMAD3 5.38411
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, EGFR, FABP3, FLT3, GSK3B, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A4, SRC, TEK, TYR 5.38106
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 5.32723
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, CYP19A1, DUSP3, EGFR, ESR1, ESR2, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.32201
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, APP, DUSP3, EGFR, FLT3, HRH4, IGF1R, INSR, KDR, KIT, PTPN1, SRC, TEK, XDH 5.32201
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.27721
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, HRH4, IGF1R, INSR, KDR, KIT, MMP9, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 5.24553
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, CA2, CYP19A1, EGFR, GSK3B, INSR, KCNH2, MMP12, PTGS2, SLC6A4, SMAD3, SRC, TERT 5.24553
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 5.22637
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS2 5.20799
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, EGFR, HSPA1A, IDO1 5.19291
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, APP, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, KIT, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.18987
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, APP, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, KIT, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.18987
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SLC6A4, SRC 5.16428
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, EGFR, KIT, MMP9, TERT 5.13659
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, EGFR, INSR, KIT, MET, SRC, TEK, XDH 5.03306
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, GSK3B, KIT, PPARA, RORC, SLC6A4, SRC 5.00949
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, EGFR, INSR, KIT, MET, SRC, TEK 4.98744
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS2 4.93256
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 4.93256
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 4.93146
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, APP, AURKB, CDC25B, DHFR, EGFR, ESR1, ESR2, FLT3, GSK3B, HSPA1A, INSR, KIT, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.89427
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, AKR1C3, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GSK3B, HRH3, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 4.89175
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.87774
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 4.87748
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR 4.82386
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, MMP9, SRC 4.79877
[BP] GO:0032787 None AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, IDO1, PPARA, PTGS2 4.79608
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AKR1C3, APP, AURKB, CSNK2A1, DHFR, DUSP3, ESR1, ESR2, ESRRA, FABP4, GSK3B, HRH3, HRH4, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH 4.68639
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, CYP1B1, DHFR, EGFR, INSR, PTGS2, SMAD3, XDH 4.68004
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, APP, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, HRH4, INSR, KCNH2, MET, SMAD3 4.66125
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, RORC 4.65618
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, APP, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, IDO1, INSR, KIT, MMP2, MMP9, PTGS2, SLC6A4, SRC 4.63546
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.57429
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD17B1, HSD17B2 4.5362
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HRH4, IGF1R, INSR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 4.53012
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, APP, EGFR, FLT3, INSR, KDR, KIT, PTPN1, SRC, TEK, XDH 4.52315
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, APP, AXL, CA2, CYP1B1, EGFR, ESRRB, HSPA1A, IDO1, KDR, KIT, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 4.50646
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DHFR, EGFR, FABP3, KCNH2, KDR, PTGS2, SLC6A2, SLC6A4, SRC 4.46309
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC, TEK 4.45595
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2, TYR 4.4442
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 4.42958
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, APP, CDC25B, EGFR, ESRRB, FLT3, INSR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 4.42462
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR 4.41806
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, KIT, PTPN1, SRC 4.38257
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, APP, AURKB, CDC25B, DHFR, EGFR, ESR1, FLT3, GSK3B, HSPA1A, INSR, KIT, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.3601
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, AKR1C3, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GSK3B, HRH3, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 4.3601
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PTGS2, SRC 4.35481
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.31413
[BP] GO:0080135 regulation of cellular response to stress APP, DHFR, DUSP3, EGFR, GSK3B, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, TERT, XDH 4.2953
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GSK3B, IGF1R, INSR, KIT, PTPN1, SRC, TEK 4.2953
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GSK3B, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 4.2953
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 4.29319
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, AKR1C3, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GSK3B, HRH3, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 4.2891
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.2891
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH 4.21586
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, APP, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GSK3B, HSPA1A, INSR, KDR, KIT, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.18977
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, DUSP3, EGFR, ESR1, ESR2, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 4.13921
[BP] GO:0043393 regulation of protein binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SRC, TERT 4.12559
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.12058
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, GPR35, HRH3, KCNH2, MMP9, PTGS2 4.11158
[BP] GO:0051172 None ADRA2A, APP, AURKB, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HRH3, HRH4, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH 4.09964
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPR35, GSK3B, HRH3, HRH4, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 4.09964
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SLC6A4, SRC, TERT 4.08925
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, APP, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GSK3B, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.07015
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process AKR1C3, EGFR, INSR, PTGS2, SMAD3, XDH 4.05651
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.04106
[BP] GO:0071248 cellular response to metal ion AKR1C3, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.98688
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, APP, CDC25B, EGFR, FLT3, INSR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 3.98445
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2, TYR 3.97512
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AOX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DHFR, DUSP3, EGFR, ESR1, FLT3, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TYR, XDH 3.96995
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, APP, CDC25B, EGFR, ESR1, FLT3, GSK3B, HSPA1A, INSR, KDR, KIT, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.93891
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, IDO1, PPARA, PTGS2, SMAD3, TEK 3.93617
[BP] GO:0010906 None ESRRB, GSK3B, INSR, PPARA, RORC, SRC 3.91497
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, KIT, PTGS2, SLC6A4 3.91497
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, KIT, PTGS2, SLC6A4 3.91497
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2, TYR 3.89832
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, AXL, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, KIT, PTGS2, SRC 3.89832
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, GSK3B, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SRC 3.88063
[BP] GO:0003018 None ADORA1, ADRA2A, EGFR, PTGS2, SLC6A4, SRC, TEK 3.88063
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.83075
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, PTPN1, SRC, TEK 3.83075
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.83075
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS2 3.82934
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GSK3B, HRH3, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 3.81865
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, GSK3B, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 3.80234
[BP] GO:0050730 None ADORA1, ADRA2A, APP, EGFR, FLT3, KIT, PTPN1, SRC 3.80138
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APP, AXL, CA2, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, GSK3B, HRH3, HRH4, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK 3.76589
[BP] GO:0050793 regulation of developmental process APP, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GSK3B, IDO1, INSR, KDR, KIT, NUAK1, PIM1, PPARA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 3.73434
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CES1, CYP19A1, CYP1A1, CYP1B1, DHFR, TYR 3.72023
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.68918
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.65442
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.65442
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.65442
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD17B1, HSD17B2 3.63083
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.61502
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, GSK3B, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SRC 3.60789
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, ESR1, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.5908
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, MMP9, SRC 3.58711
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, KIT, MET, PIM1, SRC, TEK, TYR 3.5525
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DHFR, EGFR, PPARA, SMAD3 3.51094
[BP] GO:0051098 regulation of binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SMAD3, SRC, TERT 3.50889
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, FABP4, IDO1, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, TEK 3.50889
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.49915
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, APP, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GSK3B, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.48293
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.47976
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, PTPN1, SRC 3.47976
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9 3.42548
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, INSR, KIT, PTPN1, SRC 3.41829
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 3.4078
[BP] GO:0010675 None ESRRB, GSK3B, INSR, PPARA, RORC, SRC 3.4078
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, IDO1 3.40089
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, CYP19A1, ESR1, HSD17B2, INSR, KIT, SRC 3.35805
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 3.35805
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2, SLC6A4 3.35296
[BP] GO:0050890 None ADORA1, APP, EGFR, HRH3, INSR, KIT, PTGS2, SLC6A4 3.33783
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.33611
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 3.33547
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.33547
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 3.32429
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CES1, CYP19A1, HSD17B1, HSD17B2 3.32429
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 3.28646
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, CYP1B1, FABP3, HSPA1A, IDO1, PTGS2, SLC6A4, SMAD3, TERT, XDH 3.27825
[BP] GO:2000026 regulation of multicellular organismal development APP, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, GSK3B, IDO1, INSR, KDR, KIT, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 3.26132
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 3.25406
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KCNH2, KDR, PTGS2, SRC 3.24239
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, APP, AXL, CDC25B, CES1, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, GSK3B, KDR, KIT, MET, MMP2, MMP9, PTGS2, RORC, SMAD3, SRC, TEK, TERT 3.23354
[BP] GO:0044089 positive regulation of cellular component biogenesis ESR1, GSK3B, HSPA1A, KDR, KIT, MET, MMP1, SMAD3, SRC, TEK 3.18346
[BP] GO:0003013 None ADORA1, ADRA2A, EGFR, PTGS2, SLC6A4, SRC, TEK 3.17866
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APP, AURKB, AXL, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPR35, GSK3B, HRH3, HRH4, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 3.17486
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, APP, CA2, CA7, GPR35, HRH3, KCNH2, MMP9, PTGS2, SLC6A4 3.12424
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, APP, GPR35, GSK3B, HRH3, HSPA1A, KCNH2, MMP9, PTGS2 3.11417
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AURKB, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, HSPA1A, IGF1R, KDR, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH 3.10875
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, KIT, PTPN1, SRC 3.06436
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 3.047
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 3.03715
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.03495
[BP] GO:0016488 None AKR1B10, AKR1C3 3.03161
[BP] GO:0016487 None AKR1B10, AKR1C3 3.03161
[BP] GO:0016107 None AKR1B10, AKR1C3 3.03161
[BP] GO:0009115 None AOX1, XDH 3.03161
[BP] GO:0006714 None AKR1B10, AKR1C3 3.03161
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 3.03161
[BP] GO:0009889 regulation of biosynthetic process ADORA3, ADRA2A, AKR1C3, APP, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GSK3B, HRH3, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TERT 3.03058
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TERT 3.03058
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC, TERT 3.03058
[BP] GO:0043086 negative regulation of catalytic activity ADRA2A, APP, CSNK2A1, DUSP3, FABP4, GSK3B, HRH3, HRH4, IGF1R, MMP9, PTGS2, PTPN1, SRC 3.01985
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 3.0064
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 3.0064
[BP] GO:1900180 regulation of protein localization to nucleus APP, EGFR, GSK3B, PTGS2, SMAD3, SRC, TERT 3.00385
[BP] GO:0042058 None ADORA1, ADRA2A, APP, EGFR, MMP9 3.00105
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 3.00105
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.99357
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.96058
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.93141
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, GSK3B, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.88124
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, APP, CDC25B, EGFR, FLT3, INSR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 2.8677
[BP] GO:0001954 positive regulation of cell-matrix adhesion GSK3B, KDR, SMAD3, TEK 2.85613
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT 2.8445
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, GSK3B, HSPA1A, IDO1, SRC, XDH 2.82836
[BP] GO:0042136 neurotransmitter biosynthetic process ACHE, CYP1B1, DHFR, SLC6A4 2.82196
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.80614
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.80308
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, EGFR, FLT3, INSR, KIT, PTPN1, SRC, TEK 2.79575
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, HRH4, KCNH2, SMAD3 2.79575
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.79575
[BP] GO:0070920 None EGFR, ESR1, TERT 2.79575
[BP] GO:0003008 None ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, CYP1B1, EGFR, HRH3, INSR, KCNH2, KIT, PTGS2, SLC6A4, SRC, TEK, TYR 2.79575
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AXL, CYP1A1, EGFR, ESR1, KIT, PTGS2, SLC6A4, SRC 2.78634
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, CES1, CYP19A1, DHFR, TYR 2.7845
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.7845
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TERT 2.7845
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.77851
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, EGFR 2.77851
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX5, CES1, CYP19A1, CYP1A1, DHFR, IDO1, PTGS2 2.77687
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, CES1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PTGS2 2.7755
[BP] GO:1901184 None ADORA1, ADRA2A, APP, EGFR, MMP9 2.73961
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, APP, CA2, EGFR, GSK3B, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.73757
[BP] GO:2000351 None AKR1C3, KDR, TEK, TERT 2.73757
[BP] GO:0009896 positive regulation of catabolic process ADRA2A, CSNK2A1, ESRRB, GSK3B, HSPA1A, INSR, KDR, PPARA, PTPN1 2.73722
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, EGFR, FLT3, INSR, KIT, PTPN1, SRC, TEK 2.72367
[BP] GO:0032870 cellular response to hormone stimulus ADRA2A, AKR1C3, EGFR, ESR1, FLT3, INSR, KIT, SRC 2.72067
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.71566
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.71566
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.71566
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.71566
[BP] GO:0051094 positive regulation of developmental process APP, AXL, CA2, CYP1B1, ESRRB, IDO1, INSR, KDR, KIT, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 2.69422
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.67975
[BP] GO:0001952 regulation of cell-matrix adhesion GSK3B, KDR, SMAD3, SRC, TEK 2.67838
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.67013
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, FLT3, INSR, KIT, PTPN1, SRC 2.66253
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.6601
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.6601
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.6601
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, KIT, PTPN1, SRC 2.6601
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, GSK3B, INSR, PPARA, RORC, SRC 2.6473
[BP] GO:0046110 None AOX1, XDH 2.64509
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.64509
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.64509
[BP] GO:0016095 None AKR1B10, AKR1C3 2.64509
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, KDR, KIT, PTGS2, TEK, TERT 2.64304
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC, TERT 2.64042
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.63911
[BP] GO:0071396 cellular response to lipid AKR1C3, AXL, EGFR, ESR1, FLT3, RORC, SLC6A4, SRC 2.63843
[BP] GO:0031326 regulation of cellular biosynthetic process ADORA3, ADRA2A, AKR1C3, APP, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GSK3B, HRH3, HRH4, HSPA1A, IGF1R, INSR, KIT, MET, MMP12, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TERT 2.61632
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.61404
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.61404
[BP] GO:0008406 gonad development AKR1C3, CYP19A1, ESR1, INSR, KIT 2.60604
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CSNK2A1, EGFR, FLT3, GPR35, GSK3B, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 2.5737
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPR35, GSK3B, HRH3, HRH4, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.5737
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, EGFR, KDR, PTGS2, SRC 2.56468
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.53258
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.53258
[BP] GO:0031327 None ADRA2A, AKR1C3, AURKB, DHFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, HRH3, HRH4, HSPA1A, MMP12, PPARA, RORC, SMAD3, SRC 2.51369
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.50642
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.50054
[BP] GO:0010628 positive regulation of gene expression APP, EGFR, ESR1, ESR2, ESRRA, ESRRB, GSK3B, HSPA1A, INSR, KIT, MET, MMP12, PPARA, RORC, SLC6A4, SMAD3, SRC, TERT 2.49455
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.49166
[BP] GO:0006066 None AKR1B1, AKR1B10, AKR1C3, APP, CES1, CYP1B1, DHFR 2.49104
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT 2.48761
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, IDO1, KDR, MET, PTGS2, SMAD3 2.46373
[BP] GO:0009890 None ADRA2A, AKR1C3, AURKB, DHFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, HRH3, HRH4, HSPA1A, MMP12, PPARA, RORC, SMAD3, SRC 2.45744
[BP] GO:2001233 regulation of apoptotic signaling pathway GSK3B, HSPA1A, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT 2.45744
[BP] GO:0010638 positive regulation of organelle organization AURKB, GSK3B, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.45287
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.44921
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.44921
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.4418
[BP] GO:0007584 response to nutrient AKR1C3, CYP1A1, EGFR, PTGS2, SLC6A4, TYR 2.4418
[BP] GO:0071229 cellular response to acid chemical AKR1C3, EGFR, KDR, MMP2, SLC6A4, SRC 2.43266
[BP] GO:0051336 regulation of hydrolase activity APP, CSNK2A1, EGFR, ESR1, GSK3B, HSPA1A, KIT, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, XDH 2.42975
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, CYP1B1, ESR1, ESR2, HSPA1A, KIT, PIM1 2.41429
[BP] GO:0051953 None ADORA1, ADRA2A, HRH3 2.40164
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.40164
[BP] GO:0006145 None AOX1, XDH 2.39808
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.39808
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.39808
[BP] GO:0033554 cellular response to stress AKR1B1, AKR1C3, AXL, CA2, CA9, CYP1B1, DHFR, EGFR, GSK3B, HSPA1A, MMP9, NUAK1, PTGS2, PTPN1, SRC, TERT 2.39767
[BP] GO:0035556 intracellular signal transduction ADRA2A, AKR1B1, AXL, CYP1B1, EGFR, GSK3B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PTPN1, SRC, TEK 2.39641
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, CA2, CYP19A1, DUSP3, ESR1, ESRRA, HSPA1A, IDO1, KIT, MMP12, MMP2, PTPN1, SMAD3, SRC 2.39409
[BP] GO:0001819 positive regulation of cytokine production ADRA2A, CYP1B1, HSPA1A, IDO1, MMP12, PTGS2, SMAD3, SRC 2.37721
[BP] GO:0031331 positive regulation of cellular catabolic process ADRA2A, ESRRB, GSK3B, HSPA1A, INSR, KDR, PPARA, PTPN1 2.37721
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, PTGS2, SLC6A4 2.37581
[BP] GO:0097746 None ADORA1, ADRA2A, EGFR, PTGS2, SLC6A4 2.37387
[BP] GO:0035296 None ADORA1, ADRA2A, EGFR, PTGS2, SLC6A4 2.37387
[BP] GO:0051894 None KDR, SMAD3, TEK 2.36374
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.36374
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, EGFR, FLT3, INSR, KIT, PTPN1, SRC 2.35663
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.35663
[BP] GO:0006940 None ADORA1, ADRA2A, KIT, PTGS2 2.35663
[BP] GO:0098771 inorganic ion homeostasis APP, CA12, CA2, CA7, EGFR, ESR1, GPR35, HRH4, KCNH2, SMAD3 2.33558
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CES1, CYP1A1, CYP1B1, KDR, SLC6A4, SRC 2.33452
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, TEK 2.3337
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.3331
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, EGFR, GPR35, KCNH2, KIT, PTGS2, SMAD3 2.33024
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, GSK3B, HSPA1A, IDO1, XDH 2.32451
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.32451
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GSK3B, IGF1R, INSR, SRC 2.30245
[BP] GO:0046683 response to organophosphorus APP, PTGS2, SLC6A4, TEK, TYR 2.29206
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.29103
[BP] GO:0005979 None ESRRB, GSK3B, INSR 2.27924
[BP] GO:1903393 None KDR, SMAD3, TEK 2.27924
[BP] GO:0006693 None AKR1C3, CES2, PTGS2 2.27924
[BP] GO:0006692 None AKR1C3, CES2, PTGS2 2.27924
[BP] GO:0010962 None ESRRB, GSK3B, INSR 2.27924
[BP] GO:2001234 negative regulation of apoptotic signaling pathway HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT 2.27924
[BP] GO:0050880 None ADORA1, ADRA2A, EGFR, PTGS2, SLC6A4 2.27165
[BP] GO:0035150 None ADORA1, ADRA2A, EGFR, PTGS2, SLC6A4 2.25895
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.25895
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.25119
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.24594
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.24594
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPR35, GSK3B, HRH3, HRH4, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.24594
[BP] GO:0031349 positive regulation of defense response EGFR, FABP4, HSPA1A, IDO1, MMP12, MMP2, PTGS2, SRC 2.24594
[BP] GO:0015711 organic anion transport CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.24594
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.24374
[BP] GO:1900543 None ADRA2A, HRH3, HRH4, PPARA 2.24118
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.2399
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 2.2339
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.2339
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.2339
[BP] GO:0014050 None ADORA1, HRH3 2.2339
[BP] GO:0031099 regeneration AXL, CSNK2A1, DHFR, EGFR, FLT3 2.23293
[BP] GO:0007623 circadian rhythm EGFR, GSK3B, PPARA, RORC, SLC6A4 2.23293
[BP] GO:0051248 None APP, CSNK2A1, DHFR, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 2.23293
[BP] GO:0030155 regulation of cell adhesion CYP1B1, DUSP3, GSK3B, IDO1, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.23246
[BP] GO:0051128 regulation of cellular component organization APP, AURKB, AXL, CSNK2A1, EGFR, ESR1, ESR2, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PTPN1, SMAD3, SRC, TEK 2.23188
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, EGFR, INSR, KIT, PTPN1, SRC 2.23188
[BP] GO:0045980 None ADRA2A, HRH3, HRH4, PPARA 2.23188
[BP] GO:0051241 negative regulation of multicellular organismal process ADORA1, APP, AXL, EGFR, GPR35, GSK3B, IDO1, PTGS2, SLC6A4, SMAD3, TEK, TERT, XDH 2.23188
[BP] GO:0048545 response to steroid hormone AKR1C3, CA2, EGFR, FLT3, PTGS2, SRC 2.22202
[BP] GO:0045934 None ADRA2A, AURKB, ESR1, ESR2, ESRRA, FABP4, HRH3, HRH4, HSPA1A, MMP12, PPARA, RORC, SMAD3, SRC, TERT 2.21874
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.21183
[BP] GO:0001775 cell activation ADRA2A, ALOX5, APP, AXL, EGFR, FLT3, HSPA1A, KIT, MMP9, RORC, SMAD3, SRC 2.20136
[BP] GO:0071383 None AKR1C3, EGFR, FLT3, SRC 2.19248
[BP] GO:0061097 None ADORA1, ADRA2A, APP, PTPN1 2.19248
[BP] GO:0009991 response to extracellular stimulus AKR1C3, AXL, CYP1A1, EGFR, PTGS2, SLC6A4, SRC, TYR 2.17509
[BP] GO:0007176 None ADORA1, ADRA2A, APP 2.17509
[BP] GO:0031334 positive regulation of protein complex assembly ESR1, GSK3B, HSPA1A, MET, MMP1, SRC 2.16797
[BP] GO:1904035 regulation of epithelial cell apoptotic process AKR1C3, KDR, TEK, TERT 2.15379
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.15379
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3 2.13666
[BP] GO:0070873 None ESRRB, GSK3B, INSR 2.13666
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.13666
[BP] GO:1904645 response to amyloid-beta APP, GSK3B, IGF1R 2.13666
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.1362
[BP] GO:0014074 response to purine-containing compound APP, PTGS2, SLC6A4, TEK, TYR 2.1125
[BP] GO:1901342 regulation of vasculature development CYP1B1, KDR, KIT, PTGS2, TEK, TERT, XDH 2.1102
[BP] GO:1901890 None KDR, SMAD3, TEK 2.10223
[BP] GO:2000352 None KDR, TEK, TERT 2.10223
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.10223
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.10223
[BP] GO:0046113 None AOX1, XDH 2.10223
[BP] GO:1990535 None APP, INSR 2.10223
[BP] GO:0051934 None SLC6A2, SLC6A4 2.10223
[BP] GO:0090494 None SLC6A2, SLC6A4 2.10223
[BP] GO:0090493 None SLC6A2, SLC6A4 2.10223
[BP] GO:0051583 None SLC6A2, SLC6A4 2.10223
[BP] GO:0016115 None AKR1B10, AKR1C3 2.10223
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19 2.10223
[BP] GO:1900542 None ADRA2A, ESRRB, HRH3, HRH4, INSR, PPARA 2.10066
[BP] GO:0070542 None AKR1C3, FABP3, PTGS2, SRC 2.09232
[BP] GO:0007611 None APP, EGFR, INSR, KIT, PTGS2, SLC6A4 2.09232
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, AOX1, CYP19A1, CYP1A2, GSK3B, IDO1, XDH 2.08999
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADORA3, ADRA2A, APP, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, HRH3, HRH4, HSPA1A, IGF1R, INSR, KIT, MET, MMP12, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TERT 2.08635
[BP] GO:0051254 None APP, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT 2.08635
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.08569
[BP] GO:0007194 None ADRA2A, HRH3, HRH4 2.07842
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.07842
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.07842
[BP] GO:0043255 regulation of carbohydrate biosynthetic process ESRRB, GSK3B, INSR, PPARA 2.07842
[BP] GO:0009653 anatomical structure morphogenesis APP, AXL, CA2, CA9, CYP1B1, EGFR, ESR1, INSR, MET, MMP2, SLC6A4, SMAD3, SRC, TEK 2.06897
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, HRH3 2.06361
[BP] GO:0033273 response to vitamin CYP1A1, EGFR, PTGS2, TYR 2.06361
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3 2.06361
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.06361
[BP] GO:0006140 None ADRA2A, ESRRB, HRH3, HRH4, INSR, PPARA 2.04957
[BP] GO:1902893 None PPARA, SMAD3, TERT 2.04957
[BP] GO:0106027 None APP, IGF1R, INSR 2.04957
[BP] GO:0032885 regulation of polysaccharide biosynthetic process ESRRB, GSK3B, INSR 2.04957
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, KIT 2.04957
[BP] GO:1904063 None ADRA2A, GPR35, KCNH2, MMP9 2.04818
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, KDR, PTGS2, TEK, TERT 2.04243
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.04237
[BP] GO:0031960 response to corticosteroid AKR1C3, EGFR, FLT3, PTGS2, SRC 2.03137
[BP] GO:1901989 None APP, CDC25B, CYP1A1, TERT 2.03137
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, SMAD3, SRC 2.01856
[BP] GO:0032148 None ADRA2A, INSR, SRC 2.01856
[BP] GO:0031280 None ADRA2A, HRH3, HRH4 2.01856
[BP] GO:0032092 positive regulation of protein binding APP, GSK3B, MMP9, TERT 2.01795
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PTGS2, TEK 2.01795
[BP] GO:0045936 None ADRA2A, DUSP3, FABP4, HRH3, HRH4, IGF1R, PPARA, PTPN1, XDH 2.00564
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.00181
[BP] GO:0010563 None ADRA2A, DUSP3, FABP4, HRH3, HRH4, IGF1R, PPARA, PTPN1, XDH 2.00181
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 3.99125
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 3.97512
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, FLT3, GPR35, GSK3B, HRH3, HRH4, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP2, PIM1, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 3.80138
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, TEK 3.41829
[CC] GO:0098589 membrane region APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 3.41373
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA2A, APP, AXL, CA2, CA4, CA9, DUSP3, EGFR, FLT3, GPR35, HRH3, IGF1R, INSR, KCNH2, KDR, KIT, MET, PTGS2, SLC6A2, SLC6A4, SRC, TEK 3.14333
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, APP, AXL, CA4, FLT3, GPR35, HRH3, IGF1R, INSR, KDR, MET, SLC6A2, SLC6A4, TEK 2.56119
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, APP, AXL, FLT3, GPR35, HRH3, IGF1R, INSR, KDR, MET, SLC6A2, SLC6A4, TEK 2.27276
[CC] GO:0005783 None ADORA1, APP, CA4, CES1, CES2, CYP19A1, FLT3, HSPA1A, KDR, PTGS2, PTPN1, XDH 2.25044
[CC] GO:0009986 cell surface ACHE, APP, AXL, CA4, EGFR, KCNH2, MET, SLC6A2, TEK 2.23188
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.10223
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, AURKB, CA2, CA4, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, INSR, KCNH2, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, TYR, XDH 2.01795
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 13.0105
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, APP, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 11.0515
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, DUSP3, EGFR, FLT3, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS2, PTPN1, SRC, TEK, TERT, TYR, XDH 10.2042
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.96443
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 8.30555
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.26129
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PPARA, SLC6A4, SRC, TEK 6.77164
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 6.72316
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.54838
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 6.53559
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HRH3, HRH4, IGF1R, INSR, KCNH2, KDR, KIT, MET, PPARA, RORC, TEK 6.45498
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TYR, XDH 6.31539
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 6.15472
[MF] GO:0046872 metal ion binding ALOX5, AOX1, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TYR, XDH 6.00799
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC 5.77271
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HRH3, HRH4, IGF1R, INSR, KCNH2, KDR, KIT, MET, PPARA, RORC, TEK 5.6454
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HRH3, HRH4, IGF1R, INSR, KCNH2, KDR, KIT, MET, PPARA, RORC, SMAD3, TEK 5.60231
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 5.60031
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC 5.5349
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, IDO1, PTGS2, SRC 5.46829
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 5.45854
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HRH3, HRH4, IGF1R, INSR, KCNH2, KDR, KIT, MET, PPARA, RORC, TEK 5.45073
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.43058
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.43058
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, IDO1, PTGS2, SRC 5.26329
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 5.17201
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 5.16948
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 5.13659
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.00714
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TERT 4.98724
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS2, TYR 4.93256
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH 4.84403
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, HSD17B1, IDO1, PTGS2, SRC, XDH 4.75981
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, KIT, MET, MMP9, PTGS2, SLC6A4, SMAD3, TERT, TYR, XDH 4.75486
[MF] GO:0019899 enzyme binding ADRA2A, APP, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRB, GSK3B, HSPA1A, KCNH2, KIT, MET, PPARA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK 4.50082
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.45657
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 4.24895
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.20432
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HSD17B1, HSD17B2, XDH 4.20432
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 4.15394
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.89832
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.70519
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.65442
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, AOX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 3.57608
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 3.46619
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 3.33349
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, DHFR, EGFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, XDH 3.27504
[MF] GO:0045550 None AKR1B10, AKR1C3 3.03161
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.03161
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.01869
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, FLT3, KCNH2, KIT, PTGS2, SLC6A4, SMAD3, TERT, TYR, XDH 2.81555
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, FLT3, GPR35, HRH3, HRH4, IGF1R, INSR, KDR, KIT, MET, TEK 2.72553
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, FLT3, GPR35, HRH3, HRH4, IGF1R, INSR, KDR, KIT, MET, TEK 2.72553
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CSNK2A1, DHFR, EGFR, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, XDH 2.72111
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CSNK2A1, DHFR, EGFR, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, XDH 2.72067
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, AOX1, AXL, EGFR, FLT3, KCNH2, KIT, PTGS2, SLC6A4, SMAD3, TERT, TYR, XDH 2.71566
[MF] GO:0047718 None AKR1B10, AKR1C3 2.64509
[MF] GO:0005330 None SLC6A2, SLC6A4 2.64509
[MF] GO:0047374 None CES1, CES2 2.64509
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.55835
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 2.5422
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 2.53785
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 2.44165
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD17B1, HSD17B2 2.43426
[MF] GO:0043168 anion binding AOX1, APP, AURKB, AXL, CSNK2A1, DHFR, EGFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, XDH 2.42158
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 2.41406
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.39808
[MF] GO:0032795 None ADORA1, ADRA2A 2.39808
[MF] GO:0051425 None APP, INSR 2.39808
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, KIT, SMAD3 2.39795
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.39744
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.29206
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.27924
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.27924
[MF] GO:0019900 None ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, GSK3B, PTPN1, SMAD3, SRC 2.26321
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD17B1, HSD17B2 2.24374
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.24374
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.2339
[MF] GO:0043559 insulin binding IGF1R, INSR 2.2339
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, PPARA, RORC 2.20382
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD17B1, HSD17B2 2.17509
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.17509
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.10223
[MF] GO:0005329 None SLC6A2, SLC6A4 2.10223
[MF] GO:0055131 None HSPA1A, KCNH2 2.10223
[MF] GO:0043546 None AOX1, XDH 2.10223
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2 2.10223
[MF] GO:0004969 None HRH3, HRH4 2.10223
[MF] GO:0019901 None ADRA2A, CDC25B, DUSP3, EGFR, ESR1, GSK3B, PTPN1, SMAD3, SRC 2.06878
[MF] GO:0008013 beta-catenin binding CSNK2A1, ESR1, GSK3B, SMAD3 2.06361
[MF] GO:0008134 transcription factor binding ESR1, ESRRB, FLT3, GSK3B, PIM1, PPARA, SMAD3, SRC, TERT 2.01856
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2C19 2.01856


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 12.7857
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.0894
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 8.9237
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 7.3882
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, SMAD3, FLT3, MMP1, MMP2, KIT, PTGS2, MMP9, MET, EGFR, IGF1R 5.5827
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 5.8386
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.1032
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.2779
Metabolic pathways_Homo sapiens_hsa01100 AKR1C3, AKR1B1, PTGS2, TYR, CYP2C19, CYP19A1, DHFR, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, IDO1, CES1 5.0164
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 5.0218
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.2779
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 4.4346
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 3.8604
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 3.6613
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP2C19 3.9751
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PTGS2, CYP2C19, SLC6A4 3.4345
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, MET, EGFR, IGF1R 3.2712
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 3.2712
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, PTGS2 3.4345
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, AKR1C3, PTGS2, CYP2C19 3.2939
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET, EGFR 3.2285
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC, ESR1, ESR2 3.1465
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HRH3, GPR35, ADORA3, HRH4, ADORA1, ADRA2A 2.6442
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1987
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.6007
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, INSR, PPARA 2.5399
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.2466
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, SMAD3, ESRRB, IGF1R 2.1959
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.2923
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 2.0783
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.2357
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.1959
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRA2A 2.0101
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1223
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1521
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9248
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.5399
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1959
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP2C19 2.1461
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC, EGFR 1.9263
Prostate cancer_Homo sapiens_hsa05215 GSK3B, EGFR, IGF1R 1.9187
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.901
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.8114
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.0993
Melanogenesis_Homo sapiens_hsa04916 GSK3B, KIT, TYR 1.8145
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.5211
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC, ESR1 1.659
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1, HSPA1A 1.5211
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA, EGFR 1.5339
Cell cycle_Homo sapiens_hsa04110 GSK3B, SMAD3, CDC25B 1.6084
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, SMAD3, CSNK2A1 1.4878
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, KIT, EGFR 1.479
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B, INSR 1.5053
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.4772
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, INSR, PPARA 1.4453
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2, EGFR 1.4001
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, HSPA1A 1.1755
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, SMAD3, TERT 0.965
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.9923
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0706
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0976
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8567
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9543
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9469
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9543
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7916
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9322
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B, SMAD3 0.8074
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.1322
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1203
Influenza A_Homo sapiens_hsa05164 GSK3B, HSPA1A 0.7364
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1322
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.9194
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.1003
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2929
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP 0.761
Purine metabolism_Homo sapiens_hsa00230 XDH 0.328
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6353
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3213
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3378
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.6649
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.6985
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3269
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3274
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2102
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4117
Platelet activation_Homo sapiens_hsa04611 SRC 0.4352
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3449
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.4218
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B 0.4376
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4352
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4619
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3387
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4864
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4821
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4864
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.4821
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, SMAD3 1.364
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4874
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4921
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4916
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4864
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5046
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, EGFR 1.4772
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5204
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.51
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3449
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5093
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.5151
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.398
Peroxisome_Homo sapiens_hsa04146 XDH 0.5214
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5592
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.5592
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5592
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5577
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5605
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5462
Bile secretion_Homo sapiens_hsa04976 CA2 0.5592
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5794
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5837
Shigellosis_Homo sapiens_hsa05131 SRC 0.5815
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.605
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6282
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6313
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6313
Malaria_Homo sapiens_hsa05144 MET 0.6609
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6649
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.657
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6649
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8242
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6649
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7284
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.8438
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7272
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7129
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7959
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.761
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.761
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9935
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8368
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8119
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8074
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8368
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.937
Folate biosynthesis_Homo sapiens_hsa00790 DHFR 1.056
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1465
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3465


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)