TCM Prescription: Fu Fang Xian Ling Pi Wine



Prescription Description
Prescription IDTCMF3158
Pinyin NameFu Fang Xian Ling Pi Jiu
Chinese Name复方仙灵脾酒
English NameFu Fang Xian Ling Pi Wine
Function Description痹病, 健忘
IndicationsForgetfulness disorder, Arthritis, Rheumatoid arthritis
Disease ICD-11 Category SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Brain
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1405 Penicillium citrinum
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KCNH2, KDR, MMP2, MMP9, PPARA, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 7.31317
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, HSD17B1, HSD17B2 6.49975
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.09758
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, FABP3, FABP4, HSD17B1, HSD17B2, MET, PPARA 6.02827
[BP] GO:0048522 positive regulation of cellular process ACHE, ADRA2A, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 5.84503
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.84503
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, RORC, SLC6A4, SRC, TYR 5.84503
[BP] GO:0048518 positive regulation of biological process ACHE, ADRA2A, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 5.84503
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PPARA, RORC, SLC6A4, SRC, TYR 5.84503
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PPARA, RORC, SLC6A4, SRC, TYR 5.75617
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TYR, XDH 5.64256
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TYR, XDH 5.63834
[BP] GO:0065008 regulation of biological quality ACHE, ADRA2A, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KCNH2, KDR, MET, PPARA, SLC6A2, SLC6A4, SRC, TERT, XDH 5.56704
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.56704
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA12, CA2, CA4, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, TYR, XDH 5.48338
[BP] GO:0032501 multicellular organismal process ADRA2A, AKR1B1, AKR1B10, ALOX5, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SRC, TYR 5.33046
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.25966
[BP] GO:0042127 regulation of cell proliferation ADRA2A, AKR1B1, CDC25B, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SLC6A4, SRC, TERT, XDH 5.12983
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.03823
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.84405
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, PPARA, SLC6A4, SRC 4.7446
[BP] GO:0032502 developmental process ACHE, AKR1B1, AURKB, AXL, CA2, CA9, CDC25B, CES1, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A4, SRC, TERT, TYR 4.73373
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.73119
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, RORC 4.73119
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.56136
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.53632
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC, TERT 4.50491
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, PPARA, SLC6A4, SRC 4.48129
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, RORC, SLC6A4, SRC, TERT 4.43263
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.40855
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, RORC, SLC6A4, SRC, TYR 4.37009
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.33368
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 4.28979
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, CDC25B, CHRM1, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, TERT 4.27085
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PPARA 4.22735
[BP] GO:0007200 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, ESR1 4.17555
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 4.05065
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.93418
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH 3.93115
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.93115
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.93115
[BP] GO:0010647 positive regulation of cell communication ADRA2A, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 3.9255
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, MET, PPARA 3.9255
[BP] GO:0023056 positive regulation of signaling ADRA2A, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 3.90738
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.83591
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.82612
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.82612
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.82612
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.75959
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT, XDH 3.75334
[BP] GO:0019216 regulation of lipid metabolic process ADRA2A, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC 3.65892
[BP] GO:0050896 response to stimulus ACHE, ADRA2A, AKR1B1, AURKB, AXL, CA2, CA9, CES1, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KCNH2, KDR, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 3.61273
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.58319
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B1, HSD17B2, TYR, XDH 3.57015
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, PTPN1, RORC, SLC6A4, SRC, TERT 3.51434
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.46524
[BP] GO:0010817 regulation of hormone levels ACHE, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B1, HSD17B2 3.42305
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TYR, XDH 3.34739
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 3.31241
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, RORC, SRC, TYR 3.25022
[BP] GO:0007193 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5 3.23926
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, XDH 3.18785
[BP] GO:0015872 None CHRM5, SLC6A2, SLC6A4 2.9794
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT 2.97729
[BP] GO:0032879 regulation of localization ACHE, ADRA2A, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT 2.96499
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.96499
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, RORC, SLC6A4, SRC 2.92454
[BP] GO:0010646 regulation of cell communication ACHE, ADRA2A, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 2.92278
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KCNH2, KDR, SLC6A2, SLC6A4, SRC 2.90672
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.90449
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.90449
[BP] GO:0023051 regulation of signaling ACHE, ADRA2A, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 2.84571
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PPARA 2.82366
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.82046
[BP] GO:0009115 None AOX1, XDH 2.818
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TYR, XDH 2.80701
[BP] GO:0051937 None CHRM5, SLC6A2, SLC6A4 2.7434
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.71111
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.66146
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.62261
[BP] GO:0051050 positive regulation of transport ACHE, ADRA2A, AXL, CA2, CHRM1, CYP19A1, HCAR2, KCNH2, MMP12, SLC6A4, SRC, TERT 2.62054
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.62054
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.60725
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, PPARA, RORC, SLC6A4, SRC 2.5843
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.57462
[BP] GO:0009987 cellular process ACHE, ADRA2A, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR, XDH 2.56296
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.55572
[BP] GO:0048523 negative regulation of cellular process ACHE, ADRA2A, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 2.55572
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CES1, CYP1A1, CYP1B1, KDR, SLC6A4, SRC 2.55568
[BP] GO:0044092 negative regulation of molecular function ADRA2A, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 2.52674
[BP] GO:0051239 regulation of multicellular organismal process ADRA2A, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, ESR1, ESRRA, ESRRB, HCAR2, KCNH2, KDR, MET, MMP12, MMP9, PIM1, SLC6A4, SRC, TERT, XDH 2.52514
[BP] GO:0042592 homeostatic process ADRA2A, AKR1B1, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, KCNH2, MET, SRC, TERT 2.49698
[BP] GO:0015711 organic anion transport CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.45009
[BP] GO:0046110 None AOX1, XDH 2.43706
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.43706
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 2.43036
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.42901
[BP] GO:0043393 regulation of protein binding AURKB, MET, MMP9, PPARA, SRC, TERT 2.42901
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, TYR 2.42066
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.39754
[BP] GO:0015844 None CHRM5, SLC6A2, SLC6A4 2.39039
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.39039
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD17B1, HSD17B2 2.37823
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.33936
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.33936
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, SLC6A4, SRC 2.31784
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.31653
[BP] GO:0022600 None ADRA2A, CHRM1, CHRM3, CHRM5 2.31653
[BP] GO:0006940 None ADRA2A, CHRM1, CHRM2, CHRM3 2.31653
[BP] GO:0048519 negative regulation of biological process ACHE, ADRA2A, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 2.31452
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.29614
[BP] GO:0051049 regulation of transport ACHE, ADRA2A, AXL, CA2, CA7, CHRM1, CYP19A1, HCAR2, KCNH2, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT 2.2655
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.24442
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, RORC, SLC6A4, SRC 2.20985
[BP] GO:0009893 positive regulation of metabolic process ADRA2A, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 2.20985
[BP] GO:0006145 None AOX1, XDH 2.20985
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.20985
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.20985
[BP] GO:0010648 negative regulation of cell communication ACHE, ADRA2A, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 2.19093
[BP] GO:0023057 negative regulation of signaling ACHE, ADRA2A, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 2.1798
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADRA2A, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 2.1798
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.1781
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.15706
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, SRC 2.1501
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, ESR1, FLT3, RORC, SLC6A4, SRC 2.13352
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, TYR 2.10775
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, TERT 2.10235
[BP] GO:0009967 positive regulation of signal transduction ADRA2A, AKR1B1, AXL, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.10235
[BP] GO:0048584 positive regulation of response to stimulus ADRA2A, AKR1B1, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, XDH 2.05197
[BP] GO:0006082 organic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, TYR 2.05065
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, AXL, CA2, CHRM3, CYP1B1, ESRRB, HCAR2, KDR, MET, MMP12, MMP9, PIM1, SRC, TERT 2.04931
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.04931
[BP] GO:0003018 None ADRA2A, CHRM1, CHRM3, SLC6A4, SRC 2.03532
[BP] GO:0046541 None CHRM1, CHRM3 2.03532
[BP] GO:0007188 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5 2.02807
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.01852
[CC] GO:0005886 plasma membrane ACHE, ADRA2A, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, ESR1, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTPN1, SLC6A2, SLC6A4, SRC, TERT 2.39039
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.91247
[CC] GO:0016323 basolateral plasma membrane ADRA2A, CA2, CA4, CA9, CHRM3 1.75338
[CC] GO:0031226 intrinsic component of plasma membrane ADRA2A, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, IGF1R, KDR, MET, SLC6A2, SLC6A4 1.74238
[CC] GO:0032279 None CHRM2, CHRM3 1.69711
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 13.5699
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR, XDH 7.84386
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 7.84386
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FLT3, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TYR, XDH 7.687
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.09758
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC 5.93374
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TYR, XDH 5.84503
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.33288
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.33288
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 5.08888
[MF] GO:0046872 metal ion binding ALOX5, AOX1, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TYR, XDH 4.97013
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.95586
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH 4.95586
[MF] GO:0038023 signaling receptor activity ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 4.84405
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SLC6A4, SRC 4.84405
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.46236
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B1, HSD17B2, TYR, XDH 4.35849
[MF] GO:0004872 receptor activity ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 4.21846
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 4.19343
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.17555
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.17555
[MF] GO:0060089 molecular transducer activity ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 4.05118
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 3.98087
[MF] GO:0044877 macromolecular complex binding ACHE, ADRA2A, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 3.82612
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.82612
[MF] GO:0008227 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5 3.76687
[MF] GO:0004871 signal transducer activity ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 3.7468
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.63572
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.61636
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 3.37822
[MF] GO:0032403 protein complex binding ACHE, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 3.34016
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, HSD17B2, XDH 3.249
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 3.22148
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.16953
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 3.04237
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 2.96499
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.83393
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, SLC6A4, TERT, TYR, XDH 2.82366
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.818
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B1, SRC, XDH 2.81327
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.6499
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 2.62054
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, SRC 2.62054
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.62054
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, PPARA, RORC 2.52674
[MF] GO:0005330 None SLC6A2, SLC6A4 2.43706
[MF] GO:0047374 None CES1, CES2 2.43706
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.43604
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.20985
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.12313
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, SRC 2.10235
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.03532
[MF] GO:0004629 None CHRM1, CHRM3, CHRM5 2.0166


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.3771
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 9.343
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.343
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.4129
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.378
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1026
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.766
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.9574
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1026
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP2C19, CYP19A1, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, CES1 3.5698
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3924
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.6362
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP2C19 3.1704
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.2879
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, CHRM5, ADRA2A 2.2329
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.6465
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 2.1599
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.2329
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5 2.1397
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2879
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP2C19 2.2371
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, MET, IGF1R 2.0023
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, PPARA 2.0154
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.2329
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1397
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 2.0082
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.971
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7486
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, CYP2C19, SLC6A4 1.8979
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.2211
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4757
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4423
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.1482
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3683
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3864
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1022
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2054
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.3452
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1637
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4587
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3847
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.1022
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, CYP2C19 1.4397
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3118
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.1714
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9165
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.058
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.93
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.8639
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.058
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9389
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.5264
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5264
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2917
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2917
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9431
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3568
Platelet activation_Homo sapiens_hsa04611 SRC 0.4681
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.5264
Purine metabolism_Homo sapiens_hsa00230 XDH 0.387
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3559
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5264
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3783
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4896
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5264
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4275
Tuberculosis_Homo sapiens_hsa05152 SRC 0.387
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4681
Measles_Homo sapiens_hsa05162 CSNK2A1 0.452
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4157
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5139
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADRA2A 0.4007
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4558
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5122
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4681
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.445
Gap junction_Homo sapiens_hsa04540 SRC 0.5264
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3783
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4484
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4681
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5095
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5264
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5209
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5122
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4558
Peroxisome_Homo sapiens_hsa04146 XDH 0.5264
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.8508
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4681
Axon guidance_Homo sapiens_hsa04360 MET 0.4638
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5264
Glioma_Homo sapiens_hsa05214 IGF1R 0.5754
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.5264
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5264
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5754
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5209
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5209
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5585
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.9578
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.582
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5754
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.6033
Bile secretion_Homo sapiens_hsa04976 CA2 0.5585
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5754
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0795
Shigellosis_Homo sapiens_hsa05131 SRC 0.5754
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9014
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8392
Malaria_Homo sapiens_hsa05144 MET 0.6505
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.654
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6523
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8392
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8321
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.862
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1704
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3683


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)