TCM Prescription: Hou Pu Wen Zhong Decoction



Prescription Description
Prescription IDTCMF2841
Pinyin NameHou Pu Wen Zhong Tang
Chinese Name厚朴温中汤
English NameHou Pu Wen Zhong Decoction
Function Description治脾胃虚寒, 心腹胀满, 及秋冬客寒犯胃, 时作疼痛
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceSATCM
Reference Book/linkhttp://www.satcm.gov.cn/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH1184 Citrus reticulata 橘皮 TCMH1184 ITSAA1245-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH215 Alpinia katsumadai 草豆蔻仁 TCMH215 KY454001
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
Reference: SATCM

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT303 KCNA3 Voltage-gated potassium channel subunit Kv1.3 Ion channel P22001
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 14.3829
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.4225
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, MMP2, MMP9, PPARA, PRKCB, PRKCD, PRKCE, TRPV1, TYR 10.5692
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, MCL1, MMP2, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, TRPV1, TYR 9.83915
[BP] GO:0042221 response to chemical AKR1B1, ALPL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, MCL1, MMP2, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, TRPV1, TYR 8.44601
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, PIM1, PPARA, TYR, XDH 7.99275
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.90908
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 7.60208
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 7.60208
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, PRKCE, TYR 7.50416
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.73131
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA, TRPV1 6.70824
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.69554
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, PRKCE, PRKCG, TRPV1, TYR 6.53717
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 6.22508
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F2, F3, FABP3, FABP4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MCL1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, TNKS, TNKS2, TRPV1, XDH 6.1934
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, PPARA, PRKCD, PRKCE, TRPV1 6.17824
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PRKCA, PRKCE 5.60847
[BP] GO:0042493 response to drug AKR1B1, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, PRKCD, PRKCE, PRKCG, TRPV1 5.56979
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FUT7, GBA2, HSD17B1, HSD17B2, MMP1, MMP2, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TYR, XDH 5.27225
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, MMP2, PPARA, PRKCD, PRKCE, TRPV1 4.76566
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.72194
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.6421
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, PRKCE 4.60424
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, MCL1, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TRPV1, XDH 4.36486
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.24124
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 4.15331
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, KCNA3, PPARA, PRKCB, PRKCE, TRPV1 3.96814
[BP] GO:0010647 positive regulation of cell communication AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, F3, MCL1, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, TNKS, TNKS2, XDH 3.95928
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 3.95928
[BP] GO:0023056 positive regulation of signaling AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, F3, MCL1, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, TNKS, TNKS2, XDH 3.94778
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CA3, CNR1, CNR2, CYP1A1, CYP1B1, PRKCD, PRKCE 3.80539
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, FABP4, FUT7, GBA2, HSD11B1, HSD17B2, MCL1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCD, TNKS2, TYR 3.79294
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 3.79294
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, MCL1, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TRPV1, XDH 3.78659
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALPL, BCL2, CA2, CA3, CA6, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F2, F3, FABP3, FABP4, HSD11B2, HSD17B2, MCL1, MMP2, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TRPV1, TYR 3.73071
[BP] GO:0018105 peptidyl-serine phosphorylation BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, TNKS 3.57384
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALPL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F2, F3, FABP4, HSD11B2, HSD17B2, MCL1, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, PRKCG, TNKS2, TRPV1, TYR 3.53863
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.53152
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F2, F3, FABP4, MCL1, MMP2, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, XDH 3.51793
[BP] GO:0030168 platelet activation F2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 3.43407
[BP] GO:0080134 regulation of response to stress CDK6, CNR1, CNR2, CYP19A1, ESR1, F2, F3, FABP4, MCL1, MMP2, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, XDH 3.4273
[BP] GO:0018209 peptidyl-serine modification BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, TNKS 3.33402
[BP] GO:0032844 regulation of homeostatic process BCL2, CA2, CA7, CDK6, CNR1, F2, PRKCE, TNKS, TNKS2, TRPV1 3.29847
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.1415
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, FABP3, HSD11B2, MMP2, PPARA, PRKCD, PRKCE, PRKCG, TRPV1, TYR 3.09031
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.01434
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, F2, FABP3, FABP4, PRKCB, PRKCE, TRPV1 2.89058
[BP] GO:0010941 regulation of cell death AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, MCL1, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTPN1, TRPV1, XDH 2.82588
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, FABP3, HSD11B2, MMP2, PPARA, PRKCD, PRKCE, PRKCG, TRPV1, TYR 2.78215
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.68344
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.68344
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, MCL1, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TRPV1, XDH 2.68344
[BP] GO:0042981 regulation of apoptotic process AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, MCL1, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, TRPV1, XDH 2.68165
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, BCL2, CSNK2A1, CYP1B1, F2, F3, MCL1, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, TNKS, TNKS2, XDH 2.65535
[BP] GO:0044092 negative regulation of molecular function CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, TNKS 2.65535
[BP] GO:0043067 regulation of programmed cell death AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, MCL1, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, TRPV1, XDH 2.65162
[BP] GO:0035408 None PRKCA, PRKCB 2.65162
[BP] GO:0009115 None AOX1, XDH 2.65162
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 2.63756
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, PPARA, TYR 2.62205
[BP] GO:0010035 response to inorganic substance AKR1B1, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, MMP9, PRKCD 2.62205
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F2, F3, MMP2, MMP9, PIM1, PRKCA 2.55429
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, F2, PRKCD, TRPV1, XDH 2.55298
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE 2.52651
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA 2.47563
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE 2.44985
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.42541
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.42541
[BP] GO:0032879 regulation of localization ACHE, BCL2, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, F2, F3, KCNA3, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TRPV1 2.42541
[BP] GO:0050994 None CNR1, PPARA, PRKCD, PRKCE 2.40338
[BP] GO:0048583 regulation of response to stimulus AKR1B1, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F2, F3, FABP4, MCL1, MMP2, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, XDH 2.39916
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.36548
[BP] GO:0042127 regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F2, F3, FABP3, MMP2, MMP9, PIM1, PRKCA, XDH 2.36338
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, ESR1, F2, F3, FABP4, PPARA, PRKCA, PRKCD, PRKCG 2.36338
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1 2.36206
[BP] GO:0050727 regulation of inflammatory response CNR1, CNR2, CYP19A1, ESR1, F2, FABP4, PPARA, PRKCD 2.36206
[BP] GO:0031347 regulation of defense response CNR1, CNR2, CYP19A1, ESR1, F2, FABP4, MMP2, PPARA, PRKCD, PRKCE, PTPN1 2.35468
[BP] GO:0050728 negative regulation of inflammatory response CNR2, CYP19A1, F2, PPARA, PRKCD 2.29885
[BP] GO:0051049 regulation of transport ACHE, BCL2, CA2, CA7, CNR1, CYP19A1, F2, KCNA3, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TRPV1 2.29885
[BP] GO:0046110 None AOX1, XDH 2.29885
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.29885
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE 2.2848
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, PPARA 2.28161
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, MMP2, MMP9, PRKCB, PRKCD, PRKCE, TRPV1 2.28161
[BP] GO:0048585 negative regulation of response to stimulus BCL2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESR2, F2, MCL1, MMP9, PPARA, PRKCB, PRKCD, PTPN1, XDH 2.28161
[BP] GO:0006950 response to stress ACHE, AKR1B1, BCL2, CA2, CA3, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, F2, HSD11B2, MCL1, MMP2, MMP9, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TRPV1 2.26204
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, ESR1, F2, FABP3, PRKCB, PRKCE, TRPV1 2.25543
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.22309
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR 2.21815
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F2, F3, MCL1, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, TNKS, TNKS2, XDH 2.21815
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, PPARA, PRKCD, PRKCE 2.20808
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 2.18719
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F2, F3, MCL1, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, TNKS, TNKS2, XDH 2.18323
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.18057
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, F2, PRKCE, TRPV1 2.17824
[BP] GO:0002682 regulation of immune system process BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESRRA, F2, MMP2, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1 2.17824
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.16725
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.13696
[BP] GO:0042592 homeostatic process AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, F2, FABP3, FABP4, MCL1, PRKCB, PRKCE, TRPV1 2.13079
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.12544
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCB, PRKCD, PTPN1 2.09241
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.09241
[BP] GO:0070213 None TNKS, TNKS2 2.08749
[BP] GO:0006145 None AOX1, XDH 2.08749
[BP] GO:0038171 None CNR1, CNR2 2.08749
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.08749
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, GBA2, HSD11B1, HSD17B2, MCL1, MMP9, PIM1, PPARA, TYR 2.0791
[BP] GO:0007165 signal transduction AKR1B1, BCL2, CA1, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, MCL1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TRPV1 2.04106
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, MMP2, PRKCB, PRKCD, PRKCE, TRPV1 2.03493
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, CNR1, F2, TNKS, TNKS2 2.02884
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, AOX1, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, F2, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MCL1, MMP2, MMP9, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 3.34677
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, CA4, PRKCA, PRKCD, PRKCE, PRKCG, TNKS2, TYR 1.78419
[CC] GO:0005829 cytosol AKR1B1, AKR1B10, AOX1, BCL2, CA1, CA2, CA3, CA7, CBR1, CDC25B, CDK6, CSNK2A1, FABP3, FABP4, HSD17B1, MCL1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 1.65728
[CC] GO:0043227 membrane-bounded organelle ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FUT7, GBA2, MCL1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TYR, XDH 1.51647
[CC] GO:0016020 membrane ACHE, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F2, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, KCNA3, MCL1, MMP2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TRPV1, TYR 1.25522
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 20.6266
[MF] GO:0046914 transition metal ion binding AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, TNKS, TYR, XDH 18.9925
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.4225
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, TNKS 12.6816
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.9763
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F2, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TYR, XDH 9.70442
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 9.16212
[MF] GO:0046872 metal ion binding ALPL, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 8.68406
[MF] GO:0043167 ion binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, HSD17B1, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 8.37868
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 7.95432
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.55999
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 6.14596
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.7252
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.37388
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.24124
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.94778
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.79294
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.79294
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.57922
[MF] GO:0008289 lipid binding ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, TRPV1 3.53863
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.45318
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.42055
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.35864
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.25515
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.88888
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.78215
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.65162
[MF] GO:0003845 None HSD11B1, HSD11B2 2.65162
[MF] GO:0035403 None PRKCA, PRKCB 2.65162
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 2.65162
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.63756
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.61853
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.6169
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.39916
[MF] GO:0004949 None CNR1, CNR2 2.29885
[MF] GO:0004699 None PRKCD, PRKCE 2.29885
[MF] GO:0008144 drug binding ACHE, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, TRPV1 2.16745
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.08749
[MF] GO:0004674 protein serine/threonine kinase activity CDK6, CSNK2A1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 2.01587


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 22.029
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.3779
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, F3 7.5735
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, CDK6, PRKCB, PRKCE, BCL2, PIM1, CYP1B1, PRKCA, MMP9, CDC25B, MCL1 7.4751
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 4.997
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA, TRPV1 4.9952
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.3766
Hepatitis B_Homo sapiens_hsa05161 PRKCG, CDK6, PRKCB, BCL2, PRKCA, MMP9 4.2447
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.373
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, PRKCE, PRKCD, PRKCA 4.2809
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, CDK6, PRKCB, MMP1, MMP2, BCL2, PRKCA, MMP9 3.8196
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.2447
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 4.0965
Estrogen signaling pathway_Homo sapiens_hsa04915 MMP2, PRKCD, MMP9, ESR1, ESR2 4.0134
Cholinergic synapse_Homo sapiens_hsa04725 PRKCG, ACHE, PRKCB, BCL2, PRKCA 3.8312
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.207
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PRKCB, PRKCA 4.217
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PRKCB, PRKCE, PRKCD, PPARA 3.8447
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, MMP2, PRKCA, MMP9, ESR1 3.768
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 4.0134
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, CDK6, PRKCB, PRKCA 3.8052
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.7742
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PRKCB, PRKCE, BCL2, PRKCA 3.7742
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PRKCB, MMP2, PRKCA, MMP9 3.7742
Glioma_Homo sapiens_hsa05214 PRKCG, CDK6, PRKCB, PRKCA 3.6451
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 3.4568
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 3.3343
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, MMP2, PRKCD, PRKCA 3.167
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 3.0362
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.5599
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, CNR1, PRKCA 3.0326
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PRKCB, BCL2, PRKCA 3.0248
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 3.0911
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PRKCB, PRKCA, ESR1 2.8114
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, CSNK2A1, PRKCB, PRKCA 2.5535
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1, MCL1 2.4312
Long-term depression_Homo sapiens_hsa04730 PRKCG, PRKCB, PRKCA 2.5754
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PRKCB, PRKCA 2.5754
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PRKCB, PRKCA 2.5654
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PRKCB, BCL2, PRKCA 2.1279
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 2.2187
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, PRKCA 2.4881
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PRKCB, PRKCA 2.2113
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, PRKCB, PRKCA 2.497
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, CNR1, PRKCA 2.0915
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.5061
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, PRKCA 2.2113
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.4312
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, PRKCA 2.1865
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA 2.1495
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 2.2057
Gap junction_Homo sapiens_hsa04540 PRKCG, PRKCB, PRKCA 2.2113
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, PRKCB, PRKCA 2.1048
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 3.167
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PRKCB, PRKCA 2.1268
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PRKCB, PRKCA 2.1096
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2 2.1677
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, PRKCB, PRKCA, CDC25B 1.8548
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 3.0248
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA 1.9927
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CNR2, CNR1, TRPV1, F2 1.7498
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, PRKCB, PRKCA 2.0073
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, PRKCA 1.8636
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PRKCB, PRKCA 1.8222
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PRKCB, PRKCA 1.655
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCG, PRKCB, PRKCA 1.5157
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, BCL2, PRKCA, MCL1 1.4821
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PRKCB, PRKCA 1.2985
Apoptosis_Homo sapiens_hsa04210 BCL2, MCL1 0.9905
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 1.0075
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, PRKCA 0.9531
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.7627
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PRKCD, BCL2 1.0885
Influenza A_Homo sapiens_hsa05164 PRKCB, PRKCA 0.8573
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 F2 0.3275
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6 0.3379
Chemokine signaling pathway_Homo sapiens_hsa04062 PRKCB, PRKCD 0.8133
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 1.0733
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3716
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3818
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3647
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9 0.3706
cAMP signaling pathway_Homo sapiens_hsa04024 PPARA 0.3443
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.3711
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PRKCE 0.3826
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4136
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.4284
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4325
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PRKCA 0.4269
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4447
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5065
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.4844
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.5426
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5348
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.336
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5507
Prostate cancer_Homo sapiens_hsa05215 BCL2 0.5682
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5675
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.4636
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5682
Peroxisome_Homo sapiens_hsa04146 XDH 0.5875
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 1.3991
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.4467
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.6336
B cell receptor signaling pathway_Homo sapiens_hsa04662 PRKCB 0.6336
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.6345
Melanoma_Homo sapiens_hsa05218 CDK6 0.6336
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6336
Leishmaniasis_Homo sapiens_hsa05140 PRKCB 0.6336
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.487
Bile secretion_Homo sapiens_hsa04976 CA2 0.6336
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.6423
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.6336
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6629
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.6912
Acute myeloid leukemia_Homo sapiens_hsa05221 PIM1 0.6882
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5986
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1 0.6629
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6944
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.7206
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7206
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PRKCB 0.7496
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7364
Type II diabetes mellitus_Homo sapiens_hsa04930 PRKCE, PRKCD 1.7523
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.7406
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.745
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8847
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.0915
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.9076
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.9872
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.9076
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 2.0433
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2171
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.9698
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9389
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9281
Other glycan degradation_Homo sapiens_hsa00511 GBA2 1.0733
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1652
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3713
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.487


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)