TCM Prescription: Shi Pi Powder



Prescription Description
Prescription IDTCMF2827
Pinyin NameShi Pi San
Chinese Name实脾散
English NameShi Pi Powder
Function Description治阴水, 先实脾土
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationSpleen
ReferenceSATCM
Reference Book/linkhttp://www.satcm.gov.cn/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH217 Amomum tsaoko crevost et lemarie 草果仁 TCMH217 GQ118666
TCMH358 Areca catechu 大腹子 TCMH358 ITSAA732-14
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH57 Wolfiporia cocos 白茯苓 TCMH57 GBPOL314-13
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: SATCM

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK, TRPV1, TYR 14.7602
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR 14.6614
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DRD3, EGFR, ESR1, F2, F3, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 13.12
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.5991
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR 12.1777
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.7824
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 11.1839
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FLT3, HSD11B2, PRKCE, PRKCG, PTGS2, RORC, SRC, TEK, TRPV1, TYR 10.3554
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F2, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.239
[BP] GO:0023056 positive regulation of signaling AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F2, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.2103
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 9.66388
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 9.59167
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PRKCE, PTGS2, RORC, SRC, TYR 9.59167
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 9.53468
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK, TRPV1 9.46189
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 9.15275
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 9.10893
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 9.10059
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, F2, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.07198
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TRPV1 8.65126
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, DRD3, EGFR, FABP3, HSD11B2, KDR, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TRPV1 8.62218
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD3, EGFR, ESRRA, F2, F3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.51559
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1, TRPV1 8.37434
[BP] GO:0042127 regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESRRA, F2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 8.29182
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, F2, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 7.83734
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.80979
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, GLO1, HSPA1A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 7.80003
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, F2, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR 7.77051
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 7.74344
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, CNR1, CNR2, DRD3, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR 7.57792
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS 7.55709
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 7.43018
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 7.39903
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CDK6, CNR1, DRD3, EGFR, F2, KDR, PIK3CB, PRKCE, PTGS2, SRC, TNKS, TNKS2, TRPV1 7.39617
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 7.39617
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F2, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.39617
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 7.30702
[BP] GO:0030168 platelet activation AXL, F2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 7.30702
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD3, EGFR, ESR1, F2, F3, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TEK 7.28847
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, EGFR, F2, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 7.28847
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F2, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.26938
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC, TRPV1 7.26938
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, CNR1, CNR2, DRD3, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR 7.08775
[BP] GO:0032879 regulation of localization ACHE, APEX1, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F2, F3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1 7.00951
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC, TRPV1 6.95662
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 6.79171
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TOP2A, TYR 6.79171
[BP] GO:0080134 regulation of response to stress CDK6, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, F2, F3, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.74705
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS 6.71874
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CNR1, CNR2, CYP1A1, CYP1B1, DRD3, KDR, PRKCD, PRKCE, SRC 6.63027
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESRRB, F2, F3, FABP4, HSD11B2, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TRPV1, TYR 6.59114
[BP] GO:0040012 regulation of locomotion APEX1, BCL2, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, DRD3, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.52309
[BP] GO:0048583 regulation of response to stimulus AKR1B1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.48039
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 6.40955
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process AURKB, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 6.39071
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.19299
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1 6.18646
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, PRKCG, SRC, TEK 6.17002
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, DRD3, EGFR, ESR1, F2, FABP3, FABP4, GPR35, INSR, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 6.12211
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD3, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GPR35, INSR, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, SRC, TRPV1 6.07837
[BP] GO:0031325 positive regulation of cellular metabolic process AURKB, BCL2, CDC25B, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.96418
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, DRD3, EGFR, ESR1, F2, F3, FABP4, KDR, MET, MMP12, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, TEK 5.94328
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 5.93662
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F2, FLT3, IGF1R, INSR, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS, TOP2A 5.92633
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PRKCD, PTGS2, SRC 5.9141
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD3, EGFR, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 5.88317
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 5.85331
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK 5.74309
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, F2, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 5.70819
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CA3, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, PTGS1, PTGS2, SRC 5.66709
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, KDR, PRKCD, PRKCE, PTGS2, SRC, TRPV1 5.64186
[BP] GO:0009893 positive regulation of metabolic process AURKB, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.64166
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD3, EGFR, F2, PIK3CB, PTGS2, TNKS, TNKS2 5.61673
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, F2, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 5.59608
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, DRD3, DUSP3, EGFR, ESR1, F2, F3, FLT3, FUT7, GBA2, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 5.58669
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK 5.53358
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PRKCA, PRKCE, SLC22A1 5.43716
[BP] GO:0010604 positive regulation of macromolecule metabolic process AURKB, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.43716
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RORC, SMAD3, SRC, TOP2A, TRPV1 5.43716
[BP] GO:0019216 regulation of lipid metabolic process CNR1, CYP1A1, DRD3, F2, FABP3, FLT3, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK 5.43716
[BP] GO:0065009 regulation of molecular function AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TRPV1, XDH 5.43716
[BP] GO:0048585 negative regulation of response to stimulus BCL2, CDK6, CNR1, CNR2, CYP19A1, DRD3, DUSP3, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.43716
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.4177
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.39946
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, F2, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TRPV1 5.39866
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 5.39866
[BP] GO:0051049 regulation of transport ACHE, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CYP19A1, DRD3, EGFR, F2, GPR35, HSPA1A, INSR, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TRPV1 5.39632
[BP] GO:0044092 negative regulation of molecular function AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DRD3, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS 5.38946
[BP] GO:0019220 regulation of phosphate metabolic process BCL2, CDC25B, DRD3, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.38946
[BP] GO:0009966 regulation of signal transduction AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F2, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.3808
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 5.3808
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.36461
[BP] GO:0051174 regulation of phosphorus metabolic process BCL2, CDC25B, DRD3, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.3315
[BP] GO:0031347 regulation of defense response CNR1, CNR2, CYP19A1, EGFR, ESR1, F2, FABP4, HSPA1A, MMP12, MMP2, PPARA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK 5.27863
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.22838
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 5.20665
[BP] GO:0050790 regulation of catalytic activity AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 5.18363
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 5.18363
[BP] GO:0010562 positive regulation of phosphorus metabolic process BCL2, CDC25B, EGFR, ESRRB, F2, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.16323
[BP] GO:0045937 positive regulation of phosphate metabolic process BCL2, CDC25B, EGFR, ESRRB, F2, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.16323
[BP] GO:0051239 regulation of multicellular organismal process AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CNR1, CYP1B1, DRD3, EGFR, ESR1, ESRRA, ESRRB, F2, F3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH 5.16323
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 5.13565
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.10506
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 5.10325
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 5.10325
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 5.09071
[BP] GO:0009894 regulation of catabolic process APEX1, BCL2, CNR1, CSNK2A1, EGFR, ESRRB, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 5.07104
[BP] GO:2000145 regulation of cell motility APEX1, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 5.03381
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 5.0246
[BP] GO:0009892 negative regulation of metabolic process APEX1, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 4.95494
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, PRKCD, SRC, TEK, TYR 4.93749
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 4.93285
[BP] GO:0007165 signal transduction AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 4.90469
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TNKS, TOP2A 4.90469
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 4.85276
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, HSD11B2, IGF1R, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 4.82256
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD3, EGFR, ESR1, PPARA, PRKCG, RORC, SRC, TOP2A 4.7966
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK 4.78651
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, GBA2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 4.77033
[BP] GO:0030334 regulation of cell migration APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 4.74635
[BP] GO:0007166 cell surface receptor signaling pathway AXL, BCL2, CA1, CHRM4, CSNK2A1, EGFR, F2, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 4.71741
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 4.71596
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CNR1, CYP1B1, DRD3, EGFR, ESRRB, F2, F3, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TRPV1 4.69982
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 4.69859
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.69859
[BP] GO:0042327 positive regulation of phosphorylation BCL2, CDC25B, EGFR, ESRRB, F2, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 4.6302
[BP] GO:0051270 regulation of cellular component movement APEX1, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 4.59537
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 4.55182
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD3, EGFR, HSD11B2, HSPA1A, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TRPV1, TYR 4.54996
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 4.51604
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FLT3, GBA2, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 4.45363
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, AURKB, BCL2, CNR1, CSNK2A1, DRD3, DUSP3, ESR1, ESR2, ESRRA, F2, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 4.44836
[BP] GO:0050727 regulation of inflammatory response CNR1, CNR2, CYP19A1, EGFR, ESR1, F2, FABP4, PPARA, PRKCD, PTGS2, SMAD3, TEK 4.40467
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 4.33935
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD3, EGFR, INSR, PTGS2, SLC22A2, SLC22A3, SMAD3, TRPV1 4.32978
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, PRKCE 4.30796
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 4.30796
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.29597
[BP] GO:0042325 regulation of phosphorylation BCL2, CDC25B, DUSP3, EGFR, ESRRB, F2, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 4.29597
[BP] GO:0001934 positive regulation of protein phosphorylation BCL2, CDC25B, EGFR, F2, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 4.27359
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.27359
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TNKS, TOP2A 4.24659
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, CNR2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 4.2309
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, BCL2, CNR1, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 4.22436
[BP] GO:0006950 response to stress ACHE, AKR1B1, APEX1, AXL, BCL2, CA2, CA3, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, F2, HSD11B2, HSPA1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1 4.2164
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, CNR2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 4.21576
[BP] GO:0002682 regulation of immune system process AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, DUSP3, ESR1, ESRRA, F2, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 4.19875
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD3, EGFR, ESR1, F2, FABP3, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.17015
[BP] GO:0030155 regulation of cell adhesion BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 4.17015
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 4.1674
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3, FABP3, PPARA, PRKCB, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, TRPV1 4.14508
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 4.14328
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD3, F2, KDR, PRKCE, SRC, TRPV1 4.13671
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC, TNKS, TNKS2 4.05489
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 4.04502
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 4.04502
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.04502
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F2, F3, FABP4, KDR, MET, PRKCA, PTGS2, SMAD3 4.03515
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC, TRPV1 4.02633
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 3.97199
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.96372
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 3.89
[BP] GO:0050728 negative regulation of inflammatory response CNR2, CYP19A1, F2, PPARA, PRKCD, SMAD3, TEK 3.87948
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.83082
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.83082
[BP] GO:0044093 positive regulation of molecular function AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F2, F3, FLT3, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.82351
[BP] GO:0051247 positive regulation of protein metabolic process BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F2, F3, FLT3, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.81505
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, INSR, PRKCA, PRKCE, SRC 3.81434
[BP] GO:0031348 negative regulation of defense response CNR2, CYP19A1, F2, MMP12, PPARA, PRKCD, SMAD3, TEK 3.79679
[BP] GO:0001932 regulation of protein phosphorylation BCL2, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 3.79358
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 3.77326
[BP] GO:0050793 regulation of developmental process AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, DRD3, EGFR, ESR1, ESRRA, ESRRB, F2, F3, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH 3.75301
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 3.74341
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.73336
[BP] GO:0031399 regulation of protein modification process BCL2, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 3.72983
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 3.72675
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, DRD3, EGFR, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.70358
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.70216
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 3.69201
[BP] GO:0051128 regulation of cellular component organization AURKB, AXL, BCL2, CNR1, CSNK2A1, DRD3, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.68391
[BP] GO:0032270 positive regulation of cellular protein metabolic process BCL2, CDC25B, EGFR, ESR1, F2, F3, FLT3, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.67373
[BP] GO:0051172 None APEX1, AURKB, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 3.59522
[BP] GO:0051050 positive regulation of transport ACHE, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD3, EGFR, F2, INSR, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TRPV1 3.59467
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1 3.58699
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.57424
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.57306
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, EGFR, ESR1, F2, F3, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.5594
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 3.53535
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, CDK6, KDR, PIK3CB, PRKCE, SMAD3, SRC, TEK 3.53517
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, EGFR, ESR1, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.44871
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TRPV1 3.42777
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, CNR1, ESRRB, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 3.42712
[BP] GO:0019222 regulation of metabolic process ACHE, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.39744
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.38372
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, DRD3, EGFR, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.38372
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.38372
[BP] GO:0010676 None ESRRB, INSR, PPARA, PRKCE, SRC 3.38372
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, EGFR, ESR1, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.38237
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, EGFR, ESR1, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.38237
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, DRD3, GPR35, MMP9, PRKCE, PTGS2 3.37419
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DRD3, DUSP3, INSR, PRKCA 3.31551
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 3.29702
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.29024
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, F2, MMP12, PRKCD, PTGS2, SMAD3, SRC 3.28846
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, SRC, TRPV1, TYR 3.26651
[BP] GO:0090087 None ACHE, CA2, CHRM1, CNR1, DRD3, EGFR, F2, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.26608
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 3.26257
[BP] GO:0008217 None CNR1, DRD3, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 3.23286
[BP] GO:0043408 regulation of MAPK cascade DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 3.21919
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.21148
[BP] GO:0070201 None ACHE, BCL2, CHRM1, CNR1, DRD3, EGFR, F2, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.20135
[BP] GO:0009605 response to external stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, DRD3, EGFR, F2, HSD11B2, MMP12, PRKCD, PTGS2, SMAD3, SRC, TRPV1, TYR 3.1997
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DRD3, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 3.19586
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 3.18248
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, DRD3, EGFR, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.16981
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 3.16981
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK 3.1611
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 3.15461
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, EGFR, F2, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.15167
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2, SRC 3.14886
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 3.14886
[BP] GO:0043085 positive regulation of catalytic activity AURKB, BCL2, CDC25B, EGFR, ESR1, F2, F3, FLT3, HSPA1A, INSR, PIK3CA, PIK3CB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.12605
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, PTGS2, SRC 3.12375
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, F2, MMP12, PRKCD, PTGS2, SMAD3, SRC 3.11017
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.10203
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 3.10017
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 3.10017
[BP] GO:0043412 macromolecule modification ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, EGFR, ESR1, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.06886
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 3.05917
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.04381
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, AURKB, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, HSPA1A, IGF1R, KDR, MMP12, MMP9, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 3.03359
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, DRD3, ESR1, F2, GPR35, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.02113
[BP] GO:0006855 None SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 3.01145
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, CNR1, CNR2, DRD3, EGFR, PRKCE, PTGS2 3.01145
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, CNR1, CNR2, DRD3, EGFR, PRKCE, PTGS2 3.01145
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, DRD3, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.00947
[BP] GO:0031401 positive regulation of protein modification process BCL2, CDC25B, EGFR, F2, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 2.99986
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A 2.98088
[BP] GO:0080090 regulation of primary metabolic process APEX1, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.98035
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 2.97822
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.97311
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.96534
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, DRD3, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.96318
[BP] GO:0043278 None CNR1, DRD3, PRKCE, PRKCG 2.96318
[BP] GO:0014072 None CNR1, DRD3, PRKCE, PRKCG 2.96318
[BP] GO:0051052 regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PIK3CA, PRKCD, PRKCG, SRC, TNKS, TNKS2 2.95819
[BP] GO:0019371 None PTGS1, PTGS2, TBXAS1 2.93909
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCB, PRKCD, PTPN1, SRC 2.93909
[BP] GO:0031323 regulation of cellular metabolic process ACHE, APEX1, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.93906
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, PPARA, PTGS1, PTGS2, TBXAS1 2.93372
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 2.92763
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 2.92763
[BP] GO:0055074 calcium ion homeostasis BCL2, DRD3, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.92499
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.92499
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.92499
[BP] GO:0045913 None ESRRB, INSR, PPARA, PRKCE, SRC 2.91834
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, INSR, MMP2, MMP9, PTGS2, SRC, TOP2A 2.9159
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, EGFR, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC, TRPV1 2.91039
[BP] GO:0051223 None ACHE, CHRM1, CNR1, DRD3, EGFR, F2, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.88926
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, DRD3, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.88616
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, DRD3, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.88576
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.87686
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK 2.87686
[BP] GO:0050878 regulation of body fluid levels AKR1B1, CHRM1, F2, F3, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 2.87273
[BP] GO:0019725 cellular homeostasis APEX1, BCL2, CA2, CA7, DRD3, ESR1, F2, GPR35, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.87259
[BP] GO:0051347 positive regulation of transferase activity AURKB, CDC25B, EGFR, F2, FLT3, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK, TNKS 2.85618
[BP] GO:0015872 None SLC22A1, SLC22A2, SLC22A3 2.85385
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 2.85385
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.85385
[BP] GO:0035408 None PRKCA, PRKCB 2.85385
[BP] GO:0009115 None AOX1, XDH 2.85385
[BP] GO:0051338 regulation of transferase activity AURKB, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK, TNKS 2.85046
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, SRC, TRPV1, TYR 2.84899
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGS2, SRC 2.84899
[BP] GO:0009611 response to wounding ACHE, BCL2, CYP1A1, EGFR, F2, PPARA, SMAD3 2.8389
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 2.83525
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.83525
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1 2.82653
[BP] GO:0010675 None ESRRB, INSR, PPARA, PRKCE, RORC, SRC 2.82653
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, EGFR, F2, FUT7, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 2.81607
[BP] GO:0050776 regulation of immune response BCL2, CNR1, DUSP3, ESR1, F2, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 2.81607
[BP] GO:0032880 regulation of protein localization ACHE, BCL2, CHRM1, CNR1, CSNK2A1, DRD3, EGFR, F2, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.79673
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, PTGS2, SRC 2.78605
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, EGFR, F2, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 2.7791
[BP] GO:0050678 None CDK6, EGFR, F3, KDR, MMP12, PRKCA, SMAD3, TEK, XDH 2.77868
[BP] GO:0032467 None AURKB, CDC25B, DRD3, PRKCE 2.77381
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.76598
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.76598
[BP] GO:0031349 positive regulation of defense response CNR1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PRKCD, PRKCE, PTGS2, SRC 2.75061
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK 2.74601
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.74141
[BP] GO:0043410 positive regulation of MAPK cascade EGFR, FLT3, INSR, KDR, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH 2.74014
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.74014
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 2.73707
[BP] GO:0043269 regulation of ion transport BCL2, CA2, CA7, CHRM1, CNR1, DRD3, F2, GPR35, MMP9, PRKCD, PRKCE, PTGS2 2.73707
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, BCL2, CHRM1, EGFR, F2, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.7136
[BP] GO:0038128 None EGFR, PIK3CA, PRKCA, SRC 2.69457
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PRKCD, PTPN1, SRC 2.69267
[BP] GO:0010564 regulation of cell cycle process APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD3, EGFR, HSPA1A, INSR, PRKCE, TNKS 2.68775
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.67779
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, EGFR, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC, TRPV1 2.67779
[BP] GO:1900182 positive regulation of protein localization to nucleus EGFR, F2, PRKCD, PTGS2, SMAD3, SRC 2.67779
[BP] GO:0009895 negative regulation of catabolic process BCL2, CNR1, EGFR, MET, PIK3CA, PPARA, PRKCG, SMAD3 2.67779
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SMAD3, SRC, TNKS 2.66983
[BP] GO:0051171 regulation of nitrogen compound metabolic process APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.6688
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, EGFR, PTGS2, TRPV1, TYR 2.66602
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.59889
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 2.59889
[BP] GO:0050900 leukocyte migration CNR2, F2, FUT7, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.59889
[BP] GO:0051937 None SLC22A1, SLC22A2, SLC22A3 2.59373
[BP] GO:0043549 regulation of kinase activity CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 2.57384
[BP] GO:0009987 cellular process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.56401
[BP] GO:0032268 regulation of cellular protein metabolic process BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.55738
[BP] GO:0009896 positive regulation of catabolic process CSNK2A1, ESRRB, HSPA1A, INSR, KDR, PIK3CB, PPARA, PRKCD, PRKCE, PTPN1 2.55219
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.53437
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, PTGS2, TEK 2.53374
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 2.53374
[BP] GO:0055065 metal ion homeostasis BCL2, DRD3, EGFR, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.52145
[BP] GO:0032102 negative regulation of response to external stimulus CNR2, CYP19A1, DRD3, F2, PPARA, PRKCD, SMAD3, TEK 2.52145
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC 2.52145
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.52145
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.52145
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.52145
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.52145
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.51064
[BP] GO:0033674 positive regulation of kinase activity CDC25B, EGFR, F2, FLT3, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 2.50638
[BP] GO:0080135 regulation of cellular response to stress CDK6, DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PRKCD, PRKCG, PTGS2, PTPN1, XDH 2.50248
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.4949
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.48572
[BP] GO:0040008 regulation of growth BCL2, CSNK2A1, DRD3, EGFR, ESR2, F2, HSPA1A, INSR, PIK3CA, PIM1, SMAD3, TNKS2 2.48219
[BP] GO:0061041 regulation of wound healing F2, F3, PRKCA, PRKCD, PRKCE, SMAD3 2.48219
[BP] GO:0032845 None BCL2, PRKCE, SRC, TNKS, TNKS2, TRPV1 2.46745
[BP] GO:2000026 regulation of multicellular organismal development AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, DRD3, EGFR, ESR1, ESRRA, F2, F3, INSR, KDR, PIM1, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK, XDH 2.46568
[BP] GO:0046110 None AOX1, XDH 2.46568
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.46568
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.46565
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.46565
[BP] GO:0009410 None CNR1, CNR2, DRD3, EGFR, PRKCE, PRKCG 2.45057
[BP] GO:0043279 None CNR1, DRD3, PRKCE, PRKCG, TRPV1 2.42954
[BP] GO:0015893 None CA2, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 2.4208
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.4208
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3 2.39694
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.39694
[BP] GO:0051704 multi-organism process AXL, BCL2, CDK6, CHRM2, CYP1A1, DRD3, EGFR, F2, HSD11B2, HSPA1A, INSR, KDR, MET, MMP1, MMP12, PRKCD, SMAD3, SRC 2.38327
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.38063
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.37161
[BP] GO:0065007 biological regulation ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.36945
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A 2.355
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.33373
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.3326
[BP] GO:0051222 positive regulation of protein transport ACHE, CHRM1, EGFR, F2, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.32837
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, F2, FLT3, KDR, TEK 2.31527
[BP] GO:0006875 cellular metal ion homeostasis BCL2, DRD3, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.30266
[BP] GO:0042307 positive regulation of protein import into nucleus EGFR, F2, PRKCD, PTGS2, SMAD3 2.29894
[BP] GO:0042752 None DRD3, PPARA, PRKCG, RORC, TOP2A 2.29894
[BP] GO:0044089 positive regulation of cellular component biogenesis ESR1, HSPA1A, KDR, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK 2.29818
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.28647
[BP] GO:0050994 None CNR1, PPARA, PRKCD, PRKCE 2.28527
[BP] GO:0043550 regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.28527
[BP] GO:1904591 positive regulation of protein import EGFR, F2, PRKCD, PTGS2, SMAD3 2.26214
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.26024
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.25701
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, PRKCD, PTGS2 2.25701
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 2.25701
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.24918
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.24918
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.24918
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.24918
[BP] GO:1903829 positive regulation of cellular protein localization BCL2, CHRM1, EGFR, F2, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.24728
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.23904
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.23358
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.23358
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.23358
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.22434
[BP] GO:0015844 None SLC22A1, SLC22A2, SLC22A3 2.22434
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.22434
[BP] GO:1901374 None SLC22A1, SLC22A2 2.22132
[BP] GO:0070213 None TNKS, TNKS2 2.22132
[BP] GO:0006145 None AOX1, XDH 2.22132
[BP] GO:0038171 None CNR1, CNR2 2.22132
[BP] GO:0015874 None SLC22A1, SLC22A2 2.22132
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.22132
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.21868
[BP] GO:0008150 biological_process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.21068
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.19924
[BP] GO:0046649 lymphocyte activation AXL, BCL2, FLT3, FUT7, PRKCB, PRKCD, RORC, SMAD3 2.19258
[BP] GO:1903827 regulation of cellular protein localization BCL2, CHRM1, CSNK2A1, EGFR, F2, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.18826
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.17738
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.17738
[BP] GO:1903034 regulation of response to wounding F2, F3, PRKCA, PRKCD, PRKCE, SMAD3 2.17547
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.17547
[BP] GO:0010811 positive regulation of cell-substrate adhesion CDK6, KDR, PRKCE, SMAD3, TEK 2.17547
[BP] GO:0072347 None CNR1, DRD3, PRKCE, PRKCG 2.16442
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.16442
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD3, GBA2, TYR 2.16193
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.15979
[BP] GO:0050866 negative regulation of cell activation AXL, CNR1, CNR2, DUSP3, F2, PRKCD 2.15238
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.12905
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.12905
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.12905
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.12905
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.12905
[BP] GO:0045321 leukocyte activation ALOX5, AXL, BCL2, FLT3, FUT7, HSPA1A, MMP9, PRKCB, PRKCD, PRKCE, RORC, SMAD3, TRPV1 2.1259
[BP] GO:0033043 regulation of organelle organization AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.11686
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.11552
[BP] GO:1901342 regulation of vasculature development CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK, XDH 2.10967
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, INSR, PPARA, PRKCE, RORC, SRC 2.10605
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, FUT7, GBA2, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 2.10153
[BP] GO:0071702 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3, FABP3, MMP12, PPARA, PRKCB, SLC22A1, SLC22A2, SLC22A3, SLC47A1, TNKS, TRPV1 2.10153
[BP] GO:0051246 regulation of protein metabolic process BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.09641
[BP] GO:0050679 None EGFR, F3, KDR, MMP12, PRKCA, TEK 2.09592
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.09306
[BP] GO:0051894 None KDR, SMAD3, TEK 2.08396
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.08396
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CDC25B, CDK6, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, KDR, MET, MMP2, MMP9, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A 2.07593
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, HSPA1A 2.0636
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PRKCE, SRC 2.06179
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.04959
[BP] GO:0043696 None CDK6, ESRRB 2.04017
[BP] GO:0043697 None CDK6, ESRRB 2.04017
[BP] GO:0010641 None F3, SRC 2.04017
[BP] GO:0046618 None SLC47A1, SLC47A2 2.04017
[BP] GO:0050927 None F3, KDR, SMAD3 2.03985
[BP] GO:0032870 cellular response to hormone stimulus APEX1, EGFR, ESR1, FLT3, INSR, PRKCD, PRKCE, SRC 2.02389
[BP] GO:0007187 None CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD3 2.00668
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.0001
[CC] GO:0005886 plasma membrane ACHE, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, DRD3, EGFR, ESR1, F2, F3, FLT3, GBA2, GLO1, GPR35, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TRPV1 5.58669
[CC] GO:0016020 membrane ACHE, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, F2, F3, FLT3, FUT7, GBA2, GLO1, GPR35, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TRPV1, TYR 4.63987
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.16687
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, CA4, EGFR, HSPA1A, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TNKS2, TYR 3.06335
[CC] GO:0098590 plasma membrane region CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, EGFR, INSR, MET, PRKCG, PTGS2, SLC22A1, SRC, TEK, TRPV1 2.98685
[CC] GO:0031226 intrinsic component of plasma membrane AXL, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD3, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 2.96318
[CC] GO:0044425 membrane part ACHE, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, F2, F3, FLT3, FUT7, GBA2, GPR35, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PRKCG, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TBXAS1, TEK, TRPV1, TYR 2.64823
[CC] GO:0044459 plasma membrane part AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD3, DUSP3, EGFR, F2, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PRKCG, PTGS2, SLC22A1, SLC22A2, SLC22A3, SRC, TEK, TRPV1 2.57762
[CC] GO:0043227 membrane-bounded organelle ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC47A1, SMAD3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.36293
[CC] GO:0005887 integral component of plasma membrane AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD3, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 2.31475
[CC] GO:0005783 None APEX1, BCL2, CA4, CYP19A1, FLT3, GBA2, HSPA1A, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH 2.19258
[CC] GO:0044464 cell part ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.04351
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TYR, XDH 18.9126
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.6469
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F2, F3, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 14.7602
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 14.7602
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TNKS 12.891
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.6186
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.584
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 10.3951
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 9.97394
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 9.14892
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 8.56275
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.83162
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.39617
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.78664
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.73551
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB, PRKCD 6.49813
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 6.40955
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.96947
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 5.66709
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.65238
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.47423
[MF] GO:0038023 signaling receptor activity AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK, TRPV1 5.43716
[MF] GO:0004871 signal transducer activity AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, PRKCE, RORC, SMAD3, TEK, TRPV1 4.9675
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.96301
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 4.94653
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 4.94519
[MF] GO:0060089 molecular transducer activity AXL, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK, TRPV1 4.93082
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.80623
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.77033
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.77033
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.77033
[MF] GO:0036094 small molecule binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 4.72074
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.6302
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.6302
[MF] GO:0004872 receptor activity AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK, TRPV1 4.6302
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.44836
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.40467
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.33935
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.29597
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, SRC, TBXAS1, XDH 4.25239
[MF] GO:0043168 anion binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 4.2309
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1, TYR 4.07874
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, F2, F3, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 4.03508
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 3.9916
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.96372
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CSNK2A1, EGFR, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 3.79679
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3 3.70216
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 3.58466
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 3.53535
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC, TRPV1 3.47384
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.44764
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 3.42726
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 3.3841
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 3.38237
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.29024
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.26257
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.20135
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3 3.16981
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 3.16981
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.16981
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.10242
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.02677
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 2.95333
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.93909
[MF] GO:0097367 carbohydrate derivative binding AURKB, AXL, CDK6, CSNK2A1, EGFR, F2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.89799
[MF] GO:0019899 enzyme binding AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HSPA1A, MET, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A 2.85385
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.85385
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.85385
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.85385
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.85385
[MF] GO:0003845 None HSD11B1, HSD11B2 2.85385
[MF] GO:0035403 None PRKCA, PRKCB 2.85385
[MF] GO:0032403 protein complex binding ACHE, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 2.84907
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.5182
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.48572
[MF] GO:0035258 None ESR1, FLT3, PRKCB, SMAD3, SRC 2.48071
[MF] GO:0097159 organic cyclic compound binding AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TRPV1, XDH 2.46617
[MF] GO:0015307 None SLC47A1, SLC47A2 2.46568
[MF] GO:1901375 None SLC22A1, SLC22A2 2.46568
[MF] GO:0004949 None CNR1, CNR2 2.46568
[MF] GO:0005333 None SLC22A1, SLC22A2 2.46568
[MF] GO:0005277 None SLC22A1, SLC22A2 2.46568
[MF] GO:0008513 None SLC22A1, SLC22A2 2.46568
[MF] GO:0004699 None PRKCD, PRKCE 2.46568
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCL2, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, SLC22A1, SMAD3, TOP2A, TRPV1, TYR, XDH 2.46565
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.46565
[MF] GO:0099600 transmembrane receptor activity AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD3, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK, TRPV1 2.40247
[MF] GO:0004888 transmembrane signaling receptor activity AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD3, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK, TRPV1 2.40247
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.39694
[MF] GO:0015238 None SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 2.37232
[MF] GO:1901363 heterocyclic compound binding AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TRPV1, XDH 2.31274
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.22132
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.22132
[MF] GO:0003674 molecular_function ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.1984
[MF] GO:0015101 None SLC22A1, SLC22A2, SLC22A3 2.08396
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.04017
[MF] GO:0043559 insulin binding IGF1R, INSR 2.04017
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.02411


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.6552
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB, F3 10.1142
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.1142
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, PRKCA, PIK3CB, MMP9, ESR1, EGFR, IGF1R, PIK3CA, KDR, MET 9.4015
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, SMAD3, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, CDK6, PIK3CA, BCL2, MET 9.0693
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, SRC, INSR, PRKCA, PIK3CB, EGFR, IGF1R, PIK3CA, CNR1, KDR, TEK, MET 9.2864
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A 9.0811
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, PRKCG, ACHE, CHRM1, PIK3CA, PRKCB, CHRM4, BCL2, PRKCA, PIK3CB 8.803
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, EGFR, CDC25B, CDK6, PIK3CA, BCL2, PIM1, CYP1B1, MET 8.803
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, INSR, BCL2, PRKCA, TEK, PIK3CB, EGFR, IGF1R 9.0324
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 8.289
Glioma_Homo sapiens_hsa05214 PRKCG, CDK6, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR, IGF1R 8.1284
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, PRKCA, PIK3CB, TRPV1 8.0932
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB, EGFR 8.0032
Hepatitis B_Homo sapiens_hsa05161 PRKCG, CDK6, SMAD3, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 7.8554
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.4327
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, INSR, PRKCA, PIK3CB, EGFR, IGF1R, CDK6, PIK3CA, KDR, BCL2, TEK, MET 7.3242
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, EGFR, IGF1R 7.6887
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PIK3CA, PRKCB, INSR, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 7.222
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PIK3CA, PRKCB, INSR, PRKCA, PIK3CB 8.2
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.777
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, CDK6, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR 7.2574
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCB, INSR, PRKCE, PRKCD, PIK3CB, PPARA 6.5388
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, EGFR 5.9642
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, PTGS2, EGFR 5.3622
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 5.7989
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, PIK3CB, PTGS2, PTGS1 5.8216
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 5.1668
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, EGFR, IGF1R 5.2502
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 5.1668
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PIK3CA, PRKCB, PRKCE, BCL2, PRKCA, PIK3CB 5.1347
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, CNR2, GPR35, CNR1, CHRM4, TRPV1, F2, DRD3 4.596
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, PIK3CA, SRC, CHRM4, PIK3CB, F2, EGFR 4.5153
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, GBA2, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.2921
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA, EGFR 4.7113
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.7342
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, PRKCB, ALOX5, PRKCA, PTGS2, PTGS1 4.2615
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 3.8847
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.4225
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.2952
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PRKCE, PRKCD, PIK3CB 4.8462
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.0965
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, PIK3CA, PIK3CB, EGFR 4.2615
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.1668
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, DUSP3, PRKCB, PRKCA, EGFR, CDC25B, HSPA1A 3.2703
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.2397
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.7064
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, PRKCG, CHRM1, PRKCB, PRKCA, EGFR 3.2588
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.7602
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.2583
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.5237
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.4904
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, CNR1, PRKCA, PTGS2 3.4781
Gap junction_Homo sapiens_hsa04540 PRKCG, PRKCB, SRC, PRKCA, EGFR 3.7212
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 3.8508
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.1737
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.2275
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.2003
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.0028
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.9944
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.9266
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA 2.9266
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PRKCA, PIK3CB, EGFR 2.9104
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.745
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.24
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2513
Long-term depression_Homo sapiens_hsa04730 PRKCG, PRKCB, PRKCA, IGF1R 3.2826
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB, HSPA1A 2.5837
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2896
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.3617
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3, PIK3CA, PIK3CB 3.038
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.34
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3278
Axon guidance_Homo sapiens_hsa04360 MET 0.3423
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 2.4667
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.35
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, CHRM1, PIK3CA, PIK3CB, PPARA 2.3586
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.6415
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 3.0217
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.4765
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4131
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.2583
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.6983
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6712
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.6192
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4316
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 2.9104
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6459
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 2.3579
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB 0.8368
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.2169
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4531
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.9531
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.3158
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 2.7104
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.038
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 2.7894
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, PRKCA, DRD3 2.2585
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4669
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.6696
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4517
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.817
Peroxisome_Homo sapiens_hsa04146 XDH 0.4685
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3246
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2, PTGS1 3.2583
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 2.0939
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.1779
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.119
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.0713
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.4173
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4928
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8374
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, INSR, PRKCE, PIK3CB 1.927
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.6627
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.659
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9602
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.971
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5249
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5275
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.5504
Shigellosis_Homo sapiens_hsa05131 SRC 0.547
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.073
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA 1.643
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8847
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.7423
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, PRKCA 1.8768
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA 1.8374
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 1.8955
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6073
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 1.9423
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6073
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 1.1664
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 1.2245
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6308
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6308
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 2.1096
Bile secretion_Homo sapiens_hsa04976 CA2, SLC22A1 1.2429
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2429
Malaria_Homo sapiens_hsa05144 MET 0.6407
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.1836
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, PRKCB, PRKCA 2.2071
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2585
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.2071
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6459
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, PRKCA 2.1931
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.1393
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2169
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6484
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6538
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1836
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3023
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3725
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.4612
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7029
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7533
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7962
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8368
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, PIK3CB 2.6192
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7739
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.817
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.817
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8428
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8063
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 2.9024
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8368
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8817
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7713
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8374
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7515
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9851
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0882
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.084
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4134
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2349


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)