TCM Prescription: Xiao Er Xiao Ji Zhi Ke Oral Liquid



Prescription Description
Prescription IDTCMF272
Pinyin NameXiao Er Xiao Ji Zhi Ke Kou Fu Ye 
Chinese Name小儿消积止咳口服液
English NameXiao Er Xiao Ji Zhi Ke Oral Liquid
Function Description小儿饮食积滞, 痰热蕴肺所致的咳嗽, 夜间加重, 喉间痰鸣, 腹胀, 口臭
IndicationsFood retention disorder, Common cold, Upper respiratory infection(uri), Dyspepsia
Disease ICD-11 Category SA54 [Food retention disorder (TM1), 食积 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的 ];
MD92 [Dyspepsia, 消化不良 ];
Human Tissues Associated with IndicationLung, Blood, Spleen, Stomach
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
TCMH705 Trichosanthes kirilowii 瓜蒌 TCMH705 ITSAO4359-14
TCMH2117 Lepidium apetalum 葶苈子 TCMH2117 ITSAB3973-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH1617 Eriobotrya japonica thunb 枇杷叶 TCMH1617 ITSAN1970-14
TCMH1240 Raphanus sativus 莱菔子 TCMH1240 ITSAD4259-14
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH235 Periostracum cicadae 蝉蜕 TCMH235
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, MIF, PPARA, PPARD, TBXAS1 7.31519
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.12374
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, POLB, PPARA, PPARD, RORC, SRC, TYR 7.09078
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.78351
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, MIF, PIM1, PPARA, PPARD, TBXAS1, TYR, XDH 6.74084
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, POLB, PPARA, PPARD, RORC, SRC, TYR 6.40326
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SRC, TBXAS1, TYR, XDH 6.35121
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, PPARD, RORC, SRC, TYR 6.32188
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.17698
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, FLT3, MET, MIF, PIM1, POLA1, PPARD, SRC, TYR 5.89384
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PPARD, PTPN1, SRC 5.70095
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PPARD, SRC, XDH 5.63988
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIM1, POLB, PPARA, PPARD, RORC, SRC, TYR 5.63988
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, POLB, PPARA, PPARD, RORC, SRC, TYR 5.54973
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SRC, TBXAS1, TYR, XDH 5.49834
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARD, PTPN1, SRC 5.40203
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, KDR, MET, MIF, POLA1, POLB, PPARA, PPARD, SRC, XDH 5.12632
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PPARD, PTPN1, SRC, XDH 4.91038
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, PPARD 4.91038
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MIF, MMP12, MMP9, PPARD, PTPN1, SRC, XDH 4.91038
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, MIF, PPARA, PPARD, TBXAS1 4.91038
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MIF, MMP12, MMP9, PPARD, PTPN1, SRC, XDH 4.91038
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 4.73568
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARD, PTPN1, SRC, XDH 4.72134
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MIF, MMP9, PIM1, PPARD, PTPN1, SRC 4.72134
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, POLB, PPARA, PPARD, SRC, TYR 4.63829
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SRC, TYR 4.62289
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PPARD 4.5725
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MIF, MMP2, MMP9, POLA1, POLB, PPARD, PTPN1, RORC, SRC 4.55952
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CHRM1, CHRM4, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PPARD, SRC 4.55952
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.4238
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PPARD, TBXAS1 4.42097
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PPARD, SRC, XDH 4.34937
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B2, KDR, MMP9, PIM1, POLB, PPARA, PPARD, RORC, SRC, TYR 4.3381
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARD 4.23712
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, XDH 4.14306
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MIF, MMP9, PIM1, PPARD, PTPN1, SRC, XDH 4.13892
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 4.11481
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 4.07285
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, RORC, SRC, TYR 3.91168
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 3.90875
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.88027
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CHRM1, CYP19A1, CYP1A2, CYP1B1, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, RORC, SRC, TYR 3.84993
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.84927
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, PPARD, TBXAS1, TYR, XDH 3.84533
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.81054
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, PPARD 3.76475
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.73971
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PPARD, SRC 3.70243
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SRC, TBXAS1, TYR, XDH 3.68986
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PPARD, RORC, SRC 3.61404
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.60977
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, POLB, PPARA, PPARD, SRC 3.5713
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, SRC 3.55196
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, POLB, SRC 3.55196
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, KDR, MET, MIF, MMP12, MMP9, PPARD, PTPN1, SRC, XDH 3.53265
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, FLT3, KDR, MET, MIF, PPARD, PTPN1, SRC, XDH 3.51676
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, XDH 3.49481
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 3.49481
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PPARD, SRC 3.49481
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, BCL2, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, SRC 3.492
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARD 3.44701
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.27376
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, PPARD, RORC, SRC 3.2652
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MET, MIF, MMP9, PPARD, PTPN1, SRC, XDH 3.2467
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PPARD, SRC 3.163
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 3.10105
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SRC, TBXAS1, TYR, XDH 3.10072
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PPARD, TBXAS1 3.02262
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.94321
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PPARD, SRC 2.93371
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTPN1, SRC 2.93369
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.90187
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, FABP4, FLT3, KDR, MET, MIF, MMP12, MMP2, MMP9, PPARD, PTPN1, SRC, XDH 2.8867
[BP] GO:0030336 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, MIF, PPARD 2.88659
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PPARD, SRC 2.87398
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, POLB, PPARD, PTPN1, SRC, XDH 2.87166
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.87077
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2, PPARD 2.86288
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, PPARA, PPARD 2.80865
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, FABP3, FABP4, FLT3, MET, POLA1, POLB, SRC 2.79711
[BP] GO:2000146 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, MIF, PPARD 2.77257
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, MMP2, POLB, PPARA, PPARD, SRC, TYR 2.74611
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, PPARD 2.74411
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.74166
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.7399
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.7399
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.7399
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.71738
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, POLB, PPARD, PTPN1, SRC, XDH 2.66511
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, PPARD, TYR 2.65789
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, PPARD, TBXAS1, TYR 2.65789
[BP] GO:0051271 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, MIF, PPARD 2.65789
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.64903
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, MIF, PPARD 2.64423
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.54653
[BP] GO:0040013 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, MIF, PPARD 2.54653
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.54653
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARD, PTPN1, SRC, XDH 2.52418
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.52418
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, FABP3, KDR, POLB, SRC 2.48976
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, PPARD 2.48519
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.47218
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.4682
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARD, PTPN1, SRC, XDH 2.45812
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.43756
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.37566
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.36274
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.33398
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.33398
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.33398
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, PPARD, TBXAS1, TYR 2.33071
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, MIF, MMP2, MMP9, POLA1, POLB, PPARA, PPARD, PTPN1, SRC 2.33071
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, KDR, MIF, SRC 2.31303
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.28912
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CHRM1, CYP19A1, MIF, MMP12, PPARD, SRC 2.27761
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, PPARD, TBXAS1, TYR 2.27239
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 2.22303
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.22231
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.22231
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, PPARA, RORC, SRC 2.19355
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1A1, CYP1A2, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLB, PPARA, PPARD, PTPN1, SRC, TYR, XDH 2.19217
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4 2.16942
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.16942
[BP] GO:0002793 None ACHE, ADORA1, MIF, MMP12, PPARD, SRC 2.12313
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.11674
[BP] GO:0016477 cell migration AXL, CYP1B1, FUT7, KDR, MIF, MMP1, MMP12, MMP9, PPARD, SRC 2.11674
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, IGF1R, MET, MIF, MMP9, PTPN1, SRC, XDH 2.10757
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTPN1, SRC 2.09638
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.09632
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, MIF, MMP12, MMP9, PPARA, PPARD, PTPN1, SRC 2.09632
[BP] GO:0040011 locomotion AXL, CYP1B1, FUT7, KDR, MET, MIF, MMP1, MMP12, MMP9, PPARD, SRC 2.09485
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, MIF, MMP12, PPARD, SRC 2.09485
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.0943
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, MMP9, RORC 2.09379
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SRC, TBXAS1, TYR, XDH 2.08371
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF 2.08371
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PPARD, TYR 2.08371
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MET, MIF, MMP2, MMP9, PIM1, POLB, PPARA, PPARD, PTPN1, RORC, SRC 2.0803
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, POLB, TYR 2.01336
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.01287
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.9352
[CC] GO:0005578 proteinaceous extracellular matrix ALPL, MMP1, MMP12, MMP2, MMP9 1.26643
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, MET, SRC 1.22477
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CSNK2A1, FLT3, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC 1.14657
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM4, FLT3, IGF1R, KDR, MET 1.11297
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, TBXAS1, TYR, XDH 11.0062
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.3964
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, SRC, TBXAS1, TYR, XDH 9.62667
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 7.12374
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SRC, TBXAS1, TYR, XDH 6.78351
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.67262
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PPARA, PPARD, PTPN1, RORC 4.91038
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.73568
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, TBXAS1, TYR, XDH 4.50976
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, TBXAS1, TYR, XDH 4.13892
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 4.11481
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 4.10157
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, PPARD, SRC 4.07786
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.07708
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 3.90835
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.85991
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.69907
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.69764
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.51676
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.35874
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.27376
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.10105
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, POLA1, SRC, TBXAS1, XDH 2.99803
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.88474
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.80046
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.79338
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.60981
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.33398
[MF] GO:0032403 protein complex binding ACHE, ADORA1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.26572
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, FLT3, IGF1R, KDR, MET, PPARA, PPARD, RORC 2.20648
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.1733
[MF] GO:0005504 None FABP3, FABP4, PPARD 2.16942
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, POLA1, POLB, SRC 2.12321
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.03097


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.9634
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.5814
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.5096
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP19A1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.4535
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.5074
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R, PPARD 3.9747
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA, PPARD 4.5626
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4, BCL2 3.8928
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1989
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.806
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 2.9622
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, BCL2, MET, IGF1R 2.7333
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.8422
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8576
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1, PPARD 2.4895
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, ADORA3, CHRM4, ADORA1 2.2971
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1249
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, CHRM1, ADORA1, PPARA 2.0283
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.2255
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.9788
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.9788
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, SRC, CHRM4 1.9788
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.9788
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 2.1248
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7788
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.8245
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.6332
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.2323
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4807
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4342
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4496
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.2105
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3647
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3909
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1157
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2022
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1613
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3897
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.4325
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4048
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2979
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.1305
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.103
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1942
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 1.0472
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.0654
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0654
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PPARD 0.9523
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.8778
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.961
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8576
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9112
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM1 0.8419
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.8419
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0326
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8419
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.7757
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.8245
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.7711
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8716
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8147
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3146
HTLV-I infection_Homo sapiens_hsa05166 POLB 0.3145
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4122
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4397
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4884
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4121
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5678
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5302
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4913
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4757
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4722
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5099
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4957
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4884
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5098
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4598
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4869
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5098
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5122
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4957
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5541
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5571
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.5098
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5605
Axon guidance_Homo sapiens_hsa04360 MET 0.5049
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5541
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.5275
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5678
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5678
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5678
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.5436
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5605
Gap junction_Homo sapiens_hsa04540 SRC 0.5678
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5678
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5678
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5605
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5678
Peroxisome_Homo sapiens_hsa04146 XDH 0.5678
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6117
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6265
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6059
Glioma_Homo sapiens_hsa05214 IGF1R 0.6265
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6265
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6128
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6265
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6256
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6265
Bile secretion_Homo sapiens_hsa04976 CA2 0.6123
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6133
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6265
Shigellosis_Homo sapiens_hsa05131 SRC 0.6265
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6851
Malaria_Homo sapiens_hsa05144 MET 0.6955
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7153
DNA replication_Homo sapiens_hsa03030 POLA1 0.7981
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8419
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8419
Base excision repair_Homo sapiens_hsa03410 POLB 0.8277
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8658
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8419
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8576
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1421
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 1.0151
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0654


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)