TCM Prescription: Frigid Extremities Decoction



Prescription Description
Prescription IDTCMF2703
Pinyin NameSi Ni Tang
Chinese Name四逆汤
English NameFrigid Extremities Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceCurrent Kampo Medicine
Reference Book/linkISSN 1559-033X
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
Reference: Current Kampo Medicine

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT601 F2 Thrombin Unclassified P00734
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 16.0106
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 15.0066
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.4457
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.94458
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FUT7, GBA2, TYR, XDH 7.92121
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.61022
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH 7.48076
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3 7.09423
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3 5.87866
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, FUT7, GBA2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH 5.68378
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, HSD11B2, HSD17B2, TYR 5.63516
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, ESRRA, HSD11B2, TYR 5.6183
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.55184
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.50876
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, ESRRA, HSD11B2, HSD17B2, TYR 5.4666
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.89669
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.63921
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.57159
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.15868
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.89521
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD3, GBA2, TYR 3.89456
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.77083
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, BCL2, CA2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, ESRRA, HSD11B2, HSD17B2, TYR 3.73173
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, TYR 3.37117
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, HSD11B2 3.2507
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.25051
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD3, ESR1, F2, F3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TNKS, TNKS2, XDH 3.22422
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.97716
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.93886
[BP] GO:0009115 None AOX1, XDH 2.7537
[BP] GO:0010647 positive regulation of cell communication AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, F2, F3, PTPN1, TNKS, TNKS2, XDH 2.67932
[BP] GO:0023056 positive regulation of signaling AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, F2, F3, PTPN1, TNKS, TNKS2, XDH 2.66531
[BP] GO:0042221 response to chemical AKR1B1, ALPL, BCL2, CA2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, ESRRA, HSD11B2, HSD17B2, TYR 2.59392
[BP] GO:0032844 regulation of homeostatic process BCL2, CA2, CA7, CDK6, DRD3, F2, TNKS, TNKS2 2.59392
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.5722
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, DRD3, F2, TNKS, TNKS2 2.52771
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.38917
[BP] GO:0046110 None AOX1, XDH 2.3563
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.3563
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, GBA2, HSD11B1, HSD17B2, TYR 2.3563
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3 2.35117
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, DRD3 2.32624
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.3039
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.25256
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CA3, CYP1A1, CYP1B1, DRD3 2.17361
[BP] GO:0042493 response to drug AKR1B1, BCL2, CA3, CA9, CDK6, CYP1A1, CYP1B1, DRD3, HSD11B2 2.17232
[BP] GO:0018958 None AKR1B1, BCL2, DRD3, TYR 2.15925
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.14216
[BP] GO:0070213 None TNKS, TNKS2 2.13468
[BP] GO:0006145 None AOX1, XDH 2.13468
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.13468
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.01906
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, FUT7, GBA2, HSD11B1, HSD17B2, TNKS2, TYR 2.01906
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, HSD11B2 2.01794
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, AOX1, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, ESR2, F2, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH 2.07426
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F2, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 1.77973
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GBA2, HSD11B1, HSD11B2, HSD17B2 1.56133
[CC] GO:0000242 None TNKS, TNKS2 0.928512
[CC] GO:0031233 None CA4, F3 0.928512
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 22.4407
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 15.0066
[MF] GO:0046914 transition metal ion binding AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, PTPN1, TNKS, TYR, XDH 14.1404
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.7023
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 9.40788
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F2, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH 9.31321
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, PTPN1, TNKS 7.96271
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, PTPN1, TNKS, TNKS2, TYR, XDH 6.99427
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.21723
[MF] GO:0043167 ion binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, HSD17B1, PTPN1, TNKS, TNKS2, TYR, XDH 6.15245
[MF] GO:0046872 metal ion binding ALPL, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, PTPN1, TNKS, TNKS2, TYR, XDH 5.63516
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.61521
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.64581
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.96074
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.89456
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.78503
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.73894
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.63062
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.23413
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.05403
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.96123
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.93886
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.82278
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 2.8135
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 2.8135
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.7537
[MF] GO:0003845 None HSD11B1, HSD11B2 2.7537
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB 2.56182
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, XDH 2.56182
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.21159
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.13468


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 24.0592
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 10.852
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 5.7479
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.6048
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.6073
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.6323
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.4992
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.4888
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, CYP1B1, CDC25B 1.7124
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.803
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8557
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4403
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0456
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.803
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.3253
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.3354
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8377
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.3253
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 BCL2, F3 1.1882
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 1.2946
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.2646
Estrogen signaling pathway_Homo sapiens_hsa04915 ESR1, ESR2 1.1882
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.1286
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.2195
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 1.0131
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 1.0558
Hepatitis B_Homo sapiens_hsa05161 CDK6, BCL2 0.9859
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.9378
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.8233
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 F2, DRD3 0.6735
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, BCL2 0.6135
Pathways in cancer_Homo sapiens_hsa05200 CDK6, BCL2 0.5712
Glioma_Homo sapiens_hsa05214 CDK6 0.6476
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6778
Prostate cancer_Homo sapiens_hsa05215 BCL2 0.601
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.6476
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.6436
Melanoma_Homo sapiens_hsa05218 CDK6 0.644
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.585
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.655
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6436
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5842
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.601
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2 0.5795
Insulin resistance_Homo sapiens_hsa04931 PTPN1 0.5712
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5859
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 ESR1 0.56
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5859
Bile secretion_Homo sapiens_hsa04976 CA2 0.644
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.56
Apoptosis_Homo sapiens_hsa04210 BCL2 0.5325
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.644
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.56
Peroxisome_Homo sapiens_hsa04146 XDH 0.6135
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7215
Dopaminergic synapse_Homo sapiens_hsa04728 DRD3 0.5388
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.5325
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.56
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.5325
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.5325
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.5325
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4799
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.5229
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4722
Proteoglycans in cancer_Homo sapiens_hsa05205 ESR1 0.4437
Focal adhesion_Homo sapiens_hsa04510 BCL2 0.4437
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6 0.4437
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.4722
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4639
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3799
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 F2 0.4339
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7064
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7215
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7215
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7652
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.7215
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8548
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8386
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3414
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8548
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.863
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8601
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9859
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0552
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2946


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)