TCM Prescription: Calm the Middle Powder



Prescription Description
Prescription IDTCMF2699
Pinyin NameAn Zhong San
Chinese Name安中散
English NameCalm the Middle Powder
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceCurrent Kampo Medicine
Reference Book/linkISSN 1559-033X
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1277 Alpinia officinarum 良姜 TCMH1277 ITSAK2176-14
TCMH1000 Foeniculum vulgare 茴香 TCMH1000 ITSAM886-14
TCMH1525 Crassostrea gigas 牡蛎 TCMH1525 BCMOL364-12
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
Reference: Current Kampo Medicine

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT714 ODC1 Ornithine decarboxylase Lyase P11926
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1350 Penicillium roqueforti
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, ESR1, FABP3, FABP4, FDPS, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, PTGES 10.7106
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FDPS, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 10.5354
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR5A, IDO1, IGF1R, PPARA, PTGES, SRC, TYR 9.87652
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR5A, IDO1, IGF1R, KDR, PPARA, PTGES, SRC, TYR 9.67964
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR5A, IDO1, PTGES, SRC, TYR 9.1798
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FLT3, HSD11B2, HTR5A, PTGES, SRC, TYR 9.17541
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, KDR, MET, PPARA, SRC, TNKS, TNKS2, XDH 9.04952
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR5A, IDO1, IGF1R, KDR, PPARA, PTGES, SRC, TYR 8.96782
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESRRA, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IDO1, IGF1R, KDR, PIM1, PTGES, SRC, XDH 8.60338
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FDPS, FUT7, GBA2, HTR2B, IDO1, PIM1, PPARA, PTGES, TYR, XDH 8.17625
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 7.95174
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 7.81285
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 7.80479
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC, TNKS, TNKS2 7.20837
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2B, IDO1, IGF1R, KDR, MET, PIM1, PPARA, PTGES, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 6.95999
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FDPS, GBA2, HTR1A, TYR 6.95999
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 6.94662
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.92869
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.91807
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.91807
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HSD11B2, HTR2A, HTR2B, KDR, SRC 6.65941
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, IGF1R, PPARA, SRC 6.48272
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, PPARA, SRC 6.43549
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.3683
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IDO1, IGF1R, MET, PIM1, PPARA, SRC, TNKS2, TYR 6.27753
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IDO1, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 6.24775
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, PIM1, PPARA, SIGMAR1, SRC, TNKS2, TYR 6.1738
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, HTR2B, IDO1, IGF1R, KDR, MET, PIM1, PPARA, PTGES, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 6.08568
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A 6.07592
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.93864
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, ALPI, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, FABP3, FABP4, FDPS, FUT7, GBA2, MET, PPARA, PTGES 5.86808
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 5.80969
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, APP, AXL, BCL2, CYP1B1, DRD2, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, PTPN1, SRC, XDH 5.80969
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.77032
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, PTGES, SRC 5.65002
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, TYR 5.43913
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 5.36192
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 5.34741
[BP] GO:0007187 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 5.31845
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IDO1, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 5.29196
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.29196
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HTR5A, KDR, PIM1, PPARA, SIGMAR1, SRC, TYR 5.29196
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 5.28722
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, MET, SRC 5.20027
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, PTPN1, SRC, XDH 5.19113
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESRRA, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, IDO1, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 5.09932
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, HTR2B, SRC, TNKS, TNKS2 4.99477
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PIM1, PPARA, PTGES, PTPN1, SIGMAR1, SRC, TNKS, TNKS2 4.99477
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR2A, HTR2B, IDO1, IGF1R, KDR, MET, PIM1, PPARA, PTGES, PTPN1, SRC, TNKS, TNKS2, XDH 4.94852
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, ESR1, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, PIM1 4.9262
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 4.87824
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, IDO1, IGF1R, KDR, PPARA, PTGES, PTPN1, SRC, TYR 4.87159
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, TYR, XDH 4.86853
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 4.78431
[BP] GO:0007188 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 4.77043
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.77043
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.70081
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPI, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FDPS, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 4.70081
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A 4.70081
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A 4.70081
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IDO1, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SIGMAR1, SRC, XDH 4.69998
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.67791
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.67093
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC, TNKS 4.67093
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, HTR2A, HTR2B, MET 4.62502
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IDO1, IGF1R, KDR, MET, PIM1, PTPN1, SIGMAR1, SRC, XDH 4.56301
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SRC 4.55628
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.46021
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.46021
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA 4.40359
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPI, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FDPS, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 4.40084
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2 4.37275
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 4.34845
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2B, IDO1, IGF1R, KDR, MET, PIM1, PPARA, PTGES, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 4.33726
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, IDO1 4.32825
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, HSD11B2, HTR2A, HTR2B, PPARA, SRC, TYR 4.32825
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.32825
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.32825
[BP] GO:0007193 None ADORA1, DRD2, DRD3, HTR1A, HTR5A, HTR7 4.31269
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.28851
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, IGF1R, KDR, MET, SRC 4.23953
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, ESR1, FABP4, IGF1R, MET, PIM1, PPARA, PTPN1, SRC, TNKS 4.20403
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.16589
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 4.15997
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALPI, CSNK2A1, CYP19A1, CYP1A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGES 4.15458
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.15458
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, IDO1, IGF1R, KDR, MET, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 4.136
[BP] GO:0050801 ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, HTR2A, HTR2B 4.12162
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR2A, HTR2B, IDO1, IGF1R, KDR, MET, PIM1, PPARA, PTGES, PTPN1, SRC, TNKS, TNKS2, XDH 4.104
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FDPS, FLT3, HTR2A, HTR2B, PPARA, SRC 4.08819
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IDO1, IGF1R, KDR, PIM1, PTPN1, SIGMAR1, SRC, XDH 4.04989
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 4.04392
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B 4.02676
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, ESR1, HTR7, PPARA, SRC 4.02211
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 4.02211
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 4.00082
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IDO1, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC 3.94473
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, SRC 3.94074
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, IDO1, IGF1R, KDR, MET, PIM1, PPARA, PTGES, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.91037
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 3.88961
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 3.88961
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2, HSD11B2 3.81492
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, APP, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, PPARA, PTPN1, SRC, XDH 3.80656
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES 3.79524
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, PPARA, PTPN1, SRC 3.79524
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, TNKS, TNKS2 3.78103
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, APP, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, PPARA, PTPN1, SRC, XDH 3.76375
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES 3.75747
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, APP, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 3.74958
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, APP, CA2, DRD1, DRD2, DRD3, ESR1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1, SRC 3.72036
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.72036
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, APP, DRD2, FLT3, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 3.72036
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 3.72036
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IDO1, IGF1R, KDR, MET, PIM1, PTPN1, SRC 3.72036
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, ESR1, F3, FLT3, FUT7, GBA2, HTR1A, HTR2B, IDO1, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.72036
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.67827
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES 3.6556
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 3.6556
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.59555
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, SRC 3.59479
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FDPS 3.59479
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, SRC 3.55149
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.54629
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.54629
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, PPARA, PTPN1, SRC, XDH 3.51297
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.51297
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MET, PIM1, PPARA, PTPN1, SRC, TNKS, XDH 3.51297
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA 3.50583
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.45923
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.39382
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 3.38779
[BP] GO:0035265 organ growth ADRA1A, BCL2, CYP19A1, ESR1 3.38779
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, DRD3, TNKS2 3.37584
[BP] GO:0030003 cellular cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.36265
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.34082
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.30833
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC 3.30195
[BP] GO:0006873 cellular ion homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.27087
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, HTR2A, HTR2B, KDR, PTPN1, SRC 3.27059
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.27059
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FDPS 3.27059
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, APP, BCL2, CDK6, CYP1B1, DRD2, FABP3, IDO1, PTGES, XDH 3.26695
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 3.24737
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 3.24716
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.24066
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, HTR2A, HTR2B, KDR, SRC 3.22834
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC, TNKS, XDH 3.21919
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, IDO1, PPARA, PTGES 3.21276
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESR2, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 3.2047
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.19579
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, APP, DRD2, FLT3, HTR2A, HTR2B, IGF1R, KDR, PTPN1, SRC, XDH 3.19579
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, APP, BCL2, CDC25B, DRD2, ESRRB, FLT3, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 3.17783
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 3.16841
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.16841
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.16841
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IDO1, IGF1R, KDR, PIM1, PTPN1, SRC 3.16841
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 3.1655
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 3.13127
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, KDR, MET, PPARA, SRC, TNKS, TNKS2 3.09087
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 3.09087
[BP] GO:0055074 calcium ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.08262
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGES 3.08262
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F3, MET, SRC, XDH 3.07704
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, HTR2A, PPARA 3.04856
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.04744
[BP] GO:0055080 cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.01706
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB, HTR2B 3.00171
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, FABP3, FLT3, HSD11B2, IGF1R, PPARA, SRC, TYR 2.98596
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.98176
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, BCL2, DRD2, DRD3, ESR1, IGF1R, MET, PTPN1, SRC, XDH 2.97826
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.97736
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.97736
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.97736
[BP] GO:0009115 None AOX1, XDH 2.95559
[BP] GO:0008217 None ADORA1, ADRA1A, DRD2, DRD3, HSD11B2, PPARA 2.92069
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.90609
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.90609
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, APP, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, ESRRB, F3, HTR2A, HTR2B, IDO1, KDR, MET, PIM1, SRC 2.89845
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.89845
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.89845
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.89845
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.89845
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, PTGES 2.89845
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.89845
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, IDO1, KDR, MET, PPARA 2.89845
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, PIM1, SRC, TYR 2.89845
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, SRC 2.89845
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.88992
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.88992
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, APP, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, PTPN1, SRC, XDH 2.88478
[BP] GO:0007610 None APP, BCL2, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, IDO1, PPARA 2.86267
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.86267
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, APP, BCL2, CYP1B1, DRD1, DRD2, DRD3, HSD11B2, HTR1A, HTR2A, HTR2B, HTR7, SRC, TYR 2.86267
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES 2.8617
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, DRD1, DRD2, DRD3, HTR2B, HTR5A, KDR 2.84489
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, APP, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F3, HTR2A, HTR2B, IDO1, KDR, MET, PIM1, SRC, TNKS2, XDH 2.83902
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.82944
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, APP, AURKB, BCL2, CDC25B, DRD2, ESR1, ESR2, F3, FLT3, HTR2A, HTR2B, MET, PTPN1, SRC, TNKS, XDH 2.79957
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, APP, BCL2, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 2.79658
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.76679
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.75396
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.75396
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.75396
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, APP, AURKB, BCL2, CDC25B, DRD2, ESR1, F3, FLT3, HTR2A, HTR2B, PTPN1, SRC, TNKS, XDH 2.75396
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, FABP3, FLT3, HSD11B2, IGF1R, PPARA, SRC, TYR 2.7346
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.7346
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, PPARA, SRC, TNKS 2.71867
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.70678
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, MET, PPARA, SRC, TNKS, TNKS2 2.70511
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.70511
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES 2.70346
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.70346
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.68785
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, PTPN1, SRC, XDH 2.67815
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, PTPN1, SRC, XDH 2.66398
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, SRC 2.66136
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.61902
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.61902
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, PPARA, SRC 2.61889
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, PPARA 2.6148
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.58917
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.58917
[BP] GO:0046110 None AOX1, XDH 2.57757
[BP] GO:0060160 None DRD2, DRD3 2.57757
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.57757
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.57757
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, IDO1, PIM1, PPARA, PTGES, TYR 2.57757
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, PPARA 2.56965
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.56965
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, IDO1 2.56919
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, GBA2, IDO1, SRC, XDH 2.56919
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.56919
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.56919
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, SRC 2.56919
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, BCL2, CDK6, CYP19A1, DRD1, DRD2, DRD3, ESR1, ESR2, IGF1R, MET, PPARA, PTPN1, SRC, XDH 2.5671
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, PPARA, SRC 2.55996
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.54869
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC, TNKS 2.54431
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.51334
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.5126
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR1A, HTR2A 2.50716
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.50085
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.47436
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGES, SRC 2.47428
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.46628
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.45646
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.45646
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, SRC 2.45641
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, BCL2, CYP1B1, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MET, PTPN1, SRC 2.45154
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.45154
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.45154
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, HTR2A 2.45154
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, KDR, SRC 2.43753
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.42541
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, DRD3, TYR 2.41125
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.40607
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, HTR2A, IGF1R, MET, PPARA, PTPN1, SRC, TNKS, TNKS2 2.39577
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.37592
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, GBA2, IDO1, XDH 2.37202
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, PPARA, SRC 2.3623
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MET, PIM1, PPARA, PTGES, PTPN1, SIGMAR1, SRC, TNKS, TNKS2, XDH 2.35701
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.35701
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35701
[BP] GO:0070213 None TNKS, TNKS2 2.33966
[BP] GO:0006145 None AOX1, XDH 2.33966
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.33966
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.33599
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.33599
[BP] GO:0009605 response to external stimulus ADORA1, ADRA1A, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, DRD3, HSD11B2, HTR2A, IDO1, PTGES, SRC, TYR 2.33012
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGES, SRC 2.33012
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.31294
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.31294
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, PPARA, SRC 2.31137
[BP] GO:0019725 cellular homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.31137
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.2979
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.26929
[BP] GO:0045913 None ESRRB, HTR2A, PPARA, SRC 2.24658
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.24658
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, IDO1, PIM1, PPARA, PTGES, TYR 2.24036
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MET, PIM1, PPARA, PTGES, PTPN1, SIGMAR1, SRC, TNKS, TNKS2, TYR, XDH 2.22548
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.22548
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.22234
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.22234
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.22234
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.20595
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, APP, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, F3, FLT3, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 2.19801
[BP] GO:0055065 metal ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.19292
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, HTR2B, SRC 2.18695
[BP] GO:0008306 None APP, DRD1, DRD2, DRD3 2.18674
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, IDO1, PIM1, PPARA, PTGES, TYR 2.18087
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.18087
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, SRC 2.17697
[BP] GO:0007189 None ADRA1A, DRD1, DRD2, DRD3 2.16783
[BP] GO:0021853 None DRD1, DRD2 2.16403
[BP] GO:0043696 None CDK6, ESRRB 2.16403
[BP] GO:0043697 None CDK6, ESRRB 2.16403
[BP] GO:0010641 None F3, SRC 2.16403
[BP] GO:1904936 None DRD1, DRD2 2.16403
[BP] GO:0042321 None ADORA1, DRD2 2.16403
[BP] GO:0090325 None DRD2, DRD3 2.16403
[BP] GO:0010513 None HTR2A, HTR2B 2.16403
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CDK6, CYP19A1, DRD2, ESR1, F3, FABP4, IDO1, IGF1R, MET, PPARA, PTPN1, SRC, XDH 2.16138
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FLT3, HTR2A, HTR2B, PTPN1, SRC, TNKS 2.16138
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.15032
[BP] GO:0014059 None DRD2, DRD3, HTR2A 2.15032
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, DRD3, HTR2A 2.12807
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B 2.09509
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, F3, IGF1R, KDR, MET, SRC 2.09442
[BP] GO:0050730 None ADORA1, APP, FLT3, HTR2A, PTPN1, SRC 2.07257
[BP] GO:0002209 None BCL2, DRD1, HTR1A 2.06726
[BP] GO:0001662 None BCL2, DRD1, HTR1A 2.06726
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.0648
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, PPARA, PTPN1, SRC 2.06279
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.05922
[BP] GO:1900542 None DRD1, DRD2, DRD3, ESRRB, HTR2A, PPARA 2.04885
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F3, HTR2A, IDO1, KDR, PIM1, PPARA, SRC, TNKS2, XDH 2.04644
[BP] GO:0040007 None ADRA1A, APP, BCL2, CYP19A1, ESR1, SRC, TNKS2 2.03983
[BP] GO:0045777 None ADORA1, ADRA1A, HSD11B2 2.03637
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R 2.03637
[BP] GO:0045744 None DRD2, DRD3, MET 2.03637
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.03637
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DRD2, DRD3, ESR1, IGF1R, KDR, MET, SRC, TNKS, TNKS2 2.02814
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.02779
[BP] GO:0001763 morphogenesis of a branching structure BCL2, DRD2, ESR1, MET, SRC 2.02779
[BP] GO:0021843 None DRD1, DRD2 2.02779
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.02779
[BP] GO:0046113 None AOX1, XDH 2.02779
[BP] GO:0021830 None DRD1, DRD2 2.02779
[BP] GO:0021826 None DRD1, DRD2 2.02779
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6 2.02779
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, TNKS 2.02779
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, F3, IGF1R, KDR, MET, SRC 2.02064
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AOX1, APP, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FDPS, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2B, IDO1, PPARA, TYR, XDH 2.01505
[BP] GO:0022029 None DRD1, DRD2, HTR6 2.01505
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.01505
[BP] GO:0042596 None BCL2, DRD1, HTR1A 2.01505
[BP] GO:0007154 None ADORA1, ADRA1A, AXL, BCL2, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7 2.00962
[BP] GO:0006140 None DRD1, DRD2, DRD3, ESRRB, HTR2A, PPARA 2.00962
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, CA4, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 5.34741
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX5, ALPI, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PIM1, PTGES, PTPN1, SIGMAR1, SRC, TNKS, TNKS2, TYR 4.81122
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, DRD1, DRD2, DRD3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 4.4077
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ALPI, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTGES, PTPN1, SIGMAR1, SRC, TYR 4.33919
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.54629
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ALPI, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F3, FLT3, GBA2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PIM1, PTPN1, SRC 3.51297
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, APP, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SRC 3.24066
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGES, PTPN1, SIGMAR1 3.16841
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGES, SIGMAR1 2.89845
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GBA2, HTR5A, KDR, PTPN1, SIGMAR1, XDH 2.81745
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, HTR5A, IDO1, KDR, PIM1, PTGES, PTPN1, SIGMAR1, SRC, TNKS, TNKS2, TYR, XDH 2.75396
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, ALPI, ALPL, APP, AXL, CA12, CA14, CA4, CA9, DRD1, DRD2, DRD3, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTGES, SIGMAR1, TYR 2.54109
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MET, PIM1, PPARA, PTGES, PTPN1, SIGMAR1, SRC, TNKS, TNKS2, TYR, XDH 2.38183
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.02779
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPI, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IDO1, IGF1R, KDR, MET, PIM1, PPARA, PTGES, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 10.6752
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, PTPN1, TNKS, TYR, XDH 10.5354
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.9211
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 8.24581
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1 7.81285
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.64736
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FDPS, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IDO1, PIM1, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 7.63929
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AXL, CDK6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1 7.33993
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.94662
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1 6.92869
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.91807
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.91807
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, F3, FDPS, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, PIM1, PTGES, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 6.91376
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.91376
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.91376
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.3683
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1 6.24775
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, TYR, XDH 5.90656
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 5.81639
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.54427
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, SIGMAR1, SRC 5.53749
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.31371
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.1473
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 5.11127
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.09101
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 5.06675
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 5.06675
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, XDH 4.70081
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B2, HSD17B1, IDO1, PTGES, SRC, XDH 4.67725
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, IDO1, SRC 4.24566
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.08379
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, IDO1, SRC 4.06693
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.04989
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, PPARA, PTPN1, TNKS 4.00709
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.93806
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.93806
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 3.83872
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.59555
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.5738
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.54629
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.51309
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.4415
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.38707
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.37584
[MF] GO:0046872 metal ion binding ALOX5, ALPI, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FDPS, IDO1, PIM1, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 3.16723
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 3.09087
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.09087
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.06894
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.97736
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.95559
[MF] GO:0003845 None HSD11B1, HSD11B2 2.95559
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 2.8617
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.8617
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 2.79307
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HSD11B2, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IDO1, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, XDH 2.63194
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.55565
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.5126
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.33966
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.29752
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.16403
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, HTR2A, IGF1R, KDR, PIM1, PPARA, PTPN1, SRC 2.11004
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.03637
[MF] GO:0004064 arylesterase activity CA1, CA2 2.02779
[MF] GO:0043546 None AOX1, XDH 2.02779
[MF] GO:0004035 alkaline phosphatase activity ALPI, ALPL 2.02779


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.0414
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.9172
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR6, HTR7, ADORA3, HTR2B, ADORA1, HTR1A, HTR2A, DRD1, HTR5A, DRD2, ADRA1A, DRD3 8.3508
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, HTR7, CYP2D6, ALOX5, HTR2B, HTR1A, HTR2A, HTR5A 8.3508
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.0674
Metabolic pathways_Homo sapiens_hsa01100 FDPS, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, ALPI, XDH, PTGES, IDO1 6.4988
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.3609
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A 4.3864
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 4.1651
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.1651
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2A, DRD1, DRD2 3.8362
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA 3.1989
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MET, CDC25B 2.3524
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, IGF1R 2.3102
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.3102
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.7817
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.2592
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.9747
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.0236
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9747
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, AOX1 1.9901
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.6453
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 BCL2, PIM1, F3 1.6405
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, MET, IGF1R 1.5896
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 1.9901
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, ESR2 1.6453
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.5348
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, BCL2, MET, IGF1R 1.3963
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.387
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3 1.4417
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.5153
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2 1.3424
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.2825
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA1A 1.2577
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.2167
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2861
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2825
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2577
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.0389
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9863
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8918
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.2413
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.9112
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9183
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0292
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.9547
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.0581
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2738
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2254
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.128
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.375
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0197
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8918
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.8918
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGES 1.2577
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.222
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6453
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8105
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A, IGF1R 0.8674
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7967
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8674
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7967
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8005
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRA1A 0.7838
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.5719
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.6796
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6796
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6269
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6269
HTLV-I infection_Homo sapiens_hsa05166 FDPS 0.2354
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2355
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6202
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2826
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5613
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3208
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3401
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3335
Influenza A_Homo sapiens_hsa05164 FDPS 0.3335
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3401
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3207
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8248
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3672
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3555
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3861
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3861
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3846
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3967
Platelet activation_Homo sapiens_hsa04611 SRC 0.4135
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3967
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4151
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4135
Axon guidance_Homo sapiens_hsa04360 MET 0.4058
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.4151
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4699
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4699
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4942
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4815
GnRH signaling pathway_Homo sapiens_hsa04912 SRC 0.4897
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4814
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4812
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.5007
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4942
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4942
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.4942
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4942
Peroxisome_Homo sapiens_hsa04146 XDH 0.5007
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5333
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5113
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5321
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5409
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5508
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5508
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5508
Bile secretion_Homo sapiens_hsa04976 CA2 0.5397
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5493
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5423
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5608
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5508
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5527
Shigellosis_Homo sapiens_hsa05131 SRC 0.5508
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5834
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6156
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6269
Malaria_Homo sapiens_hsa05144 MET 0.6269
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6269
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6269
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6269
Bladder cancer_Homo sapiens_hsa05219 SRC 0.6635
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6786
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.1413
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7066
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7508
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7729
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7729
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7951
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7852
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.927
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.8339
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8918
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2413


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)