TCM Prescription: Anti-SARS3



Prescription Description
Prescription IDTCMF2639
Pinyin NameAnti-SARS3
Chinese Name
English NameAnti-SARS3
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationBlood
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH1105 Trollius chinensis 金莲花 TCMH1105 GBVJ1059-11
TCMH381 Isatis indigotica 大青叶 TCMH381 KJ765825
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH2046 folium perillae 苏叶 TCMH2046
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1252 Alcaligenes faecalis
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1333 Human rhinovirus 1A
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, GSK3B, IDO1, IGF1R, MMP2, MMP9, PPARA, PTGS2, RORC, SRC 9.35458
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TBXAS1, TERT, TOP2A, XDH 9.16774
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MMP2, PPARA, PTGS2, RORC, SRC 9.1524
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FUT7, GLO1, IDO1, PIM1, PPARA, PTGS2, TBXAS1, XDH 8.83506
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, PTGS2, RORC, SRC, TERT 8.75366
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 8.59201
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, TOP2A, XDH 8.47554
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD17B1, KIT, MET, PPARA, PTGS2, TBXAS1 8.2963
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC, TERT, TOP2A, XDH 8.2781
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9, DHFR 8.02175
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GSK3B, IGF1R, KIT, MMP2, PPARA, PTGS2, SRC 7.99672
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PPARA, PTGS2, RORC, SRC, TBXAS1, TERT, TOP2A, XDH 7.99672
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.46162
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TERT 7.33352
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH 7.24492
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH 7.17689
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FLT3, PTGS2, RORC, SRC 7.17689
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, GSK3B, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A 7.06379
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC, TERT 7.05018
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, IDO1, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, SRC, TERT, XDH 7.00655
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH 6.94082
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, PTGS2, RORC, SRC, TERT 6.94082
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GSK3B, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, SRC, TERT, TOP2A, XDH 6.85222
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, KIT, PPARA, PTGS2, SRC 6.84442
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IDO1, PTGS2, RORC, SRC 6.31896
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, PTGS2, RORC, SRC, TERT, TOP2A 6.17368
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HSD17B1, IDO1, PTGS2, TBXAS1, XDH 6.00793
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, PTGS2, RORC, SRC 5.86953
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH 5.84014
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TBXAS1, TERT, TOP2A, XDH 5.80599
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, PIM1, SRC 5.7638
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, KDR, KIT, MET, MMP12, MMP9, PTGS2, SRC, TERT, XDH 5.48904
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GSK3B, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 5.48904
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, GSK3B, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, SRC, TERT 5.48904
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DHFR, ESR1, FABP3, FABP4, FLT3, GSK3B, HSD17B1, KDR, KIT, MET, PPARA, PTGS2, SRC, TERT, XDH 5.48904
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, KDR, KIT, MET, MMP12, MMP9, PTGS2, SRC, TERT, XDH 5.48904
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PPARA, PTGS2, RORC, SRC, TERT, TOP2A 5.24832
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.15747
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TBXAS1, TERT, TOP2A, XDH 5.08482
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1 5.02706
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.98987
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, KIT, MET, PPARA, PTGS2, TBXAS1 4.86201
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.85472
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC 4.8524
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.60867
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, ESRRB, FLT3, GSK3B, KDR, KIT, MMP9, PIM1, PPARA, PTGS2, RORC, SRC 4.57221
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, GSK3B, KIT, PPARA, RORC, SRC, TOP2A 4.55751
[BP] GO:0043393 regulation of protein binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SRC, TERT 4.51811
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.48128
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.46951
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, ESR1, GSK3B, IGF1R, MMP2, MMP9, PTGS2, RORC, SRC 4.46691
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, GSK3B, IDO1, KDR, KIT, MET, MMP12, MMP2, MMP9, PTGS2, SRC, TERT, XDH 4.36496
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGS2, TERT 4.18295
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DHFR, ESR1, FABP4, GSK3B, IDO1, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, SRC, TERT, XDH 4.12028
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 4.08375
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1 4.07566
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, IDO1, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC 4.01246
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.96567
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.96567
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, KDR, KIT, MET, MMP12, MMP9, PTGS2, SRC, TERT, XDH 3.93819
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.93656
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GSK3B, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC 3.92584
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GSK3B, IGF1R, PPARA, PTGS2, SRC 3.91436
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.86983
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.86983
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, KDR, KIT, PPARA, SRC 3.86558
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH 3.86558
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PPARA, PTGS2, SRC, TERT, XDH 3.86558
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, KIT, PPARA, PTGS2, RORC, SRC 3.80573
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CSNK2A1, ESR1, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 3.7875
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, IDO1, PPARA, PTGS2, TBXAS1 3.78658
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.75066
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PTGS2, SRC, TERT 3.74515
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.74515
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, GSK3B, KDR, KIT, MET, MMP2, MMP9, PTGS2, RORC, SRC, TERT, TOP2A 3.74515
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.70565
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTGS2, SRC, TERT, XDH 3.69513
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC 3.6912
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC 3.60904
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTGS2, SRC, TERT, XDH 3.6069
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH 3.59968
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, IDO1 3.55371
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, IDO1, KIT, MMP2, MMP9, PPARA, PTGS2, SRC, TERT, TOP2A 3.53943
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2, TBXAS1 3.51232
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.38164
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC 3.38164
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 3.37154
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH 3.34944
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, ESR1, FLT3, GSK3B, IGF1R, KIT, MMP2, PTGS2, SRC 3.34944
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.34944
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH 3.32089
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, CYP19A1, CYP1A1, ESR1, ESRRB, IDO1, KIT, MMP2, MMP9, PTGS2, SRC, TOP2A 3.26677
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SRC, TERT 3.25456
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, PTGS2, SRC, XDH 3.23122
[BP] GO:0030335 positive regulation of cell migration APP, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.22944
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS2, TBXAS1 3.22474
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 3.22474
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, DHFR, ESR1, FLT3, FUT7, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC, TOP2A, XDH 3.21484
[BP] GO:2000147 positive regulation of cell motility APP, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.12096
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.12096
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, MMP9, PTGS2, SRC 3.11813
[BP] GO:0051098 regulation of binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SRC, TERT 3.11813
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, RORC, SRC, TERT, XDH 3.09769
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DHFR, FABP3, KDR, PTGS2, SRC 3.09769
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, PPARA, PTGS2, RORC, SRC, TERT, TOP2A 3.09309
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, XDH 3.06413
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.06413
[BP] GO:0051272 positive regulation of cellular component movement APP, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.05168
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.04167
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 3.02136
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, PTGS2, SRC, XDH 3.01099
[BP] GO:0010906 None ESRRB, GSK3B, PPARA, RORC, SRC 2.97392
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.96274
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 2.96223
[BP] GO:0040017 positive regulation of locomotion APP, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 2.96188
[BP] GO:0009889 regulation of biosynthetic process ADORA3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GSK3B, IGF1R, KDR, KIT, MET, MMP12, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A 2.96188
[BP] GO:0009115 None AOX1, XDH 2.96188
[BP] GO:0002521 leukocyte differentiation AXL, FLT3, FUT7, GLO1, KIT, MMP9, RORC 2.95656
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 2.92791
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 2.91585
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.91119
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC 2.90647
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 2.90647
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS2, TBXAS1 2.88865
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.88266
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH 2.88105
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.82754
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS2, TBXAS1 2.8244
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.82368
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.78495
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, CYP1B1, FLT3, KDR, KIT, MET, PTGS2, SRC, XDH 2.78288
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, PTGS2, SRC 2.78108
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, GSK3B, IGF1R, MMP2, PTGS2, SRC 2.7803
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, CA2, CYP1B1, ESR1, ESRRA, ESRRB, GSK3B, IDO1, KDR, KIT, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TERT, XDH 2.77115
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH 2.77115
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CYP1B1, ESRRB, IDO1, KDR, KIT, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TERT 2.77115
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, DHFR, IDO1 2.75415
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, GLO1, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH 2.7402
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, KDR, SRC 2.7402
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GSK3B, IDO1, XDH 2.71773
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 2.71773
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, RORC, SRC, TERT, XDH 2.71405
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.70643
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, KIT, MMP2, PPARA, PTGS2, SRC, TERT 2.69925
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.68199
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.67894
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.67847
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, PPARA, PTGS2, RORC, SRC, TERT, TOP2A 2.67735
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AURKB, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, IGF1R, KDR, MMP12, MMP9, PPARA, PTGS2, RORC, SRC, TERT, XDH 2.66434
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, KIT, PTGS2 2.65353
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, KIT, PTGS2 2.65353
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.62776
[BP] GO:0030154 cell differentiation ALPL, AXL, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, GSK3B, KDR, KIT, MMP2, MMP9, PTGS2, RORC, TOP2A 2.61699
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.61699
[BP] GO:0010675 None ESRRB, GSK3B, PPARA, RORC, SRC 2.61699
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.61047
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, FUT7, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH 2.61047
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.61047
[BP] GO:0046110 None AOX1, XDH 2.61047
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.61047
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, GSK3B, IGF1R, MMP2, PTGS2, SRC 2.60873
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.60873
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GSK3B, IGF1R, SRC 2.59142
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH 2.58655
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.58009
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TBXAS1, TERT, TOP2A, XDH 2.58009
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.57647
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, SRC, TOP2A 2.57137
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.57088
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.57088
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH 2.57088
[BP] GO:0031326 regulation of cellular biosynthetic process ADORA3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GSK3B, IGF1R, KIT, MET, MMP12, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A 2.54781
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.54106
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, FABP3, KDR, MMP2, PTGS2, SRC 2.52089
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.52027
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.52027
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.49593
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, PPARA, RORC, SRC, TERT, TOP2A 2.47321
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.46822
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, AOX1, CYP19A1, CYP1A2, GSK3B, IDO1, XDH 2.41889
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.41874
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.41874
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ESR1, ESR2, GSK3B, IGF1R, MET, MMP12, MMP9, PTGS2, SRC, TERT, XDH 2.41482
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ESR1, ESR2, GSK3B, IGF1R, MET, MMP12, MMP9, PTGS2, SRC, TERT, XDH 2.4027
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CYP19A1, ESR1, ESR2, GSK3B, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, SRC, TERT, XDH 2.3973
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, ESR2, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTGS2, SRC, TERT, XDH 2.3973
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.39157
[BP] GO:0006145 None AOX1, XDH 2.37899
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.37899
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.37899
[BP] GO:0010556 regulation of macromolecule biosynthetic process ADORA3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GSK3B, IGF1R, KDR, KIT, MET, MMP12, PIM1, PPARA, RORC, SRC, TERT, TOP2A 2.37551
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.35616
[BP] GO:0010468 regulation of gene expression ADORA3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GSK3B, KDR, KIT, MET, MMP12, PIM1, PPARA, RORC, SRC, TERT, TOP2A, XDH 2.35569
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.33796
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, ESR1, FABP4, IDO1, KDR, MET, MMP12, PPARA, PTGS2 2.31253
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, FABP4, IDO1, MMP12, MMP2, PPARA, PTGS2, SRC 2.2972
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.2972
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.2972
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, GSK3B, MMP12, PTGS2, SRC, TERT 2.27379
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, GSK3B, IDO1, SRC, XDH 2.27379
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.26098
[BP] GO:0006355 regulation of transcription, DNA-templated ADORA3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, KIT, MET, MMP12, PIM1, PPARA, RORC, SRC, TERT, TOP2A 2.25591
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 2.24942
[BP] GO:1903506 regulation of nucleic acid-templated transcription ADORA3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, KIT, MET, MMP12, PIM1, PPARA, RORC, SRC, TERT, TOP2A 2.23009
[BP] GO:0050793 regulation of developmental process APP, AXL, CA2, CYP1B1, ESR1, ESRRA, ESRRB, GSK3B, IDO1, KDR, KIT, PIM1, PPARA, PTGS2, RORC, SRC, TERT, XDH 2.22924
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.22924
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.22924
[BP] GO:2001141 regulation of RNA biosynthetic process ADORA3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, KIT, MET, MMP12, PIM1, PPARA, RORC, SRC, TERT, TOP2A 2.22569
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, ESR1, FLT3, KIT, MET, PIM1, SRC 2.19948
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.19948
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, ESR1, GSK3B, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC 2.19807
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.19671
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, FABP4, FLT3, GSK3B, IGF1R, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, XDH 2.19284
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 2.19164
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.1915
[BP] GO:1904645 response to amyloid-beta APP, GSK3B, IGF1R 2.1915
[BP] GO:2000112 regulation of cellular macromolecule biosynthetic process ADORA3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GSK3B, IGF1R, KIT, MET, MMP12, PIM1, PPARA, RORC, SRC, TERT, TOP2A 2.15858
[BP] GO:1901989 None APEX1, APP, CYP1A1, TERT 2.14637
[BP] GO:0051172 None APEX1, APP, AURKB, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, FABP4, IGF1R, MMP12, MMP9, PPARA, PTGS2, RORC, SRC, TERT, XDH 2.14012
[BP] GO:0051099 positive regulation of binding APP, GSK3B, MET, MMP9, TERT 2.14012
[BP] GO:0032092 positive regulation of protein binding APP, GSK3B, MMP9, TERT 2.13109
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC 2.12221
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.12055
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.11875
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, CYP1B1, ESR1, ESR2, KIT, PIM1 2.11875
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, ESR1, FABP4, IDO1, PPARA, PTGS2 2.11875
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC 2.08776
[BP] GO:0010907 None ESRRB, PPARA, SRC 2.08776
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CSNK2A1, DHFR, ESR1, FABP4, FLT3, GSK3B, IGF1R, KIT, MMP9, PTGS2, SRC, TERT, XDH 2.06209
[BP] GO:0046113 None AOX1, XDH 2.06209
[BP] GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SRC 2.05459
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.05339
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, GSK3B, PPARA, RORC, SRC 2.03132
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, KDR, KIT, PTGS2, TERT 2.02114
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, CYP1B1, FABP3, IDO1, PTGS2, TERT, XDH 2.00881
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AXL, CYP1A1, ESR1, KIT, PTGS2, SRC 2.0006
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH 2.57073
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH 2.39009
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, APP, AURKB, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, GSK3B, IGF1R, KDR, KIT, MMP12, MMP2, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH 2.01759
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, APP, AURKB, CA1, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, IDO1, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, SRC, TBXAS1, TERT, TOP2A, XDH 1.88248
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.84659
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, TBXAS1, XDH 15.0521
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TBXAS1, TERT, TOP2A, XDH 14.7146
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.3883
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, FUT7, GLO1, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, SRC, TBXAS1, TERT, TOP2A, XDH 10.0413
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, TBXAS1, TERT, TOP2A, XDH 9.1524
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, TBXAS1, TERT, TOP2A, XDH 8.72439
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.46162
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, RORC 7.40739
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.94082
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD17B1, IDO1, PTGS2, TBXAS1, XDH 6.26585
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.95142
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC, TBXAS1 5.87243
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC, TBXAS1 5.66554
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.66476
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.66476
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD17B1, IDO1, PTGS2, SRC, TBXAS1, XDH 5.49551
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 5.24832
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.24349
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 5.12685
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.55751
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC, TOP2A 4.51811
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 4.37299
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.92466
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.86983
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.79642
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.75726
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 3.51232
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, PIM1, PPARA, PTGS2, RORC, SRC, TBXAS1, TERT, TOP2A, XDH 3.38164
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, SRC 3.34944
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, PIM1, PPARA, PTGS2, RORC, SRC, TBXAS1, TERT, TOP2A, XDH 3.31503
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.12096
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, TERT, TOP2A, XDH 3.04167
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.99024
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.98995
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.96223
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.96188
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 2.90647
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, SRC 2.87064
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, PPARA, RORC 2.72136
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP2A, XDH 2.68897
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, PPARA, RORC 2.68199
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TERT 2.67847
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 2.62974
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.61047
[MF] GO:0008134 transcription factor binding APEX1, ESR1, ESRRB, FLT3, GSK3B, PIM1, PPARA, SRC, TERT 2.47958
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, XDH 2.43036
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.37899
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.33796
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.2972
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, PPARA, RORC 2.23485
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.19948
[MF] GO:0043168 anion binding AOX1, APP, AURKB, AXL, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP2A, XDH 2.16615
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, PPARA, RORC 2.12221
[MF] GO:0004064 arylesterase activity CA1, CA2 2.06209
[MF] GO:0043546 None AOX1, XDH 2.06209


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.7459
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.3657
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.4853
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, CYP19A1, DHFR, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 4.7828
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, FLT3, MMP1, MMP2, KIT, PTGS2, MMP9, MET, IGF1R 4.6417
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.6417
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.7833
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.9784
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1231
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC, ESR1, ESR2 3.2815
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.2725
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3131
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, MET, IGF1R 2.7201
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 2.6605
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 3.1634
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.3923
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.4338
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.4338
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.3923
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2 2.3923
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PTGS2, MMP9, MET 2.199
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, KIT, KDR, MET, IGF1R 1.9834
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.3529
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.3728
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1509
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.2623
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.8511
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PTGS2 1.8511
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC, ESR1 1.8002
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.6724
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, ESRRB, IGF1R 1.6135
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2863
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 1.15
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.298
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.0847
Prostate cancer_Homo sapiens_hsa05215 GSK3B, IGF1R 1.15
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1414
Melanogenesis_Homo sapiens_hsa04916 GSK3B, KIT 1.0847
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.297
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4043
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2278
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.15
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.0338
Insulin resistance_Homo sapiens_hsa04931 GSK3B, PPARA 1.0338
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.1331
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9767
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9817
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9867
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1 0.919
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA 0.9252
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.9531
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8897
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1 0.9041
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA 0.871
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9133
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.857
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.857
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8425
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP 0.8425
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1 0.7585
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.7983
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.7585
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8748
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, TERT 0.6394
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1 0.6236
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3556
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3662
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4073
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.397
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4067
Influenza A_Homo sapiens_hsa05164 GSK3B 0.4073
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.449
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.4671
Insulin signaling pathway_Homo sapiens_hsa04910 GSK3B 0.4763
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4888
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5074
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B 0.5088
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5074
Cell cycle_Homo sapiens_hsa04110 GSK3B 0.5074
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.4963
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8511
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5305
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5588
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.5113
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5513
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7854
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5549
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5588
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5591
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.5513
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5589
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5675
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5589
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5549
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5678
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5683
Gap junction_Homo sapiens_hsa04540 SRC 0.5683
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.569
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.568
Peroxisome_Homo sapiens_hsa04146 XDH 0.5786
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.6202
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6202
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6191
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6236
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6394
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6394
Glioma_Homo sapiens_hsa05214 IGF1R 0.6394
Bile secretion_Homo sapiens_hsa04976 CA2 0.6223
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6379
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6394
Colorectal cancer_Homo sapiens_hsa05210 GSK3B 0.6394
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0748
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6394
Shigellosis_Homo sapiens_hsa05131 SRC 0.6394
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.6859
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6682
Malaria_Homo sapiens_hsa05144 MET 0.6998
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7062
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6966
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7029
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7097
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7983
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7585
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1 0.7983
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8274
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8425
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.3923
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8074
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8425
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.857
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8351
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.848
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.919
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1634
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2863


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)