TCM Prescription: Ershiwuwei Zhenzhu Pills



Prescription Description
Prescription IDTCMF2625
Pinyin NameEr Shi Wu Wei Zhen Zhu Wan
Chinese Name二十五味珍珠丸
English NameErshiwuwei Zhenzhu Pills
Function Description中风
IndicationsStroke
Disease ICD-11 Category 8B20 [Stroke not known if ischaemic or haemorrhagic, 缺血或出血未知的卒中 ];
Human Tissues Associated with IndicationBrain
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2605 Margarita 珍珠 TCMH2605
TCMH1741 Myristica fragrans 肉豆蔻 TCMH1741 GENG137-13, GBVH1657-11
TCMH1934 Calx pulveratum 石灰华 TCMH1934
TCMH216 Fructus tsaoko 草果 TCMH216 GQ118666
TCMH486 Syzygium aromaticum 丁香 TCMH486 GBVI185-11
TCMH1068 Dalbergia odorifera 降香 TCMH1068 ITSAJ4189-14
TCMH53 Amomum kravanh 白豆蔻 TCMH53 KT898257
TCMH826 Terminalia chebula 诃子 TCMH826
TCMH2066 Santalum album 檀香 TCMH2066 ITSAJ4584-14
TCMH2530 Fructus phyllanthi 余甘子 TCMH2530
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH1457 Fructus terminaliae billericae 毛诃子 TCMH1457
TCMH564 Eriocheir sinensis seu poramon 方海 TCMH564 BNSC602-15
TCMH1533 Saussurea lappa 木香 TCMH1533
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT286 KLF5 Kruppel-like factor 5 Unclassified Q13887
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT48 SCN5A Sodium channel protein type V alpha subunit Ion channel Q14524
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT559 ADRB2 Beta-2 adrenergic receptor GPCR P07550
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1310 Enterococcus hirae
TCMT1312 Enterococcus durans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, F10, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, MIF, PPARA, SLC1A1, SMAD3, SRC, TEK, XDH 8.49154
[BP] GO:0010647 positive regulation of cell communication ADRB1, ADRB2, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 7.64733
[BP] GO:0023056 positive regulation of signaling ADRB1, ADRB2, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 7.64733
[BP] GO:1901700 response to oxygen-containing compound ADRB2, AKR1B1, APEX1, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, GRIK5, GRM5, HSD17B2, IGF1R, INSR, KLF5, MMP2, MMP9, PPARA, RORC, SRC, TEK, TYR 7.61702
[BP] GO:0010033 response to organic substance ADRB2, AKR1B1, APEX1, AXL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KLF5, MMP2, PPARA, RORC, SMAD3, SRC, TEK, TYR 7.49882
[BP] GO:0010646 regulation of cell communication ACHE, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 7.37854
[BP] GO:0023051 regulation of signaling ACHE, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 7.26083
[BP] GO:0048522 positive regulation of cellular process ACHE, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 6.91973
[BP] GO:0042221 response to chemical ADRB2, AKR1B1, APEX1, AXL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KLF5, MMP2, MMP9, PPARA, RORC, SMAD3, SRC, TEK, TOP1, TYR 6.8919
[BP] GO:1902533 positive regulation of intracellular signal transduction ADRB1, ADRB2, AKR1B1, AXL, BCL2, CYP1B1, EGFR, F10, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MIF, PTPN1, SRC, TEK, XDH 6.69126
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.5771
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, GRIK5, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 6.5771
[BP] GO:0009967 positive regulation of signal transduction ADRB1, ADRB2, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 6.52878
[BP] GO:0048518 positive regulation of biological process ACHE, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, XDH 6.52878
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, GRIK5, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 6.52878
[BP] GO:1902531 regulation of intracellular signal transduction ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 6.47733
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX5, CA12, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FDPS, FUT7, GLO1, HSPA1A, MIF, PIM1, PPARA, TBXAS1, TYR, XDH 6.28774
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.27078
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 6.22312
[BP] GO:0019220 regulation of phosphate metabolic process ADRB1, ADRB2, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.22312
[BP] GO:0051174 regulation of phosphorus metabolic process ADRB1, ADRB2, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.16617
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FDPS, FUT7, HSD17B1, HSD17B2, MET, MIF, PPARA, TBXAS1 6.16248
[BP] GO:0070887 cellular response to chemical stimulus ADRB2, AKR1B1, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, KLF5, MMP2, MMP9, RORC, SMAD3, SRC 6.0935
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KLF5, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 6.07657
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 6.07657
[BP] GO:0009719 response to endogenous stimulus ADRB2, AKR1B1, APEX1, BCL2, CA2, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, KLF5, MMP2, PPARA, SMAD3, SRC, TEK 6.07657
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, GRIK5, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 6.03533
[BP] GO:0051716 cellular response to stimulus ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KLF5, MIF, MMP2, MMP9, NUAK1, PTPN1, RORC, SMAD3, SRC, TOP2A 5.90236
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.88588
[BP] GO:0050896 response to stimulus ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KLF5, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TYR 5.65451
[BP] GO:0008152 metabolic process ACHE, ADRB1, ADRB2, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA6, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH 5.54048
[BP] GO:0071310 cellular response to organic substance ADRB2, AKR1B1, APEX1, AXL, BCL2, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, KLF5, MMP2, RORC, SMAD3, SRC 5.42095
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 5.3977
[BP] GO:0042592 homeostatic process ADRB1, ADRB2, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3, SRC 5.38343
[BP] GO:0044237 cellular metabolic process ACHE, ADRB2, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA6, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MIF, MMP1, MMP2, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH 5.3321
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ADRB2, APEX1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK 5.33129
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 5.33129
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADRB2, BACE1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 5.32271
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADRB2, BACE1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 5.32271
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA6, CA7 5.29061
[BP] GO:0030334 regulation of cell migration ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 5.26751
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, ADRB2, AXL, BCL2, CSNK2A1, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 5.23848
[BP] GO:0048584 positive regulation of response to stimulus ADRB1, ADRB2, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.19273
[BP] GO:0032501 multicellular organismal process ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TOP1, TYR 5.13152
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.13035
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FDPS, HSD17B1, HSD17B2 5.13035
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.07118
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.01829
[BP] GO:2000145 regulation of cell motility ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 4.96646
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FDPS, FUT7, MET, MIF, PPARA, TBXAS1 4.83093
[BP] GO:1901652 response to peptide ADRB2, AKR1B1, APEX1, FABP3, GRM5, IGF1R, INSR, KLF5, PPARA, SRC, TEK 4.80198
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADRB1, ADRB2, BCL2, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.7866
[BP] GO:0045937 positive regulation of phosphate metabolic process ADRB1, ADRB2, BCL2, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.7866
[BP] GO:1901701 cellular response to oxygen-containing compound ADRB2, AKR1B1, APEX1, AXL, CYP1B1, EGFR, GRIK5, GRM5, IGF1R, INSR, KLF5, MMP2, MMP9, RORC, SRC 4.71088
[BP] GO:0010243 response to organonitrogen compound ADRB2, AKR1B1, APEX1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, KLF5, MMP2, PPARA, SRC, TEK, TYR 4.66455
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KLF5, MIF, MMP12, MMP2, MMP9, PIM1, TEK 4.62731
[BP] GO:0040012 regulation of locomotion ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 4.59845
[BP] GO:0051270 regulation of cellular component movement ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 4.58404
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FDPS 4.49823
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.48096
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.48096
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.409
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 4.40883
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.35347
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.35173
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA6, CA7 4.34503
[BP] GO:1901698 response to nitrogen compound ADRB2, AKR1B1, APEX1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, KLF5, MMP2, PPARA, SRC, TEK, TYR 4.32704
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FDPS, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TOP1, XDH 4.31825
[BP] GO:0050790 regulation of catalytic activity ADORA3, ADRB1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 4.31101
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.31024
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 4.30424
[BP] GO:0014070 response to organic cyclic compound APEX1, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, KLF5, RORC, SRC, TEK, TYR 4.20253
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FDPS 4.12294
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.12294
[BP] GO:0044238 primary metabolic process ACHE, ADRB2, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH 4.03007
[BP] GO:0009628 response to abiotic stimulus ADRB1, ADRB2, AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, GRM1, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TYR 4.02639
[BP] GO:0009987 cellular process ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA6, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH 4.02639
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FDPS, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TOP1, XDH 4.02581
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP1, TOP2A 4.02581
[BP] GO:0032502 developmental process ACHE, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, GLO1, HSD17B2, INSR, KDR, KLF5, MET, MIF, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TOP2A, TYR 4.00911
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.00338
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.99506
[BP] GO:0065009 regulation of molecular function ADORA3, ADRB1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.95532
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HSPA1A, IGF1R, KDR, KLF5, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.95051
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 3.94197
[BP] GO:0009725 response to hormone AKR1B1, APEX1, BCL2, CA2, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, SRC, TEK 3.93894
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.87714
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.8739
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.85127
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, PPARA, RORC, SRC, TOP1, TOP2A 3.83036
[BP] GO:1901653 cellular response to peptide ADRB2, AKR1B1, APEX1, GRM5, IGF1R, INSR, KLF5, SRC 3.83036
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK, XDH 3.78698
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.78625
[BP] GO:0042325 regulation of phosphorylation ADRB2, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MIF, MMP9, PPARA, PTPN1, SRC, TEK, XDH 3.73692
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3 3.7091
[BP] GO:0001934 positive regulation of protein phosphorylation ADRB2, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.70099
[BP] GO:0009056 catabolic process ACHE, AKR1B10, ALDH2, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.69689
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 3.69689
[BP] GO:0009966 regulation of signal transduction ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.69522
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 3.68258
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.66577
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 3.65646
[BP] GO:0001932 regulation of protein phosphorylation ADRB2, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.65217
[BP] GO:0071417 cellular response to organonitrogen compound ADRB2, AKR1B1, APEX1, EGFR, GRM5, IGF1R, INSR, KLF5, MMP2, SRC 3.62687
[BP] GO:0043408 regulation of MAPK cascade ADRB2, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 3.61273
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.61273
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADRB1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.6126
[BP] GO:0033993 response to lipid AXL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 3.60103
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.60103
[BP] GO:0043549 regulation of kinase activity ADRB2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, MIF, PTPN1, SRC, TEK 3.56907
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HSPA1A, IGF1R, KDR, KLF5, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.55023
[BP] GO:0042327 positive regulation of phosphorylation ADRB2, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.52109
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 3.52109
[BP] GO:0043410 positive regulation of MAPK cascade ADRB2, EGFR, FLT3, GRM1, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 3.52021
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, ADRB2, AKR1B1, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, F10, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH 3.50512
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FDPS, TYR 3.49214
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic EGFR, GRM1, GRM3, GRM5, GRM8 3.49214
[BP] GO:0044236 multicellular organism metabolic process ADRB1, ADRB2, MMP1, MMP12, MMP2, MMP9 3.49214
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.45313
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.43263
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.42454
[BP] GO:0051338 regulation of transferase activity ADRB2, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, MIF, PTPN1, SRC, TEK 3.4211
[BP] GO:0031399 regulation of protein modification process ADRB2, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.40829
[BP] GO:0071704 organic substance metabolic process ACHE, ADRB2, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH 3.39461
[BP] GO:1901699 cellular response to nitrogen compound ADRB2, AKR1B1, APEX1, EGFR, GRM5, IGF1R, INSR, KLF5, MMP2, SRC 3.39461
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRB2, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.37279
[BP] GO:0031325 positive regulation of cellular metabolic process ADRB1, ADRB2, AURKB, BCL2, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.36798
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, FLT3, MET, MIF, PIM1, SRC, TEK, TYR 3.3304
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, MIF, PTPN1, SRC 3.3304
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.32244
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.31102
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 3.31102
[BP] GO:0033674 positive regulation of kinase activity ADRB2, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, MIF, PTPN1, SRC, TEK 3.29731
[BP] GO:0045859 regulation of protein kinase activity ADRB2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, MIF, PTPN1, SRC 3.26011
[BP] GO:0048583 regulation of response to stimulus ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FABP4, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.25605
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.19446
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.19446
[BP] GO:0065007 biological regulation ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FDPS, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP1, TOP2A, XDH 3.17294
[BP] GO:0071495 cellular response to endogenous stimulus ADRB2, AKR1B1, APEX1, EGFR, FLT3, GRM5, IGF1R, INSR, KLF5, MMP2, SMAD3, SRC 3.17204
[BP] GO:0051347 positive regulation of transferase activity ADRB2, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, MIF, PTPN1, SRC, TEK 3.1615
[BP] GO:0051049 regulation of transport ACHE, ADRB2, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, GRIK5, GRM5, HSPA1A, INSR, MIF, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.14556
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, ADRB2, AXL, BCL2, CA2, CYP1B1, EGFR, HSPA1A, KDR, MET, MIF, MMP12, MMP9, PIM1, SLC1A1, SMAD3, SRC, TEK 3.13439
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, FDPS, HSD17B1, HSD17B2 3.13439
[BP] GO:0009893 positive regulation of metabolic process ADRB1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.12466
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, ADRB1, ADRB2, APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FDPS, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, XDH 3.0912
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, SRC 3.07175
[BP] GO:0043393 regulation of protein binding ADRB2, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.98055
[BP] GO:0043085 positive regulation of catalytic activity ADRB1, ADRB2, AURKB, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HSPA1A, INSR, MIF, PTPN1, SMAD3, SRC, TEK, XDH 2.97386
[BP] GO:0044093 positive regulation of molecular function ADRB1, ADRB2, AURKB, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.97364
[BP] GO:0010648 negative regulation of cell communication ACHE, ADRB2, BCL2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.91333
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, TBXAS1 2.90084
[BP] GO:0023057 negative regulation of signaling ACHE, ADRB2, BCL2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.90084
[BP] GO:0010638 positive regulation of organelle organization ADRB2, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.86831
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.86141
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADRB2, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, MIF, PTPN1, SRC 2.85954
[BP] GO:0051247 positive regulation of protein metabolic process ADRB2, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.84702
[BP] GO:0042391 None ADRB2, BCL2, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.84111
[BP] GO:0080134 regulation of response to stress CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.83814
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, SMAD3, SRC, TOP2A 2.79762
[BP] GO:0045860 positive regulation of protein kinase activity ADRB2, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, MIF, PTPN1, SRC 2.79527
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, HSPA1A, IGF1R, MET, MIF, MMP9, PTPN1, SRC, XDH 2.77556
[BP] GO:0080090 regulation of primary metabolic process ADORA3, ADRB1, ADRB2, APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FDPS, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.76688
[BP] GO:0048585 negative regulation of response to stimulus ADRB2, BCL2, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.75869
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.74842
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.74156
[BP] GO:0015711 organic anion transport CA12, CA14, CA2, CA4, CA6, CA7, FABP3, PPARA, SLC1A1 2.71434
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HSPA1A 2.71315
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 2.68639
[BP] GO:0007165 signal transduction ADORA3, ADRB1, ADRB2, AKR1B1, AXL, BCL2, CA2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK 2.68072
[BP] GO:0007188 None ADRB1, ADRB2, GRM1, GRM3, GRM5, GRM8 2.67452
[BP] GO:0031401 positive regulation of protein modification process ADRB2, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 2.64715
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 2.64715
[BP] GO:0035556 intracellular signal transduction ADRB1, ADRB2, AKR1B1, AXL, BCL2, CYP1B1, EGFR, GRM5, IGF1R, INSR, KDR, MET, MIF, NUAK1, PTPN1, SRC, TEK 2.63007
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADRB2, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.61742
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.58332
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, FDPS, HSD17B1, HSD17B2, MIF 2.56099
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ADRB2, AXL, BCL2, CDC25B, CYP1A1, EGFR, FABP4, FLT3, FUT7, GLO1, KDR, KLF5, MET, MIF, MMP2, MMP9, RORC, SMAD3, SRC, TEK, TOP2A 2.51852
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.51852
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.51852
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.51852
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.51852
[BP] GO:0051098 regulation of binding ADRB2, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC 2.51648
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 2.5089
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.50524
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.48666
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, INSR, SLC1A1, SMAD3 2.46879
[BP] GO:0099566 None GRM1, GRM5 2.46879
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.46879
[BP] GO:0002025 None ADRB1, ADRB2 2.46879
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADRB2, EGFR, FLT3, GRM1, INSR, MIF, PTPN1, SRC 2.46879
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, CYP1A1, CYP1B1, EGFR, FLT3, KLF5, RORC, SRC 2.46879
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.43815
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.43815
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.4306
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.4306
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.4306
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.42823
[BP] GO:0043406 positive regulation of MAP kinase activity EGFR, FLT3, GRM1, INSR, MIF, PTPN1, SRC 2.40185
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, FABP3, FDPS, FLT3, PPARA, RORC, SRC, TEK 2.38621
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.37415
[BP] GO:0007187 None ADRB1, ADRB2, GRM1, GRM3, GRM5, GRM8 2.35913
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.35094
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.34846
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MIF, PPARA, TBXAS1 2.33943
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.3279
[BP] GO:0001503 ossification BCL2, EGFR, MMP2, MMP9, TEK 2.32665
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.32665
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DUSP3, EGFR, KDR, MIF, PTPN1, SRC, TEK 2.31954
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.30634
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CYP1A1, CYP1B1, EGFR, FABP3, KDR, SRC, TOP1 2.29171
[BP] GO:0051130 positive regulation of cellular component organization ADRB2, AURKB, AXL, BCL2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.26485
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.25561
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, SRC 2.25049
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.23484
[BP] GO:0006950 response to stress ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MIF, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 2.23004
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.23004
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.23004
[BP] GO:0009968 negative regulation of signal transduction ADRB2, BCL2, DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.23004
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, FDPS, HSPA1A, INSR, KDR, MET, MMP1, SMAD3, SRC, TOP1 2.22411
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA3, ADRB1, ADRB2, APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.22286
[BP] GO:0050789 regulation of biological process ACHE, ADORA3, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BACE1, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FDPS, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP1, TOP2A, XDH 2.21854
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.2067
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.195
[BP] GO:0051894 None KDR, SMAD3, TEK 2.195
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.195
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, HSD17B1, HSD17B2 2.18818
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.18337
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.18337
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, ADRB1, ADRB2, APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.18056
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.1417
[BP] GO:0009894 regulation of catabolic process ADRB2, APEX1, BCL2, CSNK2A1, EGFR, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.13663
[BP] GO:0019538 protein metabolic process ACHE, ADRB2, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 2.11369
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.10424
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.10424
[BP] GO:1903393 None KDR, SMAD3, TEK 2.10424
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.09475
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 2.09061
[BP] GO:0044267 cellular protein metabolic process ADRB2, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 2.08647
[BP] GO:0031347 regulation of defense response CYP19A1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 2.08617
[BP] GO:1904646 cellular response to amyloid-beta ADRB2, GRM5, IGF1R 2.06532
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, ADRB1, ADRB2, AXL, BCL2, CA2, CYP1B1, EGFR, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIM1, SLC1A1, SMAD3, SRC, TEK, XDH 2.04686
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, KLF5, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 2.04635
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.04326
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.04326
[BP] GO:0050873 None ADRB1, ADRB2, FABP4 2.02938
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.02278
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, EGFR, FABP3, GPR35, GRM1, GRM5, SMAD3 2.02278
[BP] GO:0006820 anion transport CA12, CA14, CA2, CA4, CA6, CA7, FABP3, PPARA, SLC1A1 2.00538
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, ADRB1, ADRB2, AXL, BACE1, CA4, F10, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK 4.409
[CC] GO:0098590 plasma membrane region ADRB2, CA2, CA4, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK 4.13918
[CC] GO:0044459 plasma membrane part ADORA3, ADRB1, ADRB2, AXL, BACE1, CA2, CA4, DUSP3, EGFR, F10, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SRC, TEK 3.78625
[CC] GO:0005887 integral component of plasma membrane ADORA3, ADRB1, ADRB2, AXL, BACE1, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK 3.56366
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ADRB1, ADRB2, AXL, BACE1, CA12, CA14, CA2, CA4, CSNK2A1, EGFR, F10, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK 3.50021
[CC] GO:0043235 receptor complex ADRB2, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 3.48912
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.40793
[CC] GO:0009330 None TOP1, TOP2A 2.8574
[CC] GO:0043227 membrane-bounded organelle ACHE, ADRB1, ADRB2, AKR1B1, AKR1B10, ALDH2, APEX1, AURKB, AXL, BACE1, BCL2, CA2, CA4, CA6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GRIA4, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KLF5, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TOP1, TOP2A, TYR, XDH 2.5089
[CC] GO:0044444 cytoplasmic part ACHE, ADRB1, ADRB2, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, AURKB, BACE1, BCL2, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KLF5, MIF, MMP2, MMP9, PIM1, PTPN1, SMAD3, SRC, TBXAS1, TOP1, TOP2A, TYR, XDH 2.3279
[CC] GO:0016020 membrane ACHE, ADORA3, ADRB1, ADRB2, ALOX5, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, F10, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TYR 2.26485
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.22194
[CC] GO:0044425 membrane part ACHE, ADORA3, ADRB1, ADRB2, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, IGF1R, INSR, KDR, MET, PTPN1, SLC1A1, SRC, TBXAS1, TEK, TYR 2.0683
[MF] GO:0046914 transition metal ion binding ALOX5, CA12, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 8.49154
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, AURKB, AXL, BACE1, CA12, CA14, CA2, CA4, CA6, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH 8.49154
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.64733
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA6, CA7 7.61702
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.99593
[MF] GO:0043167 ion binding ACHE, ALOX5, APEX1, AURKB, AXL, CA12, CA14, CA2, CA4, CA6, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, F10, FABP3, FABP4, FDPS, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KLF5, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH 6.99593
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.40169
[MF] GO:0038023 signaling receptor activity ADORA3, ADRB1, ADRB2, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 5.33152
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA12, CA14, CA2, CA4, CA6, CA7 5.33129
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.14858
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.13543
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP1, TOP2A 5.13035
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.92923
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.84451
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA6, CA7 4.81341
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 4.78657
[MF] GO:0099600 transmembrane receptor activity ADORA3, ADRB1, ADRB2, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, TEK 4.71088
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, ADRB1, ADRB2, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, TEK 4.71088
[MF] GO:0004872 receptor activity ADORA3, ADRB1, ADRB2, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 4.65683
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.65683
[MF] GO:0004871 signal transducer activity ADORA3, ADRB1, ADRB2, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, RORC, SMAD3, TEK 4.62566
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, XDH 4.50994
[MF] GO:0060089 molecular transducer activity ADORA3, ADRB1, ADRB2, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 4.47211
[MF] GO:0016829 lyase activity APEX1, CA12, CA14, CA2, CA4, CA6, CA7, GLO1 4.13212
[MF] GO:0044877 macromolecular complex binding ACHE, ADRB2, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 4.10348
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 4.0651
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.94418
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 3.89935
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, AURKB, CA12, CA14, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, FDPS, GLO1, KLF5, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TOP2A, TYR, XDH 3.88487
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.88487
[MF] GO:0032403 protein complex binding ACHE, ADRB2, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.84044
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA6, CA7, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 3.74583
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 3.63838
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.53027
[MF] GO:0046872 metal ion binding ALOX5, APEX1, AURKB, CA12, CA14, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, FDPS, GLO1, KLF5, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TOP2A, TYR, XDH 3.49214
[MF] GO:0001540 amyloid-beta binding ACHE, ADRB2, BACE1, GRIA2, INSR 3.46316
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.32633
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.32633
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TOP1 3.20249
[MF] GO:0048037 cofactor binding ALDH2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, SRC, TBXAS1, XDH 2.99277
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.84151
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.82894
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, XDH 2.71434
[MF] GO:0019899 enzyme binding ADRB1, ADRB2, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, GRM5, HSPA1A, MET, MIF, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 2.71434
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.56356
[MF] GO:0036094 small molecule binding ALDH2, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SLC1A1, SRC, TEK, TOP1, TOP2A, XDH 2.54945
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.46879
[MF] GO:0004939 None ADRB1, ADRB2 2.46879
[MF] GO:0099583 None GRM1, GRM5 2.46879
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.43815
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.43815
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, CYP19A1, CYP1A2, XDH 2.4192
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.40185
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A 2.31954
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.23004
[MF] GO:0004971 None GRIA2, GRIA4 2.23004
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.23004
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A 2.22411
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.22194
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, INSR, KDR, SMAD3 2.22055
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A 2.20062
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.11044
[MF] GO:0000166 nucleotide binding ALDH2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, XDH 2.0683
[MF] GO:1901265 nucleoside phosphate binding ALDH2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, XDH 2.06818
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.05812
[MF] GO:0043559 insulin binding IGF1R, INSR 2.05812
[MF] GO:0051380 None ADRB1, ADRB2 2.05812
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.04326


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.9355
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.9931
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, GPR35, ADORA3, GRIK5, GRM8, ADRB1, ADRB2, GRM1, GRIA4 6.9957
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA6, CA14 8.8401
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.2985
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.7796
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, ADRB1, ADRB2, MET, EGFR, IGF1R, HSPA1A 5.2014
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.2014
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1, EGFR, HSPA1A 4.6343
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 3.9439
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, BCL2, MMP9, MET, EGFR, IGF1R 3.8778
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 3.8778
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, GRM1, EGFR 3.8758
Metabolic pathways_Homo sapiens_hsa01100 FDPS, AKR1B1, TYR, CYP3A4, CYP19A1, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, XDH 3.6914
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, ADRB1, GRM1, EGFR 3.8114
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.5342
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, CYP1B1 3.8758
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.1887
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.1862
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADRB1, ADRB2 3.3991
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.0299
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 2.9289
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 3.1165
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, ADRB1, ADRB2, GRM1, EGFR 2.6407
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1165
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1 2.6407
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.0717
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, ADRB1, ADRB2, PPARA, GRIA4 2.4704
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.6407
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP3A4 2.927
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2, MMP9 2.1472
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADRB1, ADRB2 1.9638
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.1651
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.2337
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.2418
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8671
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.1506
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.1472
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1041
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.1579
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.8658
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8483
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1472
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.6714
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.4472
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.5887
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.414
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, ADRB2 1.3856
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.8038
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.1208
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.9389
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8837
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0255
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.085
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2 0.8911
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0471
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8814
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8986
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0443
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8365
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8438
Salivary secretion_Homo sapiens_hsa04970 ADRB1, ADRB2 1.0729
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8814
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.8617
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0699
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8318
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0498
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8318
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2941
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8318
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8318
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2887
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8002
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3042
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3118
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1599
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3246
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2756
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.7883
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3111
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7523
Alzheimer's disease_Homo sapiens_hsa05010 BACE1 0.3367
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7883
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3421
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2695
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3642
Influenza A_Homo sapiens_hsa05164 FDPS, HSPA1A 0.7314
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6306
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7272
HTLV-I infection_Homo sapiens_hsa05166 FDPS, SMAD3 0.5421
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.2941
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.2637
Renin secretion_Homo sapiens_hsa04924 ADRB1, ADRB2 1.2756
Apoptosis_Homo sapiens_hsa04210 BCL2 0.391
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4031
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.2293
Axon guidance_Homo sapiens_hsa04360 MET 0.4187
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.427
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.2462
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4327
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2756
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4358
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4548
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.2941
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.4514
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4721
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4796
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4796
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4796
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4817
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.487
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4862
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5039
Taste transduction_Homo sapiens_hsa04742 GRM1 0.5119
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.414
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5039
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5106
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1 0.5039
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.4375
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.505
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5039
Peroxisome_Homo sapiens_hsa04146 XDH 0.5119
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5039
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5421
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5424
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5239
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5303
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5421
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5498
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.4744
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5656
Shigellosis_Homo sapiens_hsa05131 SRC 0.5678
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.5632
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5835
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6225
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6409
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.626
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.6409
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2, GLO1 1.5835
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7762
Malaria_Homo sapiens_hsa05144 MET 0.6535
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.6492
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.6714
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.658
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2 0.658
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.7959
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.73
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7272
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.6853
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7585
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.957
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8318
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7918
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7783
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.7918
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8318
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7967
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8318
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.8318
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.8398
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.8617
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9389
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0717


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)