TCM Prescription: SQSJ Blood Tonification Decoction



Prescription Description
Prescription IDTCMF2458
Pinyin NameShen Qi Shan Jia Tang
Chinese Name
English NameSQSJ Blood Tonification Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH877 Radix ginseng rubra 红参 TCMH877 GBVE1679-11
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH1036 Spatholobus suberectus 鸡血藤 TCMH1036 ITSAK2607-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH541 Colla corii asini 阿胶 TCMH541
TCMH744 Colla carapacis et plastri testudinis 龟板胶 TCMH744
TCMH1862 Cornus officinalis 山茱萸 TCMH1862 ITSAO2979-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH2491 Alpinia oxyphylla 益智仁 TCMH2491 ITSAJ4276-14
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH1822 Manidae 山甲珠 TCMH1822
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, FABP3, FABP4, FDPS, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, PPARG, TRPV1 12.9985
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, F10, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, KCNH2, KDR, MET, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 10.4728
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, ESR1, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2 10.3847
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, FABP3, FDPS, FUT7, HMGCR, PIM1, PPARA, PPARG, TYR, XDH 9.98323
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 9.12714
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 8.86604
[BP] GO:0007193 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 8.80733
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PPARA, PPARG, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 8.78337
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, FABP3, FABP4, FDPS, FUT7, HMGCR, MET, PPARA, PPARG 8.76555
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 8.75501
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA, PPARG 8.65733
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, PPARG, TYR, XDH 8.64594
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, HSP90AB1, IGF1R, MMP2, MMP9, NR3C1, PPARA, PPARG, RORC, SLC6A4, SRC, TRPV1, TYR 7.97475
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP2, NR3C1, PPARA, PPARG, RORC, SLC6A4, SRC, TRPV1, TYR 7.97475
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 7.43924
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP3A4, HSP90AB1, RORC 7.34436
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 7.33893
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 6.92216
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, SLC6A4, SRC, TERT, TRPV1, XDH 6.78689
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.77488
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.58351
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.41637
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.41637
[BP] GO:0007188 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 6.20266
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.15376
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PPARG, RORC, SLC6A4, SRC, TERT, TRPV1 6.13757
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA, PPARG 6.13413
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2 5.84942
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 5.84384
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, PPARG, RORC, SRC 5.82053
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SRC, TRPV1, TYR 5.78348
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG, RORC, SRC 5.77722
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.77722
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CHRM5, CYP1A1, FABP3, FDPS, FLT3, HCAR2, HMGCR, PPARA, PPARG, RORC, SRC 5.77722
[BP] GO:0007187 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 5.67681
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 5.64498
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, ALOX12, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, KCNH2, MET, PPARG, SRC, TERT, TRPV1 5.57947
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, NR3C1, PPARG, RORC, SLC6A4, SRC, TYR 5.54933
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.54933
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSP90AB1, NR3C1, PPARG, RORC, SLC6A4, SRC, TRPV1, TYR 5.52666
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, CDC25B, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARG, SLC6A4, SRC, TERT, XDH 5.47123
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC, TERT, TRPV1, XDH 5.45041
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PPARG, PTPN1, SRC, TERT, TRPV1, XDH 5.41235
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, F10, GRIK5, GRM5, HCAR2, HMGCR, HSP90AB1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PPARA, PPARG, PTPN1, SLC6A4, SRC, TERT, TRPV1 5.41003
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, NR3C1, PPARA, PPARG, SLC6A4, SRC, TRPV1 5.31667
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.26473
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FDPS, HMGCR, TYR 5.23068
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GRM5, IGF1R, MMP2, NR3C1, PPARA, PPARG, SLC6A4, SRC, TRPV1 5.1615
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, KDR, MMP2, NR3C1, PPARG, RORC, SLC6A4, SRC, TRPV1 5.11435
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CES1, CYP19A1, CYP3A4, FDPS, HMGCR, TYR 5.10459
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2 5.10068
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.03634
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG, RORC, SRC 5.02354
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.96756
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.96756
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A4, SRC, TERT, TYR, XDH 4.96701
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, MMP9, PIM1, PPARG, PTPN1, SRC, TERT, TRPV1, XDH 4.91948
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.88045
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.88045
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, GRM1, HCAR2, HMGCR, HSP90AB1, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 4.87311
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FDPS, HMGCR 4.86539
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.86446
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, GRM1, HCAR2, HMGCR, HSP90AB1, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 4.85089
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, HMGCR, HSP90AB1, KCNH2, KDR, NR3C1, PPARG, SLC6A2, SLC6A4, SRC, TRPV1 4.7759
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.73292
[BP] GO:0007200 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 4.72889
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CES1, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MMP12, MMP2, MMP9, NR3C1, PPARA, PPARG, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 4.67577
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, FABP3, FABP4, FUT7, HSP90AA1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.6547
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, PPARG, TYR 4.63484
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, MET, MMP12, MMP9, PPARG, PTPN1, SLC6A4, SRC, TERT, XDH 4.61231
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19, CYP3A4 4.53097
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AB1, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PPARG, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1 4.40229
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARG, SLC1A1, TRPV1 4.38788
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.34843
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 4.34161
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, MET, MMP12, MMP9, PPARG, PTPN1, SLC6A4, SRC, TERT, XDH 4.32245
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, RORC, SLC6A4, SRC, TRPV1 4.26126
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.26126
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, TERT, TRPV1, TYR, XDH 4.17273
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FDPS 4.17273
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG, RORC 4.12576
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, PPARG, TYR 4.08347
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, HMGCR, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 4.06779
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSP90AB1, KDR, PPARA, PPARG, SRC, TYR 4.06472
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.03205
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, AXL, CA2, CA7, CHRM1, CYP19A1, GRIK5, GRM5, HCAR2, HMGCR, HSP90AB1, KCNH2, MMP12, MMP9, PPARA, PPARG, PTPN1, SLC6A4, SRC, TERT, TRPV1 4.01056
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MET, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, TRPV1 3.9998
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, PPARG, TYR 3.99634
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC, TERT 3.98885
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4 3.9871
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4 3.9871
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, PPARG, RORC, SLC6A4, SRC, TRPV1 3.97166
[BP] GO:0007154 None ADORA1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PPARG, SLC1A1, SLC6A2, TRPV1 3.92079
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, HMGCR, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT 3.92079
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 3.83494
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, ALOX12, CDC25B, CHRM1, CSNK2A1, ESR1, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, TERT 3.83489
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, GRM1, HMGCR, HSP90AA1, HSP90AB1, MMP2, PPARA, PPARG, SLC6A4, SRC, TERT, TRPV1, TYR 3.80855
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ALOX12, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, ESR1, ESRRA, ESRRB, GRM1, HCAR2, HMGCR, HSP90AB1, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARG, SLC1A1, SLC6A4, SRC, TERT, TRPV1, XDH 3.72745
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CES1, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B2, HSP90AB1, KDR, MET, MMP2, MMP9, PIM1, PPARA, PPARG, RORC, SLC6A4, SRC, TERT, TYR 3.72363
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, GRIK5, HSP90AA1, HSP90AB1, SLC1A1, SLC6A2, SLC6A4, TRPV1 3.67232
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.67022
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP3A4 3.67022
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, KCNH2, SLC1A1, SLC6A2 3.67022
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, KCNH2, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A4, TRPV1 3.54114
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 3.52924
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, ALOX12, CA12, CA2, CA7, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, KCNH2, MET, PPARG, TRPV1 3.49865
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4 3.45979
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.45979
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, TERT, TRPV1, TYR, XDH 3.45979
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.45979
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.45979
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.45979
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.45979
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PPARG, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 3.45647
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, CHRM5, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AB1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.44264
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG, RORC 3.44264
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CHRM1, CYP19A1, HCAR2, HSP90AB1, KCNH2, MMP12, PPARG, SLC6A4, SRC, TERT, TRPV1 3.41923
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.39618
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, CHRM5, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AB1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.39399
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PPARG, PTPN1, RORC, SRC, TERT, TRPV1, XDH 3.39004
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, HMGCR, HSP90AB1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 3.39004
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, HSP90AB1, KCNH2, KDR, NR3C1, SRC, TRPV1 3.37475
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARG, SLC1A1, TRPV1 3.35985
[BP] GO:0003018 None ADORA1, ADRA2A, CHRM1, CHRM3, HMGCR, SLC6A4, SRC 3.24409
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, F10, FLT3, GRM1, HMGCR, HSP90AB1, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 3.23607
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, ALOX12, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PPARG, SRC, TERT 3.22124
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.20722
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PPARG, PTPN1, RORC, SRC, TERT, TRPV1, XDH 3.19667
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, ALOX12, CHRM1, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PPARG, SRC, TERT 3.19493
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8 3.19356
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PPARG, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 3.16564
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC 3.04098
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CES1, CYP1A1, CYP1B1, HMGCR, HSP90AA1, KDR, SLC6A4, SRC 3.01457
[BP] GO:0006940 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3 3.01009
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.00088
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, ESRRA, F10, FABP4, FLT3, GRM1, HMGCR, HSP90AA1, HSP90AB1, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, XDH 2.97835
[BP] GO:0042737 drug catabolic process ACHE, ALDH2, CYP1A2, CYP2A6, CYP2C19, CYP3A4 2.97402
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, ALOX12, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PPARG, SRC, TERT 2.94947
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, ALOX12, CYP19A1, ESR1, FABP4, HMGCR, HSP90AA1, HSP90AB1, IGF1R, MET, MMP12, MMP2, PPARA, PPARG, PTPN1, SRC, TERT, XDH 2.92074
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HMGCR, HSP90AB1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 2.89751
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 2.89751
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, CHRM1, CHRM2, CHRM3, GRM1, HCAR2, KCNH2, SLC1A1, TRPV1 2.84673
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSP90AB1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 2.79375
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 2.79375
[BP] GO:0097746 None ADORA1, ADRA2A, CHRM1, CHRM3, HMGCR, SLC6A4 2.79053
[BP] GO:0035296 None ADORA1, ADRA2A, CHRM1, CHRM3, HMGCR, SLC6A4 2.79053
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CYP1B1, F10, FLT3, GRM1, HMGCR, KDR, MET, PTPN1, SRC, XDH 2.78091
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 2.78091
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 2.78091
[BP] GO:0015872 None CHRM5, SLC6A2, SLC6A4 2.77849
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 2.76317
[BP] GO:0009115 None AOX1, XDH 2.74731
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.74731
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.74731
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.74731
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR 2.74644
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PPARG, TERT 2.74127
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 2.74127
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, TERT 2.7406
[BP] GO:0010243 response to organonitrogen compound AKR1B1, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, SLC6A4, SRC, TRPV1, TYR 2.70075
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.70075
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.69721
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.69248
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ALOX12, AXL, CA2, CHRM3, CYP1B1, ESRRB, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PIM1, PPARG, SLC1A1, SRC, TERT, TRPV1 2.69184
[BP] GO:0050880 None ADORA1, ADRA2A, CHRM1, CHRM3, HMGCR, SLC6A4 2.68133
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 2.68127
[BP] GO:0035150 None ADORA1, ADRA2A, CHRM1, CHRM3, HMGCR, SLC6A4 2.67199
[BP] GO:0006066 None AKR1B1, AKR1B10, ALDH2, CES1, CYP1B1, CYP3A4, FDPS, HMGCR 2.65096
[BP] GO:0051234 None ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, F10, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, KCNH2, MMP12, MMP9, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 2.64081
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, PPARG, PTPN1, SRC 2.63997
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, ALOX12, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PPARG, SRC, TERT 2.63437
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.61771
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC, TRPV1 2.60157
[BP] GO:0003013 None ADORA1, ADRA2A, CHRM1, CHRM3, HMGCR, SLC6A4, SRC 2.59468
[BP] GO:0043393 regulation of protein binding AURKB, HSP90AB1, MET, MMP9, PPARA, SRC, TERT 2.59468
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, PPARA, PPARG, RORC, SLC6A4, SRC 2.57849
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, CHRM1, CHRM2, CHRM3, KCNH2, SLC1A1 2.56937
[BP] GO:0051937 None CHRM5, SLC6A2, SLC6A4 2.53794
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, ESR1, FLT3, GRM5, IGF1R, MMP2, NR3C1, PPARG, SLC6A4, SRC, TRPV1 2.53103
[BP] GO:0061098 None ADORA1, ADRA2A, GRM5, PTPN1 2.53001
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PPARG, SLC6A4, SRC, TERT 2.51544
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, HCAR2, HMGCR, KDR, SRC, TRPV1 2.51484
[BP] GO:0006810 None ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, F10, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, KCNH2, MMP12, MMP9, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A4, SRC, TRPV1, XDH 2.49106
[BP] GO:0046165 None AKR1B1, CES1, CYP3A4, FDPS, HMGCR 2.46888
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.46601
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.46601
[BP] GO:0051179 None ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, ESR1, F10, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, KCNH2, MMP12, MMP9, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 2.42456
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSP90AB1, KDR, MMP9, PIM1, PPARA, PPARG, RORC, SRC, TYR 2.42296
[BP] GO:1901698 response to nitrogen compound AKR1B1, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, SLC6A4, SRC, TRPV1, TYR 2.41858
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 2.40259
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A4 2.39449
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX12, ALOX15, CYP19A1, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PPARG, PTPN1, SRC, TERT, XDH 2.39336
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.3765
[BP] GO:0042391 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC, TRPV1 2.3765
[BP] GO:0099566 None GRM1, GRM5 2.3765
[BP] GO:0046110 None AOX1, XDH 2.3765
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.3765
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 2.3765
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.34886
[BP] GO:0007004 None HSP90AA1, HSP90AB1, TERT 2.34327
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, FLT3, GRM1, HMGCR, KDR, PTPN1, SRC, XDH 2.29848
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F10, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 2.28781
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 2.27751
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PPARG, SLC6A4, SRC 2.26503
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.26363
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PPARG, PTPN1, RORC, SRC, TERT, TRPV1, XDH 2.25128
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 2.18766
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.17102
[BP] GO:0015844 None CHRM5, SLC6A2, SLC6A4 2.16023
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, GRM5, PTPN1, SRC 2.14072
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARG, PTPN1, SLC6A4, SRC, TERT, XDH 2.14008
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.13827
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARG, PTPN1, SLC6A4, SRC, TERT, XDH 2.12903
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA2A, CA2, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG, SRC 2.12903
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, GRM1, HMGCR, IGF1R, PTPN1, SRC 2.12903
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.12903
[BP] GO:0006145 None AOX1, XDH 2.12903
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.12903
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.12903
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.12432
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.12432
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.12432
[BP] GO:0051098 regulation of binding AURKB, HSP90AB1, MET, MMP9, PPARA, PPARG, SRC, TERT 2.11852
[BP] GO:0030335 positive regulation of cell migration ADRA2A, ALOX12, F10, IGF1R, KDR, MET, MMP9, SRC, TERT 2.10604
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, NR3C1, PPARG, SRC 2.1018
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.07735
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GRM5, IGF1R, PPARA, PPARG, SRC, TRPV1 2.07299
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.07299
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, PTPN1, SRC 2.04266
[BP] GO:0008299 None CYP1A1, FDPS, HMGCR 2.02291
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.02291
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.02291
[BP] GO:0071396 cellular response to lipid AXL, ESR1, FLT3, NR3C1, PPARG, RORC, SLC6A4, SRC 2.02202
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.00756
[BP] GO:2000147 positive regulation of cell motility ADRA2A, ALOX12, F10, IGF1R, KDR, MET, MMP9, SRC, TERT 2.00568
[CC] GO:0098590 plasma membrane region ADORA1, ADRA2A, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, MET, SLC1A1, SRC, TRPV1 7.15895
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 5.84942
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA2A, ALOX15, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, F10, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MET, SLC1A1, SLC6A2, SLC6A4, SRC, TRPV1 5.28273
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, F10, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A4, TRPV1 5.08697
[CC] GO:0044456 None ACHE, ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4, SRC, TRPV1 5.05658
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, ESR1, F10, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1 5.03541
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, F10, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 4.38824
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 4.26126
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A4, TRPV1 4.20747
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, F10, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MET, PTPN1, SLC1A1, SLC6A2, SLC6A4, SRC, TRPV1, TYR 3.98885
[CC] GO:0043005 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A4, SRC 3.10488
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.09814
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, CHRM3, HSP90AB1 2.79375
[CC] GO:0014069 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 2.67526
[CC] GO:0099572 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 2.67526
[CC] GO:0044432 endoplasmic reticulum part CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, F10, FLT3, GRIA2, HMGCR, HSD11B1, HSD17B2, PTPN1 2.58393
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, SRC, TRPV1 2.47318
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, SRC, TRPV1 2.47318
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, KCNH2, KDR, MMP2, MMP9, NR3C1, PIM1, PPARG, PTPN1, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 2.35638
[CC] GO:0098793 None ADORA1, CHRM1, CHRM2, CHRM3, GRIK5, SLC6A4 2.22656
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MET, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 2.17577
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, TYR, XDH 16.3878
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PPARG, RORC, TRPV1 9.98323
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.39085
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, XDH 9.3366
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 9.15302
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PPARG, RORC, TRPV1 8.93019
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, F10, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TYR, XDH 8.7688
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PPARG, RORC, TRPV1 8.76543
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 8.7026
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PPARG, RORC, TRPV1 8.14381
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 7.95062
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.83882
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, TERT, TRPV1, TYR, XDH 7.1052
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG, RORC 6.98316
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, TYR 6.77332
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.54398
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP3A4 6.35516
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, TERT, TRPV1, TYR, XDH 6.32135
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM5 6.3118
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PPARA, PPARG, PTPN1, RORC 6.23291
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC 6.15376
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC 6.15376
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.15376
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, RORC 5.85567
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.84723
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, SRC 5.81988
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP3A4 5.66213
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2, XDH 5.64355
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP3A4, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PPARA, PPARG, SLC6A4, SRC, TRPV1 5.62456
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, SRC 5.60072
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARG, TRPV1 5.5472
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARG, TRPV1 5.5472
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, HMGCR, HSD17B1, SRC, XDH 5.33135
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, TYR 5.24583
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, HSD17B1, NR3C1, PPARA, PPARG, RORC, TRPV1 5.189
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.10068
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 3.91092
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 3.88953
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.85064
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, CSNK2A1, ESR1, ESR2, FLT3, GRIK5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MET, MMP9, PPARG, SLC6A4, TERT, TRPV1, TYR, XDH 3.85044
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 3.74079
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 3.72745
[MF] GO:0030235 nitric-oxide synthase regulator activity ESR1, HSP90AA1, HSP90AB1 3.45979
[MF] GO:0008227 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5 3.25141
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.13169
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.09814
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 3.09138
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.04128
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, KCNH2, TRPV1 3.01009
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 2.85994
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 2.81786
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.74731
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.74731
[MF] GO:0008389 None CYP2A13, CYP2A6 2.74731
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.70075
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.67561
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R, NR3C1 2.54825
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRB, GRM5, HMGCR, HSP90AA1, HSP90AB1, KCNH2, MET, NR3C1, PPARA, PPARG, PTPN1, SLC6A4, SRC 2.54692
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.39449
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.39449
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.3765
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.3765
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.3765
[MF] GO:0005330 None SLC6A2, SLC6A4 2.3765
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.3765
[MF] GO:0099583 None GRM1, GRM5 2.3765
[MF] GO:0047374 None CES1, CES2 2.3765
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.27751
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.27751
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.21568
[MF] GO:0004930 None ADORA1, ADORA3, ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG 2.20763
[MF] GO:0001047 None ESR1, ESR2, ESRRB, MMP12, NR3C1, PPARG 2.20223
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSP90AB1, KDR, NR3C1 2.18766
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KCNH2, KDR, MET, PIM1, SRC 2.12903
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.12903
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.12903
[MF] GO:0004971 None GRIA2, GRIA4 2.12903
[MF] GO:0032795 None ADORA1, ADRA2A 2.12903
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.12903
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, FLT3, HMGCR, HSP90AA1, HSP90AB1, KCNH2, SLC6A4, TERT, TYR, XDH 2.02352


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, TRPV1, NR3C1, GRM1, ADRA2A, GRM3, GRM5, ADORA3, GRM8, ADORA1, GRIA4 11.4021
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.6424
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, ALOX15, AKR1B1, ALOX12, HMGCR, TYR, CYP3A4, CYP2C19, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, CES1 7.7739
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19 8.5777
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.4279
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.7739
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.5236
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, MMP2, MMP9, ESR1, GRM1, ESR2 6.8374
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.4033
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, AOX1, CYP1B1 5.0354
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12, CYP2C19 4.194
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH, CES2, CES1 4.7926
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.7956
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, ADORA1, PPARA, GRIA4 3.8289
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.1364
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, HSP90AB1, FLT3, MMP1, MMP2, PPARG, MMP9, MET, IGF1R 3.5777
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4, CYP2C19 4.0627
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.9382
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 4.0627
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.2108
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, GRM1 3.2108
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, ALOX12, CYP2C19, SLC6A4 3.2108
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4, CYP2C19 4.194
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, HSP90AA1, HSP90AB1, CHRM1, KDR, MET, IGF1R 2.5294
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.7567
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, CDC25B, IGF1R 2.4073
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.3735
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MMP9, MET, IGF1R 2.3431
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.0497
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 1.8894
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.0497
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.0497
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.8735
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.9442
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 1.5854
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, IGF1R 1.6603
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.5854
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.5027
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.4477
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 1.8788
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 1.6633
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2081
AMPK signaling pathway_Homo sapiens_hsa04152 PPARG, HMGCR, IGF1R 1.3552
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.5957
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA2A 1.1105
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.8573
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 0.8674
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7364
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9223
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PPARG, IGF1R 0.9038
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8219
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9017
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 0.9872
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2081
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7744
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7744
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.7678
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.1105
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.0571
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.7314
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1105
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.0831
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.7277
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.9
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1685
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7135
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2081
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1831
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0291
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7086
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1 0.6155
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.7033
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.6527
Huntington's disease_Homo sapiens_hsa05016 GRM5, PPARG 0.5522
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2381
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.237
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1 1.0326
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.257
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2655
HTLV-I infection_Homo sapiens_hsa05166 FDPS, TERT 0.4173
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1105
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2653
Influenza A_Homo sapiens_hsa05164 FDPS 0.2655
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.257
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.2919
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3029
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3192
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3228
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3267
Osteoclast differentiation_Homo sapiens_hsa04380 PPARG 0.3308
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3308
Platelet activation_Homo sapiens_hsa04611 SRC 0.3441
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.2081
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3441
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.3441
Axon guidance_Homo sapiens_hsa04360 MET 0.3394
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3712
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.3508
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.3905
Melanogenesis_Homo sapiens_hsa04916 TYR 0.394
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3939
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4173
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4086
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4173
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4169
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.3078
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4173
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.2993
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4126
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4173
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.4173
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4173
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4173
Peroxisome_Homo sapiens_hsa04146 XDH 0.4173
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4173
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.4271
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4681
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.484
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4823
Glioma_Homo sapiens_hsa05214 IGF1R 0.484
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.484
Shigellosis_Homo sapiens_hsa05131 SRC 0.484
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.484
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.4806
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4414
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6164
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.549
Malaria_Homo sapiens_hsa05144 MET 0.5549
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5522
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.5522
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.5256
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5667
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5854
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.5884
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.6171
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8114
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.7135
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7058
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7135
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.7058
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7277
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7086
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7277
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 1.8383
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.7277
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.744
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0354
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1939


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)