TCM Prescription: Xiao Er Kang Xian Capsule



Prescription Description
Prescription IDTCMF241
Pinyin NameXiao Er Kang Xian Jiao Nang 
Chinese Name小儿抗痫胶囊
English NameXiao Er Kang Xian Capsule
Function Description原发性全身性强直, 癫痫
IndicationsEpilepsy
Disease ICD-11 Category 8A6Z [Epilepsy or seizures, unspecified, 癫痫或癫痫发作，未特指的 ];
Human Tissues Associated with IndicationBrain, Heart
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH404 Rhizoma arisaema cum bile 胆南星 TCMH404
TCMH2090 Gastrodia elata 天麻 TCMH2090
TCMH2059 Radix pseudostellariae 太子参 TCMH2059
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1984 Typhonium flagelliforme 水半夏 TCMH1984 GBVT1159-13, GBVT1242-13
TCMH1179 Citri exocarpium rubrum 橘红 TCMH1179
TCMH1163 Rhizoma anemones altaicae 九节菖蒲 TCMH1163
TCMH1683 Canarium album 青果 TCMH1683 ITSAM870-14
TCMH916 Succinus 琥珀 TCMH916
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT242 HRH3 Histamine H3 receptor GPCR Q9Y5N1
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1310 Enterococcus hirae
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APEX1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FLT3, GPR35, HRH3, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, POLA1, POLB, PPARA, SMAD3, SRC, TEK, XDH 8.99556
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, POLB, PPARA, SMAD3, SRC, TEK, TYR 7.9307
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.05903
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, POLB, PPARA, SMAD3, SRC, TEK, TYR 6.85335
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, POLB, PPARA, SRC, TEK, TYR 6.68945
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.5954
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, XDH 6.57862
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRA2C, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, XDH 6.56794
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRA2C, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, XDH 6.5561
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, TOP2A, XDH 6.39624
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 6.39624
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GLO1, HSPA1A, PIM1, PPARA, TBXAS1, TYR, XDH 6.31433
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK 6.23021
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.17667
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK 6.04776
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 5.93937
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK 5.93937
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SRC, TEK, XDH 5.93937
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIM1, SMAD3, SRC, TEK, TOP2A, XDH 5.78834
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.78399
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.77071
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.77071
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APEX1, AXL, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, POLA1, POLB, SMAD3, SRC 5.73922
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.73922
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, SRC, TEK 5.73087
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 5.52148
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.46835
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, GLO1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, POLB, PPARA, SMAD3, SRC, TEK, TOP2A, TYR 5.44848
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, AXL, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, SRC, TEK, XDH 5.38689
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIM1, SMAD3, SRC, TEK 5.30678
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, POLA1, POLB, SMAD3, SRC, TOP2A 5.30678
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, APEX1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HRH3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, SMAD3, SRC, TEK 5.30678
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 5.2313
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 5.18826
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, HSD17B1, HSD17B2 5.16388
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, XDH 5.15001
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.13251
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.12139
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, XDH 5.08693
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 5.05163
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 5.05163
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, SMAD3, SRC, TEK, TOP2A, TYR 4.76691
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.73016
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.58496
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, SMAD3, SRC 4.57956
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 4.57956
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 4.48731
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, XDH 4.41271
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 4.3951
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, DUSP3, EGFR, FABP3, FABP4, FLT3, HRH3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 4.34729
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, DUSP3, EGFR, FABP3, FABP4, FLT3, HRH3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 4.29852
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HRH3, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, XDH 4.25701
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, AXL, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK, XDH 4.21627
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.21086
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 4.08031
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, TYR 4.06431
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 4.06431
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, MET, PPARA, TBXAS1 4.03538
[BP] GO:0030335 positive regulation of cell migration ADRA2A, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.97937
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2 3.93627
[BP] GO:0051953 None ADORA1, ADRA2A, ADRA2C, HRH3 3.90728
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, HRH3, HSD17B2, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TYR 3.8672
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AXL, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, POLB, PPARA, SMAD3, SRC, TEK, TYR 3.86284
[BP] GO:2000147 positive regulation of cell motility ADRA2A, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.86284
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, EGFR, HSPA1A, MMP2, POLB, PPARA, SMAD3, SRC, TEK, TYR 3.86266
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, HRH3, IGF1R, MET, MMP9, PIM1, PPARA, SRC 3.86067
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.86067
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.86067
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, SRC, TEK, XDH 3.83534
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, SRC, TYR 3.82068
[BP] GO:0014070 response to organic cyclic compound APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, SRC, TEK, TYR 3.79343
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.79318
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.75317
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, AURKB, AXL, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, SRC, TEK, XDH 3.6985
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, SMAD3, SRC 3.6845
[BP] GO:0040017 positive regulation of locomotion ADRA2A, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.6845
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 3.6845
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 3.62043
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, ADRA2C, AURKB, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HRH3, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, XDH 3.58839
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, EGFR, FLT3, INSR, KDR, SRC, TEK, XDH 3.53014
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, POLB, PPARA, SMAD3, SRC, TEK 3.52188
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.49904
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP2, MMP9, SRC, XDH 3.49284
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, FLT3, MET, PIM1, POLA1, SRC, TEK, TYR 3.46058
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, AURKB, AXL, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, SRC, TEK, XDH 3.46058
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 3.46058
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, SMAD3, SRC, TEK, TOP2A 3.4245
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK, XDH 3.41589
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, ADRA2C, AURKB, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HRH3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 3.37426
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.36519
[BP] GO:0032148 None ADRA2A, ADRA2C, INSR, SRC 3.36099
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.36025
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 3.3488
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HRH3, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, XDH 3.28725
[BP] GO:0045742 None ADORA1, ADRA2A, ADRA2C, MMP9 3.22684
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 3.14783
[BP] GO:1901186 None ADORA1, ADRA2A, ADRA2C, MMP9 3.14783
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 3.14783
[BP] GO:0042058 None ADORA1, ADRA2A, ADRA2C, EGFR, MMP9 3.14783
[BP] GO:0045741 None ADORA1, ADRA2A, ADRA2C 3.1343
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX5, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 3.13036
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, SRC 3.113
[BP] GO:0003018 None ADORA1, ADRA2A, ADRA2C, EGFR, SRC, TEK 3.11173
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 3.09646
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.09646
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.09646
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, TEK 3.06846
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 3.06846
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, POLB, SRC 3.05871
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, INSR, PPARA, SRC, TEK 3.05408
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.05408
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 3.02167
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.94862
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, PPARA, SRC, TEK 2.94309
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.94096
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.93257
[BP] GO:1901184 None ADORA1, ADRA2A, ADRA2C, EGFR, MMP9 2.90311
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ADRA2C, AXL, CA2, CA7, CYP19A1, EGFR, GPR35, HRH3, HSPA1A, INSR, MMP9, PPARA, SMAD3, SRC 2.8848
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.87884
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.87884
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.87884
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.87884
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, EGFR, FABP3, FLT3, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 2.87884
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, EGFR, FABP3, FLT3, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 2.87884
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.87342
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP9, SMAD3, SRC, XDH 2.87083
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP9, SMAD3, SRC, XDH 2.86062
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.85219
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.84859
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.83874
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, PPARA, SMAD3 2.83874
[BP] GO:0014061 None ADRA2A, ADRA2C, HRH3 2.83388
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.79024
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, SRC, TEK, XDH 2.78009
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.77544
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, SRC 2.75698
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 2.7552
[BP] GO:0016310 phosphorylation AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.71908
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HRH3, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 2.71853
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.71696
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.71696
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.71696
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, GPR35, HRH3, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TEK, TOP2A, XDH 2.71696
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, KDR, POLB, SRC 2.71287
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.67114
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, TBXAS1 2.64689
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, EGFR, FLT3, IGF1R, INSR, MMP2, SMAD3, SRC 2.64689
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.63681
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.62974
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ADRA2C, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, SRC, TEK, XDH 2.61187
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, ADRA2C, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, SRC, TEK 2.60168
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, ADRA2C, AURKB, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, SRC, TEK 2.60168
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.60168
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, SRC, TEK, XDH 2.60074
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.60074
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.60074
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.60074
[BP] GO:0003013 None ADORA1, ADRA2A, ADRA2C, EGFR, SRC, TEK 2.5848
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.56899
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.55156
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.54385
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.54385
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.54385
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 2.53285
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX5, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 2.49897
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.46993
[BP] GO:0006940 None ADORA1, ADRA2A, ADRA2C, CHRM2 2.46227
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.43837
[BP] GO:0051894 None KDR, SMAD3, TEK 2.38515
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.38515
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, HSPA1A, INSR, KDR, MET, PPARA, SMAD3 2.35505
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, HSPA1A, INSR, KDR, MET, MMP1, POLA1, SMAD3, SRC 2.35375
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, EGFR, IGF1R, INSR, MMP2, MMP9, SRC 2.35375
[BP] GO:0035625 None ADRA2A, ADRA2C 2.35375
[BP] GO:0032811 None ADRA2A, ADRA2C 2.35375
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.35375
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.35375
[BP] GO:0050730 None ADORA1, ADRA2A, ADRA2C, EGFR, FLT3, SRC 2.34551
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, GPR35, HRH3, MMP9 2.33534
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.31732
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, APEX1, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HRH3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, POLA1, PPARA, SMAD3, SRC, TEK, TOP2A, XDH 2.31362
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP9, PPARA, SMAD3, SRC, TEK, XDH 2.31362
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.30991
[BP] GO:1903393 None KDR, SMAD3, TEK 2.30991
[BP] GO:0010638 positive regulation of organelle organization AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.30414
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, EGFR, KDR, SRC 2.30354
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AXL, CA1, CA2, CHRM2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HRH3, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, SMAD3, SRC, TEK 2.30354
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA, TBXAS1 2.28016
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, EGFR, FLT3, INSR, KDR, MMP9, SRC, TEK, XDH 2.25895
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.25673
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.25673
[BP] GO:0051952 None ADORA1, ADRA2A, ADRA2C, HRH3 2.25002
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.25002
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.25002
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CA2, CHRM2, CYP1B1, EGFR, GPR35, HSPA1A, INSR, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, XDH 2.242
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK 2.23682
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 2.23194
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, SRC 2.23106
[BP] GO:0001775 cell activation ADRA2A, ADRA2C, ALOX5, AXL, EGFR, FLT3, FUT7, HSPA1A, MMP9, SMAD3, SRC 2.22476
[BP] GO:0033554 cellular response to stress AKR1B1, APEX1, AXL, CA2, CA9, CYP1B1, EGFR, HSPA1A, MMP9, NUAK1, POLA1, POLB, SRC, TOP2A 2.22184
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, APEX1, AURKB, CA9, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HRH3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, POLA1, PPARA, SMAD3, SRC, TEK, TOP2A, XDH 2.22184
[BP] GO:0035556 intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, AXL, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, POLB, SRC, TEK 2.22184
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, AXL, CA2, CYP1B1, EGFR, HSPA1A, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK 2.20268
[BP] GO:0007176 None ADORA1, ADRA2A, ADRA2C 2.20268
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.19805
[BP] GO:0035624 None ADRA2A, ADRA2C 2.19805
[BP] GO:0098501 polynucleotide dephosphorylation APEX1, POLB 2.19805
[BP] GO:0014060 None ADRA2A, ADRA2C 2.19805
[BP] GO:0014050 None ADORA1, HRH3 2.19805
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, SRC 2.1809
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CYP1A1, DUSP3, EGFR, INSR, SRC 2.1809
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.1809
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.1809
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, HRH3, INSR, SMAD3 2.1809
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, HRH3 2.16841
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.16841
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TOP2A 2.16042
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, EGFR, FLT3, INSR, KDR, MMP9, SRC, TEK, XDH 2.14888
[BP] GO:1901890 None KDR, SMAD3, TEK 2.14888
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.14888
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.14888
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, EGFR, MET, PPARA, SMAD3 2.1195
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, INSR, SRC 2.11353
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.11353
[BP] GO:2000273 None ADORA1, ADRA2A, ADRA2C 2.11353
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, ADRA2C, CHRM2, EGFR, GPR35, SMAD3 2.11069
[BP] GO:0051704 multi-organism process ADRA2C, AXL, CHRM2, CYP1A1, EGFR, HSPA1A, INSR, KDR, MET, MMP1, POLA1, SMAD3, SRC 2.08835
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, FABP4, PPARA, SMAD3, TEK 2.08378
[BP] GO:0048534 hematopoietic or lymphoid organ development FLT3, KDR, POLB, TEK, TYR 2.08312
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.08312
[BP] GO:0010907 None INSR, PPARA, SRC 2.08312
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HSPA1A 2.07091
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, SMAD3, XDH 2.06963
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.06963
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.06963
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, APEX1, AURKB, CA9, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HRH3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, POLA1, PPARA, SMAD3, SRC, TEK, TOP2A, XDH 2.05718
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, EGFR, IGF1R, INSR, MMP2, SRC 2.05598
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.05323
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, XDH 2.05318
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, ADRA2C, AURKB, EGFR, FLT3, INSR, SRC, TEK 2.05318
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.04558
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, ADRA2C, FLT3, SRC 2.03517
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, CSNK2A1, EGFR, FLT3, HSPA1A, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 2.02889
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, SRC, TEK 2.02696
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, TBXAS1, TYR 2.01707
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, TEK 3.70514
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CA4, CHRM2, FLT3, GPR35, HRH3, IGF1R, INSR, KDR, MET, TEK 2.87678
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CA2, CA4, CA9, CHRM2, DUSP3, EGFR, FLT3, GPR35, HRH3, IGF1R, INSR, KDR, MET, SRC, TEK 2.59916
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, EGFR, FLT3, GLO1, GPR35, HRH3, IGF1R, INSR, KDR, MET, MMP2, PIM1, SMAD3, SRC, TEK 2.54385
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CHRM2, FLT3, GPR35, HRH3, IGF1R, INSR, KDR, MET, TEK 2.53731
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FLT3, FUT7, GLO1, GPR35, HRH3, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIM1, SMAD3, SRC, TBXAS1, TEK, TYR 2.19805
[CC] GO:0098590 plasma membrane region ADORA1, ADRA2A, CA2, CA4, CA9, CHRM2, EGFR, INSR, MET, SRC, TEK 2.1809
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 10.1533
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1533
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, MMP1, MMP2, MMP9, PIM1, PPARA, SMAD3, TBXAS1, TYR, XDH 9.51351
[MF] GO:0043167 ion binding ACHE, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 8.99556
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 8.61213
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.68259
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.90812
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP2A 6.85335
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1, POLB 6.78866
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.5954
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.82288
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.52891
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 5.31636
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.30678
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, XDH 5.15001
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.99081
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, SMAD3, SRC 4.60293
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 4.58456
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK 4.50165
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.49679
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, TBXAS1, TOP2A, TYR, XDH 4.42643
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 4.41271
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.29055
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.19927
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, SMAD3, SRC 4.14816
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 4.12617
[MF] GO:0046872 metal ion binding ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, TBXAS1, TOP2A, TYR, XDH 4.0909
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.85039
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CHRM2, EGFR, FLT3, GPR35, HRH3, IGF1R, INSR, KDR, MET, PPARA, TEK 3.74229
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, POLA1, SRC, TBXAS1, XDH 3.70691
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, TOP2A, XDH 3.56892
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CHRM2, EGFR, FLT3, GPR35, HRH3, IGF1R, INSR, KDR, MET, TEK 3.55702
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CHRM2, EGFR, FLT3, GPR35, HRH3, IGF1R, INSR, KDR, MET, TEK 3.55702
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.47923
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.47923
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP2, MMP9, PPARA, SMAD3 3.38672
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CHRM2, EGFR, FLT3, GPR35, HRH3, IGF1R, INSR, KDR, MET, PPARA, SMAD3, TEK 3.28249
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CHRM2, EGFR, FLT3, GPR35, HRH3, IGF1R, INSR, KDR, MET, PPARA, TEK 3.16807
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.16023
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CHRM2, EGFR, FLT3, GPR35, HRH3, IGF1R, INSR, KDR, MET, PPARA, TEK 3.04598
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.86329
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, TOP2A, XDH 2.83786
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, TOP2A, XDH 2.83747
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.77116
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.74413
[MF] GO:0008227 None ADRA2A, ADRA2C, CHRM2, HRH3 2.63681
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.60074
[MF] GO:0004938 None ADRA2A, ADRA2C 2.60074
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.47163
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.35375
[MF] GO:0032795 None ADORA1, ADRA2A 2.35375
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.35375
[MF] GO:0097367 carbohydrate derivative binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, TOP2A 2.22522
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.20268
[MF] GO:0046982 protein heterodimerization activity ADORA1, ADRA2A, ADRA2C, AXL, EGFR, SMAD3, TOP2A, TYR 2.20057
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.19805
[MF] GO:0043559 insulin binding IGF1R, INSR 2.19805
[MF] GO:0043168 anion binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.08312
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.07091
[MF] GO:0004936 None ADRA2A, ADRA2C 2.06963
[MF] GO:0004064 arylesterase activity CA1, CA2 2.06963
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP3A4 2.05718
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ADRA2C, CSNK2A1, EGFR, FLT3, IGF1R, KDR, MET, MMP9, SMAD3, TOP2A, TYR, XDH 2.01319


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 10.1956
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.687
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.0122
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.3748
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.6108
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.5194
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.4744
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.945
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.8283
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.9389
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HRH3, GPR35, ADORA3, ADORA1, ADRA2C, ADRA2A 3.8517
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP3A4, CYP19A1, POLA1, FUT7, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, XDH 3.5794
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.4483
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, INSR, KDR, TEK, MET, EGFR, IGF1R 3.4483
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRA2C, ADRA2A 3.1711
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.389
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4483
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.8486
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.9248
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.2421
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.5578
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR 2.225
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.4054
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.5578
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.9248
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.3807
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.3385
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1812
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3778
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.4027
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.9682
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 2.084
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.656
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.5812
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, ADORA1, PPARA 1.3005
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, EGFR 1.236
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3624
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3944
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 1.0907
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.44
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3598
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1897
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.1884
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE 1.052
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1608
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 1.0587
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2606
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.333
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.3914
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.1891
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1877
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 1.0073
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.319
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 1.0189
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0189
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.013
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.9439
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9543
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 1.0017
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.9307
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.9307
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8965
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.9263
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.934
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8775
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, EGFR 0.8184
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5974
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.8294
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.7716
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.766
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.6478
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.4149
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.394
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4037
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.4063
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4347
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3937
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4426
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4829
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.4731
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5042
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.5042
Axon guidance_Homo sapiens_hsa04360 MET 0.4989
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5342
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5556
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5153
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5556
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5553
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5553
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5481
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.5311
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5553
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.556
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5645
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5558
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.5481
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5602
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5694
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5792
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5694
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5691
Peroxisome_Homo sapiens_hsa04146 XDH 0.5797
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.6173
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6183
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6162
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.6048
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6251
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.644
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6548
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6457
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.9551
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.6478
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.8564
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.6457
Shigellosis_Homo sapiens_hsa05131 SRC 0.6457
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.657
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6731
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6934
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6755
Malaria_Homo sapiens_hsa05144 MET 0.7124
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.716
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1171
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7804
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8091
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8392
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7752
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8775
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8315
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8091
DNA replication_Homo sapiens_hsa03030 POLA1 0.8083
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8294
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8083
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8775
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8775
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2421


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)