Prescription Description
| Prescription ID | TCMF218 |
| Pinyin Name | San Jin Pian |
| Chinese Name | 三金片 |
| English Name | San Jin Tablet |
| Function Description | 热淋 |
| Indications | Heat stranguria disorder, Acute prostatitis, Chronic prostatitis, Salmonella pyelonephritis, Chronic pyelonephritis, Cystitis, Urethritis |
| Disease ICD-11 Category |
SA91 [Heat stranguria disorder (TM1), 热淋 (TM1)
]; GA91.Y [Other specified inflammatory and other diseases of prostate, 其他特指的前列腺炎性疾病 ]; GA91.0 [Chronic prostatitis, 慢性前列腺炎 ]; GC2Z [Diseases of the urinary system, unspecified, 泌尿系统疾病，未特指的 ]; GB55.Z [Chronic tubulo-interstitial nephritis, unspecified, 慢性肾小管-间质肾炎，未特指的 ]; GC00 [Cystitis, 膀胱炎 ]; GC02.Y [Other specified urethritis and urethral syndrome, 其他特指的尿道炎和尿道综合征 ]; |
| Human Tissues Associated with Indication | Bladder |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1132 | Radix rosae laevigatae | 金樱根 | TCMH1132 | |
| TCMH37 | Smilax china | 菝葜 | TCMH37 | CPBOL4044-11 |
| TCMH2433 | Akebia puinata | 羊开口 | TCMH2433 | |
| TCMH1118 | Lygodium japonicum | 金沙藤 | TCMH1118 | ITSAJ4232-14 |
| TCMH1033 | Centella asiatica | 积雪草 | TCMH1033 | ITSAJ4523-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
| TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
| TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
Showing 1 to 10 of 90 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1207 | Legionella pneumophila |
| TCMT1208 | Escherichia coli K12 |
Showing 1 to 10 of 48 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC | 2.9803 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 3.34588 |
| [BP] GO:0001503 | ossification | ALPL, EGFR, MMP2, MMP9, TEK | 2.75895 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, EGFR, INSR, PTGS2, SMAD3 | 2.22147 |
| [BP] GO:0001525 | angiogenesis | CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK | 3.05303 |
| [BP] GO:0001666 | response to hypoxia | CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT | 3.90612 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 | 2.99258 |
| [BP] GO:0001775 | cell activation | ALOX5, APP, AXL, EGFR, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC | 3.46641 |
| [BP] GO:0001932 | regulation of protein phosphorylation | APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 4.39774 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 4.18267 |
Showing 1 to 10 of 410 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.9462 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 8.8309 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.6698 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, PIK3CB | 1.052 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, PIK3CA, MMP2, PIM1, PIK3CB | 4.2348 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, INSR, PIK3CB | 3.1754 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.4072 |
| Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.3115 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, INSR, PIK3CB, IGF1R | 2.9059 |
| Antigen processing and presentation_Homo sapiens_hsa04612 | HSPA1A | 0.6461 |
Showing 1 to 10 of 151 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples