TCM Prescription: Decoction for Chyluria



Prescription Description
Prescription IDTCMF2169
Pinyin Nameru mi niao tang
Chinese Name
English NameDecoction for Chyluria
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH170 Dioscorea hypoglauca 萆薢 TCMH170 GBVU109-13, GBVT4961-13
TCMH177 Polygonum aviculare 萹蓄 TCMH177 ITSAG3700-14
TCMH780 Lygodium japonicum 海金砂 TCMH780 ITSAJ4232-14
TCMH1953 Pyrrosia lingua 石韦 TCMH1953 GBVQ3369-13
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1189 Pseudomonas fluorescens
TCMT1198 Serratia marcescens
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1390 Human herpesvirus 2 strain G
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 8.63222
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TOP2A, TYR, XDH 8.03767
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PPARA, RORC, SRC, TYR 7.36322
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.36322
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GLO1, PIM1, PPARA, TYR, XDH 6.948
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC 6.69042
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PPARA, RORC, SRC, TYR 6.65375
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.23075
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2 6.06061
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, RORC, SRC, TOP2A, TYR, XDH 5.87654
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH 5.82669
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 5.823
[BP] GO:0042221 response to chemical AKR1B1, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, RORC, SRC, TYR 5.823
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 5.823
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, RORC, SRC, TYR 5.61297
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 5.61297
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TOP2A, XDH 5.61297
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.5486
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, KDR, MET, PPARA, SRC, XDH 5.47589
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP4, FLT3, FUT7, GLO1, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TOP2A, TYR 5.41763
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 5.38886
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CDC25B, CSNK2A1, CYP1B1, DRD2, F3, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, XDH 5.21473
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 5.13282
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, ALPI, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, FABP3, FABP4, FUT7, MET, PPARA 5.12389
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 5.08867
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TOP2A, XDH 5.05693
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GLO1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 5.00932
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.90999
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TOP2A, TYR, XDH 4.76795
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 4.74381
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 4.73538
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, F3, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TYR 4.64229
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.56023
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.42487
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, TYR 4.40917
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, F3, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SRC, TOP2A, TYR 4.40447
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 4.38764
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A2, DRD1, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 4.29111
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC 4.19199
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TOP2A, TYR, XDH 4.10166
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 4.0844
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 4.08383
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TYR, XDH 3.94719
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.90884
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, F3, FLT3, FUT7, GLO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TOP2A, TYR, XDH 3.86263
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 3.86165
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.85944
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.84718
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.77849
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, RORC, SRC 3.73913
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, HSD17B1, HSD17B2 3.73058
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2 3.67678
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.67632
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, DRD2, F3, FLT3, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.65153
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTPN1, RORC, SRC, TOP2A 3.63421
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, KDR, SRC 3.63421
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, CYP1B1, DRD2, F3, FLT3, KDR, MET, PTPN1, SRC, XDH 3.61831
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TOP2A, XDH 3.59421
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 3.59421
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPI, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, SRC, XDH 3.59114
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.57396
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, KDR, SRC 3.56568
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, DRD1, DRD2, FABP3, FABP4, FLT3, MET, SRC 3.55208
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 3.5466
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.4643
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 3.46254
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, APP, AXL, CYP1A1, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, RORC, SRC 3.4028
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, F3, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 3.4028
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPI, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, SRC, XDH 3.36352
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.34417
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, DRD2, F3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 3.34014
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, KDR, SRC 3.29339
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, DRD1, IGF1R, MMP2, MMP9, RORC, SRC 3.19673
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.1815
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, APP, CYP1A1, CYP1B1, DRD1, FLT3, RORC, SRC 3.1763
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, SRC 3.11073
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.10218
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, DRD2, F3, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, XDH 3.04945
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.0163
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 3.01516
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, RORC, SRC, TYR 2.9706
[BP] GO:0042752 None ADORA1, DRD2, PPARA, RORC, TOP2A 2.96205
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.94671
[BP] GO:0009725 response to hormone AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, SRC 2.91781
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 2.85435
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, MMP2, PPARA, SRC, TYR 2.85435
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2 2.85435
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2 2.85275
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, KDR, SRC 2.83842
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, PPARA, RORC, SRC, TOP2A 2.82217
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.81751
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.81751
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.80143
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.7867
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.72561
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALPI, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1, HSD17B2 2.72108
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.70126
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2 2.6905
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2 2.6905
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TOP2A, XDH 2.68215
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.64232
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.63616
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DRD2, F3, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, XDH 2.63391
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.63379
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.62389
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.62365
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.57672
[BP] GO:0030335 positive regulation of cell migration APP, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.57672
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F3, MET, SRC, XDH 2.56596
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9 2.56413
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.55389
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 2.54191
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, CDC25B, DRD1, DRD2, FABP3, FLT3, KDR, MMP9, PTPN1, SRC, XDH 2.54191
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, CDC25B, DRD1, DRD2, FABP3, FLT3, KDR, MMP9, PTPN1, SRC, XDH 2.54191
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.54191
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TOP2A, XDH 2.54039
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, CDC25B, DRD1, DRD2, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.53987
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52965
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.50599
[BP] GO:2000147 positive regulation of cell motility APP, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.50599
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, CDC25B, DRD1, DRD2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.50371
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, MMP2, MMP9, PPARA, PTPN1, SRC, TOP2A 2.50371
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.48578
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, CDC25B, DRD1, DRD2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.47069
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.46477
[BP] GO:0051272 positive regulation of cellular component movement APP, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.4364
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, MMP9, SRC 2.4214
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, F3, FABP4, KDR, MET, MMP12, PPARA 2.4214
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, KDR, SRC 2.4214
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.41561
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TOP2A, XDH 2.40345
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.40345
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, PPARA, SRC 2.3896
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.3896
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.3746
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.37284
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, CDC25B, DRD1, DRD2, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TOP2A, XDH 2.36508
[BP] GO:0040017 positive regulation of locomotion APP, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.36475
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TOP2A, XDH 2.33724
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, CDC25B, DRD1, DRD2, FABP4, FLT3, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.33724
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.3138
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, PPARA, RORC, SRC 2.31101
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.31101
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.31101
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.30055
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, SRC 2.2621
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, DRD2, FLT3, KDR, PTPN1, SRC, XDH 2.25327
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, FUT7, KDR, MMP1, MMP12, MMP9, SRC 2.24566
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, TYR 2.22771
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, FUT7, KDR, MET, MMP1, MMP12, MMP9, SRC 2.22165
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.21574
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.21311
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SRC 2.20365
[BP] GO:0002521 leukocyte differentiation AXL, FLT3, FUT7, GLO1, MMP9, RORC 2.18745
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.17752
[BP] GO:0048869 cellular developmental process ACHE, APP, AXL, CDC25B, CYP1A1, DRD1, DRD2, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, RORC, SRC, TOP2A 2.16047
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2 2.15779
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TOP2A, TYR, XDH 2.15467
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SRC 2.14428
[BP] GO:0021853 None DRD1, DRD2 2.1391
[BP] GO:0010641 None F3, SRC 2.1391
[BP] GO:1904936 None DRD1, DRD2 2.1391
[BP] GO:0042321 None ADORA1, DRD2 2.1391
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1 2.13826
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, IGF1R, MMP2, SRC 2.1367
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, DRD2, F3, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.12198
[BP] GO:0001659 None ADORA1, DRD1, DRD2 2.12198
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, SRC, TOP2A 2.11311
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.11132
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2 2.11075
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALPI, CSNK2A1, DRD2, FABP3, FABP4, MET 2.09177
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, XDH 2.09177
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA 2.08192
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2 2.06732
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DRD2, FLT3, IGF1R, KDR, PTPN1, SRC, XDH 2.06237
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, PPARA 2.01192
[BP] GO:0021843 None DRD1, DRD2 2.01192
[BP] GO:0021830 None DRD1, DRD2 2.01192
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.01192
[BP] GO:0021826 None DRD1, DRD2 2.01192
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.01192
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2 2.00169
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SRC 2.00169
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.01192
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPI, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, F3, FLT3, GLO1, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC 1.95431
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, SRC 1.85171
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.81178
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPI, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, F3, FLT3, FUT7, GLO1, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC, TYR 1.70172
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 13.6604
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPI, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TOP2A, TYR, XDH 10.6364
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.6364
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F3, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TOP2A, TYR, XDH 10.3514
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.36322
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.73579
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TOP2A, TYR, XDH 6.5926
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.91474
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC 5.87654
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.60573
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.38886
[MF] GO:0046872 metal ion binding ALOX5, ALPI, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TOP2A, TYR, XDH 5.00221
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 4.91494
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TYR, XDH 4.8364
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.34892
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 4.19199
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.17037
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.74935
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 3.59114
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.59114
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.4643
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.44122
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.35946
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.18992
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 3.0163
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.85637
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.52965
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.42794
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, SRC, XDH 2.38602
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.31101
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.31101
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.30535
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.1391
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.12198
[MF] GO:0017171 serine hydrolase activity ACHE, F3, MMP1, MMP12, MMP2, MMP9 2.04601
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP3A4 2.02117
[MF] GO:0004064 arylesterase activity CA1, CA2 2.01192


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 12.0378
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.6552
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.3592
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.4646
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP3A4, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPI, XDH 3.8083
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0982
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.7124
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.3477
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3934
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.7734
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.1946
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.4089
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8589
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 2.1851
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.3295
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, DRD1, DRD2, PPARA 2.0296
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1196
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 2.0269
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3 1.961
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2 2.0296
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.9666
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7625
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, DRD1, DRD2 1.6745
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.2554
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4815
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.48
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4489
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3832
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1209
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4642
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3828
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2192
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.381
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.169
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.58
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.3823
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.2192
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.1025
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3143
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.381
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.6192
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 1.0901
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.9333
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0296
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 1.0131
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9412
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0616
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0664
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.9547
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9055
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.963
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.9169
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8687
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.782
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.8327
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8668
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5426
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3242
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.51
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5426
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3888
Platelet activation_Homo sapiens_hsa04611 SRC 0.4949
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.377
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.51
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4171
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5342
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5373
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3875
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5321
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.4169
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5426
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4473
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4959
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5293
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4113
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4949
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4776
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4557
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5426
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5321
Tuberculosis_Homo sapiens_hsa05152 SRC 0.417
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4816
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4949
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4739
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4739
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.4296
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4473
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4739
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4816
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4959
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5426
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5373
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5426
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5373
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5998
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5822
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4949
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4113
Axon guidance_Homo sapiens_hsa04360 MET 0.4903
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5769
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5373
Glioma_Homo sapiens_hsa05214 IGF1R 0.5998
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5998
Peroxisome_Homo sapiens_hsa04146 XDH 0.5427
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5566
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5877
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5998
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5996
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5995
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5998
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5998
Shigellosis_Homo sapiens_hsa05131 SRC 0.5998
Malaria_Homo sapiens_hsa05144 MET 0.6704
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7471
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7959
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8327
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8133
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.87
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8327
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8687
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.17
Folate biosynthesis_Homo sapiens_hsa00790 ALPI 1.0667


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)