TCM Prescription: Conduit Opening Circulation Enhancing Decoction



Prescription Description
Prescription IDTCMF2149
Pinyin NameTong Qiao Huo Xue Tang
Chinese Name通窍活血汤
English NameConduit Opening Circulation Enhancing Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH334 Allium fistulosum 葱白 TCMH334 ITSAD961-14
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH388 Ziziphus jujuba 大枣 TCMH388 ITSAM869-14
TCMH1880 Moschus moschiferus 麝香 TCMH1880 GBMA2112-09
TCMH1153 Vinum TCMH1153
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT203 G6PD Glucose-6-phosphate 1-dehydrogenase Oxidoreductase P11413
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT649 DRD5 Dopamine D5 receptor GPCR P21918
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AR, AXL, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, GPER1, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, PTGES, RORC, SRC, TEK, TRPV1, TYR 12.2091
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AR, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, PTGES, RORC, SMAD3, SRC, TEK, TRPV1, TYR 12.1775
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AR, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PPARA, PTGES, RORC, SMAD3, SRC, TEK, TERT, TRPV1, TYR 11.0925
[BP] GO:0014070 response to organic cyclic compound ALPL, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FLT3, GPER1, PTGES, RORC, SRC, TEK, TRPV1, TYR 10.727
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, AR, AURKB, AXL, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPER1, GPR35, HCAR2, HSD11B1, HSD17B2, HSD17B3, HSPA1A, INSR, KDR, MAOA, MET, MTNR1B, PPARA, SMAD3, SRC, TEK, TERT, TRPV1, XDH 10.6846
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AR, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PTGES, SMAD3, SRC, TEK, TERT, XDH 9.93956
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPER1, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.89948
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPER1, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.89113
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B2, HSD17B3, MET, PPARA, PTGES, TBXAS1, TRPV1 9.86737
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TRPV1, TYR, XDH 9.49493
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, AR, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPER1, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 9.46683
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, AR, CA2, CA9, CSNK2A1, CYP1A2, DRD1, DRD5, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1 8.3724
[BP] GO:0033993 response to lipid ALPL, AR, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD17B2, PTGES, RORC, SRC, TYR 8.21229
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 8.11749
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, AR, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPER1, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 8.04785
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AR, AXL, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, RORC, SMAD3, SRC, TERT, TRPV1 8.04161
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPER1, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1B, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.04161
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPER1, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1B, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.88915
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, NQO2, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TYR, XDH 7.85083
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, AR, AXL, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPER1, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1B, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1 7.85083
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AR, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 7.66788
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 7.66723
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 7.55189
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FUT7, HSD17B3, HSPA1A, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 7.54292
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F10, F3, GPER1, INSR, MET, SRC, TEK, XDH 7.54292
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 7.49409
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GPER1, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 7.32976
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AR, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPER1, GPR35, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.32976
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, INSR, PPARA, SRC, TEK, TRPV1 7.32976
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 7.32976
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GPER1, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 7.3155
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 7.17264
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 7.15093
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AR, AXL, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPER1, GPR35, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 7.12682
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 7.10618
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, GPER1, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, TEK, TERT 7.04674
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AR, AXL, CDK6, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MMP2, RORC, SMAD3, SRC, TRPV1 7.00064
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.98552
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, AR, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MMP9, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.87128
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 6.87128
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, GPER1, GPR35, INSR, MET, MTNR1B, SMAD3, SRC, TERT, TRPV1 6.85852
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGES, SRC, TERT 6.82132
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, AR, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MMP9, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.82132
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AR, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, GPER1, HSD17B2, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1, TYR 6.77079
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GPER1, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 6.75465
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AR, AURKB, AXL, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GPER1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, TYR 6.6178
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 6.36911
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, AR, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FLT3, GPER1, RORC, SRC, TRPV1 6.3435
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, GPER1, HCAR2, HSD11B1, HSD17B2, HSD17B3, MTNR1B 6.31477
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, AR, CDC25B, DRD1, DRD2, DRD5, EGFR, ESRRB, FABP3, FLT3, GPER1, INSR, KDR, MMP9, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH 6.31477
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, AR, CDC25B, DRD1, DRD2, DRD5, EGFR, ESRRB, FABP3, FLT3, GPER1, INSR, KDR, MMP9, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH 6.31477
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AR, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 6.2669
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD17B2, HSD17B3, MAOA, NQO2, TBXAS1, TYR, XDH 6.23503
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PIM1, PPARA, RORC, SRC 6.21479
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, AR, CDK6, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPER1, HSPA1A, IGF1R, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.21063
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AR, AURKB, AXL, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1 6.21063
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AR, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPER1, GPR35, HSPA1A, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.21063
[BP] GO:0030335 positive regulation of cell migration DRD1, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.19049
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A, MAOA 6.15428
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC, SRC 6.15428
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AR, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TYR 6.14361
[BP] GO:2000147 positive regulation of cell motility DRD1, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.01414
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 6.00105
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPER1, GPR35, HSPA1A, IGF1R, MET, MMP9, PTPN1, SMAD3, SRC, TERT, XDH 5.96891
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, HSD11B1, HSD17B2, HSD17B3 5.96048
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPER1, GPR35, HSPA1A, IGF1R, MET, MMP9, PTPN1, SMAD3, SRC, TERT, XDH 5.95411
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, GPER1, GPR35, INSR, MET, MTNR1B, SMAD3, TRPV1 5.93672
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AR, AURKB, CDC25B, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 5.92768
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AR, AXL, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 5.92201
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT 5.9035
[BP] GO:0051272 positive regulation of cellular component movement DRD1, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.9035
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CDK6, DRD1, DRD2, DRD3, EGFR, GPER1, HCAR2, KDR, SRC, TRPV1 5.86148
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, GPER1, INSR, MAOA, SMAD3, TRPV1 5.85443
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.84103
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AR, AXL, CDK6, CYP1B1, DRD1, DRD5, EGFR, ESR1, GPER1, IGF1R, INSR, MMP2, MMP9, RORC, SRC, TRPV1 5.83483
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PPARA, PTGES, TBXAS1 5.83072
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 5.82806
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, GPER1, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 5.78855
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 5.7503
[BP] GO:0040017 positive regulation of locomotion DRD1, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.7483
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AR, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 5.7147
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AR, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, GPR35, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 5.7147
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, GPER1, KDR, SRC, TRPV1 5.63683
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, TRPV1 5.6241
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 5.60122
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AR, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, GPR35, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 5.51498
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, MTNR1A, MTNR1B, PPARA, RORC, SRC 5.44192
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AR, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.35269
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, GPER1, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 5.35269
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC, SRC 5.34634
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGES, TBXAS1 5.2764
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AR, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.19619
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 5.11878
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, DRD5, EGFR, PPARA, SMAD3 5.10754
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, GPER1, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.09644
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AR, AXL, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 5.0484
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B2, HSD17B3 4.99875
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.98504
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.92874
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TRPV1, TYR, XDH 4.92097
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TERT, TRPV1, TYR 4.90258
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HSD17B3, MAOA, TYR 4.7952
[BP] GO:0009891 positive regulation of biosynthetic process AR, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, IGF1R, INSR, KDR, MET, MTNR1A, PPARA, RORC, SMAD3, SRC, TERT, TRPV1 4.79185
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AR, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.74894
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, AR, DRD2, EGFR, FLT3, GPER1, INSR, KDR, PTPN1, SRC, TEK, XDH 4.71049
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TRPV1, TYR, XDH 4.6856
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.66442
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, AR, DRD2, DUSP3, EGFR, FLT3, GPER1, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 4.61611
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPER1, GPR35, HCAR2, HSPA1A, INSR, MMP9, MTNR1B, PPARA, PTPN1, SMAD3, SRC, TERT, TRPV1 4.59958
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AR, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, IGF1R, INSR, MET, MTNR1A, PPARA, PTPN1, RORC, SMAD3, SRC, TERT 4.57274
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.56857
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, KDR, SRC, TRPV1 4.49625
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, GPER1, HCAR2, PPARA, RORC, SRC, TEK 4.47896
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, TRPV1 4.42604
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2, HSD17B3 4.4107
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, GPER1, INSR, SRC, TERT 4.3962
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, GPER1, HCAR2 4.34537
[BP] GO:0031328 positive regulation of cellular biosynthetic process AR, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, IGF1R, INSR, MET, MTNR1A, PPARA, RORC, SMAD3, SRC, TERT, TRPV1 4.34399
[BP] GO:0001963 None DRD1, DRD2, DRD3, DRD5 4.34098
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AR, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 4.33364
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, AR, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 4.31783
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, GPER1 4.30822
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, GPER1 4.30822
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, GPER1, GPR35, SMAD3, TRPV1 4.2439
[BP] GO:1900542 None DRD1, DRD2, DRD3, DRD5, ESRRB, GPER1, INSR, MTNR1A, PPARA 4.24033
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 4.22625
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, GPER1, KDR, MET, PPARA, SMAD3, TEK 4.1952
[BP] GO:0051240 positive regulation of multicellular organismal process AR, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F3, GPER1, HCAR2, HSPA1A, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, TERT, TRPV1 4.1952
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AR, DRD1, DRD5, EGFR, ESR1, FLT3, GPER1, IGF1R, INSR, MMP2, SMAD3, SRC, TRPV1 4.14956
[BP] GO:0006140 None DRD1, DRD2, DRD3, DRD5, ESRRB, GPER1, INSR, MTNR1A, PPARA 4.14876
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, EGFR, GPER1 4.12314
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGES, TERT 4.10393
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, KDR, SRC 4.10252
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, MAOA 4.04807
[BP] GO:0045776 None ADORA1, DRD2, DRD3, DRD5, PPARA 4.04807
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.04807
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, MAOA, TYR 4.04356
[BP] GO:0007187 None ADORA1, DRD1, DRD2, DRD3, DRD5, GPER1, MTNR1A, MTNR1B 4.03907
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AR, AURKB, AXL, DRD2, DRD3, ESR1, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 4.03907
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, MAOA 4.01156
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, MAOA 4.01156
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.98672
[BP] GO:0044093 positive regulation of molecular function ADORA1, AR, AURKB, CDC25B, DRD2, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPER1, HSPA1A, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.94566
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AR, AXL, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPER1, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 3.93617
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.9324
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 3.92644
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DRD3, DUSP3, ESR1, GPER1, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 3.92001
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPER1, HCAR2, INSR, SMAD3, SRC, TERT, TRPV1 3.84587
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.84272
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.84272
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, MTNR1A, MTNR1B, PPARA, RORC 3.84272
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AR, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, DRD5, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, MMP2, MMP9, MTNR1A, SRC 3.81342
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AR, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 3.76506
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DRD2, DUSP3, EGFR, GPER1, KDR, PTPN1, SRC, TEK 3.75951
[BP] GO:0098771 inorganic ion homeostasis CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPER1, GPR35, SMAD3, TRPV1 3.74414
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, AR, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.71747
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, AR, CDC25B, DRD2, EGFR, ESRRB, FLT3, GPER1, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.71747
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, GPER1, PPARA, SMAD3, TEK 3.70349
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, EGFR, KDR, SRC, TRPV1 3.66743
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, AR, AURKB, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPER1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 3.66686
[BP] GO:0010676 None ESRRB, GPER1, INSR, PPARA, SRC 3.649
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AR, AURKB, AXL, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TYR, XDH 3.60668
[BP] GO:0008217 None ADORA1, AR, DRD2, DRD3, DRD5, PPARA, SMAD3 3.6055
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.56608
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.53514
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, GPER1, HSPA1A, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 3.5261
[BP] GO:0003018 None ADORA1, DRD1, DRD5, EGFR, GPER1, SRC, TEK 3.50587
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, GPER1, HCAR2, SRC, TRPV1 3.50375
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGES, TBXAS1 3.46721
[BP] GO:0001975 None DRD1, DRD2, DRD3, DRD5 3.46224
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.46089
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.46089
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.46089
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.43234
[BP] GO:0009968 negative regulation of signal transduction AR, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPER1, HSPA1A, IGF1R, MET, MMP9, PTPN1, SMAD3, SRC, TERT, XDH 3.40591
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, DRD1, DRD5, EGFR, GPER1, IGF1R, INSR, MMP2, SRC, TRPV1 3.39468
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, AR, CDK6, CYP1B1, DRD2, FABP3, GPER1, HSPA1A, PTGES, SMAD3, TERT, XDH 3.36768
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.35108
[BP] GO:0042417 None DRD1, DRD2, DRD3, MAOA 3.35108
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B2, HSD17B3 3.35108
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, AR, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, GPER1, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.35108
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, AR, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.34468
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, SRC 3.34324
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.3392
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, AR, CDC25B, DRD2, EGFR, FLT3, GPER1, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.33241
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, GPER1, PPARA, SMAD3, TEK 3.26826
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, DRD5 3.26281
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, DRD3, GPER1, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.24005
[BP] GO:0050793 regulation of developmental process AR, AXL, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPER1, INSR, KDR, NUAK1, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 3.23081
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 3.21795
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, NQO2, RORC 3.21795
[BP] GO:0072507 divalent inorganic cation homeostasis DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPER1, GPR35, SMAD3, TRPV1 3.2118
[BP] GO:1900544 None DRD1, DRD5, ESRRB, GPER1, INSR, MTNR1A 3.20319
[BP] GO:0045981 None DRD1, DRD5, ESRRB, GPER1, INSR, MTNR1A 3.20319
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, GPER1, PPARA, SMAD3, TEK 3.20319
[BP] GO:0001659 None ADORA1, DRD1, DRD2, TRPV1 3.20195
[BP] GO:0007191 None DRD1, DRD3, DRD5 3.18621
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.18621
[BP] GO:0055080 cation homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPER1, GPR35, SMAD3, TRPV1 3.16965
[BP] GO:0045913 None ESRRB, GPER1, INSR, PPARA, SRC 3.15913
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GPER1, GPR35, HCAR2, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TRPV1, TYR, XDH 3.15913
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, AR, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, GPER1, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.15913
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.15913
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET, TRPV1 3.15606
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MAOA, MMP1, MMP2, MMP9, SRC, XDH 3.15439
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, DRD1, DRD5, EGFR, GPER1, IGF1R, INSR, MMP2, SRC, TRPV1 3.14974
[BP] GO:0030802 None DRD1, DRD2, DRD3, DRD5, GPER1, MTNR1A 3.14338
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD5, EGFR, GPER1, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PTGES, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1 3.14333
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.11776
[BP] GO:0010675 None ESRRB, GPER1, INSR, PPARA, RORC, SRC 3.10675
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.07948
[BP] GO:0019371 None CBR1, PTGES, TBXAS1 3.07948
[BP] GO:0007189 None DRD1, DRD2, DRD3, DRD5, GPER1 3.06164
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, CDC25B, DRD2, DRD5, EGFR, ESR1, F3, FLT3, GPER1, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.04294
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GPER1, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 3.04294
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.04022
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 3.03267
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK, TYR 3.03267
[BP] GO:0071383 None AR, EGFR, FLT3, GPER1, SRC 3.01595
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.01022
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, CDC25B, CDK6, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT 3.0044
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, GPER1, MMP2, MMP9, TERT 2.99087
[BP] GO:0071396 cellular response to lipid AR, AXL, CDK6, EGFR, ESR1, FLT3, GPER1, RORC, SRC 2.98938
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, ESR1, HSD17B2, HSD17B3, INSR, SRC 2.98938
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.98579
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPER1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.97929
[BP] GO:1900371 None DRD1, DRD2, DRD3, DRD5, GPER1, MTNR1A 2.97929
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.9731
[BP] GO:0030808 None DRD1, DRD2, DRD3, DRD5, GPER1, MTNR1A 2.9632
[BP] GO:0051726 regulation of cell cycle AURKB, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, GPER1, HSPA1A, INSR, PIM1, SMAD3, SRC, TERT 2.96062
[BP] GO:0007212 None DRD1, DRD2, DRD3, DRD5 2.95611
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.95611
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, DRD2, EGFR, GPER1, KDR, SRC, TEK 2.95474
[BP] GO:0042060 None ALOX15, DRD5, EGFR, PPARA, SMAD3 2.95436
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.93375
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, SRC 2.92993
[BP] GO:0046960 None DRD1, DRD5 2.92656
[BP] GO:0009115 None AOX1, XDH 2.92656
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.92381
[BP] GO:0014075 None DRD1, DRD2, DRD3, DRD5 2.92381
[BP] GO:0030003 cellular cation homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPER1, GPR35, SMAD3, TRPV1 2.91948
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.89663
[BP] GO:0060158 None DRD1, DRD2, DRD5 2.89663
[BP] GO:0002009 morphogenesis of an epithelium AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.88591
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation GPER1, MMP2, MMP9, TERT 2.88545
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.86638
[BP] GO:0003013 None ADORA1, DRD1, DRD5, EGFR, GPER1, SRC, TEK 2.86638
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, GPER1, MMP9, SMAD3, SRC, XDH 2.85418
[BP] GO:0006873 cellular ion homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPER1, GPR35, SMAD3, TRPV1 2.83297
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 2.80869
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.80869
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.80869
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.80869
[BP] GO:0006874 cellular calcium ion homeostasis DRD1, DRD2, DRD3, DRD5, ESR1, GPER1, GPR35, SMAD3, TRPV1 2.80512
[BP] GO:0030799 None DRD1, DRD2, DRD3, DRD5, GPER1, MTNR1A 2.78873
[BP] GO:0045931 positive regulation of mitotic cell cycle CDC25B, CYP1A1, DRD3, DUSP3, INSR, TERT 2.75577
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AR, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, IGF1R, INSR, KDR, MET, PPARA, RORC, SMAD3, SRC, TERT 2.7556
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GPER1, PPARA, SMAD3, TEK 2.7499
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.73683
[BP] GO:0055074 calcium ion homeostasis DRD1, DRD2, DRD3, DRD5, ESR1, GPER1, GPR35, SMAD3, TRPV1 2.70907
[BP] GO:0048545 response to steroid hormone ALPL, AR, CA2, EGFR, FLT3, GPER1, SRC 2.70434
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.69893
[BP] GO:0010564 regulation of cell cycle process AURKB, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, GPER1, HSPA1A, INSR, TERT 2.69893
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, TRPV1, XDH 2.67422
[BP] GO:0072503 cellular divalent inorganic cation homeostasis DRD1, DRD2, DRD3, DRD5, ESR1, GPER1, GPR35, SMAD3, TRPV1 2.67422
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.66971
[BP] GO:0097366 None DRD1, DRD2, DRD3, DRD5 2.66971
[BP] GO:0019933 None DRD1, DRD2, DRD3, DRD5, GPER1 2.65633
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.65234
[BP] GO:0070920 None EGFR, ESR1, TERT 2.65234
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.65234
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AR, AXL, CBR1, CDC25B, CDK6, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, KDR, MET, MMP2, MMP9, RORC, SMAD3, SRC, TEK, TERT 2.64754
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, PTGES, TBXAS1, TYR 2.61282
[BP] GO:0007188 None ADORA1, DRD1, DRD2, DRD3, DRD5, GPER1 2.58682
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.58329
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, AR, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.56617
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.5574
[BP] GO:0044057 None ADORA1, ADORA3, DRD2, DRD3, EGFR, GPER1, GPR35, HCAR2, SMAD3, TRPV1 2.55158
[BP] GO:2000351 None GPER1, KDR, TEK, TERT 2.5396
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, GPER1, KDR, TEK 2.5396
[BP] GO:0019932 second-messenger-mediated signaling DRD1, DRD2, DRD3, DRD5, EGFR, GPER1, KDR 2.53813
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, SRC 2.53209
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, GPER1, MMP9, SMAD3, SRC, XDH 2.5292
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.5292
[BP] GO:0030817 None DRD1, DRD2, DRD3, DRD5, GPER1 2.52706
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC 2.52706
[BP] GO:0046110 None AOX1, XDH 2.52706
[BP] GO:0060160 None DRD2, DRD3 2.52706
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52706
[BP] GO:2000026 regulation of multicellular organismal development AR, AXL, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, GPER1, INSR, KDR, PIM1, SMAD3, SRC, TEK, TERT, XDH 2.52024
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.52024
[BP] GO:0019935 None DRD1, DRD2, DRD3, DRD5, GPER1 2.49596
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.49596
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.48159
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.48159
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.48159
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.48159
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.48159
[BP] GO:0050678 None AR, CDK6, EGFR, F3, KDR, SMAD3, TEK, XDH 2.48159
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.46594
[BP] GO:0072593 reactive oxygen species metabolic process CYP1A1, CYP1A2, CYP1B1, DRD5, EGFR 2.46438
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.46127
[BP] GO:0007617 None DRD1, DRD5, MTNR1A 2.46127
[BP] GO:0001952 regulation of cell-matrix adhesion CDK6, KDR, SMAD3, SRC, TEK 2.44767
[BP] GO:0055082 cellular chemical homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPER1, GPR35, SMAD3, TRPV1 2.44608
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH 2.43588
[BP] GO:0055065 metal ion homeostasis DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPER1, GPR35, SMAD3, TRPV1 2.41295
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.41164
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.41164
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.40586
[BP] GO:0048148 None DRD1, DRD2, DRD3 2.40586
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.40586
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.40501
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, SMAD3, TEK 2.40319
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, AR, AXL, CYP1A1, DRD1, DRD5, EGFR, ESR1, MTNR1A, SRC 2.39273
[BP] GO:0051898 None DRD2, DRD3, GPER1, XDH 2.39273
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.39273
[BP] GO:0051098 regulation of binding AURKB, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TERT 2.38958
[BP] GO:0051254 None AR, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, INSR, MET, PPARA, RORC, SMAD3, SRC, TERT 2.38867
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, GPER1, INSR, PPARA, RORC, SRC 2.38621
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.38621
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B2, HSD17B3, PTGES 2.38084
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, GPER1, KDR, TEK, TERT 2.37577
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, GPER1, HCAR2, SRC 2.37359
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.37188
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.35804
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.35804
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.34599
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.34599
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, SRC 2.34266
[BP] GO:0002791 None ACHE, ADORA1, DRD2, DRD3, EGFR, GPER1, HCAR2, MTNR1B, SRC 2.33662
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPER1, GPR35, HCAR2, HSD11B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.33475
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, AR, AURKB, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.33475
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, AR, CDC25B, DRD2, EGFR, FLT3, GPER1, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.3266
[BP] GO:0031324 negative regulation of cellular metabolic process AR, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, IGF1R, MET, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 2.30767
[BP] GO:0048729 tissue morphogenesis AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.3075
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.3075
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.3075
[BP] GO:0046883 regulation of hormone secretion ADORA1, CYP19A1, DRD2, EGFR, GPER1, HCAR2, MTNR1B 2.30597
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR 2.29893
[BP] GO:0006145 None AOX1, XDH 2.29849
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.29849
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.29849
[BP] GO:0090087 None ACHE, ADORA1, CA2, DRD2, DRD3, EGFR, GPER1, HCAR2, MTNR1B, PTPN1, SMAD3, SRC 2.29474
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TRPV1 2.29474
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, PTGES, TBXAS1, TYR 2.26919
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, GPER1, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SRC, TEK 2.26342
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.26304
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.26304
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, CA2, CDK6, CYP19A1, DRD2, DUSP3, ESR1, ESRRA, GPER1, HCAR2, HSPA1A, MMP2, PTPN1, SMAD3, SRC 2.26304
[BP] GO:0030814 None DRD1, DRD2, DRD3, DRD5, GPER1 2.26262
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.25266
[BP] GO:0051172 None AR, AURKB, CSNK2A1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, IGF1R, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 2.24912
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, CDK6, KDR, SMAD3, SRC, TEK 2.24147
[BP] GO:0050890 None ADORA1, DRD1, DRD2, DRD3, DRD5, EGFR, INSR 2.23581
[BP] GO:0090068 positive regulation of cell cycle process AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR, TERT 2.21716
[BP] GO:0051894 None KDR, SMAD3, TEK 2.21716
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.21716
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.21716
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, PTGES, TBXAS1, TYR 2.20755
[BP] GO:0043434 None FABP3, GPER1, INSR, PPARA, SRC, TEK, TRPV1 2.18315
[BP] GO:0050927 None F3, KDR, SMAD3 2.16619
[BP] GO:0051128 regulation of cellular component organization ALOX15, AR, AURKB, AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPN1, SMAD3, SRC, TEK 2.16619
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.15582
[BP] GO:0045893 None AR, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, PPARA, RORC, SMAD3, SRC, TERT 2.1545
[BP] GO:1903508 None AR, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, PPARA, RORC, SMAD3, SRC, TERT 2.1545
[BP] GO:0051094 positive regulation of developmental process AR, AXL, CA2, CYP1B1, DRD2, ESRRB, F3, GPER1, INSR, KDR, PIM1, SMAD3, SRC, TEK, TERT 2.15394
[BP] GO:1902680 None AR, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, PPARA, RORC, SMAD3, SRC, TERT 2.15291
[BP] GO:0006875 cellular metal ion homeostasis DRD1, DRD2, DRD3, DRD5, ESR1, GPER1, GPR35, SMAD3, TRPV1 2.14844
[BP] GO:0097746 None ADORA1, DRD1, DRD5, EGFR, GPER1 2.14814
[BP] GO:0035296 None ADORA1, DRD1, DRD5, EGFR, GPER1 2.14814
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, GPER1 2.14814
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, GPER1, KDR, TEK 2.14757
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.14757
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.14627
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, GPER1, HSPA1A, MMP9, PTPN1, SMAD3, SRC, TERT 2.1407
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.13756
[BP] GO:0046887 positive regulation of hormone secretion CYP19A1, DRD2, EGFR, GPER1, HCAR2 2.13756
[BP] GO:0051480 regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, GPER1, GPR35, SMAD3, TRPV1 2.13602
[BP] GO:0050926 None F3, KDR, SMAD3 2.13436
[BP] GO:1903393 None KDR, SMAD3, TEK 2.13436
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.13125
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B2, HSD17B3 2.12986
[BP] GO:0021853 None DRD1, DRD2 2.12986
[BP] GO:0043696 None CDK6, ESRRB 2.12986
[BP] GO:0043697 None CDK6, ESRRB 2.12986
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.12986
[BP] GO:0010641 None F3, SRC 2.12986
[BP] GO:0090325 None DRD2, DRD3 2.12986
[BP] GO:0007598 None F10, F3 2.12986
[BP] GO:1904936 None DRD1, DRD2 2.12986
[BP] GO:0042321 None ADORA1, DRD2 2.12986
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.11748
[BP] GO:0045934 None AR, AURKB, DRD2, DRD3, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, PPARA, RORC, SMAD3, SRC, TERT, TRPV1 2.11715
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, GPER1, HCAR2, MTNR1B, SRC, TRPV1 2.10248
[BP] GO:0045745 None DRD2, DRD3, GPER1 2.10033
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, AR, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.09971
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HSD17B3 2.09838
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, DRD1, DRD2, DRD3, DRD5, ESR1, GPER1, GPR35, HCAR2, INSR, MTNR1A, MTNR1B, SRC 2.09095
[BP] GO:0043393 regulation of protein binding AURKB, MET, MMP9, PPARA, SRC, TERT 2.08446
[BP] GO:0030804 None DRD1, DRD5, GPER1, MTNR1A 2.07779
[BP] GO:0008209 androgen metabolic process CYP19A1, ESR1, HSD17B3 2.05874
[BP] GO:0008306 None DRD1, DRD2, DRD3, DRD5 2.05574
[BP] GO:0050880 None ADORA1, DRD1, DRD5, EGFR, GPER1 2.05474
[BP] GO:0035150 None ADORA1, DRD1, DRD5, EGFR, GPER1 2.04035
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.03962
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.03583
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, HSPA1A, MMP9, PTPN1, SRC, TERT 2.02566
[BP] GO:0019098 None DRD1, DRD5, MTNR1A 2.02151
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET 2.00525
[BP] GO:0007612 None DRD1, DRD2, DRD3, DRD5, INSR 2.00327
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F10, F3, FLT3, GPER1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1 4.5812
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, DRD1, DRD2, DRD3, DRD5, F10, F3, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 4.47194
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, DRD5, GPER1, INSR, SRC, TRPV1 4.14876
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F10, F3, FLT3, FUT7, GPER1, GPR35, HCAR2, HSD11B1, HSD17B2, HSD17B3, IGF1R, INSR, KDR, MAOA, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TEK, TERT, TRPV1, TYR 3.88649
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F10, F3, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SRC, TEK, TRPV1 3.5261
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPER1, GPR35, HCAR2, HSD11B1, HSD17B2, HSD17B3, IGF1R, INSR, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, PTPN1, SRC, TBXAS1, TEK, TRPV1, TYR 3.43636
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 3.10043
[CC] GO:0032589 None ADORA1, GPER1, INSR, TRPV1 2.80869
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, DRD1, DRD2, DRD5, EGFR, GPER1, INSR, MET, SRC, TEK, TRPV1 2.65234
[CC] GO:0044432 endoplasmic reticulum part CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, EGFR, F10, FLT3, GPER1, HSD11B1, HSD17B2, HSD17B3, PTGES, PTPN1, TBXAS1 2.52024
[CC] GO:0031233 None CA4, F10, F3 2.40586
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, EGFR, GPER1, HSD11B1, HSD17B2, HSD17B3, PTGES, TBXAS1 2.38052
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.26287
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AR, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GPER1, HSD11B1, HSD17B2, HSD17B3, HSPA1A, INSR, KDR, MAOA, MMP2, MMP9, NQO2, PIM1, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TERT, TRPV1, TYR, XDH 2.14814
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, AR, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 15.2288
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TRPV1, TYR, XDH 11.8734
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 11.8734
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, F10, F3, FLT3, FUT7, HSD11B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, PTGES, PTPN1, SRC, TBXAS1, TEK, TERT, TYR, XDH 9.82558
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK, TRPV1 9.49493
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CDK6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK, TRPV1 8.75198
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK, TRPV1 8.31309
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, SMAD3, TEK, TRPV1 8.12892
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 7.85083
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 7.85083
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TERT, TRPV1, TYR, XDH 7.66794
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3 7.54292
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.53333
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, PPARA, SRC, TEK, TRPV1 7.52956
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, GPER1, IGF1R, INSR, MTNR1A, NQO2, SHBG 7.50762
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD17B2, HSD17B3, MAOA, NQO2, TBXAS1, TYR, XDH 7.49409
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 7.33226
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.20999
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 6.64612
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, XDH 6.53263
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.48231
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, RORC, SHBG 6.2328
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, GPER1, PPARA, RORC, SHBG, TRPV1 5.68804
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPER1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 5.52141
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPER1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 5.52141
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TERT, TRPV1, TYR, XDH 5.29204
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.25728
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.07303
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.99875
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD17B2, HSD17B3, XDH 4.89822
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, TYR 4.74874
[MF] GO:0004952 None DRD1, DRD2, DRD3, DRD5 4.72071
[MF] GO:0035240 None DRD1, DRD2, DRD3, DRD5 4.5812
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.34804
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 4.09586
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 4.02437
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC, TBXAS1 3.99005
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.92644
[MF] GO:1901338 None DRD1, DRD2, DRD3, DRD5 3.8859
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC, TBXAS1 3.80459
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.54005
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, TYR 3.50587
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, NQO2, PTGES, SRC, TBXAS1, XDH 3.4426
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.3392
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.31656
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.17439
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.15181
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B2, HSD17B3 3.14338
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TERT 3.04584
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, DRD5 3.04022
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.92656
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 2.92381
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, AR, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MTNR1A, NQO2, NUAK1, PIM1, PPARA, PTPN1, RORC, SHBG, SMAD3, SRC, TBXAS1, TEK, TERT, TRPV1, XDH 2.78877
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.70082
[MF] GO:0008502 None MTNR1A, MTNR1B 2.52706
[MF] GO:0043168 anion binding ALOX15, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, PTGES, SRC, TEK, TRPV1, XDH 2.52024
[MF] GO:0042802 identical protein binding ACHE, AOX1, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, NQO2, SMAD3, TERT, TRPV1, TYR, XDH 2.40723
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.40586
[MF] GO:0001588 None DRD1, DRD5 2.29849
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.29849
[MF] GO:0005497 None AR, SHBG 2.29849
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 2.13602
[MF] GO:0043559 insulin binding IGF1R, INSR 2.12986
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B2, HSD17B3 2.10033
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.08207
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, SRC, TEK, TRPV1, XDH 2.03366
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B2, HSD17B3 2.02151
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.02151


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 12.8824
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.3421
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.4681
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, GPER1, MMP9, ESR1, EGFR, ESR2, HSPA1A 6.8447
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 6.9991
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, ALOX15, HSD17B3, AKR1B1, TYR, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 5.3753
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 MTNR1A, GPR35, MTNR1B, ADORA3, ADORA1, TRPV1, DRD1, DRD2, DRD3, DRD5 5.5183
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.7675
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 5.1247
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.1075
Pathways in cancer_Homo sapiens_hsa05200 AR, CDK6, SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 4.4314
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.6796
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.0981
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, PTGES 4.3356
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.1955
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 3.767
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, DRD1, DRD2, PPARA, DRD5 2.9642
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, DRD1, DRD2, DRD3, DRD5 2.9642
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.9642
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.7889
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, INSR, KDR, TEK, MET, EGFR, IGF1R 2.672
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP2D6, CYP1A2, AOX1 2.9642
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 2.9535
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, F3 2.4541
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9642
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2, EGFR 2.6649
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.4372
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.2638
Serotonergic synapse_Homo sapiens_hsa04726 MAOA, CYP2D6, ALOX5, ALOX15 2.3301
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.0947
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, SRC, MMP9 2.0287
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 2.0709
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.2078
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.0709
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, EGFR 2.0635
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1, DRD2 2.3354
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7528
Prostate cancer_Homo sapiens_hsa05215 AR, EGFR, IGF1R 1.7602
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.0562
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9991
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.6887
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.7528
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.0709
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0488
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.3097
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.5817
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.34
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.2747
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.4387
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.3066
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.1828
Alcoholism_Homo sapiens_hsa05034 MAOA, DRD1, DRD2 1.1267
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1, EGFR, DRD5 1.1267
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.012
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.9727
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, TRPV1 0.9614
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9614
Circadian entrainment_Homo sapiens_hsa04713 MTNR1A, MTNR1B 0.9727
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9893
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8283
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 1.1267
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8425
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9918
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8425
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.8425
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8353
Oocyte meiosis_Homo sapiens_hsa04114 AR, IGF1R 0.8274
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7852
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8265
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7713
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.7773
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0851
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7773
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2347
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7713
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, DRD1 1.1799
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, EGFR 1.2747
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2842
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.7703
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2933
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.2997
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2678
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7261
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.7496
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2929
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2933
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2839
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0814
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7261
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6029
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3278
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.5766
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5971
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1905
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3678
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, TERT 0.4985
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2473
Axon guidance_Homo sapiens_hsa04360 MET 0.3827
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4257
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4257
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4424
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4495
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4495
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4495
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4587
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4582
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4631
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4765
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4835
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4765
Small cell lung cancer_Homo sapiens_hsa05222 CDK6 0.4782
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4757
Peroxisome_Homo sapiens_hsa04146 XDH 0.4845
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5054
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5168
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5306
Bile secretion_Homo sapiens_hsa04976 CA2 0.5289
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5325
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5458
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5502
Shigellosis_Homo sapiens_hsa05131 SRC 0.5481
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5677
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5588
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6041
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5938
Malaria_Homo sapiens_hsa05144 MET 0.6196
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6156
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6238
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.624
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7208
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6238
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6284
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5842
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.7406
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.6861
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6749
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6801
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7256
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7773
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9007
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7577
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7713
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.783
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7665
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7773
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8063
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.908
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9642
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9727
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.237


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)