TCM Prescription: Qi Clearing Phlegm Dissolving pills



Prescription Description
Prescription IDTCMF2142
Pinyin NameQing Qi Hua Tan Wan
Chinese Name清气化痰丸
English NameQi Clearing Phlegm Dissolving pills
Function Description咳嗽
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationLung
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH404 Rhizoma arisaema cum bile 胆南星 TCMH404
TCMH705 Trichosanthes kirilowii 瓜蒌 TCMH705 ITSAO4359-14
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH1184 Citrus reticulata 橘皮 TCMH1184 ITSAA1245-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, PTGES, TBXAS1, TRPV1 7.31529
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, KDR, MAOA, MCL1, MET, MTNR1B, POLA1, POLB, PPARA, SRC, TNKS, TNKS2, TRPV1, XDH 6.86681
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.86681
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MCL1, MMP2, POLB, PPARA, PTGES, SRC, TRPV1, TYR 6.73745
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 6.36431
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MCL1, MMP2, MMP9, POLB, PPARA, PTGES, SRC, TRPV1, TYR 6.36431
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, POLB, PPARA, PTGES, SRC, TRPV1, TYR 6.33341
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 6.19867
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 5.98453
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.90421
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 5.84978
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGES, SRC 5.03187
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES, TBXAS1 4.81606
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, PTGES, SRC, TYR 4.78738
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 4.78738
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 4.78738
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PTGES, PTPRS, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 4.58771
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 4.58494
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 4.58494
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PPARA, PTGES, TBXAS1 4.22299
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CBR1, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, HSD17B2, KDR, MCL1, MET, MMP2, MMP9, PIM1, POLB, PPARA, PTPRS, SRC, TNKS2, TYR 4.14477
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MCL1, MET, MMP12, MMP9, SRC, TNKS, TNKS2, XDH 4.09423
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MCL1, MET, MMP12, MMP9, SRC, TNKS, TNKS2, XDH 4.0782
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, TYR 3.64406
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.58609
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MCL1, MMP12, MMP2, MMP9, POLA1, POLB, PPARA, PTGES, SRC, TRPV1, TYR 3.48242
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP2, NQO2, PIM1, POLA1, POLB, PPARA, PTGES, PTPRS, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 3.46934
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.46492
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.43186
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, PTGES, SRC, TRPV1, TYR 3.3016
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CDK6, KDR, SRC, TNKS, TNKS2, TRPV1 3.29991
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.2949
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, POLB, PPARA, PTPRS, SRC, TYR 3.29285
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES, TBXAS1 3.29285
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, CA9, CDK6, CYP1A1, CYP1B1, FABP3, KDR, POLB, SRC, TRPV1 3.29036
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, CA12, CA2, CA7, FABP3, FABP4, FLT3, MCL1, MET, MTNR1B, POLA1, POLB, SRC, TRPV1 3.29036
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B2, KDR, MCL1, MMP9, PIM1, POLB, PPARA, PTPRS, SRC, TYR 3.29036
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.17655
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MCL1, MMP2, MMP9, POLA1, POLB, SRC, TRPV1 3.04425
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 2.98378
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.98378
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDK6, CSNK2A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGES, SRC, XDH 2.98378
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, SRC, TRPV1 2.98378
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, SRC, TRPV1, XDH 2.98378
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 2.98378
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, SRC 2.98378
[BP] GO:0019371 None CBR1, PTGES, TBXAS1 2.89939
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, CDK6, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC, TRPV1 2.89939
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TRPV1 2.85901
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, SRC, TNKS, TNKS2, TRPV1, XDH 2.81572
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, FLT3, KDR, MCL1, MET, MMP12, MMP9, SRC, TNKS, TNKS2, XDH 2.81572
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MCL1, MET, MMP9, PIM1, SRC, TRPV1, XDH 2.79987
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGES, TBXAS1, TYR 2.74205
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, IGF1R, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, SRC, TNKS, TNKS2, TRPV1, XDH 2.73365
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.72014
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MCL1, MET, MMP9, PIM1, SRC 2.70793
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2 2.66889
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, CDK6, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, SRC, TRPV1 2.62443
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, AXL, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP12, MMP9, MTNR1B, PPARA, SRC, TRPV1 2.59492
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MCL1, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, PIM1, POLA1, POLB, PPARA, PTGES, PTPRS, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TUBB3, TYR, XDH 2.56918
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, IGF1R, KDR, MCL1, MET, MMP12, MMP9, MTNR1B, PTPRS, SRC, TNKS, TNKS2, XDH 2.51669
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, IGF1R, KDR, MCL1, MET, MMP12, MMP9, MTNR1B, PTPRS, SRC, TNKS, TNKS2, XDH 2.43031
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.42932
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.41316
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.41316
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2, MTNR1B 2.41316
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGES, TBXAS1, TYR 2.4044
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.39564
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.39564
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, SRC, TRPV1 2.38404
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, CYP1A1, FLT3, MET, PIM1, POLA1, SRC, TYR 2.38292
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.38214
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGES, TBXAS1, TYR 2.36305
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MCL1, MMP9, PIM1, SRC, TRPV1, XDH 2.33736
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, KDR, POLB, SRC 2.33614
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.28288
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.22747
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX15, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, FABP4, HSD17B2, IGF1R, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TNKS2, TRPV1, TYR 2.21253
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.21086
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.21086
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PTGES 2.20608
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, POLB, PTPRS, SRC, TNKS, XDH 2.20608
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, KDR, MCL1, MET, MMP12, MMP2, MMP9, SRC, TNKS, TNKS2, XDH 2.20387
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.20387
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MCL1, MMP9, PIM1, SRC 2.18724
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.1548
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.13183
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGES 2.12993
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.12808
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGES, SRC 2.11134
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.07812
[BP] GO:0070213 None TNKS, TNKS2 2.05709
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.05709
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.05709
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, POLB, PTPRS, SRC, TNKS, XDH 2.00226
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HSD17B2, IGF1R, KDR, MAOA, MCL1, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTGES, PTPRS, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR 2.38292
[CC] GO:0005641 nuclear envelope lumen ALOX5, PTGES 1.54043
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM2, FLT3, IGF1R, KDR, MET, MTNR1A, MTNR1B, PTPRS, TRPV1 1.48633
[CC] GO:0099055 None ADORA1, PTPRS 1.47803
[CC] GO:0099699 None ADORA1, PTPRS 1.47803
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PTGES, PTPRS, SRC, TBXAS1, TNKS, TNKS2, TUBB3, TYR, XDH 11.7739
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1914
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, TBXAS1, TNKS, TYR, XDH 10.1914
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PTGES, PTPRS, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TUBB3, TYR, XDH 9.71217
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.86681
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.35746
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 5.61658
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.70438
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, NQO2, PIM1, PPARA, SRC, TRPV1 4.44358
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.31438
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 4.24179
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, NQO2, POLA1, PTGES, SRC, TBXAS1, XDH 4.06193
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 3.9189
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.67683
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, TNKS 3.5482
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.51248
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.33786
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.30701
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.10175
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 2.97545
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.93562
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, MTNR1A, NQO2 2.81572
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 2.74205
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.6085
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CDK6, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIM1, POLA1, SRC, TRPV1, TUBB3, XDH 2.55148
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.42932
[MF] GO:0043168 anion binding ABCB1, ALOX15, AURKB, AXL, CDK6, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIM1, PTGES, PTPRS, SRC, TRPV1, TUBB3, XDH 2.41316
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.41316
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.38292
[MF] GO:0008502 None MTNR1A, MTNR1B 2.28288
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, POLA1, POLB, SRC 2.20608
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, CBR1, HSD17B1, HSD17B2, XDH 2.05709


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.5855
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.2073
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, ALOX15, AKR1B1, TYR, CYP19A1, POLA1, FUT7, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 5.95
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.1908
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, PTGES 4.6282
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.9838
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9838
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.4577
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ABCB1, PIM1, CYP1B1, MMP9, MET, MCL1 3.4681
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.959
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.1926
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.1926
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.233
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, MTNR1A, MTNR1B, ADORA3, ADORA1, TRPV1 2.959
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, KDR, MET, MCL1, IGF1R 2.5002
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.085
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.0992
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9237
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.7854
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.7739
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.7739
Serotonergic synapse_Homo sapiens_hsa04726 MAOA, ALOX5, ALOX15 1.677
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5119
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, MMP9 1.4076
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, SRC 1.1653
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.2311
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, ADORA1, PPARA 1.1801
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2984
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2984
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2564
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0754
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2198
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2198
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.2311
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.0183
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2 1.2198
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0722
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, TRPV1 1.0327
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.971
Circadian entrainment_Homo sapiens_hsa04713 MTNR1A, MTNR1B 1.0478
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2082
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3 1.0785
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE 0.971
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1653
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.6474
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9314
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9314
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8557
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9322
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.7739
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, MCL1 0.7804
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8468
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8952
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7535
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7416
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC 0.6396
HTLV-I infection_Homo sapiens_hsa05166 POLB 0.2812
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3534
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2 0.3811
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3754
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3811
Alcoholism_Homo sapiens_hsa05034 MAOA 0.3811
Apoptosis_Homo sapiens_hsa04210 MCL1 0.4415
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5137
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4235
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3752
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4415
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4149
Phagosome_Homo sapiens_hsa04145 TUBB3 0.4202
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4415
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.4887
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4642
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5072
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.454
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4642
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4887
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5137
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4707
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.454
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.501
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5043
Cell cycle_Homo sapiens_hsa04110 CDK6 0.4642
Axon guidance_Homo sapiens_hsa04360 MET 0.4593
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5043
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5109
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA 0.4574
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5137
Small cell lung cancer_Homo sapiens_hsa05222 CDK6 0.5137
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5137
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5137
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4707
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5137
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5109
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5109
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.498
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5109
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5137
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5522
Peroxisome_Homo sapiens_hsa04146 XDH 0.5137
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5527
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5518
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5664
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5664
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5586
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5664
Amphetamine addiction_Homo sapiens_hsa05031 MAOA 0.5658
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5772
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5664
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5592
Shigellosis_Homo sapiens_hsa05131 SRC 0.5664
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5936
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.5784
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.595
Malaria_Homo sapiens_hsa05144 MET 0.6299
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.6299
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6276
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6396
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6492
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6819
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.7535
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7471
DNA replication_Homo sapiens_hsa03030 POLA1 0.7187
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7416
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7187
Base excision repair_Homo sapiens_hsa03410 POLB 0.7416
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7838
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7804
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8097
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9314
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.097
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.971


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)