TCM Prescription: Kuoqing Decoction



Prescription Description
Prescription IDTCMF2042
Pinyin NameKuo Qing Yin
Chinese Name廓清饮
English NameKuoqing Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH357 Pericarpium arecae 大腹皮 TCMH357
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH1240 Raphanus sativus 莱菔子 TCMH1240 ITSAD4259-14
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
TCMH79 Sinapis alba 白芥子 TCMH79 ITSAD4265-14
TCMH1184 Citrus reticulata 橘皮 TCMH1184 ITSAA1245-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1352 Colletotrichum truncatum
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, APEX1, AURKB, AXL, CA12, CA2, CA7, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD17B1, HSD17B2, KDR, MCL1, MET, MIF, POLA1, POLB, PPARA, PPARD, SLC1A1, SRC, TRPV1, XDH 8.76215
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AXL, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, GRIK5, GRM5, HSD17B2, IGF1R, MMP2, MMP9, POLB, PPARA, PPARD, SRC, TRPV1, TYR 8.22435
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MCL1, MMP2, POLB, PPARA, PPARD, SRC, TRPV1, TYR 7.70896
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.82801
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.82801
[BP] GO:0042221 response to chemical AKR1B1, APEX1, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MCL1, MMP2, MMP9, POLB, PPARA, PPARD, SRC, TRPV1, TYR 6.50591
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIM1, PPARA, PPARD, SRC, TOP2A, TRPV1, XDH 6.39534
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, MIF, PPARA, PPARD, TBXAS1, TRPV1 6.36202
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIM1, PPARD, SRC, TOP2A, TRPV1, XDH 6.31493
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, MIF, PIM1, PPARA, PPARD, TBXAS1, TYR, XDH 6.20596
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.8631
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, IGF1R, KDR, MCL1, MIF, MMP9, PIM1, PPARD, SRC, TOP2A, TRPV1, XDH 5.70178
[BP] GO:0007193 None CHRM1, CHRM2, CHRM4, GRM1, GRM3, GRM5, GRM8 5.5115
[BP] GO:0007187 None CHRM1, CHRM2, CHRM4, CNR1, CNR2, GRM1, GRM3, GRM5, GRM8 5.43109
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARD, SLC1A1, TRPV1 5.43109
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.14709
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, AXL, CA12, CA2, CA7, CNR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MCL1, MET, POLA1, POLB, SRC, TRPV1 5.00794
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MCL1, MIF, MMP2, MMP9, POLA1, POLB, PPARD, SRC, TOP2A, TRPV1 4.9395
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 4.92065
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PPARD, TBXAS1 4.88167
[BP] GO:0099536 None CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.86535
[BP] GO:0099537 None CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.86535
[BP] GO:0007188 None CHRM1, CHRM2, CHRM4, CNR1, GRM1, GRM3, GRM5, GRM8 4.86535
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, CNR1, CNR2, GRIK5, GRM1, GRM3, GRM5, GRM8 4.86535
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, CNR1, CNR2, GRIK5, GRM1, GRM3, GRM5, GRM8 4.86535
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, PPARD, SRC, TYR 4.81061
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 4.81061
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, IGF1R, KDR, MCL1, MIF, MMP12, MMP2, MMP9, POLA1, POLB, PPARA, PPARD, SRC, TOP2A, TRPV1, TYR 4.72177
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.45092
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM4, CYP1A1, FLT3, MET, MIF, PIM1, POLA1, PPARD, SRC, TYR 4.45092
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARD, SLC1A1, TRPV1 4.41455
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIM1, PPARA, PPARD, SRC 4.21896
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 4.21179
[BP] GO:0032502 developmental process ACHE, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CBR1, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, GLO1, HSD17B2, KDR, MCL1, MET, MIF, MMP2, MMP9, PIM1, POLB, PPARA, PPARD, SRC, TOP2A, TYR 4.16731
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, MIF, PPARA, PPARD, TBXAS1 4.16644
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MIF, PPARA, PPARD, TBXAS1 4.0778
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, AXL, CA1, CHRM4, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MCL1, MET, MIF, MMP2, MMP9, SRC, TRPV1 4.07612
[BP] GO:0007268 None CHRM1, CHRM2, CHRM4, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.0154
[BP] GO:0098916 None CHRM1, CHRM2, CHRM4, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.0154
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 4.0154
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, KDR, POLB, SRC, TRPV1 3.97747
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIM1, PPARD, SRC 3.97747
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CNR1, CNR2, CYP1A1, CYP1B1, KDR, POLB, SRC 3.89186
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, SRC, TOP2A, TRPV1, XDH 3.88428
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, PPARD, TBXAS1, TYR, XDH 3.84687
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, CNR1, CNR2, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TRPV1, TYR 3.84687
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, TBXAS1 3.83227
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, TYR 3.83227
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.79564
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.72663
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AXL, CA1, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MCL1, MET, MIF, MMP2, MMP9, PIM1, POLB, PPARA, PPARD, SRC, TRPV1 3.72663
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, PPARD, SRC, XDH 3.7204
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.65014
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, PPARD, SRC, XDH 3.62756
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, PPARD 3.62756
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, SLC1A1, SRC, TOP2A, TRPV1, XDH 3.61166
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.59418
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.59418
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, GRM1, GRM3, GRM5, GRM8 3.58532
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, CNR1, CNR2, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TRPV1, TYR 3.5721
[BP] GO:0032501 multicellular organismal process AKR1B1, ALOX5, AXL, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, SRC, TRPV1, TYR 3.56596
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TRPV1 3.49389
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, KDR, MCL1, MET, MIF, MMP12, MMP9, PPARD, SRC, XDH 3.4719
[BP] GO:0023056 positive regulation of signaling AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, KDR, MCL1, MET, MIF, MMP12, MMP9, PPARD, SRC, XDH 3.44978
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.44535
[BP] GO:0032879 regulation of localization ACHE, ADORA3, APEX1, AXL, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, GRIK5, GRM5, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PPARD, SRC, TRPV1 3.44535
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, PPARD, SRC, TRPV1 3.43032
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MCL1, MIF, MMP9, PIM1, PPARD, SRC 3.43011
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MIF, PIM1, PPARA, PPARD, TBXAS1, TYR 3.41188
[BP] GO:0014070 response to organic cyclic compound APEX1, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, SRC, TRPV1, TYR 3.39015
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.30023
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, POLB, PPARA, PPARD, SRC, TYR 3.30017
[BP] GO:0040012 regulation of locomotion ADORA3, APEX1, CHRM1, CHRM4, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PPARD, SRC 3.25325
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2 3.25106
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PPARD, SRC, TRPV1 3.24447
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, PPARD, SRC, TRPV1 3.19175
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.19175
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.19175
[BP] GO:0042391 None CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 3.15213
[BP] GO:0060078 None GRIA2, GRIA4, GRIK5, GRM5, TRPV1 3.11787
[BP] GO:0009725 response to hormone AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, SRC, TRPV1 3.03457
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MIF, PIM1, PPARA, PPARD, TBXAS1, TYR 3.00386
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, CHRM1, CSNK2A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PPARD, SRC, XDH 2.94579
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MIF, PIM1, PPARA, PPARD, TBXAS1, TYR 2.92759
[BP] GO:0009987 cellular process ACHE, ADORA3, AKR1B1, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, IGF1R, KDR, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, SLC1A1, SRC, TBXAS1, TOP2A, TRPV1, TYR, XDH 2.91647
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PPARD, SLC1A1, TRPV1 2.87399
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.86092
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.79206
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, GRM3, GRM8, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, PIM1, PPARA, PPARD, SRC, TOP2A, TRPV1, XDH 2.76992
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, SRC 2.7595
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, IGF1R, KDR, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, SLC1A1, SRC, TOP2A, TRPV1, XDH 2.71453
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, GRM5, IGF1R, PPARA, SRC, TRPV1 2.71294
[BP] GO:0007154 None AXL, CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TRPV1 2.6951
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.62644
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CHRM1, CSNK2A1, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PPARD 2.62567
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.61462
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.59336
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.52551
[BP] GO:0007267 None CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.49661
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.49528
[BP] GO:0030334 regulation of cell migration ADORA3, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PPARD, SRC 2.47388
[BP] GO:0032496 response to lipopolysaccharide AXL, CNR1, CNR2, CYP1A1, CYP1A2, PPARD, SRC 2.46444
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.45666
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2, PPARD 2.43082
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, SRC, TRPV1 2.42618
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.42618
[BP] GO:0099566 None GRM1, GRM5 2.41153
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.41153
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.41153
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, CNR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, TRPV1 2.41153
[BP] GO:0009056 catabolic process ACHE, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PPARD, SRC, XDH 2.41147
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.39011
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.33083
[BP] GO:0002237 response to molecule of bacterial origin AXL, CNR1, CNR2, CYP1A1, CYP1A2, PPARD, SRC 2.33033
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.32347
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.30501
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.30501
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AXL, CYP1B1, FLT3, GRM1, KDR, MCL1, MET, MIF, PPARD, SRC, XDH 2.29659
[BP] GO:2000145 regulation of cell motility ADORA3, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PPARD, SRC 2.28557
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, APEX1, AXL, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, MCL1, MIF, MMP2, MMP9, POLA1, POLB, PPARA, PPARD, SRC, TOP2A, TRPV1 2.27319
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AXL, CSNK2A1, CYP1B1, FLT3, GRM1, KDR, MCL1, MET, MIF, MMP12, MMP9, PPARD, SRC, XDH 2.24297
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, KDR, MIF, MMP1, MMP12, MMP9, PPARD, SRC 2.23615
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.22628
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.22628
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.22628
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, MIF, PPARD 2.22457
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.22335
[BP] GO:0033554 cellular response to stress AKR1B1, APEX1, AXL, CA2, CA9, CYP1B1, MCL1, MIF, MMP9, POLA1, POLB, PPARD, SRC, TOP2A, TRPV1 2.22315
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, CA2, CYP1A1, GRM1, MMP2, POLB, PPARA, PPARD, SRC, TRPV1, TYR 2.21143
[BP] GO:0023052 None CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.20027
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.18609
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.1826
[BP] GO:0038171 None CNR1, CNR2 2.1826
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.1826
[BP] GO:0060079 None GRIA2, GRIA4, GRIK5, TRPV1 2.14577
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, KDR, MET, MIF, MMP1, MMP12, MMP9, PPARD, SRC 2.14577
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.09999
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AXL, CNR1, CSNK2A1, CYP1B1, FABP4, FLT3, GRM1, KDR, MCL1, MET, MIF, MMP12, MMP2, MMP9, PPARD, SRC, XDH 2.09939
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.06219
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.0609
[BP] GO:0007568 aging APEX1, AURKB, CNR1, CYP1A1, MIF, POLB 2.05761
[BP] GO:0051270 regulation of cellular component movement ADORA3, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PPARD, SRC 2.0348
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, APEX1, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, GRM3, GRM8, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, PIM1, PPARA, PPARD, SRC, TOP2A, TRPV1, XDH 2.03364
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.02773
[BP] GO:0098501 polynucleotide dephosphorylation APEX1, POLB 2.00133
[CC] GO:0097060 None CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 6.82801
[CC] GO:0098590 plasma membrane region CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC, TRPV1 6.20596
[CC] GO:0044456 None ACHE, CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC, TRPV1 4.92065
[CC] GO:0042734 None CNR1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.76211
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, TRPV1 4.65238
[CC] GO:0005887 integral component of plasma membrane ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, TRPV1 4.21896
[CC] GO:0045211 None CHRM1, CHRM2, CHRM4, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 4.0154
[CC] GO:0044459 plasma membrane part ADORA3, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SRC, TRPV1 3.83227
[CC] GO:0005886 plasma membrane ACHE, ADORA3, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, PIM1, SLC1A1, SRC, TRPV1 3.55793
[CC] GO:0043005 None CA2, CHRM1, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 3.04464
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, IGF1R, KDR, MCL1, MET, MMP2, PIM1, SLC1A1, SRC, TBXAS1, TRPV1, TYR 2.62462
[CC] GO:0014069 None CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 2.34573
[CC] GO:0099572 None CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 2.34573
[CC] GO:0044425 membrane part ACHE, ADORA3, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, IGF1R, KDR, MCL1, MET, SLC1A1, SRC, TBXAS1, TRPV1, TYR 2.16161
[CC] GO:0097458 None CA2, CHRM1, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC, TRPV1 2.06219
[CC] GO:0044463 None AKR1B1, CA4, CA9, CHRM1, CHRM2, CNR1, GRIA2, GRIA4, GRIK5, GRM3, SRC, TRPV1 2.04017
[CC] GO:0120038 None AKR1B1, CA4, CA9, CHRM1, CHRM2, CNR1, GRIA2, GRIA4, GRIK5, GRM3, SRC, TRPV1 2.04017
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.57355
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, TBXAS1, TYR, XDH 8.59256
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 8.22435
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.22435
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1, POLB 6.39527
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.31493
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA, PPARD, TRPV1 6.31228
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, GRIA2, GRIA4, GRIK5, GRM1, GRM5 5.78298
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, SRC, TBXAS1, TOP2A, TYR, XDH 5.64822
[MF] GO:0004872 receptor activity ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA, PPARD, TRPV1 5.5115
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, TRPV1 5.5115
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, TRPV1 5.5115
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA, PPARD, TRPV1 5.35678
[MF] GO:0043167 ion binding ACHE, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, SLC1A1, SRC, TBXAS1, TOP2A, TRPV1, TYR, XDH 5.1691
[MF] GO:0004871 signal transducer activity ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA, PPARD, TRPV1 4.92065
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, PPARD, SRC, TOP2A, TRPV1 4.88885
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 4.0154
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.01435
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, SLC1A1, TBXAS1, TOP2A, TRPV1, TYR, XDH 3.93044
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.83734
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 3.75708
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.7204
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PPARD 3.61166
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.55793
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.50044
[MF] GO:0046872 metal ion binding ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, SLC1A1, TBXAS1, TOP2A, TRPV1, TYR, XDH 3.50035
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.25106
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.09196
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.07018
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 2.83725
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.72268
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.62604
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, POLA1, SRC, TBXAS1, XDH 2.58342
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.5056
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.47438
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.42388
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.42388
[MF] GO:0004949 None CNR1, CNR2 2.41153
[MF] GO:0099583 None GRM1, GRM5 2.41153
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.22335
[MF] GO:0004971 None GRIA2, GRIA4 2.1826
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, CBR1, HSD17B1, HSD17B2, XDH 2.13695
[MF] GO:0005504 None FABP3, FABP4, PPARD 2.0609
[MF] GO:0005230 None GRIA2, GRIA4, GRIK5, TRPV1 2.03364


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM1, CHRM4, GRIK5, TRPV1, GRM1, GRM3, GRM5, CNR2, CNR1, ADORA3, GRM8, GRIA4 11.3745
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.4418
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.2416
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 7.2653
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.2962
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA, PPARD 4.3827
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CNR1, GRM1, GRIA4 3.6914
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9144
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.3492
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, TYR, CYP19A1, POLA1, FUT7, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, XDH 3.1251
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R, PPARD 2.8245
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.1251
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.1251
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1 2.7637
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4 2.6442
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, GRIA2, CHRM1, PPARA, GRIA4 2.6467
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.0179
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, MET, MCL1, IGF1R 2.4911
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, MET, IGF1R 2.5758
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7637
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.3376
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1, PPARD 2.4199
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, MCL1 2.0477
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.374
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, GRM5, CHRM1, GRM1 2.0477
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, TBXAS1 2.3509
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.3065
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0477
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.9076
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, SRC, CHRM4 1.8315
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 2.0233
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5907
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0872
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.334
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.289
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.0341
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0872
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9547
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, TRPV1 1.0492
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2619
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.289
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0649
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.2928
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2872
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1952
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9201
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.8851
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.93
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8216
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.8697
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PPARD 0.8351
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8438
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, MCL1 0.7838
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.5049
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7383
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.654
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6521
HTLV-I infection_Homo sapiens_hsa05166 POLB 0.2662
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.337
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3479
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3547
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3636
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5007
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3547
Apoptosis_Homo sapiens_hsa04210 MCL1 0.4268
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.408
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3 0.3811
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3962
Taste transduction_Homo sapiens_hsa04742 GRM1 0.5007
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4332
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4912
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4256
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5007
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.4739
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4739
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4372
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4887
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4856
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5007
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4944
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4544
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4887
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4605
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3 0.4584
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5007
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4544
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.7533
Axon guidance_Homo sapiens_hsa04360 MET 0.4498
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.4715
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4605
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4944
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4944
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5007
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5007
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4827
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4944
Peroxisome_Homo sapiens_hsa04146 XDH 0.5007
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5378
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5322
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5007
Glioma_Homo sapiens_hsa05214 IGF1R 0.5511
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5382
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5511
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5505
Bile secretion_Homo sapiens_hsa04976 CA2 0.5379
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5385
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.5877
Shigellosis_Homo sapiens_hsa05131 SRC 0.5511
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.5727
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.791
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6192
Malaria_Homo sapiens_hsa05144 MET 0.6295
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6492
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0477
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6938
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.7734
DNA replication_Homo sapiens_hsa03030 POLA1 0.7307
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7667
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7807
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7602
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7307
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8052
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7964
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.93
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0726


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)