TCM Prescription: Added Flavor GZFL Bolus



Prescription Description
Prescription IDTCMF1954
Pinyin NameJia Wei Gui Zhi Fu Ling Wan
Chinese Name加味桂枝茯苓丸
English NameAdded Flavor GZFL Bolus
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH1525 Crassostrea gigas 牡蛎 TCMH1525 BCMOL364-12
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1405 Penicillium citrinum
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CA2, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PPARA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 10.1582
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, BCL2, CA12, CA2, CA4, CA6, CA7, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 9.23408
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, BCL2, CA12, CA2, CA4, CA6, CA7, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 9.23408
[BP] GO:0048522 positive regulation of cellular process ACHE, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 9.00276
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, RORC, SLC6A4, SMAD3, SRC, TEK, TYR 8.85946
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ESR1, FABP3, FABP4, FDPS, FUT7, HSD17B2, MET, PPARA 8.45519
[BP] GO:0042127 regulation of cell proliferation ADRA2A, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 8.39623
[BP] GO:0010647 positive regulation of cell communication ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.365
[BP] GO:0023056 positive regulation of signaling ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.3607
[BP] GO:0048518 positive regulation of biological process ACHE, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 8.13031
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA12, CA2, CA4, CA6, CA7, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FDPS, FUT7, HSPA1A, PIM1, PPARA, TYR, XDH 8.09371
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, RORC, SLC6A4, SMAD3, SRC, TERT 7.73837
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, RORC, SLC6A4, SRC, TEK, TYR 7.31876
[BP] GO:0065008 regulation of biological quality ACHE, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MET, PPARA, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 7.2805
[BP] GO:0010646 regulation of cell communication ACHE, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 7.19331
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 7.11779
[BP] GO:0023051 regulation of signaling ACHE, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 7.08705
[BP] GO:0032501 multicellular organismal process ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, FABP4, HSD17B2, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TYR 6.97149
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, FABP3, FABP4, FDPS, FUT7, MET, PPARA 6.94915
[BP] GO:1902531 regulation of intracellular signal transduction ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 6.91655
[BP] GO:0009967 positive regulation of signal transduction ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.9155
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, BCL2, CA2, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK 6.86411
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC, TERT 6.79935
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, BCL2, CA2, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, PPARA, SLC6A4, SRC, TEK 6.77857
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.70772
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, FDPS, HSD17B2 6.57965
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, BCL2, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 6.57965
[BP] GO:0050896 response to stimulus ACHE, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 6.40737
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.37458
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT 6.33865
[BP] GO:0033993 response to lipid AXL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, RORC, SLC6A4, SRC, TYR 6.32199
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 6.3061
[BP] GO:0048584 positive regulation of response to stimulus ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.25176
[BP] GO:1902533 positive regulation of intracellular signal transduction ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 6.20204
[BP] GO:0030335 positive regulation of cell migration ADRA2A, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 6.13976
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 6.11282
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 6.11282
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK, TERT 6.00561
[BP] GO:2000147 positive regulation of cell motility ADRA2A, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.99105
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CBR1, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 5.98798
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NUAK1, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT 5.96549
[BP] GO:0032879 regulation of localization ACHE, ADRA2A, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT 5.96549
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PPARA 5.94549
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.90271
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, BCL2, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 5.90271
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.77808
[BP] GO:0040017 positive regulation of locomotion ADRA2A, BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.73473
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, RORC, SLC6A4, SMAD3, SRC 5.65162
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA6, CA7 5.65162
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.62129
[BP] GO:0014070 response to organic cyclic compound BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, RORC, SLC6A4, SRC, TEK, TYR 5.52606
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.51352
[BP] GO:0048583 regulation of response to stimulus ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.48747
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 5.47311
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.47311
[BP] GO:0010648 negative regulation of cell communication ACHE, ADRA2A, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 5.35841
[BP] GO:0023057 negative regulation of signaling ACHE, ADRA2A, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 5.34268
[BP] GO:0030334 regulation of cell migration ADRA2A, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.23997
[BP] GO:0009966 regulation of signal transduction ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.23883
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.22053
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FDPS, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 5.22053
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.22053
[BP] GO:0048585 negative regulation of response to stimulus ADRA2A, ALOX15, BCL2, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.14323
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.06193
[BP] GO:0042592 homeostatic process ADRA2A, AKR1B1, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, KCNH2, MET, SMAD3, SRC, TERT 5.02475
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 5.02475
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.01433
[BP] GO:2000145 regulation of cell motility ADRA2A, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 4.94417
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FDPS, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 4.90081
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, FDPS 4.86115
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.82078
[BP] GO:0019220 regulation of phosphate metabolic process ADRA2A, ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.79161
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADRA2A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 4.76323
[BP] GO:0051174 regulation of phosphorus metabolic process ADRA2A, ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.74591
[BP] GO:0009893 positive regulation of metabolic process ADRA2A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 4.71055
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, RORC 4.70366
[BP] GO:0048523 negative regulation of cellular process ACHE, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 4.69255
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.66223
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA6, CA7 4.61837
[BP] GO:0080134 regulation of response to stress ADRA2A, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.60443
[BP] GO:0040012 regulation of locomotion ADRA2A, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 4.56319
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADRA2A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 4.56319
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.55445
[BP] GO:0051270 regulation of cellular component movement ADRA2A, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 4.55382
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 4.49721
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, FDPS 4.47557
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.46775
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 4.40546
[BP] GO:0051049 regulation of transport ACHE, ADRA2A, ALOX15, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, HSPA1A, INSR, KCNH2, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TERT 4.38424
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.38424
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 4.38424
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.38424
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, KCNH2, MET, SMAD3 4.28763
[BP] GO:0031325 positive regulation of cellular metabolic process ADRA2A, ALOX15, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 4.27987
[BP] GO:0048519 negative regulation of biological process ACHE, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 4.25308
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, PPARA, RORC, SLC6A4, SRC 4.21234
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADRA2A, ALOX15, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.21234
[BP] GO:0045937 positive regulation of phosphate metabolic process ADRA2A, ALOX15, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.21234
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PPARA 4.17531
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 4.14203
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK, XDH 4.14203
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.12212
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 4.00004
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.00004
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 3.98535
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 3.98535
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.88177
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, FDPS, TYR 3.86223
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, TERT 3.85925
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.85925
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B2, TYR, XDH 3.85925
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, BCL2, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TERT, XDH 3.85925
[BP] GO:0042325 regulation of phosphorylation ADRA2A, ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 3.85211
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, HSPA1A 3.82462
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK, TYR 3.75876
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.75136
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.68536
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.68536
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.64682
[BP] GO:0009611 response to wounding ACHE, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.56762
[BP] GO:0001503 ossification ALOX15, BCL2, EGFR, MMP2, MMP9, TEK 3.55945
[BP] GO:0065009 regulation of molecular function ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.53123
[BP] GO:0051050 positive regulation of transport ACHE, ADRA2A, AXL, BCL2, CA2, CYP19A1, EGFR, INSR, KCNH2, MMP12, SLC6A4, SMAD3, SRC, TERT 3.52449
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.48375
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AOX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TYR, XDH 3.45766
[BP] GO:0019216 regulation of lipid metabolic process ADRA2A, CYP1A1, FABP3, FDPS, FLT3, PPARA, RORC, SRC, TEK 3.44657
[BP] GO:0009987 cellular process ACHE, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, BCL2, CA12, CA2, CA4, CA6, CA7, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GPR35, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 3.42586
[BP] GO:0042327 positive regulation of phosphorylation ADRA2A, ALOX15, BCL2, CDC25B, EGFR, ESRRB, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.40909
[BP] GO:0043408 regulation of MAPK cascade ADRA2A, ALOX15, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 3.39169
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SLC6A4, SRC, TERT 3.3883
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.37426
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, TYR 3.35941
[BP] GO:0044092 negative regulation of molecular function ADRA2A, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.29815
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CYP1A1, CYP1B1, EGFR, FABP3, KCNH2, KDR, SLC6A2, SLC6A4, SRC 3.29795
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.29711
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.28324
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 3.27129
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.2609
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.23937
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 3.2165
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, RORC, SLC6A4, SRC 3.20852
[BP] GO:0051239 regulation of multicellular organismal process ADRA2A, AXL, BCL2, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GPR35, HSPA1A, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIM1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 3.20456
[BP] GO:0010243 response to organonitrogen compound AKR1B1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SLC6A4, SRC, TEK, TYR 3.17505
[BP] GO:0043410 positive regulation of MAPK cascade ADRA2A, ALOX15, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 3.16789
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, AXL, BCL2, CA2, CYP1B1, EGFR, ESRRB, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TERT 3.16641
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, BCL2, CES1, CYP1A1, CYP1B1, KDR, SLC6A4, SRC 3.15578
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 3.1353
[BP] GO:0001932 regulation of protein phosphorylation ADRA2A, ALOX15, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.1224
[BP] GO:0050790 regulation of catalytic activity ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.09956
[BP] GO:0044093 positive regulation of molecular function ADRA2A, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, FLT3, HSPA1A, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.06334
[BP] GO:0031347 regulation of defense response CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 3.04766
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT 3.01999
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 3.00521
[BP] GO:0031399 regulation of protein modification process ADRA2A, ALOX15, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 2.98565
[BP] GO:0001934 positive regulation of protein phosphorylation ADRA2A, ALOX15, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.9724
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SLC6A4, SRC 2.9724
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, TYR 2.96615
[BP] GO:0009115 None AOX1, XDH 2.94097
[BP] GO:0051247 positive regulation of protein metabolic process ADRA2A, ALOX15, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.90791
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.90791
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, SLC6A4, SMAD3, SRC 2.90546
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.90546
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, TYR 2.90546
[BP] GO:1901698 response to nitrogen compound AKR1B1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SLC6A4, SRC, TEK, TYR 2.90273
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.85303
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.85303
[BP] GO:0043405 regulation of MAP kinase activity ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.83553
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTPN1, SRC 2.82852
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CES1, CYP19A1, FDPS, TYR 2.82852
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.81616
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TERT 2.81616
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.81249
[BP] GO:0048869 cellular developmental process ACHE, AXL, BCL2, CBR1, CDC25B, CES1, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, KDR, MET, MMP2, MMP9, RORC, SMAD3, SRC, TEK, TERT 2.78665
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, EGFR, ESR1, FLT3, RORC, SLC6A4, SRC 2.75209
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.75203
[BP] GO:0070920 None EGFR, ESR1, TERT 2.75203
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 2.74225
[BP] GO:0051726 regulation of cell cycle AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SLC6A4, SMAD3, SRC, TERT 2.73438
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, SLC6A2, SLC6A4, SMAD3 2.73438
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.72884
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.72884
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.72884
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.72884
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.71249
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.71189
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.69325
[BP] GO:0003006 developmental process involved in reproduction AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, SRC 2.67533
[BP] GO:0022414 reproductive process AKR1B1, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, MMP2, MMP9, SLC6A4, SRC 2.65901
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADRA2A, ALOX15, BCL2, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.65652
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.63984
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TERT 2.62831
[BP] GO:0009892 negative regulation of metabolic process ADRA2A, AURKB, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.62576
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.61409
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.61033
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.60693
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.589
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.589
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.57329
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.56386
[BP] GO:0046110 None AOX1, XDH 2.56386
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.56386
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.54021
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, SMAD3, SRC, TEK 2.53656
[BP] GO:0009894 regulation of catabolic process ADRA2A, BCL2, CSNK2A1, EGFR, ESRRB, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.52501
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.51483
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, EGFR, ESR1, MET, SMAD3, SRC 2.5129
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KCNH2, KDR, SRC 2.5129
[BP] GO:0010817 regulation of hormone levels ACHE, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD17B2 2.49233
[BP] GO:0043085 positive regulation of catalytic activity ADRA2A, AURKB, BCL2, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, TERT, XDH 2.4687
[BP] GO:0010675 None ESRRB, INSR, PPARA, RORC, SRC 2.41128
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT 2.40201
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.39925
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.39925
[BP] GO:0019222 regulation of metabolic process ACHE, ADRA2A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.39092
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.38708
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, SLC6A4 2.37191
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.35989
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.35989
[BP] GO:0001775 cell activation ADRA2A, ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, RORC, SMAD3, SRC 2.35601
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35244
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, FDPS, HSD17B2 2.34834
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, KCNH2, SMAD3 2.34674
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.34674
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.3285
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.32204
[BP] GO:0015711 organic anion transport CA12, CA14, CA2, CA4, CA6, CA7, FABP3, PPARA 2.32083
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AURKB, BCL2, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.32083
[BP] GO:0050793 regulation of developmental process AXL, BCL2, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, INSR, KDR, NUAK1, PIM1, PPARA, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.32083
[BP] GO:0006145 None AOX1, XDH 2.32065
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.32065
[BP] GO:0051894 None KDR, SMAD3, TEK 2.31856
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.31856
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.31856
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT 2.31856
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTPN1, SRC, TERT 2.31821
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, MET, SMAD3, SRC 2.27607
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.27429
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, FDPS, HSD17B2 2.27114
[BP] GO:0032268 regulation of cellular protein metabolic process ADRA2A, ALOX15, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.25664
[BP] GO:0019538 protein metabolic process ACHE, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 2.2279
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.22518
[BP] GO:1903393 None KDR, SMAD3, TEK 2.22518
[BP] GO:0051172 None ADRA2A, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.22144
[BP] GO:0043549 regulation of kinase activity ADRA2A, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.20524
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.18872
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, SRC 2.18183
[BP] GO:0035556 intracellular signal transduction ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, EGFR, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PTPN1, SRC, TEK 2.18075
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.16961
[BP] GO:0051338 regulation of transferase activity ADRA2A, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.16948
[BP] GO:0009896 positive regulation of catabolic process ADRA2A, CSNK2A1, ESRRB, HSPA1A, INSR, KDR, PPARA, PTPN1 2.16948
[BP] GO:0043271 negative regulation of ion transport ADRA2A, BCL2, GPR35, KCNH2, MMP9 2.16442
[BP] GO:0051128 regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, CSNK2A1, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPN1, SMAD3, SRC, TEK 2.13623
[BP] GO:0045931 positive regulation of mitotic cell cycle CDC25B, CYP1A1, DUSP3, INSR, TERT 2.12692
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.11404
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.0947
[BP] GO:0031401 positive regulation of protein modification process ADRA2A, ALOX15, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.08232
[BP] GO:0051704 multi-organism process AXL, BCL2, CYP1A1, EGFR, FDPS, HSPA1A, INSR, KDR, MET, MMP1, MMP12, SLC6A4, SMAD3, SRC 2.07728
[BP] GO:0006950 response to stress ACHE, AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 2.07072
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.07072
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.07072
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.07072
[BP] GO:0080090 regulation of primary metabolic process ADRA2A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 2.07072
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.06496
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, INSR, PPARA, SRC, TEK 2.0387
[BP] GO:1901890 None KDR, SMAD3, TEK 2.03808
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.03808
[BP] GO:2000352 None KDR, TEK, TERT 2.03808
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.03206
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT 2.02799
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.01747
[BP] GO:0032844 regulation of homeostatic process ADRA2A, AURKB, BCL2, CA2, CA7, EGFR, KDR, SRC 2.01747
[BP] GO:0003018 None ADRA2A, EGFR, SLC6A4, SRC, TEK 2.01747
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, FDPS, HSPA1A, INSR, KDR, MET, MMP1, SMAD3, SRC 2.01747
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, EGFR, ESR1, MET, SMAD3, SRC 2.01747
[BP] GO:0071396 cellular response to lipid AXL, EGFR, ESR1, FLT3, RORC, SLC6A4, SRC 2.01747
[BP] GO:1904063 None ADRA2A, GPR35, KCNH2, MMP9 2.01747
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.01747
[BP] GO:0046113 None AOX1, XDH 2.01747
[BP] GO:0051934 None SLC6A2, SLC6A4 2.01747
[BP] GO:0090494 None SLC6A2, SLC6A4 2.01747
[BP] GO:0090493 None SLC6A2, SLC6A4 2.01747
[BP] GO:0051583 None SLC6A2, SLC6A4 2.01747
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.01747
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19 2.01747
[CC] GO:0045121 membrane raft EGFR, INSR, KDR, SLC6A2, SLC6A4, SRC, TEK 2.41406
[CC] GO:0098857 membrane microdomain EGFR, INSR, KDR, SLC6A2, SLC6A4, SRC, TEK 2.40201
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, BCL2, CA2, CA4, CA7, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MMP2, MMP9, PIM1, PTPN1, SLC6A4, SMAD3, SRC, TERT, TYR, XDH 2.08761
[CC] GO:0005886 plasma membrane ACHE, ADRA2A, ALOX15, AXL, CA12, CA14, CA2, CA4, CSNK2A1, EGFR, ESR1, F10, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIM1, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 2.06312
[CC] GO:0098589 membrane region EGFR, INSR, KDR, SLC6A2, SLC6A4, SRC, TEK 2.01747
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.01747
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA12, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 13.9957
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, AOX1, AURKB, AXL, CA12, CA14, CA2, CA4, CA6, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 10.1582
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, CA12, CA14, CA2, CA4, CA6, CA7, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, EGFR, F10, FDPS, FLT3, FUT7, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TERT, TYR, XDH 10.0436
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA6, CA7 8.13031
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.51606
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.86411
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, AOX1, AURKB, CA12, CA14, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TYR, XDH 6.77857
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA6, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 6.45189
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, AOX1, AURKB, CA12, CA14, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TYR, XDH 6.43459
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH 5.98726
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.60292
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SLC6A4, SRC, TEK 5.45268
[MF] GO:0044877 macromolecular complex binding ACHE, ADRA2A, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC 5.45268
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.43449
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.43449
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 5.26348
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA6, CA7 5.177
[MF] GO:0032403 protein complex binding ACHE, ADRA2A, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC 5.12519
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.02167
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B2, TYR, XDH 4.76943
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA6, CA7 4.48494
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 4.44906
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.20465
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 4.04517
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, BCL2, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, SLC6A4, SMAD3, TERT, TYR, XDH 4.00004
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK, TERT 3.97038
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 3.97038
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.85925
[MF] GO:0038023 signaling receptor activity ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 3.72615
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.66935
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 3.43279
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.42586
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRB, HSPA1A, KCNH2, MET, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TEK 3.39169
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 3.30769
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD17B2, XDH 3.18329
[MF] GO:0004871 signal transducer activity ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, SMAD3, TEK 3.16249
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 3.15883
[MF] GO:0004872 receptor activity ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 3.11679
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, RORC 2.99479
[MF] GO:0060089 molecular transducer activity ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 2.95909
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.94097
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, PPARA, RORC 2.93845
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 2.91261
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.87814
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.80632
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.61033
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA6, CA7 2.57497
[MF] GO:0005330 None SLC6A2, SLC6A4 2.56386
[MF] GO:0047374 None CES1, CES2 2.56386
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.5129
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, FLT3, KCNH2, SLC6A4, SMAD3, TERT, TYR, XDH 2.41128
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.36932
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.32065
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.30829
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.13623
[MF] GO:0043559 insulin binding IGF1R, INSR 2.13623
[MF] GO:0097159 organic cyclic compound binding ADRA2A, AOX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.12139
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.10313
[MF] GO:0008134 transcription factor binding BCL2, ESR1, ESRRB, FLT3, PIM1, PPARA, SMAD3, SRC, TERT 2.08845
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.03808
[MF] GO:0005329 None SLC6A2, SLC6A4 2.01747
[MF] GO:0055131 None HSPA1A, KCNH2 2.01747
[MF] GO:0043546 None AOX1, XDH 2.01747


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.0356
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.2579
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA6, CA14 8.8864
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 6.0395
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.2568
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.2917
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, ALOX15, AKR1B1, TYR, CYP2C19, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, CES1 4.7272
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, BCL2, MMP9, MET, EGFR, IGF1R 4.2058
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.2058
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.7272
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.7397
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, CYP2C19 4.1159
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.7364
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.0547
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.443
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.443
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.2345
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 3.2061
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, CYP2C19 3.443
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1 2.768
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.2345
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2847
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, CYP2C19, SLC6A4 2.6319
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3673
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2, MMP9 2.2626
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2636
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2501
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2626
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2175
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0211
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2453
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.2125
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.6354
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.9851
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP2C19 2.2403
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.969
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.7809
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.5822
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.7153
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5345
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.5235
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.4165
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP2C19 3.2011
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.2159
HTLV-I infection_Homo sapiens_hsa05166 FDPS, SMAD3, TERT 1.0031
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.0031
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1479
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0876
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR 1.4165
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1139
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3465
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3747
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9682
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9423
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1349
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8901
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8952
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.1458
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9682
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1157
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.414
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.221
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9423
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8851
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8745
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3417
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8697
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8851
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.3695
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8557
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8324
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3939
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.8033
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3465
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 INSR, ADRA2A 0.8069
Influenza A_Homo sapiens_hsa05164 FDPS, HSPA1A 0.7875
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7802
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6776
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3206
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADRA2A 0.5596
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3534
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3436
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3493
cAMP signaling pathway_Homo sapiens_hsa04024 PPARA 0.3267
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3433
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3967
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4048
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4207
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4326
Platelet activation_Homo sapiens_hsa04611 SRC 0.4563
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4584
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.4584
Axon guidance_Homo sapiens_hsa04360 MET 0.4482
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4563
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4829
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5074
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5074
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5078
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5074
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5122
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5119
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5399
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5336
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5336
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5348
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.533
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5702
Peroxisome_Homo sapiens_hsa04146 XDH 0.5406
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.569
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5556
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5596
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5784
Bile secretion_Homo sapiens_hsa04976 CA2 0.5769
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5972
Shigellosis_Homo sapiens_hsa05131 SRC 0.5991
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6264
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8492
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7491
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6494
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6523
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6704
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8049
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6739
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7352
Malaria_Homo sapiens_hsa05144 MET 0.6811
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6849
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6849
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6849
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7552
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0328
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7875
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8557
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8207
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.833
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8573
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8292
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8557
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.8935
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2061
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3411


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)