TCM Prescription: Seven Ingredients Kidney Decoction



Prescription Description
Prescription IDTCMF1944
Pinyin NameQi Wei Zhi Shen Tang
Chinese Name起痿至神汤
English NameSeven Ingredients Kidney Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1455 Ranunculus japonicus 茅根 TCMH1455 ITSAF2010-14
TCMH2134 Smilax glabra 土茯苓 TCMH2134 CPBOL4081-11
TCMH2244 Prunella vulgaris 夏枯草 TCMH2244 ITSAH2424-14
TCMH2629 Cortex mori radicis praeparata 桑白皮 TCMH2629
TCMH357 Pericarpium arecae 大腹皮 TCMH357
TCMH2297 Cirsium setosum 小蓟 TCMH2297 ITSAJ4303-14
TCMH235 Periostracum cicadae 蝉蜕 TCMH235
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 8.62069
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 6.42497
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CDC25B, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TYR 5.94827
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 5.90278
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 5.88572
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 5.82279
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 5.82279
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 5.82279
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.70316
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, PTGS2, RORC, SRC, TYR 5.59206
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 5.59206
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CHRM1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, XDH 5.52752
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.44974
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.44974
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, CA2, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 5.25213
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 5.25213
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CHRM1, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 5.24818
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.21681
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC 5.21681
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.21681
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.14869
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.14197
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 5.08191
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 5.02887
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 4.95753
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR 4.9184
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 4.90619
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC, TYR 4.90619
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, CHRM1, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 4.78539
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.76093
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 4.70936
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 4.69241
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR 4.64852
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM4, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR 4.52931
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 4.50555
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 4.48586
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP4, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 4.47455
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 4.22237
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 4.20202
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.18733
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RORC, SRC 4.12083
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CHRM1, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 4.09436
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.09436
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 4.09436
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.05763
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.05763
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.97683
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.90203
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.85742
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.82973
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 3.81089
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SRC 3.7935
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.78629
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.75017
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FLT3, PPARA, PTGS2, SRC 3.74686
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, CYP1B1, FLT3, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.72859
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC 3.69934
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 3.67358
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.67358
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.53894
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.44801
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CHRM1, CHRM4, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.35629
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.32672
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 3.31395
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.31395
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 3.24641
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.23048
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 3.21872
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.21484
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC 3.21331
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.15499
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 3.12019
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.01881
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 2.94215
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.93646
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 2.88822
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.83271
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.81503
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.80874
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.795
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.795
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 2.76555
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PPARA, PTGS1, PTGS2 2.76505
[BP] GO:0042325 regulation of phosphorylation ADORA1, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.57424
[BP] GO:0051896 regulation of protein kinase B signaling AXL, MET, PIK3CA, PIK3CB, SRC, XDH 2.56998
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.54704
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.53382
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 2.50407
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.48637
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.47497
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.47497
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.47497
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.47447
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.43862
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, PTGS2 2.43862
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.42089
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, KDR, PIK3CB, PTGS2, SRC 2.42089
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, FABP4, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC 2.42089
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.42089
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, CA12, CA2, CA7, ESR1, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC 2.41103
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.39271
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.39271
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.39271
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.36626
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.34764
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.34764
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FLT3, PPARA, PTGS2, RORC, SRC 2.29456
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.29083
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.28859
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.28054
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, CDC25B, CHRM1, CSNK2A1, CYP1A1, CYP1A2, ESR1, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TYR, XDH 2.27037
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.27037
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.27037
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, MET, PIK3CA, PIK3CB, SRC 2.24246
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4 2.24246
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.24246
[BP] GO:1902532 negative regulation of intracellular signal transduction ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.23008
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.23008
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2 2.21942
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.19396
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.19268
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 2.17139
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, ESR1, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, XDH 2.16126
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.15799
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.15631
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.14928
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PTGS2, TYR 2.14928
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.14928
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.14928
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC 2.14343
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP4 2.1274
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, KDR, SRC 2.0956
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling IGF1R, PIK3CA, PIK3CB 2.0956
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.09142
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, PTGS2, SRC 2.08062
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.07901
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, ESR1 2.07901
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.06565
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.06563
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.06379
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, PTGS2, SRC 2.05197
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.04586
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, PPARA, RORC, SRC 2.04586
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.04586
[BP] GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SRC 2.04586
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, PIM1, PPARA, RORC, SRC 2.04586
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.04586
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.04586
[BP] GO:0015711 organic anion transport CA12, CA14, CA2, CA4, CA7, CA9, PPARA 2.03151
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HSD17B2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TYR 2.62424
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SRC 2.50407
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HSD17B2, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TYR 2.14928
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.98361
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, MET, PTGS2, SRC 1.84335
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH 10.6164
[MF] GO:0046914 transition metal ion binding ALOX5, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, TYR, XDH 10.6164
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 8.28437
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 7.49474
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.2302
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC 5.55411
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 5.27489
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC 5.1856
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 4.74228
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.7296
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 4.56894
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, TYR, XDH 4.44262
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 4.27791
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 4.20202
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, TYR, XDH 4.06005
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 3.9795
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.97367
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.80681
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.7935
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, XDH 3.4899
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.35629
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.21872
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.149
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 3.12019
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.02994
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 2.99461
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.97381
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.96363
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.88822
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.88772
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 2.85557
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.81503
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.81503
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.64433
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 2.63623
[MF] GO:0032403 protein complex binding ACHE, ADORA1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.40063
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, ESR1, FLT3, IGF1R, KDR, MET, PPARA, RORC 2.38311
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.27501
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.23008
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.15631
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, NQO2 2.10148
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.0956


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.2991
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 7.3085
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.3578
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 9.8677
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.8781
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, PIK3CA, CHRM4, PIK3CB 5.225
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 5.4538
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.1536
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.1664
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.8824
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.8824
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.1204
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, CHRM1, PIK3CA, ADORA1, PIK3CB, PPARA 4.0787
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.6977
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 4.0696
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 4.013
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, PIK3CA, KDR, PIK3CB, MET, IGF1R 3.8867
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, PIK3CA, SRC, CHRM4, PIK3CB 4.0017
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.4828
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 4.0207
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.7528
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.8324
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.7479
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, PIM1, PIK3CB 3.2574
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 3.2924
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.7428
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.6469
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 3.1581
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 3.1592
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 3.0445
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 3.0445
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 3.0679
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 3.0679
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, PIK3CB, MMP9 2.7652
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PIK3CB 3.0529
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, ADORA3, CHRM4, ADORA1 2.7153
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.7014
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.6308
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.5191
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.7153
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.7242
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.7153
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.2025
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, PIK3CB, IGF1R 2.4065
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGS1 2.7535
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.426
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 2.3121
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 2.4313
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.3556
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 2.0593
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, PIK3CB, IGF1R 2.2586
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, PTGS2, PTGS1 2.1712
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB 2.1226
PPAR signaling pathway_Homo sapiens_hsa03320 FABP4, MMP1, PPARA 2.6807
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 2.0729
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 2.02
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.9996
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 2.02
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.9
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.961
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.9801
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, PIK3CB 1.8582
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.6946
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB 1.6377
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.6362
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3305
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.3881
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4444
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4333
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4436
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.7815
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 1.1874
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 1.036
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM1 1.0241
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.5177
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.2071
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.1887
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 1.1699
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 1.1529
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.2203
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.4607
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.4531
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 1.291
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.401
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5613
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.5613
Axon guidance_Homo sapiens_hsa04360 MET 0.5556
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.3881
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.4042
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.3808
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.4156
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.3881
Melanogenesis_Homo sapiens_hsa04916 TYR 0.6325
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.4531
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.6325
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.643
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.6325
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.6423
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.6562
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.6572
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.6592
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.6592
Gap junction_Homo sapiens_hsa04540 SRC 0.6592
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.6582
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.6362
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.6686
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.6362
Peroxisome_Homo sapiens_hsa04146 XDH 0.6714
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.6383
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.6824
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.739
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.7151
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.7133
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.7245
Bile secretion_Homo sapiens_hsa04976 CA2 0.7226
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.6686
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, PIK3CB 1.7174
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.6895
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.7265
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.7846
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.7469
Shigellosis_Homo sapiens_hsa05131 SRC 0.7469
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.7471
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.7678
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.7469
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.841
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.8962
Malaria_Homo sapiens_hsa05144 MET 0.8422
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 2.02
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.9378
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.8554
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.8604
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.1912
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 2.1514
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 2.0729
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.9694
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 1.036
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.3885
Circadian rhythm_Homo sapiens_hsa04710 RORC 1.0259
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 1.0577
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.3015
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.4954


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)