TCM Prescription: Decoction with Direct Effect on Moyuan



Prescription Description
Prescription IDTCMF1899
Pinyin NameDa Yuan Yin
Chinese Name达原饮
English NameDecoction with Direct Effect on Moyuan
Function Description瘟疫初起先憎寒而后发热, 日后但热而无憎寒也, 脉不浮不沉而数, 昼夜发热, 日晡益甚, 头疼身痛
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationLung, blood
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH216 Fructus tsaoko 草果 TCMH216 GQ118666
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA, TBXAS1 7.87413
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.87413
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, MAOB, TYR 6.8058
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.72351
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.70315
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, TBXAS1, TYR, XDH 6.62917
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, ALOX15, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FABP3, FABP4, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, PPARA, TNKS, TNKS2, XDH 6.62917
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, AOX1, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, PDE5A, PPARA, TBXAS1, TYR, XDH 6.45898
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.4908
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, MAOB, PPARA, TYR 5.24146
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 4.99453
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.92419
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.77297
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.7613
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, MAOB, PPARA, TYR 4.67232
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.4039
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, MAOB, TYR 4.33591
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.21782
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, MAOB, TYR 3.94264
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, MAOB, PPARA 3.92465
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, BCL2, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, MAOB, PPARA, TYR 3.90504
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.90504
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, PPARA, TBXAS1 3.89346
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, PDE5A, PPARA, PTPN1, PTPRS, TBXAS1, TNKS, TNKS2, TYR, XDH 3.85944
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.85944
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.79117
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.7102
[BP] GO:0006690 icosanoid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.7102
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, PPARA, PTPRS, TYR 3.68654
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.64022
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.64022
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, BCL2, CA2, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, GBA2, HSD11B1, HSD17B2, MAOB, PPARA, PTPRS, TYR 3.38409
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, BCL2, CA2, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FUT7, GBA2, HSD11B1, HSD17B2, MAOB, PPARA, PTPRS, TNKS2, TYR 3.38409
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.3761
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FUT7, GBA2, HSD17B1, HSD17B2, MAOB, PDE5A, PPARA, PTPN1, PTPRS, TBXAS1, TNKS, TNKS2, TYR, XDH 3.36154
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.34623
[BP] GO:0006631 fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, TBXAS1 3.31053
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2 3.22002
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA 3.20092
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.12648
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.11815
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.11815
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.89152
[BP] GO:0042493 response to drug ABCB1, AKR1B1, BCL2, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, MAOB 2.89152
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, MAOB 2.89152
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, HCAR2, PDE5A, PTPN1, TNKS, TNKS2, XDH 2.80469
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 2.80469
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.7987
[BP] GO:0032787 None ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PPARA, TBXAS1 2.7987
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, HCAR2, PDE5A, PTPN1, TNKS, TNKS2, XDH 2.7987
[BP] GO:0009115 None AOX1, XDH 2.70206
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.64208
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MAOB 2.64015
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, HCAR2, MAOB, PDE5A, PPARA, PTPN1, TNKS, TNKS2, XDH 2.59424
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.56915
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HCAR2, MAOB, PDE5A, PPARA, PTPN1, TNKS, TNKS2, XDH 2.56389
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, MAOB, PPARA 2.56204
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, MAOB 2.53401
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, MAOB 2.51302
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.44345
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA 2.44345
[BP] GO:0046110 None AOX1, XDH 2.30844
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.30844
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.26055
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MAOB 2.26055
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.2187
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.16171
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.16171
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.16171
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, CNR1, HCAR2, TNKS, TNKS2 2.14554
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F3, HCAR2, PDE5A, PTPN1, PTPRS, TNKS, TNKS2, XDH 2.1364
[BP] GO:0032844 regulation of homeostatic process BCL2, CA2, CA7, CDK6, CNR1, HCAR2, TNKS, TNKS2 2.07765
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F3, HCAR2, PDE5A, PTPN1, PTPRS, TNKS, TNKS2, XDH 2.07765
[BP] GO:0070213 None TNKS, TNKS2 2.07765
[BP] GO:0006145 None AOX1, XDH 2.07765
[BP] GO:0038171 None CNR1, CNR2 2.07765
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.07765
[CC] GO:0031233 None CA4, F10, F3 2.30844
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX15, AOX1, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, F10, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, PDE5A, PTPN1, PTPRS, TBXAS1, TNKS, TNKS2, TYR, XDH 1.82781
[CC] GO:0044425 membrane part ABCB1, ACHE, ALOX15, ALPL, BCL2, CA12, CA14, CA2, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, F3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, MAOB, PTPN1, PTPRS, TBXAS1, TYR 1.70286
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1, TBXAS1 1.64085
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GBA2, HSD11B1, HSD11B2, HSD17B2, TBXAS1 1.60316
[MF] GO:0046914 transition metal ion binding ALOX15, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, PPARA, PTPN1, TBXAS1, TNKS, TYR, XDH 8.3598
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 7.87413
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, TBXAS1, TYR, XDH 7.66887
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, PDE5A, PTPN1, PTPRS, TBXAS1, TNKS, TNKS2, TUBB3, TYR, XDH 7.06723
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.62917
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.9716
[MF] GO:0005506 iron ion binding ALOX15, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.86128
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD17B1, MAOB, PDE5A, PPARA, PTPN1, PTPRS, TBXAS1, TNKS, TNKS2, TUBB3, TYR, XDH 4.77297
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.50609
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.33591
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.02167
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.90504
[MF] GO:0008289 lipid binding ALOX15, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 3.89346
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.89346
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.89346
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.89167
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.68654
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 3.64173
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.60244
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, MAOB, TBXAS1, XDH 3.5583
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.51952
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.45904
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.36154
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, PPARA, PTPN1, TNKS 3.25757
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 2.89152
[MF] GO:0043169 cation binding ACHE, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, PDE5A, PPARA, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 2.80936
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.74777
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.71383
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.70206
[MF] GO:0003845 None HSD11B1, HSD11B2 2.70206
[MF] GO:0046872 metal ion binding ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, PDE5A, PPARA, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 2.59061
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.56411
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.44345
[MF] GO:0004949 None CNR1, CNR2 2.30844
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.24683
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.11905
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.07765


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.7642
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOB, ALOX15, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 7.3235
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.7642
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1 5.7409
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 5.3386
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.587
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4, BCL2 3.8139
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.4026
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, AOX1, TYR 2.9241
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX15, TBXAS1 2.2254
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, CNR2, CNR1, CHRM4 2.2211
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2211
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ABCB1, BCL2, CYP1B1, CDC25B 2.114
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2, AOX1 2.2211
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, PPARA 1.9344
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.2211
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, BCL2 1.2378
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2907
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, CHRM4 1.1543
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.1914
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.1914
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.1889
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 BCL2, F3 1.0211
Estrogen signaling pathway_Homo sapiens_hsa04915 ESR1, ESR2 1.0241
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.1105
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1543
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8105
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.061
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9731
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8035
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, ALOX15 0.9646
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6885
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9634
Hepatitis B_Homo sapiens_hsa05161 CDK6, BCL2 0.8239
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8681
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9069
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.7875
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7693
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM1 0.7416
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.7496
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6794
Pathways in cancer_Homo sapiens_hsa05200 CDK6, BCL2 0.4602
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.5054
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5054
Prostate cancer_Homo sapiens_hsa05215 BCL2 0.5213
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5054
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 ESR1 0.4664
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4664
Platelet activation_Homo sapiens_hsa04611 TBXAS1 0.4651
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4472
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3064
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2 0.5032
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.4664
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4472
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5054
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.4664
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4479
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4078
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.4472
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.5054
Gap junction_Homo sapiens_hsa04540 TUBB3 0.5213
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.4472
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4343
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB 0.4543
Focal adhesion_Homo sapiens_hsa04510 BCL2 0.3675
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5054
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4369
Rap1 signaling pathway_Homo sapiens_hsa04015 CNR1 0.3621
Proteoglycans in cancer_Homo sapiens_hsa05205 ESR1 0.3675
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6 0.3675
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5213
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4472
Alcoholism_Homo sapiens_hsa05034 MAOB 0.3965
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3894
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.3965
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5701
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PDE5A 0.4078
Phagosome_Homo sapiens_hsa04145 TUBB3 0.4317
Glioma_Homo sapiens_hsa05214 CDK6 0.5786
Melanoma_Homo sapiens_hsa05218 CDK6 0.5743
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5786
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5701
Peroxisome_Homo sapiens_hsa04146 XDH 0.5311
Amphetamine addiction_Homo sapiens_hsa05031 MAOB 0.5786
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5743
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5899
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.6242
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5743
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6242
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6242
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6449
Cocaine addiction_Homo sapiens_hsa05030 MAOB 0.6428
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.6419
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6411
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6794
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6438
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6449
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6449
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6484
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.6794
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7496
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0768
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7607
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7875
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7815
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.8016
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.9048
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8918
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9646
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1914


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)