TCM Prescription: Four Deity Pills



Prescription Description
Prescription IDTCMF1816
Pinyin NameSi Shen Wan
Chinese Name四神丸
English NameFour Deity Pills
Function Description目昏云翳
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationLiver
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH1741 Myristica fragrans 肉豆蔻 TCMH1741 GENG137-13, GBVH1657-11
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH2216 Evodia rutaecarpa 吴茱萸 TCMH2216
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
TCMH388 Ziziphus jujuba 大枣 TCMH388 ITSAM869-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT48 SCN5A Sodium channel protein type V alpha subunit Ion channel Q14524
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT559 ADRB2 Beta-2 adrenergic receptor GPCR P07550
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT609 CTSL Cathepsin L Unclassified P07711
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT649 DRD5 Dopamine D5 receptor GPCR P21918
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1312 Enterococcus durans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MAOA, MET, MTNR1B, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1, XDH 13.6213
[BP] GO:0042221 response to chemical ADRB2, AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, PPARG, PTGES, RORC, SMAD3, SRC, TEK, TRPV1, TYR 13.6213
[BP] GO:0010033 response to organic substance ADRB2, AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, PPARG, PTGES, RORC, SMAD3, SRC, TEK, TRPV1, TYR 13.5153
[BP] GO:1901700 response to oxygen-containing compound ADRB2, AKR1B1, ALPL, AXL, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, HSD17B2, HSP90AB1, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, PPARG, PTGES, RORC, SRC, TEK, TRPV1, TYR 13.0978
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B2, MET, PPARA, PPARG, PTGES, TBXAS1, TRPV1 12.075
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FLT3, GPR35, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MTNR1A, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 12.075
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 12.018
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 12.0005
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, ADRB2, AKR1B1, ALOX12, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, INSR, MET, MTNR1B, PPARG, SMAD3, SRC, TRPV1 11.7378
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, PTGES, RORC, SRC, TEK, TRPV1, TYR 10.717
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 10.6494
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MTNR1A, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 10.6494
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 10.401
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP9, MTNR1B, NUAK1, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 10.1598
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP9, MTNR1B, NUAK1, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 10.0077
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PPARG, PTGES, SMAD3, SRC, TEK, XDH 9.87089
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 9.67924
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 9.47452
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRB2, ALOX12, ALOX15, AXL, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, GPR35, HCAR2, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, MTNR1B, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TRPV1 9.44545
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 9.41467
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FABP3, FUT7, HSPA1A, HTR2B, HTR2C, PIM1, PPARA, PPARG, PTGES, TBXAS1, TYR, XDH 9.41467
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 9.36788
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, AXL, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 9.24782
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 9.20013
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, MMP2, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1, TYR 9.01986
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, HSP90AB1, HTR2A, HTR2B, HTR2C, KDR, NR3C1, PPARG, SRC, TRPV1 8.95362
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, MTNR1B, PPARG, SMAD3, TRPV1 8.68697
[BP] GO:0070887 cellular response to chemical stimulus ADRB2, AKR1B1, ALOX15, ALPL, AXL, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARG, RORC, SMAD3, SRC, TRPV1 8.63936
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, ADRB2, ALOX15, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 8.57451
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PPARA, PPARG, PTGES, TBXAS1 8.5443
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, ADRB2, ALOX15, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 8.50643
[BP] GO:0009719 response to endogenous stimulus ADRB2, AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, DRD1, DRD5, EGFR, ESR1, FABP3, FLT3, IGF1R, INSR, MMP2, NR3C1, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1 8.4112
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, ADRB2, ALOX15, CDC25B, DRD1, DRD2, DRD5, EGFR, FABP3, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH 8.28944
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, ADRB2, ALOX15, CDC25B, DRD1, DRD2, DRD5, EGFR, FABP3, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH 8.28944
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 8.28693
[BP] GO:0044237 cellular metabolic process ACHE, ADRB2, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, NQO2, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 8.27782
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, ADRB2, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NR3C1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 8.25477
[BP] GO:0071310 cellular response to organic substance ADRB2, AKR1B1, ALOX15, ALPL, AXL, CDK6, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP2, NR3C1, PPARG, RORC, SMAD3, SRC, TRPV1 8.25477
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PPARG, PTGES, TBXAS1 8.08698
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PPARA, PPARG, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR 7.83137
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRB1, ADRB2, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 7.82631
[BP] GO:0001659 None ADORA1, ADRB1, ADRB2, DRD1, DRD2, HTR2A, TRPV1 7.80971
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, ADRB2, ALOX15, AURKB, CDC25B, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FABP3, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NR3C1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 7.80971
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSP90AB1, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 7.79592
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 7.79135
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSP90AB1, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARG, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 7.79135
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRB1, ADRB2, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 7.77473
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 7.75592
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AXL, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP2, MMP9, MTNR1A, MTNR1B, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 7.703
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, ADRB2, AKR1B1, ALOX12, DRD1, DRD2, HTR2A, MET, TRPV1 7.68116
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR2C, KDR, SRC, TRPV1 7.68024
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD17B2, MAOA, NQO2, PPARG, TBXAS1, TYR, XDH 7.60327
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, ADRB2, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FABP3, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NR3C1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 7.51662
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FABP4, HSD17B2, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1, TYR 7.51402
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, NR3C1, PPARG, PTGES, RORC, SRC, TYR 7.50629
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CDK6, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2A, HTR2B, HTR2C, KDR, SRC, TRPV1 7.49323
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, RORC, SRC, TRPV1 7.24584
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, ADRB2, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MMP9, NUAK1, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 7.21395
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSP90AB1, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIM1, PPARG, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 7.21395
[BP] GO:0010243 response to organonitrogen compound ADRB2, AKR1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, SRC, TEK, TRPV1, TYR 7.15633
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HCAR2, HSD11B1, HSD17B2, HTR2A, HTR2C, MTNR1B 7.09823
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, PPARA, PPARG, RORC, SRC, TEK 7.08732
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GPR35, HCAR2, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 7.06257
[BP] GO:0045776 None ADORA1, ADRB1, ADRB2, DRD2, DRD3, DRD5, PPARA 6.96878
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, ADRB2, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MTNR1A, NR3C1, PPARA, PPARG, RORC, SMAD3, SRC, TRPV1 6.95665
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, TEK 6.93575
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, ESR1, HSD11B1, HSD17B2 6.93039
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC, TEK 6.91305
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK 6.89943
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.8489
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, HSP90AA1, HSP90AB1, INSR, MAOA, SMAD3, TRPV1 6.79138
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRB2, ALOX15, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, HCAR2, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, MMP9, MTNR1B, PPARA, PPARG, PTPN1, SMAD3, SRC, TRPV1 6.73921
[BP] GO:1901698 response to nitrogen compound ADRB2, AKR1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, SRC, TEK, TRPV1, TYR 6.68734
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRB2, AKR1B1, ALOX12, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GPR35, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PPARG, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 6.68734
[BP] GO:0003018 None ADORA1, ADRB1, ADRB2, DRD1, DRD5, EGFR, HTR2A, HTR2B, SRC, TEK 6.68734
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK 6.68515
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, HSP90AB1, NQO2, RORC 6.61702
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 6.56062
[BP] GO:0051716 cellular response to stimulus ADRB2, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PPARG, PTPN1, RORC, SMAD3, SRC, TRPV1 6.5005
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, ADRB2, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, MTNR1A, NR3C1, PPARA, PPARG, RORC, SMAD3, SRC, TRPV1 6.49872
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, NR3C1, PPARA, PPARG, SRC, TEK, TRPV1 6.49327
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSP90AB1, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 6.48963
[BP] GO:1901701 cellular response to oxygen-containing compound ADRB2, AKR1B1, AXL, CDK6, CYP1B1, DRD1, DRD5, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARG, RORC, SRC, TRPV1 6.4827
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PPARG, SRC, TEK 6.35867
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, MTNR1A, MTNR1B, PPARA, PPARG, RORC, SRC 6.35326
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSP90AB1, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 6.34788
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK 6.33168
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRB2, ALOX15, DRD2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, PTPN1, SRC, TEK, XDH 6.26733
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, CDK6, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 6.16844
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK 6.16844
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, HSPA1A, MAOA 6.10057
[BP] GO:0007187 None ADORA1, ADRB1, ADRB2, DRD1, DRD2, DRD3, DRD5, HTR6, MTNR1A, MTNR1B 6.07952
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRB1, ADRB2, AURKB, CDC25B, DRD2, DRD5, EGFR, ESR1, ESR2, F3, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, INSR, MET, MMP9, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 6.05343
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRB2, ALOX12, ALOX15, CDK6, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 6.05343
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 6.02853
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRB2, ALOX15, DRD2, DUSP3, EGFR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 6.01599
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 5.96832
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGES, SRC 5.9433
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.8896
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRB2, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP9, PPARG, PTPN1, SMAD3, SRC, XDH 5.8341
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.8341
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRB2, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC 5.8341
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRB2, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP9, PPARG, PTPN1, SMAD3, SRC, XDH 5.81775
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.81666
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.81666
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PPARG, PTGES, TBXAS1 5.77629
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, ADRB2, AURKB, CDC25B, DRD2, DRD5, EGFR, ESR1, F3, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, INSR, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 5.76413
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSP90AB1, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 5.73909
[BP] GO:0008217 None ADORA1, ADRB1, ADRB2, DRD2, DRD3, DRD5, PPARA, PPARG, SMAD3 5.73528
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, PPARA, PPARG, SMAD3, SRC, TEK, TYR 5.73277
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSP90AA1, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 5.72586
[BP] GO:0009266 None ADORA1, ADRB1, ADRB2, HSP90AA1, HSPA1A, HTR2A, HTR2B, PPARG, TRPV1 5.7187
[BP] GO:0003013 None ADORA1, ADRB1, ADRB2, DRD1, DRD5, EGFR, HTR2A, HTR2B, SRC, TEK 5.68593
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSP90AB1, HTR2A, HTR2B, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, PPARG, RORC, SMAD3, SRC, TEK, TYR 5.67509
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 5.66355
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, ADRB2, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 5.63127
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, MAOA, TYR 5.62602
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRB2, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, XDH 5.60252
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 5.60252
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 5.60252
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F3, INSR, MET, SRC, TEK, XDH 5.59329
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, PPARG, TRPV1 5.59329
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB1, ADRB2, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, IGF1R, INSR, MET, MTNR1A, NR3C1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC 5.59233
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DRD2, DUSP3, EGFR, HTR2A, HTR2B, HTR2C, KDR, PTPN1, SRC, TEK 5.58626
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC, TEK 5.55808
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.53273
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, EGFR, HSP90AB1, KDR, NR3C1, SRC, TRPV1 5.46584
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRB2, ALOX15, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 5.44783
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRB2, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, IGF1R, INSR, PPARG, PTPN1, SRC, TEK 5.41585
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, ADRB2, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 5.40713
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRB2, ALOX15, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 5.37739
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRB2, ALOX15, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 5.3767
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRB2, ALOX15, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 5.37203
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSP90AA1, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 5.37203
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.35139
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRB2, ALOX15, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 5.2476
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, ADRB2, ALOX12, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, F3, HCAR2, HSPA1A, HTR2A, HTR2B, KDR, MET, MMP9, PIM1, PPARG, SMAD3, SRC, TEK, TRPV1 5.23445
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, HSP90AA1, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 5.21873
[BP] GO:0097746 None ADORA1, ADRB1, ADRB2, DRD1, DRD5, EGFR, HTR2A, HTR2B 5.21672
[BP] GO:0035296 None ADORA1, ADRB1, ADRB2, DRD1, DRD5, EGFR, HTR2A, HTR2B 5.21672
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRB2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, HTR2A 5.21672
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRB2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, HTR2A 5.21672
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRB1, ADRB2, CA2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, INSR, MTNR1A, MTNR1B, PPARG, SRC 5.20816
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, ADRB2, ALOX12, AXL, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, GPR35, HCAR2, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MET, MMP9, PIM1, PPARG, SMAD3, SRC, TEK, TRPV1, XDH 5.20711
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRB2, ALOX15, CDC25B, DRD2, EGFR, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 5.16597
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, DRD5, EGFR, PPARA, SMAD3 5.14675
[BP] GO:0098771 inorganic ion homeostasis CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 5.14088
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRB2, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, HSP90AB1, HTR2B, INSR, PPARG, SMAD3, SRC, TRPV1 5.059
[BP] GO:0007200 None DRD1, DRD2, DRD5, ESR1, HTR2A, HTR2B, HTR2C 5.04808
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 5.04748
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B2 5.04212
[BP] GO:0050880 None ADORA1, ADRB1, ADRB2, DRD1, DRD5, EGFR, HTR2A, HTR2B 5.03983
[BP] GO:0035150 None ADORA1, ADRB1, ADRB2, DRD1, DRD5, EGFR, HTR2A, HTR2B 5.01658
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1, XDH 4.96143
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, HSP90AA1, KDR, SRC 4.92587
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRB2, ALOX15, CDC25B, DRD2, EGFR, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 4.91492
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALOX15, AURKB, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.91078
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX15, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD5, EGFR, HSP90AA1, HSP90AB1, HSPA1A, HTR2C, MMP2, MMP9, NUAK1, PPARA, PPARG, PTGES, PTPN1, SMAD3, SRC, TEK, TRPV1 4.91078
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, KDR, MET, PPARA, PPARG, SMAD3, TEK 4.84179
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, DRD2, EGFR, HTR2A, HTR2B, HTR2C, KDR, SRC, TEK 4.83883
[BP] GO:0071495 cellular response to endogenous stimulus ADRB2, AKR1B1, DRD1, DRD5, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, NR3C1, PPARG, SMAD3, SRC, TRPV1 4.83883
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 4.83883
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRB2, AURKB, CDC25B, DRD2, EGFR, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, INSR, PTPN1, SRC, TEK 4.82662
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.81477
[BP] GO:0072507 divalent inorganic cation homeostasis DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 4.76936
[BP] GO:0009410 None DRD1, DRD2, DRD3, DRD5, EGFR, HSP90AB1, NR3C1, PPARG 4.74352
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRB2, ALOX15, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 4.74173
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, MMP9, PIM1, PPARA, PPARG, RORC, SMAD3, SRC, TEK, TYR 4.63536
[BP] GO:0044057 None ADORA1, ADORA3, ADRB1, ADRB2, DRD2, DRD3, EGFR, GPR35, HCAR2, HTR2A, HTR2C, SMAD3, TRPV1 4.63536
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, ADRB2, AKR1B1, ALPL, AURKB, AXL, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, HSP90AA1, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TYR, XDH 4.5959
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD1, DRD2, DRD3, PPARA, PPARG, SMAD3, TEK 4.59583
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, DRD5, HTR2A 4.56202
[BP] GO:0030335 positive regulation of cell migration ALOX12, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.52946
[BP] GO:0055080 cation homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 4.50796
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.50109
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR 4.50109
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.49071
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B2 4.47919
[BP] GO:0001963 None DRD1, DRD2, DRD3, DRD5 4.44424
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 4.44256
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRB2, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HSP90AB1, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC, TEK 4.42328
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, PPARG, TRPV1 4.42081
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRB2, CDC25B, DRD2, EGFR, FLT3, HSP90AB1, HTR2A, HTR2B, INSR, PTPN1, SRC, TEK 4.39568
[BP] GO:2000147 positive regulation of cell motility ALOX12, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.38978
[BP] GO:0007190 None ADORA3, ADRB1, ADRB2, DRD1, DRD5 4.38276
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PPARG, PTGES, TBXAS1, TYR 4.36673
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.33743
[BP] GO:0006874 cellular calcium ion homeostasis DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 4.31281
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1, XDH 4.31072
[BP] GO:0007154 None ADORA1, ADRB1, ADRB2, AXL, DRD1, DRD2, DRD3, DRD5, ESR2, HTR2A, HTR2C, HTR6, MTNR1B, PPARG, TEK, TRPV1 4.31072
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRB1, ADRB2, ALOX15, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.31072
[BP] GO:0007189 None ADRB1, ADRB2, DRD1, DRD2, DRD3, DRD5 4.29771
[BP] GO:1900542 None ADRB1, DRD1, DRD2, DRD3, DRD5, HTR2A, INSR, MTNR1A, PPARA 4.2809
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.2809
[BP] GO:0019932 second-messenger-mediated signaling ADRB1, ADRB2, DRD1, DRD2, DRD3, DRD5, EGFR, HTR2B, KDR 4.26887
[BP] GO:0030003 cellular cation homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 4.25571
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.20972
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, NR3C1, PIM1, PPARA, PPARG, RORC, SRC 4.20972
[BP] GO:0055074 calcium ion homeostasis DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 4.19968
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.19373
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRB2, CA2, CA7, DRD1, DRD2, EGFR 4.18954
[BP] GO:0006140 None ADRB1, DRD1, DRD2, DRD3, DRD5, HTR2A, INSR, MTNR1A, PPARA 4.18954
[BP] GO:0071417 cellular response to organonitrogen compound ADRB2, AKR1B1, DRD1, DRD5, EGFR, IGF1R, INSR, MMP2, PPARG, SRC, TRPV1 4.1849
[BP] GO:0072503 cellular divalent inorganic cation homeostasis DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 4.15606
[BP] GO:0006873 cellular ion homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 4.15395
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSP90AB1, HSPA1A, MMP2, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK 4.14692
[BP] GO:0040017 positive regulation of locomotion ALOX12, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.1427
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRB2, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HSP90AB1, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 4.13649
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, MAOA, TYR 4.1214
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR 4.10965
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, MAOA 4.10461
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, MAOA 4.09922
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, MAOA 4.09922
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALOX15, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.07719
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, HSP90AA1, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.06578
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRB2, ALOX15, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 4.06578
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, HSP90AA1, HSPA1A, MAOA, MMP1, MMP2, MMP9, SRC, XDH 4.03763
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRB2, DUSP3, EGFR, FLT3, HSP90AB1, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 4.02294
[BP] GO:0050793 regulation of developmental process ADRB1, ADRB2, ALOX12, AXL, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, HSP90AB1, HTR2A, HTR2C, INSR, KDR, NUAK1, PIM1, PPARA, PPARG, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.02195
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, NR3C1, PPARA, PPARG, RORC, SRC 4.01455
[BP] GO:1903426 None EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 4.01455
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, HTR2C, TRPV1 4.01455
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, HTR2C, TRPV1 4.01455
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.98365
[BP] GO:0051130 positive regulation of cellular component organization ADRB2, ALOX15, AURKB, AXL, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, SMAD3, SRC, TEK 3.97846
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.9606
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.9606
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRB2, CDC25B, DRD2, EGFR, FLT3, HSP90AB1, HTR2A, HTR2B, INSR, PTPN1, SRC 3.94068
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.92791
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 3.92278
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, MTNR1A, MTNR1B, PPARA, RORC 3.89653
[BP] GO:1901699 cellular response to nitrogen compound ADRB2, AKR1B1, DRD1, DRD5, EGFR, IGF1R, INSR, MMP2, PPARG, SRC, TRPV1 3.89328
[BP] GO:0051098 regulation of binding ADRB2, AURKB, CYP2D6, HSP90AB1, MET, MMP9, PPARA, PPARG, SMAD3, SRC 3.89309
[BP] GO:0006939 None DRD1, DRD2, HTR2A, HTR2B, TRPV1 3.8892
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PPARG, PTGES, TBXAS1, TYR 3.88288
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 3.84989
[BP] GO:0007267 None ADORA1, ADRB1, ADRB2, DRD1, DRD2, DRD3, DRD5, ESR2, HTR2A, HTR2C, HTR6, MTNR1B, TEK 3.83978
[BP] GO:1901652 response to peptide ADRB2, AKR1B1, FABP3, IGF1R, INSR, PPARA, PPARG, SRC, TEK, TRPV1 3.83605
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRB2, EGFR, FLT3, HSP90AB1, HTR2A, HTR2B, INSR, PTPN1, SRC 3.81532
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRB2, ALOX15, CDC25B, DRD2, EGFR, FLT3, HSP90AB1, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.81225
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PPARG, PTGES, TBXAS1, TYR 3.79494
[BP] GO:0043279 None DRD2, DRD3, DRD5, HSP90AB1, PPARG, TRPV1 3.78195
[BP] GO:0019933 None ADRB1, ADRB2, DRD1, DRD2, DRD3, DRD5 3.78195
[BP] GO:0032845 None ADORA1, DRD2, HTR2A, HTR2B, HTR2C, SRC, TRPV1 3.75293
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.75173
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.75173
[BP] GO:0007610 None DRD1, DRD2, DRD3, DRD5, EGFR, HTR2A, HTR2B, HTR2C, INSR, MTNR1A, PPARA, TRPV1 3.75134
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 3.73243
[BP] GO:0055065 metal ion homeostasis DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 3.71295
[BP] GO:0007210 None HTR2A, HTR2B, HTR2C, HTR6 3.69559
[BP] GO:0098664 None HTR2A, HTR2B, HTR2C, HTR6 3.69559
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRB1, ADRB2, ALOX15, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 3.69507
[BP] GO:0051480 regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 3.67619
[BP] GO:0040008 regulation of growth ADRB1, ADRB2, ALOX12, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIM1, PPARG, SMAD3 3.66877
[BP] GO:0055082 cellular chemical homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 3.66877
[BP] GO:0090066 None ADORA1, ADRB1, ADRB2, ALOX15, DRD1, DRD5, EGFR, HSP90AB1, HTR2A, HTR2B 3.65027
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSP90AB1, INSR, SRC 3.63081
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F3, INSR, MET, SRC, TEK 3.6208
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, PPARG, RORC 3.62048
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, PPARG, SMAD3, SRC, TEK 3.61206
[BP] GO:0035556 intracellular signal transduction ADRB1, ADRB2, AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SRC, TEK 3.6058
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.57748
[BP] GO:0031649 None ADRB1, ADRB2, TRPV1 3.57748
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.57748
[BP] GO:0019935 None ADRB1, ADRB2, DRD1, DRD2, DRD3, DRD5 3.57748
[BP] GO:0001975 None DRD1, DRD2, DRD3, DRD5 3.57068
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, HTR2C, TRPV1 3.56768
[BP] GO:0007188 None ADORA1, ADRB1, ADRB2, DRD1, DRD2, DRD3, DRD5 3.56164
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.56164
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.56164
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.56164
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.56164
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR2B, SRC, TRPV1 3.53999
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, DRD5, EGFR 3.53938
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2 3.50607
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, HTR2A 3.50607
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP4, HCAR2, HSP90AB1, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 3.46143
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, ADRB2, AXL, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TRPV1 3.45991
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRB2, CSNK2A1, EGFR, HCAR2, HSP90AB1, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PPARA, PTPN1, SMAD3 3.45991
[BP] GO:0042417 None DRD1, DRD2, DRD3, MAOA 3.4578
[BP] GO:0044236 multicellular organism metabolic process ADRB1, ADRB2, MMP1, MMP2, MMP9, TRPV1 3.45404
[BP] GO:0006875 cellular metal ion homeostasis DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 3.45173
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B2 3.44424
[BP] GO:0002024 None ADRB1, ADRB2, TRPV1 3.43322
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.41462
[BP] GO:0023052 None ADORA1, ADRB1, ADRB2, DRD1, DRD2, DRD3, DRD5, ESR2, HTR2A, HTR2C, HTR6, MTNR1B, TEK 3.401
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, NR3C1, PPARA, PPARG, RORC, SRC 3.39537
[BP] GO:0090087 None ACHE, ADORA1, CA2, DRD2, DRD3, EGFR, HCAR2, HSP90AB1, HTR2B, HTR2C, MTNR1B, PTPN1, SMAD3, SRC 3.38948
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR2A, HTR2B 3.35446
[BP] GO:0060402 None DRD2, HTR2A, HTR2B, HTR2C, TRPV1 3.35446
[BP] GO:0051336 regulation of hydrolase activity ADRB1, CSNK2A1, DRD2, EGFR, ESR1, F3, HSP90AB1, HSPA1A, HTR2A, HTR2B, MMP9, NUAK1, PPARG, PTPN1, SMAD3, SRC, XDH 3.35131
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGES 3.33819
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, PPARA, PPARG, SMAD3, TEK 3.33653
[BP] GO:0051282 None DRD1, DRD2, HTR2A, HTR2B, HTR2C, TRPV1 3.31471
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PPARG, PTGES, SRC 3.30918
[BP] GO:0042220 None DRD2, DRD3, DRD5, HSP90AB1 3.30138
[BP] GO:0045744 None ADRB2, DRD2, DRD3, MET 3.30138
[BP] GO:0007191 None DRD1, DRD3, DRD5 3.30108
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.30108
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, CYP3A4, MAOA 3.30108
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 3.30108
[BP] GO:1900544 None ADRB1, DRD1, DRD5, HTR2A, INSR, MTNR1A 3.28281
[BP] GO:0045981 None ADRB1, DRD1, DRD5, HTR2A, INSR, MTNR1A 3.28281
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, PPARG, SMAD3, TEK 3.28281
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA, PPARG 3.27409
[BP] GO:0010638 positive regulation of organelle organization ADRB2, ALOX15, AURKB, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.25914
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.25914
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.25914
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, TRPV1 3.25914
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, PPARG, SRC 3.24397
[BP] GO:0050678 None CDK6, EGFR, F3, HTR2B, KDR, PPARG, SMAD3, TEK, XDH 3.24387
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 3.23246
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, DRD5, EGFR, ESR1, HSD17B2, HSP90AB1, INSR, MMP2, MMP9, MTNR1A, PPARG, SRC 3.22241
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B 3.21146
[BP] GO:0030802 None ADRB1, DRD1, DRD2, DRD3, DRD5, MTNR1A 3.21146
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR2A, HTR2B, HTR2C, MTNR1B, SRC, TRPV1 3.20667
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.18791
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.13603
[BP] GO:0009895 negative regulation of catabolic process ADORA1, EGFR, HCAR2, HSP90AB1, HTR2B, MET, PPARA, SMAD3 3.09126
[BP] GO:0046883 regulation of hormone secretion ADORA1, CYP19A1, DRD2, EGFR, HCAR2, HTR2A, HTR2C, MTNR1B 3.09126
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, PTPN1, SRC 3.08047
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.07324
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 3.07324
[BP] GO:1900274 regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B 3.07286
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 3.06238
[BP] GO:0051094 positive regulation of developmental process ADRB2, ALOX12, AXL, CA2, CYP1B1, DRD2, F3, HSP90AB1, HTR2A, HTR2C, INSR, KDR, PIM1, PPARG, SMAD3, SRC, TEK 3.05555
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.05171
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 3.04021
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3, PPARG 3.04021
[BP] GO:0060401 None DRD2, HTR2A, HTR2B, HTR2C, TRPV1 3.04021
[BP] GO:1900371 None ADRB1, DRD1, DRD2, DRD3, DRD5, MTNR1A 3.03928
[BP] GO:0007212 None DRD1, DRD2, DRD3, DRD5 3.03928
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 3.03928
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGES 3.03928
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.03928
[BP] GO:0007208 None HTR2A, HTR2C 3.03928
[BP] GO:0046960 None DRD1, DRD5 3.03928
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 3.03928
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 3.03928
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 3.03928
[BP] GO:0048608 reproductive structure development AXL, CYP19A1, ESR1, HSD17B2, HSP90AB1, INSR, PPARG, SRC 3.03815
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.03815
[BP] GO:0030808 None ADRB1, DRD1, DRD2, DRD3, DRD5, MTNR1A 3.03254
[BP] GO:0042060 None ALOX15, DRD5, EGFR, PPARA, SMAD3 3.03173
[BP] GO:0071396 cellular response to lipid AXL, CDK6, EGFR, ESR1, FLT3, NR3C1, PPARG, RORC, SRC 3.03006
[BP] GO:0050890 None ADORA1, DRD1, DRD2, DRD3, DRD5, EGFR, HTR2A, INSR 3.02029
[BP] GO:0051128 regulation of cellular component organization ADRB2, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, PTPN1, SMAD3, SRC, TEK 3.01546
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, CDC25B, CDK6, CYP1A1, DRD3, DUSP3, EGFR, HSP90AA1, HSPA1A, INSR, PIM1, SMAD3 3.01546
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B2, PTGES 3.01367
[BP] GO:0002791 None ACHE, ADORA1, DRD2, DRD3, EGFR, HCAR2, HTR2B, HTR2C, MTNR1B, SRC 3.01367
[BP] GO:0014075 None DRD1, DRD2, DRD3, DRD5 3.01367
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.99978
[BP] GO:0060158 None DRD1, DRD2, DRD5 2.99978
[BP] GO:0001936 None F3, HTR2B, KDR, PPARG, TEK, XDH 2.98958
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRB2, ALOX15, AURKB, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.97335
[BP] GO:0097756 None ADORA1, DRD5, HTR2A, HTR2B 2.97311
[BP] GO:0019725 cellular homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 2.94402
[BP] GO:1901655 None AKR1B1, EGFR, NR3C1, PPARG, SRC 2.94172
[BP] GO:0051726 regulation of cell cycle AURKB, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, PIM1, SMAD3, SRC 2.92591
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, HTR2C, PPARA, PPARG, TRPV1 2.92545
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PPARG, TYR 2.9188
[BP] GO:0043393 regulation of protein binding ADRB2, AURKB, HSP90AB1, MET, MMP9, PPARA, SRC 2.91547
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.91031
[BP] GO:1990845 None ADRB1, ADRB2, TRPV1 2.91031
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.91031
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.91031
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PPARG, SMAD3, SRC, XDH 2.90682
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR2A, HTR2B, HTR2C, MTNR1B, SRC 2.89175
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.87684
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, GPR35, HTR2A, MMP9 2.86388
[BP] GO:0009968 negative regulation of signal transduction ADRB2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PPARG, PTPN1, SMAD3, SRC, XDH 2.85776
[BP] GO:0030799 None ADRB1, DRD1, DRD2, DRD3, DRD5, MTNR1A 2.8485
[BP] GO:0007268 None DRD1, DRD2, DRD3, DRD5, HTR2A, HTR2C, HTR6, MTNR1B 2.83172
[BP] GO:0098916 None DRD1, DRD2, DRD3, DRD5, HTR2A, HTR2C, HTR6, MTNR1B 2.83172
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.82632
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.82632
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, SRC 2.82552
[BP] GO:0060359 None DRD1, DRD2, DRD3, DRD5, HSP90AB1 2.79152
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PPARG, SMAD3, TEK 2.77727
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.76971
[BP] GO:0099536 None DRD1, DRD2, DRD3, DRD5, HTR2A, HTR2C, HTR6, MTNR1B 2.76907
[BP] GO:0099537 None DRD1, DRD2, DRD3, DRD5, HTR2A, HTR2C, HTR6, MTNR1B 2.76907
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.76165
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.75721
[BP] GO:0097366 None DRD1, DRD2, DRD3, DRD5 2.75721
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.75339
[BP] GO:0051131 None HSP90AA1, HSP90AB1, HSPA1A 2.75339
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.75339
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.75339
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, HSP90AB1, INSR, PPARG, SRC 2.73461
[BP] GO:0009409 None ADRB1, ADRB2, HSP90AA1, PPARG 2.72646
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, SRC, TEK 2.7123
[BP] GO:0010564 regulation of cell cycle process AURKB, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR 2.69898
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process ADRB2, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, RORC, SMAD3, SRC 2.68866
[BP] GO:0051241 negative regulation of multicellular organismal process ADORA1, ADRB1, ADRB2, ALOX12, AXL, CDK6, DRD2, DRD3, EGFR, GPR35, HSP90AB1, PPARG, SMAD3, TEK, XDH 2.65493
[BP] GO:0043112 None ACHE, DRD2, DRD3, HTR2B, PPARG 2.65178
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, CA2, CDK6, CYP19A1, DRD2, DUSP3, ESR1, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PPARG, PTPN1, SMAD3, SRC 2.63831
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.63831
[BP] GO:0060160 None DRD2, DRD3 2.63831
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.63831
[BP] GO:0002025 None ADRB1, ADRB2 2.63831
[BP] GO:0003008 None ADORA1, ADRB1, ADRB2, AKR1B1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, HTR2A, HTR2B, INSR, SRC, TEK, TRPV1, TYR 2.63504
[BP] GO:0010518 positive regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B 2.63423
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.61318
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ADRB2, ALPL, AXL, CDC25B, CDK6, CYP1A1, DRD1, DRD2, EGFR, ESR1, FABP4, FLT3, FUT7, HTR2B, KDR, MET, MMP2, MMP9, PPARG, RORC, SMAD3, SRC, TEK 2.60738
[BP] GO:0051345 None ADRB1, EGFR, ESR1, F3, HSP90AB1, HSPA1A, HTR2A, HTR2B, PPARG, PTPN1, SMAD3, XDH 2.60688
[BP] GO:0097755 None ADRB1, ADRB2, DRD1, EGFR 2.60394
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, NR3C1, PPARA, PPARG, RORC 2.60394
[BP] GO:0030817 None ADRB1, DRD1, DRD2, DRD3, DRD5 2.60388
[BP] GO:0098657 import into cell ACHE, ADORA1, ADRB2, ALOX15, AXL, DRD2, DRD3, HSP90AA1, HTR2B, TRPV1 2.59773
[BP] GO:0007611 None DRD1, DRD2, DRD3, DRD5, EGFR, HTR2A, INSR 2.59723
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PPARG, SMAD3, SRC, XDH 2.58647
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.57826
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.573
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, HSP90AA1, HSPA1A, MAOA, XDH 2.56273
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.55368
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.55368
[BP] GO:0007617 None DRD1, DRD5, MTNR1A 2.55368
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 2.5226
[BP] GO:0015909 None DRD2, DRD3, FABP3, PPARG 2.51647
[BP] GO:0001952 regulation of cell-matrix adhesion CDK6, KDR, SMAD3, SRC, TEK 2.51267
[BP] GO:0071363 cellular response to growth factor stimulus EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.49456
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.49032
[BP] GO:0071880 None ADRB1, ADRB2, DRD2 2.49032
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.48947
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.48947
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 2.47823
[BP] GO:0080135 regulation of cellular response to stress CDK6, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, NUAK1, PTPN1, XDH 2.46596
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.46253
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.46253
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, SMAD3, TEK 2.46253
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.45273
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP9, SRC, TEK 2.45205
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK, TYR 2.44134
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.43463
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.42893
[BP] GO:0072347 None DRD2, DRD3, DRD5, HSP90AB1 2.40939
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.40939
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, HTR2B, SRC 2.40251
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.3821
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.3821
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.3821
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.3821
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.36726
[BP] GO:0010517 regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B 2.36026
[BP] GO:0070988 demethylation CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.36026
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, SRC, TEK 2.35692
[BP] GO:0009889 regulation of biosynthetic process ADORA3, ADRB1, ADRB2, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FABP3, FABP4, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MTNR1A, NR3C1, PIM1, PPARA, PPARG, RORC, SMAD3, SRC, TRPV1 2.34775
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.32977
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.32977
[BP] GO:0030814 None ADRB1, DRD1, DRD2, DRD3, DRD5 2.29828
[BP] GO:0006897 endocytosis ACHE, ADORA1, ADRB2, ALOX15, AXL, DRD2, DRD3, HSP90AA1, HTR2B 2.29716
[BP] GO:0060193 positive regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B 2.28232
[BP] GO:0051894 None KDR, SMAD3, TEK 2.2809
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.2809
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.2809
[BP] GO:0007202 None EGFR, HTR2A, HTR2B 2.2809
[BP] GO:0071875 None ADRB1, ADRB2, DRD2 2.2809
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.2809
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, CDK6, KDR, SMAD3, SRC, TEK 2.26864
[BP] GO:0045598 None HTR2A, HTR2C, PPARG, RORC, SMAD3 2.23916
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C 2.23785
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, SRC 2.23785
[BP] GO:0050927 None F3, KDR, SMAD3 2.23284
[BP] GO:0042311 None ADRB1, ADRB2, DRD1 2.23284
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, PPARG, TRPV1, TYR 2.21267
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, CDK6, CYP1B1, DRD2, FABP3, HSPA1A, PPARG, PTGES, SMAD3, XDH 2.19985
[BP] GO:0043434 None FABP3, INSR, PPARA, PPARG, SRC, TEK, TRPV1 2.1994
[BP] GO:0070848 response to growth factor EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.19883
[BP] GO:0021853 None DRD1, DRD2 2.19883
[BP] GO:0010641 None F3, SRC 2.19883
[BP] GO:0090325 None DRD2, DRD3 2.19883
[BP] GO:0071502 None HTR2B, TRPV1 2.19883
[BP] GO:1904936 None DRD1, DRD2 2.19883
[BP] GO:0032800 receptor biosynthetic process ACHE, PPARG 2.19883
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.19883
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.19883
[BP] GO:0042321 None ADORA1, DRD2 2.19883
[BP] GO:0010891 None PPARA, PPARG 2.19883
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.19883
[BP] GO:0050926 None F3, KDR, SMAD3 2.19883
[BP] GO:1903393 None KDR, SMAD3, TEK 2.19883
[BP] GO:0001775 cell activation ALOX5, AXL, EGFR, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, MMP9, RORC, SMAD3, SRC, TRPV1 2.19883
[BP] GO:0040014 regulation of multicellular organism growth ADRB1, ADRB2, DRD2, DRD3 2.18146
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.17932
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.17913
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, HSP90AA1, HSPA1A, MAOA, SRC, XDH 2.17358
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B2 2.16534
[BP] GO:0045913 None HTR2A, INSR, PPARA, SRC 2.16159
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.16159
[BP] GO:0035304 regulation of protein dephosphorylation ADORA1, DRD2, HSP90AB1, NUAK1 2.16159
[BP] GO:0031326 regulation of cellular biosynthetic process ADORA3, ADRB1, ADRB2, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FABP3, FABP4, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, MTNR1A, NR3C1, PIM1, PPARA, PPARG, RORC, SMAD3, SRC, TRPV1 2.15456
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.15113
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PPARG 2.1399
[BP] GO:0030804 None ADRB1, DRD1, DRD5, MTNR1A 2.11859
[BP] GO:0051482 None DRD1, GPR35, HTR2C 2.11693
[BP] GO:0046320 None FABP3, PPARA, PPARG 2.11693
[BP] GO:0050873 None ADRB1, ADRB2, FABP4 2.11693
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.11693
[BP] GO:0014059 None DRD2, DRD3, HTR2A 2.11693
[BP] GO:0051052 regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, PPARG, SRC 2.10816
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, NR3C1, PPARA, PPARG, RORC 2.10587
[BP] GO:0008306 None DRD1, DRD2, DRD3, DRD5 2.10114
[BP] GO:0043269 regulation of ion transport ADORA1, ADRB2, CA2, CA7, DRD1, DRD2, DRD3, GPR35, HTR2A, MMP9 2.10022
[BP] GO:0015718 None DRD2, DRD3, FABP3, PPARA, PPARG 2.08688
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, HSP90AA1, KDR, SRC 2.0805
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGES 2.07921
[BP] GO:0019098 None DRD1, DRD5, MTNR1A 2.07921
[BP] GO:0042310 None DRD5, HTR2A, HTR2B 2.07921
[BP] GO:1901653 cellular response to peptide ADRB2, AKR1B1, IGF1R, INSR, PPARG, SRC 2.07883
[BP] GO:0031324 negative regulation of cellular metabolic process AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, ESR2, FABP4, HSP90AB1, HSPA1A, HTR2B, IGF1R, MET, MMP9, NR3C1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.07565
[BP] GO:0043627 response to estrogen CA2, ESR1, PPARG, TEK 2.06225
[BP] GO:0010887 None PPARA, PPARG 2.05711
[BP] GO:0010871 None PPARA, PPARG 2.05711
[BP] GO:0021843 None DRD1, DRD2 2.05711
[BP] GO:0021830 None DRD1, DRD2 2.05711
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.05711
[BP] GO:0021826 None DRD1, DRD2 2.05711
[BP] GO:0046958 None DRD1, DRD5 2.05711
[BP] GO:0071383 None EGFR, FLT3, NR3C1, SRC 2.04702
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.04571
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.04571
[BP] GO:0031099 regeneration AXL, CSNK2A1, EGFR, FLT3, PPARG 2.04413
[BP] GO:0007612 None DRD1, DRD2, DRD3, DRD5, INSR 2.04413
[BP] GO:2000026 regulation of multicellular organismal development ADRB2, ALOX12, AXL, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, INSR, KDR, PIM1, PPARG, SMAD3, SRC, TEK, XDH 2.04413
[BP] GO:0032413 None DRD2, DRD3, GPR35, MMP9 2.02931
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PPARG, SRC, TEK 2.0159
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET 2.01349
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.01349
[BP] GO:1901890 None KDR, SMAD3, TEK 2.01349
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.01349
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R 2.01349
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.01349
[BP] GO:0032868 None FABP3, INSR, PPARA, PPARG, SRC 2.00935
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CDK6, CYP19A1, DRD2, DUSP3, PPARG 2.00607
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRB1, ADRB2, AXL, CA4, DRD1, DRD2, DRD3, DRD5, F3, FLT3, GPR35, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 6.7742
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALOX12, ALOX15, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAOA, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR 6.73675
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, PTPN1, SRC, TBXAS1, TEK, TRPV1, TYR 6.64713
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRB1, ADRB2, ALOX15, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FLT3, GPR35, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SRC, TEK, TRPV1 6.35955
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALOX12, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, GPR35, HCAR2, HSP90AA1, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1 6.17192
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRB1, ADRB2, AXL, DRD1, DRD2, DRD3, DRD5, FLT3, GPR35, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 5.8341
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, DRD5, HSP90AA1, HSP90AB1, INSR, SRC, TRPV1 5.04212
[CC] GO:0098590 plasma membrane region ADORA1, ADRB2, CA2, CA4, CA9, DRD1, DRD2, DRD5, EGFR, HSP90AA1, HSP90AB1, HTR2A, INSR, MET, SRC, TEK, TRPV1 4.32933
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALPL, AXL, CA12, CA14, CA4, CA9, CYP3A4, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, TBXAS1, TEK, TRPV1, TYR 3.38665
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, HSP90AB1, TEK 3.13339
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, INSR, KDR, MAOA, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARG, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TRPV1, TYR, XDH 3.05007
[CC] GO:0016021 None ADORA1, ADORA3, ADRB1, ADRB2, ALPL, AXL, CA12, CA14, CA9, CYP3A4, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, TBXAS1, TEK, TRPV1, TYR 2.96435
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, HSD11B1, HSD17B2, PTGES, TBXAS1 2.89175
[CC] GO:0044432 endoplasmic reticulum part CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, FLT3, HSD11B1, HSD17B2, PTGES, PTPN1, TBXAS1 2.47823
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAOA, MET, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 2.26285
[CC] GO:1904813 None ALOX5, HSP90AA1, HSP90AB1, HSPA1A, MMP9 2.19417
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.05711
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 15.7067
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 13.6213
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, PPARA, PPARG, SRC, TEK, TRPV1 13.0143
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, ADRB2, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, NR3C1, PPARA, PPARG, RORC, TEK, TRPV1 12.3456
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, ADRB2, AXL, CDK6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, NR3C1, PPARA, PPARG, RORC, TEK, TRPV1 11.5812
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, ADRB2, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, NR3C1, PPARA, PPARG, RORC, TEK, TRPV1 11.1157
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, ADRB2, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, NR3C1, PPARA, PPARG, RORC, SMAD3, TEK, TRPV1 10.8052
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 10.0108
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.0027
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, XDH 9.97423
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, ADRB2, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARG, TEK, TRPV1 9.44545
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, ADRB2, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARG, TEK, TRPV1 9.44545
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 8.65528
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, TYR 8.45905
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, ESR1, ESR2, HTR2A, HTR2B, HTR2C, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, TBXAS1, TRPV1, TYR, XDH 8.42596
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DUSP3, EGFR, F3, FLT3, FUT7, HSD11B1, HSD17B2, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, PTGES, PTPN1, SRC, TBXAS1, TEK, TYR, XDH 8.3424
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 8.23639
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, SRC, TBXAS1 7.37196
[MF] GO:1901338 None ADRB1, ADRB2, DRD1, DRD2, DRD3, DRD5 7.31556
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.26657
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, SRC, TBXAS1 7.09281
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 6.78638
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, DRD5, HTR2A, HTR2B, HTR2C 6.77556
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, TYR 6.68734
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.54852
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.25388
[MF] GO:0008227 None ADRB1, ADRB2, DRD2, HTR2A, HTR2B, HTR2C, HTR6 6.15637
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 6.11855
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, NR3C1, PPARA, PPARG, PTPN1, RORC, SMAD3 6.04007
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 6.03104
[MF] GO:0030235 nitric-oxide synthase regulator activity EGFR, ESR1, HSP90AA1, HSP90AB1 5.81666
[MF] GO:0030594 None DRD1, DRD2, DRD3, DRD5, HTR2A, HTR2B, HTR2C, HTR6 5.60252
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.44349
[MF] GO:0042562 hormone binding ACHE, EGFR, IGF1R, INSR, MTNR1A, NQO2, NR3C1 5.11156
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 5.05179
[MF] GO:0004930 None ADORA1, ADORA3, ADRB1, ADRB2, DRD1, DRD2, DRD3, DRD5, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, MTNR1A, MTNR1B, PPARG 4.96143
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, NQO2, PTGES, SRC, TBXAS1, XDH 4.95241
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRB2, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HTR2A, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 4.92587
[MF] GO:0004952 None DRD1, DRD2, DRD3, DRD5 4.83883
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRB2, EGFR, FLT3, HSP90AA1, HSP90AB1, HTR2A, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 4.78182
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, NR3C1, PPARA, PPARG, RORC 4.75993
[MF] GO:0035240 None DRD1, DRD2, DRD3, DRD5 4.69691
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, TBXAS1, TRPV1, TYR, XDH 4.49071
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRB1, ADRB2, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MTNR1A, NQO2, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TRPV1, XDH 4.3912
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.16261
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, PPARG, RORC 3.84989
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, PPARG, RORC 3.84989
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.75257
[MF] GO:0004993 None HTR2A, HTR2B, HTR2C, HTR6 3.69559
[MF] GO:0099589 None HTR2A, HTR2B, HTR2C, HTR6 3.69559
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, F3, FABP3, FABP4, NR3C1, PPARA, PPARG, RORC, TRPV1 3.53209
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSP90AB1, HSPA1A, KDR, NR3C1 3.47149
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.43322
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.43322
[MF] GO:0019899 enzyme binding ADRB1, ADRB2, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, F3, HSP90AA1, HSP90AB1, HSPA1A, MET, NR3C1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK 3.40049
[MF] GO:0042802 identical protein binding ACHE, ADRB2, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NQO2, PPARG, SMAD3, TRPV1, TYR, XDH 3.26097
[MF] GO:0043176 None HTR2A, HTR2B, HTR2C 3.18791
[MF] GO:0051378 None HTR2A, HTR2B, HTR2C 3.18791
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.16164
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.03928
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 3.03928
[MF] GO:0008389 None CYP2A13, CYP2A6 3.03928
[MF] GO:0071886 None HTR2A, HTR2C 3.03928
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.03173
[MF] GO:0099528 None HTR2A, HTR2B, HTR2C, HTR6 3.01367
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, NR3C1, RORC 2.83172
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.82193
[MF] GO:0043168 anion binding ALOX15, AURKB, AXL, CDK6, CSNK2A1, EGFR, F3, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, PPARG, PTGES, SRC, TEK, TRPV1, XDH 2.79798
[MF] GO:0035258 None ESR1, FLT3, PPARG, SMAD3, SRC 2.79152
[MF] GO:0004935 None ADRB1, ADRB2, DRD2 2.75339
[MF] GO:0033218 amide binding ACHE, ADRB2, HSP90AB1, IGF1R, INSR, NQO2, PPARG, PTGES 2.72734
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.70624
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.67139
[MF] GO:0008502 None MTNR1A, MTNR1B 2.63831
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.63831
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.63831
[MF] GO:0004939 None ADRB1, ADRB2 2.63831
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.63831
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, PPARG, SRC, TEK, TRPV1, XDH 2.60442
[MF] GO:0019902 phosphatase binding EGFR, MET, PPARA, PPARG, PTPN1, SMAD3 2.55368
[MF] GO:0042165 neurotransmitter binding ACHE, HTR2A, HTR2B, HTR2C 2.54748
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.42893
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, HSP90AA1, HSP90AB1, NR3C1, PTPN1, SMAD3, SRC 2.41533
[MF] GO:0001588 None DRD1, DRD5 2.3821
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.3821
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.3821
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.3821
[MF] GO:0042277 peptide binding ACHE, ADRB2, HSP90AB1, IGF1R, INSR, PPARG, PTGES 2.28283
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, HSP90AA1, HSP90AB1, NR3C1, PTPN1, SMAD3, SRC 2.24229
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, INSR, KDR, SMAD3 2.21009
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.19883
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.19883
[MF] GO:0043559 insulin binding IGF1R, INSR 2.19883
[MF] GO:0051380 None ADRB1, ADRB2 2.19883
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.19883
[MF] GO:0005504 None FABP3, FABP4, PPARG 2.157
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.157
[MF] GO:0005102 receptor binding ADORA1, ADRB1, DRD2, DRD3, EGFR, ESR1, ESR2, FLT3, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, PPARG, PTPN1, SMAD3, SRC 2.14978
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRB1, ADRB2, AXL, DRD2, EGFR, FLT3, HSP90AA1, HSP90AB1, NQO2, PPARG, SMAD3, TYR, XDH 2.12617
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.11421
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, F3, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 2.08362
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.07921
[MF] GO:0050543 None FABP3, PPARG 2.05711
[MF] GO:0004064 arylesterase activity CA1, CA2 2.05711
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B2, XDH 2.04413
[MF] GO:0104005 hijacked molecular function AXL, EGFR, HSPA1A, HTR2A 2.01349
[MF] GO:0001618 virus receptor activity AXL, EGFR, HSPA1A, HTR2A 2.01349
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.01349
[MF] GO:0097718 None HSP90AA1, HSP90AB1, HSPA1A 2.01349
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 2.00607


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, HTR2B, HTR2C, ADRB1, TRPV1, HTR2A, ADRB2, NR3C1, HTR6, MTNR1A, MTNR1B, ADORA3, ADORA1, DRD1, DRD2, DRD3, DRD5 12.8576
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 7.9104
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.7018
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.7284
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.7284
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, MAOA, CYP2D6, ALOX5, ALOX15, HTR2B, HTR2C, ALOX12, HTR2A 7.7284
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.5817
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, ADRB1, HTR2A, DRD1, DRD2, EGFR 7.3152
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, CDK6, SMAD3, HSP90AB1, FLT3, MMP1, MMP2, PPARG, MMP9, MET, EGFR, IGF1R 6.0768
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR2B, HTR2C, ADRB1, HTR2A, ADRB2, DRD1, EGFR, DRD5 6.1781
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.2235
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, ADORA1, ADRB1, ADRB2, DRD1, DRD2, PPARA, DRD5 5.8768
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 5.3887
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.2012
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, ADRB1, ADRB2, MET, EGFR, IGF1R, HSPA1A 5.0293
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.8441
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.7423
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2C, ALOX12, TRPV1, HTR2A 4.657
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 HSP90AA1, CDK6, HSP90AB1, INSR, KDR, TEK, MET, EGFR, IGF1R 4.2228
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.2086
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, ADRB1, ADRB2 4.64
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, ALOX12, PTGES 4.4395
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP2D6, CYP1A2, CYP3A4 4.2472
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 4.2472
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.9846
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, DRD1, DRD2, DRD3, DRD5 3.0074
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.813
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 2.9846
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRB1, ADRB2 2.5753
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.0975
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, EGFR, IGF1R 2.6596
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, F3 2.4899
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, CDC25B, IGF1R 2.527
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MMP9, MET, IGF1R 2.4765
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.4765
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.9176
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.2865
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.1148
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, SRC, MMP9 2.0352
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.1072
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 2.0977
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.7572
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, EGFR 2.0884
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0171
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.079
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, ADRB2 2.1072
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, PPARG, IGF1R 1.7345
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.3111
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.5887
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.3533
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0699
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, PPARG, IGF1R 1.4526
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.2837
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.4526
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1, HSPA1A 1.9431
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1, DRD2 2.4013
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, HSPA1A 1.1742
Alcoholism_Homo sapiens_hsa05034 MAOA, DRD1, DRD2 1.129
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.4706
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.1862
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8142
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8289
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8289
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8216
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7657
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0126
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.8289
Huntington's disease_Homo sapiens_hsa05016 PPARG 0.2609
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.755
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2674
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.755
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2764
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.755
Tuberculosis_Homo sapiens_hsa05152 SRC 0.276
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2764
Circadian entrainment_Homo sapiens_hsa04713 MTNR1A, MTNR1B 0.9718
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2672
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9944
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.755
Salivary secretion_Homo sapiens_hsa04970 ADRB1, ADRB2 1.0006
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3034
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.755
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3105
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9974
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.5743
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.7537
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.7328
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRB1, ADRB2 0.7428
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.5491
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5724
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 1.133
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3501
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7091
Osteoclast differentiation_Homo sapiens_hsa04380 PPARG 0.352
Axon guidance_Homo sapiens_hsa04360 MET 0.3617
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3694
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0923
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4013
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4012
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, DRD1 1.1834
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4176
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4248
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.9678
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4248
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4248
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2463
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4337
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4332
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.1492
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2837
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, EGFR 1.2837
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4381
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4481
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4548
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4481
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1 0.4466
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2015
Small cell lung cancer_Homo sapiens_hsa05222 CDK6 0.4496
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4473
Peroxisome_Homo sapiens_hsa04146 XDH 0.4558
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4704
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.2837
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4912
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.267
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5085
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5105
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5236
Shigellosis_Homo sapiens_hsa05131 SRC 0.5258
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5491
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5402
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5724
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5857
Malaria_Homo sapiens_hsa05144 MET 0.6012
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5972
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6054
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6098
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.6759
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7345
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.622
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7113
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6698
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.755
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6057
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7645
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6899
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7481
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.766
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7537
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7645
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9397
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.794
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9076
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9788
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2086


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)