TCM Prescription: Four Fresh Ingredients Pills



Prescription Description
Prescription IDTCMF1675
Pinyin NameSi Sheng Wan
Chinese Name四生丸
English NameFour Fresh Ingredients Pills
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH825 Nelumbo nucifera 荷叶 TCMH825 ITSAI3109-14
TCMH12 Artemisia argyi 艾叶 TCMH12 ITSAE2504-14
TCMH224 Thuja orientalis 侧柏叶 TCMH224 ITSAJ4756-14
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT953 PNMT Phenylethanolamine N-methyltransferase Transferase P11086


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, MET, PPARA, PTGS1, PTGS2 10.7018
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, HMGCR, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 9.89331
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, BCL2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, PPARA, PTGS2, SRC, TYR 9.54266
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP2A, TYR, XDH 9.26657
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, PTGS2, SRC 9.15927
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP2A, TYR, XDH 8.66208
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, PPARA, PTGS2, SRC, TYR 8.66208
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, ALPI, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FUT7, HMGCR, MET, PPARA, PTGS1, PTGS2 7.79439
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.64984
[BP] GO:0042221 response to chemical AKR1B1, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PTGS2, SRC, TYR 7.61503
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.22981
[BP] GO:0042127 regulation of cell proliferation AKR1B1, APP, BCL2, CSNK2A1, CXCL8, CYP1B1, DRD2, FABP3, FLT3, HMGCR, HTR1A, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 6.91587
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, PTGS1, PTGS2, TYR, XDH 6.44509
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.43182
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD2, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSD17B2, HTR1A, KDR, MET, PPARA, PTGS1, PTGS2, SRC, XDH 6.4069
[BP] GO:0032502 developmental process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC, TOP2A, TYR 6.4069
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2 6.34648
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TOP2A, XDH 6.1428
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP1A2, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC 6.00045
[BP] GO:0033993 response to lipid AXL, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, PTGS2, SRC, TYR 5.86507
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, SRC, TOP2A, XDH 5.86507
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FLT3, PTGS2, SRC, TYR 5.85016
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.51081
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.51081
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD2, HMGCR, HTR1A, TYR 5.46244
[BP] GO:0010647 positive regulation of cell communication AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PTGS2, SRC, XDH 5.37072
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, SRC 5.37072
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DRD2, FABP3, FLT3, HMGCR, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC, TOP2A, XDH 5.37072
[BP] GO:0023056 positive regulation of signaling AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PTGS2, SRC, XDH 5.37072
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.37072
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GLO1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTGS2, SRC, TOP2A, XDH 5.19261
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 5.19003
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, SRC 4.98356
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD2, FABP3, HMGCR, KDR, PTGS2, SRC 4.91332
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, DRD2, FLT3, HMGCR, HTR1A, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 4.90445
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPI, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD2, FABP4, HMGCR, HSD17B2, HTR1A, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC, TYR 4.8704
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DRD2, FABP3, FABP4, FLT3, HMGCR, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC, TOP2A, XDH 4.78903
[BP] GO:0030334 regulation of cell migration APEX1, APP, BCL2, CXCL8, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.71099
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FLT3, HMGCR, HSD17B2, HTR1A, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PTGS1, PTGS2, SRC, TOP2A, TYR 4.70525
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 4.68305
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD2, HMGCR, KDR, SRC 4.65788
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, APP, AURKB, AXL, BCL2, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP2A, TYR, XDH 4.63767
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.6231
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, APP, AXL, BCL2, CXCL8, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTGS2, SRC 4.6035
[BP] GO:0009725 response to hormone AKR1B1, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, PTGS2, SRC 4.6035
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 4.54675
[BP] GO:2000145 regulation of cell motility APEX1, APP, BCL2, CXCL8, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.49166
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, PTGS2 4.48186
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALPI, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD17B1, HSD17B2, PTGS1, PTGS2 4.44978
[BP] GO:0032879 regulation of localization ACHE, APEX1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD2, HMGCR, HTR1A, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, SRC 4.44978
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.39848
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 4.34731
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTGS2, SRC 4.34731
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, APP, AXL, BCL2, CXCL8, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, PTGS2, SRC 4.22106
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.22106
[BP] GO:0040012 regulation of locomotion APEX1, APP, BCL2, CXCL8, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.16016
[BP] GO:0051270 regulation of cellular component movement APEX1, APP, BCL2, CXCL8, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.14951
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 4.09989
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA, PTGS1, PTGS2 4.08956
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 4.06916
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 4.06916
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 4.06916
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 4.06884
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, APP, AURKB, AXL, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP2A, TYR, XDH 4.01004
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 4.00293
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.97522
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD2, FLT3, HMGCR, HTR1A, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, SRC, XDH 3.95375
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, HMGCR, HSD17B1, HSD17B2, HTR1A 3.9078
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTGS2, SRC, TOP2A 3.88673
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD2, FLT3, HMGCR, HTR1A, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, SRC, XDH 3.88673
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PTGS2, SRC, XDH 3.88673
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.85533
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, APP, AXL, BCL2, CSNK2A1, CXCL8, CYP1B1, DRD2, FABP4, FLT3, HMGCR, KDR, MET, MMP12, MMP2, MMP9, PTGS2, SRC, XDH 3.85417
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, APP, AXL, BCL2, CYP1B1, DRD2, FLT3, HMGCR, KDR, MET, PTGS2, SRC, XDH 3.83125
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPI, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, DRD2, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, PTGS2, SRC, XDH 3.82798
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.79664
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CSNK2A1, CYP1B1, DRD2, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC 3.77461
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, DRD2, FLT3, FUT7, GLO1, HMGCR, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC, TOP2A, TYR, XDH 3.7629
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 3.75574
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 3.73832
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD2, HMGCR, MMP2, PPARA, PTGS2, SRC, TYR 3.7287
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 3.72106
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 3.62023
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PTGS2, SRC, XDH 3.61044
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPI, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, DRD2, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, PTGS2, SRC, XDH 3.57829
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.56891
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2 3.55732
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, CXCL8, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.53906
[BP] GO:0018958 None AKR1B1, BCL2, DRD2, HTR1A, TYR 3.50901
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.45166
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, CXCL8, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.42759
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD2, FABP3, FABP4, GLO1, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, SRC, TOP2A, XDH 3.39058
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CXCL8, CYP1B1, IGF1R, MMP2, MMP9, PTGS2, SRC 3.36759
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, CXCL8, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.33928
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, PPARA, PTGS2, SRC 3.3368
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.3368
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, DRD2, HMGCR, KDR, PTGS2, SRC 3.32032
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 3.23619
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, CXCL8, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.23538
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, APP, AXL, BCL2, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, PTGS2, SRC, TYR 3.21289
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CXCL8, CYP1B1, DRD2, HMGCR, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC 3.19891
[BP] GO:0006950 response to stress ACHE, AKR1B1, APEX1, APP, AXL, BCL2, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD2, HTR1A, MMP2, MMP9, PPARA, PTGS1, PTGS2, SRC, TOP2A 3.19664
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 3.18066
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 3.17787
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.13818
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, DRD2, FABP3, FABP4, FLT3, MET, SRC 3.11368
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 3.11368
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, FLT3, HTR1A, MET, PIM1, SRC, TYR 3.11368
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, HMGCR, IGF1R, MET, MMP9, PTGS2, SRC, XDH 3.07248
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD2, HTR1A 2.99012
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, PTGS2, SRC 2.9777
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, PPARA, SRC, TOP2A 2.96078
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD2, HMGCR, PTGS2, TYR 2.95392
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.94851
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.91485
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 2.90713
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.85609
[BP] GO:0048869 cellular developmental process ACHE, APP, AXL, BCL2, CBR1, CYP1A1, DRD2, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, MET, MMP2, MMP9, PTGS2, SRC, TOP2A 2.78686
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.75585
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.74967
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.71987
[BP] GO:0050806 positive regulation of synaptic transmission APP, CA2, CA7, DRD2, PTGS2 2.70527
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD2, KDR, SRC 2.70145
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.68413
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.67933
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.6538
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR 2.6538
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.6538
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD17B1, HSD17B2 2.63982
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.62927
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.62927
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2 2.61494
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.61399
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.59552
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.58115
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.58115
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.538
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD2, FABP3, FABP4, GLO1, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, SRC, TOP2A, XDH 2.538
[BP] GO:0032101 regulation of response to external stimulus CXCL8, CYP19A1, DRD2, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PTGS2 2.53059
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.51266
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, HMGCR, PTGS2 2.493
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.47559
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CSNK2A1, CXCL8, CYP1A1, DRD2, PIM1, PTGS2, SRC, TOP2A 2.47559
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, APP, CYP1A1, CYP1B1, FLT3, PTGS2, SRC 2.45882
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.42682
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.38231
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, FABP3, FLT3, HMGCR, PPARA, PTGS2, SRC 2.37818
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.36875
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.36255
[BP] GO:0051049 regulation of transport ACHE, APP, AXL, BCL2, CA2, CA7, CYP19A1, DRD2, HMGCR, HTR1A, MMP12, MMP9, PPARA, PTGS2, SRC 2.36255
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.34335
[BP] GO:0016477 cell migration AXL, CXCL8, CYP1B1, DRD2, FUT7, KDR, MMP1, MMP12, MMP9, SRC 2.33035
[BP] GO:0040011 locomotion AXL, CXCL8, CYP1B1, DRD2, FUT7, KDR, MET, MMP1, MMP12, MMP9, SRC 2.31076
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.24846
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, CXCL8, FLT3, IGF1R, MMP2, PTGS2, SRC 2.24846
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9 2.23807
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, DRD2 2.23754
[BP] GO:0080134 regulation of response to stress APP, CYP19A1, DRD2, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, SRC, XDH 2.22058
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.21697
[BP] GO:0048583 regulation of response to stimulus AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD2, FABP4, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTGS2, SRC, XDH 2.19378
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CXCL8, CYP1B1, DRD2, HMGCR, KDR, PIM1, PTGS2, SRC 2.18789
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, IGF1R, MMP2, PTGS2, SRC 2.18122
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.17679
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.17679
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, SRC, TOP2A 2.17679
[BP] GO:0048585 negative regulation of response to stimulus BCL2, CXCL8, CYP19A1, DRD2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, SRC, XDH 2.16573
[BP] GO:0045744 None CXCL8, DRD2, MET 2.14185
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.14185
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.13958
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, CXCL8, DRD2, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, SRC, XDH 2.13958
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALPI, CSNK2A1, DRD2, FABP3, FABP4, MET 2.13958
[BP] GO:0032496 response to lipopolysaccharide AXL, CXCL8, CYP1A1, CYP1A2, PTGS2, SRC 2.13212
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, CXCL8, DRD2, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, SRC, XDH 2.13212
[BP] GO:0042325 regulation of phosphorylation APP, BCL2, DRD2, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTGS2, SRC, XDH 2.12937
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, DRD2 2.11496
[BP] GO:0019220 regulation of phosphate metabolic process APP, BCL2, DRD2, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTGS2, SRC, XDH 2.11468
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.11259
[BP] GO:0051174 regulation of phosphorus metabolic process APP, BCL2, DRD2, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTGS2, SRC, XDH 2.08458
[BP] GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SRC 2.08458
[BP] GO:0010562 positive regulation of phosphorus metabolic process APP, BCL2, DRD2, FABP3, FLT3, HMGCR, KDR, MMP9, PTGS2, SRC, XDH 2.08458
[BP] GO:0045937 positive regulation of phosphate metabolic process APP, BCL2, DRD2, FABP3, FLT3, HMGCR, KDR, MMP9, PTGS2, SRC, XDH 2.08458
[BP] GO:0048870 cell motility AXL, CXCL8, CYP1B1, DRD2, FUT7, KDR, MMP1, MMP12, MMP9, SRC 2.05186
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, DRD2, HMGCR, PTGS2, TYR 2.04625
[BP] GO:0009611 response to wounding ACHE, BCL2, CYP1A1, DRD2, PPARA 2.04517
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.0236
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, IGF1R, MMP2, PTGS2, SRC 2.01609
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, SRC 2.00914
[BP] GO:0009987 cellular process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP2A, TYR, XDH 2.00914
[BP] GO:0002237 response to molecule of bacterial origin AXL, CXCL8, CYP1A1, CYP1A2, PTGS2, SRC 2.00914
[CC] GO:0005783 None APEX1, APP, BCL2, CA4, CYP19A1, FLT3, HMGCR, KDR, PTGS2, XDH 1.98113
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, KDR, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, TOP2A, TYR, XDH 1.86085
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.83779
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HMGCR, HSD17B2, PTGS1, PTGS2 1.61484
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B2, PTGS1, PTGS2 1.49613
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, TYR, XDH 10.7018
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.7018
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPI, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP2A, TYR, XDH 10.4002
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, TOP2A, TYR, XDH 10.0082
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.64984
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, PTGS1, PTGS2, TYR, XDH 7.64984
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.01422
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, GLO1, HTR1A, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, TOP2A, TYR, XDH 6.35483
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 6.1819
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 4.81397
[MF] GO:0046872 metal ion binding ALOX5, ALPI, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS1, PTGS2, TOP2A, TYR, XDH 4.68305
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2, XDH 4.68305
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 4.65788
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA 4.55119
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 4.39848
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, PTGS1, PTGS2, SRC, XDH 4.06916
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 4.06884
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.90246
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.88673
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2 3.88673
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 3.87313
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.48537
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.25506
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.15037
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.08316
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.99746
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.99596
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DRD2, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PTGS2, TOP2A, TYR, XDH 2.94816
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, SRC 2.43252
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.37843
[MF] GO:0004064 arylesterase activity CA1, CA2 2.0236


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.6319
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 12.0688
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, PTGS1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPI, XDH 6.1713
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.594
Pathways in cancer_Homo sapiens_hsa05200 CXCL8, FLT3, MMP1, MMP2, BCL2, PTGS2, MMP9, MET, IGF1R 5.0092
Bladder cancer_Homo sapiens_hsa05219 CXCL8, SRC, MMP1, MMP2, MMP9 5.8778
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.8392
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.4954
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, HTR1A, PTGS2, PTGS1 3.8857
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGS2, PTGS1 3.6759
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.4848
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.4848
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.5325
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 CXCL8, MMP2, BCL2, PIM1 3.0972
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET 3.189
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 CXCL8, FLT3, MMP9, MET, IGF1R 3.189
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 3.0569
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.9897
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CXCL8, CSNK2A1, BCL2, PTGS2 3.189
Hepatitis B_Homo sapiens_hsa05161 CXCL8, SRC, BCL2, MMP9 2.6064
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PTGS2, PTGS1 2.6782
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.6064
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.0569
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 CXCL8, SRC, MET 2.4855
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 2.0465
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.8041
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 CXCL8, FLT3, KDR, MET 1.7825
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, BCL2, MET, IGF1R 1.4523
cAMP signaling pathway_Homo sapiens_hsa04024 HTR1A, DRD2, PPARA 1.3847
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.2647
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4757
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4595
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.4006
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3847
Malaria_Homo sapiens_hsa05144 CXCL8, MET 1.5901
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4144
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.2482
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.1139
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2482
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, PTGS2 1.2572
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.1139
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3174
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.1568
Gap junction_Homo sapiens_hsa04540 SRC, DRD2 1.2482
Shigellosis_Homo sapiens_hsa05131 CXCL8, SRC 1.4144
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.3847
Rheumatoid arthritis_Homo sapiens_hsa05323 CXCL8, MMP1 1.2482
Platelet activation_Homo sapiens_hsa04611 SRC, PTGS1 1.071
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.0896
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0896
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 CXCL8, PPARA 0.9416
Hepatitis C_Homo sapiens_hsa05160 CXCL8, PPARA 1.0183
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 1.0659
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.9208
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.9208
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9914
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.857
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.7937
Chemokine signaling pathway_Homo sapiens_hsa04062 CXCL8, SRC 0.8336
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9378
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8108
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1A, DRD2 0.6295
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8972
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3871
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3982
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4477
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4403
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4297
Parkinson's disease_Homo sapiens_hsa05012 DRD2 0.4959
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4959
Alcoholism_Homo sapiens_hsa05034 DRD2 0.4378
Influenza A_Homo sapiens_hsa05164 CXCL8 0.4403
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.4477
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4973
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5666
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4959
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.5018
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.488
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5249
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5666
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4959
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5666
Phospholipase D signaling pathway_Homo sapiens_hsa04072 CXCL8 0.4944
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5772
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.5494
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5194
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.5249
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5249
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.5819
Axon guidance_Homo sapiens_hsa04360 MET 0.5113
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5666
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 CXCL8 0.5561
Dopaminergic synapse_Homo sapiens_hsa04728 DRD2 0.5093
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5666
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5666
Amoebiasis_Homo sapiens_hsa05146 CXCL8 0.5666
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 CXCL8 0.5594
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5666
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5772
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5772
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5666
Salmonella infection_Homo sapiens_hsa05132 CXCL8 0.5772
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5772
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.614
Peroxisome_Homo sapiens_hsa04146 XDH 0.5819
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6128
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1361
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6133
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6202
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6295
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6286
Glioma_Homo sapiens_hsa05214 IGF1R 0.6295
Pertussis_Homo sapiens_hsa05133 CXCL8 0.6123
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6402
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6202
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6325
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 CXCL8 0.6202
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 CXCL8 0.6554
Legionellosis_Homo sapiens_hsa05134 CXCL8 0.6643
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6893
Cocaine addiction_Homo sapiens_hsa05030 DRD2 0.6998
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7201
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7716
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.815
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8471
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.862
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8336
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8945
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8854
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9416
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2582
Folate biosynthesis_Homo sapiens_hsa00790 ALPI 1.0896


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)