Prescription Description
| Prescription ID | TCMF1655 |
| Pinyin Name | Gui Gan Cao Long Gu Mu Li Tang |
| Chinese Name | 桂枝甘草龙骨牡蛎汤 |
| English Name | Decoction of Cinnamomi, Glycyrrhizae, etc. |
| Function Description | |
| Indications | None |
| Disease ICD-11 Category | |
| Human Tissues Associated with Indication | |
| Reference | Chinese Classical Prescriptions |
| Reference Book/link | ISBN 7-5023-3930-2 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH761 | Cinnamomum cassia | 桂枝 | TCMH761 | GQ255631 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
| TCMH1321 | Os draconis | 龙骨 | TCMH1321 | |
| TCMH1525 | Crassostrea gigas | 牡蛎 | TCMH1525 | BCMOL364-12 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
| TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
| TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
| TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
| TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
| TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
| TCMT162 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | Transferase | P22309 |
| TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
| TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
| TCMT209 | HSD11B2 | 11-beta-hydroxysteroid dehydrogenase 2 | Oxidoreductase | P80365 |
| TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
| TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
| TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
| TCMT23 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Hydrolase | P05186 |
| TCMT231 | GBA2 | Beta-glucosidase | Hydrolase | Q9HCG7 |
| TCMT236 | ESR2 | Estrogen receptor beta | Nuclear receptor | Q92731 |
| TCMT249 | CDK6 | Cyclin-dependent kinase 6 | Kinase | Q00534 |
| TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
| TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
| TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
| TCMT344 | AOX1 | Aldehyde oxidase | Oxidoreductase | Q06278 |
| TCMT46 | F3 | Coagulation factor III | Unclassified | P13726 |
| TCMT47 | BCL2 | Apoptosis regulator Bcl-2 | Ion channel | P10415 |
| TCMT506 | PTK2B | Protein tyrosine kinase 2 beta | Kinase | Q14289 |
| TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
| TCMT591 | ESRRA | Estrogen-related receptor alpha | Nuclear receptor | P11474 |
| TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
| TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
| TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
| TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
| TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
| TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
| TCMT907 | FDPS | Farnesyl diphosphate synthase | Lyase | P14324 |
| TCMT910 | ESRRB | Estrogen-related receptor beta | Nuclear receptor | O95718 |
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1208 | Escherichia coli K12 |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1212 | Verticillium dahliae |
| TCMT1214 | Enterococcus faecium |
| TCMT1215 | Pseudomonas aeruginosa PAO1 |
| TCMT1218 | Staphylococcus aureus |
| TCMT1223 | Staphylococcus epidermidis |
| TCMT1224 | Proteus mirabilis |
| TCMT1226 | Klebsiella pneumoniae |
| TCMT1227 | Streptococcus |
| TCMT1229 | Enterococcus faecalis |
| TCMT1232 | Pseudomonas aeruginosa |
| TCMT1234 | Bacillus coagulans |
| TCMT1235 | Clostridium sporogenes |
| TCMT1236 | Mycobacterium bovis |
| TCMT1237 | Mycobacterium kansasii |
| TCMT1238 | Mycobacterium xenopi |
| TCMT1239 | Mycobacterium marinum |
| TCMT1243 | Aspergillus flavus |
| TCMT1246 | Escherichia coli |
| TCMT1248 | Hepatitis C virus |
| TCMT1249 | Dengue virus 2 |
| TCMT1251 | Candida albicans |
| TCMT1253 | Penicillium chrysogenum |
| TCMT1255 | Human immunodeficiency virus 1 |
| TCMT1284 | Penicillium expansum |
| TCMT1286 | Bacillus cereus |
| TCMT1294 | Human parainfluenza virus 3 |
| TCMT1346 | Helicobacter pylori |
| TCMT1349 | Helicobacter pylori SS1 |
| TCMT1412 | Salmonella typhimurium |
| TCMT1438 | Plasmodium falciparum |
| TCMT1439 | Mycobacterium smegmatis |
| TCMT1442 | Leishmania donovani |
| TCMT1443 | Leishmania amazonensis |
| TCMT1447 | Respiratory syncytial virus |
| TCMT1448 | Enterobacter aerogenes |
| TCMT1449 | Influenza A virus |
| TCMT1450 | Plasmodium falciparum 3D7 |
| TCMT1454 | Bacillus subtilis |
| TCMT1455 | Mycobacterium tuberculosis H37Rv |
| TCMT1457 | Leishmania major |
| TCMT1458 | Filobasidiella neoformans |
| TCMT1462 | Streptococcus mutans |
| TCMT1463 | Mycobacterium tuberculosis |
| TCMT1465 | Entamoeba histolytica |
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FDPS, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 11.161 |
| [BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 8.24629 |
| [BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR | 7.69949 |
| [BP] GO:0006629 | lipid metabolic process | ACHE, AKR1B1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FDPS, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 6.4656 |
| [BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA7 | 6.35783 |
| [BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 5.73059 |
| [BP] GO:0008152 | metabolic process | ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FDPS, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH | 5.71738 |
| [BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 5.66381 |
| [BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FDPS, FUT7, GBA2, TYR, XDH | 5.51201 |
| [BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 5.38467 |
| [BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH | 5.34612 |
| [BP] GO:0033993 | response to lipid | ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, HSD11B2, HSD17B2, TYR | 5.34612 |
| [BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA7 | 5.17861 |
| [BP] GO:0010817 | regulation of hormone levels | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 4.69688 |
| [BP] GO:0032847 | regulation of cellular pH reduction | BCL2, CA2, CA7 | 4.6481 |
| [BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, FDPS, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 4.39537 |
| [BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, FDPS, GBA2, TYR | 4.37287 |
| [BP] GO:0014070 | response to organic cyclic compound | ALPL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, TYR | 4.37287 |
| [BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FDPS, FUT7, GBA2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH | 4.14544 |
| [BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 4.14544 |
| [BP] GO:0048513 | animal organ development | ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, TYR | 4.14544 |
| [BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, ALPL, BCL2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, HSD17B2, TYR | 3.83637 |
| [BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.42538 |
| [BP] GO:0065008 | regulation of biological quality | ACHE, AKR1B1, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TNKS, TNKS2, XDH | 3.16847 |
| [BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS | 3.14074 |
| [BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 3.12727 |
| [BP] GO:0009725 | response to hormone | AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, HSD11B2 | 2.99287 |
| [BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS | 2.88936 |
| [BP] GO:0009115 | None | AOX1, XDH | 2.88936 |
| [BP] GO:0048856 | anatomical structure development | ACHE, AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, GBA2, HSD11B1, HSD17B2, TYR | 2.82039 |
| [BP] GO:0016137 | None | AKR1B1, AKR1B10, GBA2 | 2.76269 |
| [BP] GO:1901360 | None | ACHE, AKR1B1, AKR1B10, AOX1, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FDPS, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH | 2.7352 |
| [BP] GO:0044238 | primary metabolic process | ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FDPS, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH | 2.7352 |
| [BP] GO:0010033 | response to organic substance | AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, HSD17B2, TYR | 2.64786 |
| [BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 2.58023 |
| [BP] GO:0046110 | None | AOX1, XDH | 2.4833 |
| [BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.4833 |
| [BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.4833 |
| [BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.43221 |
| [BP] GO:0022900 | electron transport chain | AKR1B1, AOX1, CYP19A1, CYP1A2, XDH | 2.43097 |
| [BP] GO:0071704 | organic substance metabolic process | ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FDPS, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH | 2.32361 |
| [BP] GO:0032502 | developmental process | ACHE, AKR1B1, ALPL, BCL2, CA2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FUT7, GBA2, HSD11B1, HSD17B2, TNKS2, TYR | 2.2429 |
| [BP] GO:0070213 | None | TNKS, TNKS2 | 2.23717 |
| [BP] GO:0006145 | None | AOX1, XDH | 2.23717 |
| [BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.23717 |
| [BP] GO:0035265 | organ growth | BCL2, CYP19A1, ESR1 | 2.18087 |
| [BP] GO:0010647 | positive regulation of cell communication | AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, PTPN1, TNKS, TNKS2, XDH | 2.13882 |
| [BP] GO:0023056 | positive regulation of signaling | AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, PTPN1, TNKS, TNKS2, XDH | 2.12595 |
| [BP] GO:0043696 | None | CDK6, ESRRB | 2.05409 |
| [BP] GO:0043697 | None | CDK6, ESRRB | 2.05409 |
| [BP] GO:0072593 | reactive oxygen species metabolic process | BCL2, CYP1A1, CYP1A2, CYP1B1 | 2.01271 |
| [CC] GO:0044444 | cytoplasmic part | ACHE, AKR1B1, AKR1B10, AOX1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FDPS, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH | 2.07825 |
| [CC] GO:0005789 | endoplasmic reticulum membrane | BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GBA2, HSD11B1, HSD11B2, HSD17B2 | 2.03018 |
| [CC] GO:0044432 | endoplasmic reticulum part | BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 | 1.68061 |
| [CC] GO:0000242 | None | TNKS, TNKS2 | 1.03416 |
| [CC] GO:0031233 | None | CA4, F3 | 1.03416 |
| [MF] GO:0046914 | transition metal ion binding | AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, PTPN1, TNKS, TYR, XDH | 9.08899 |
| [MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA7 | 9.01326 |
| [MF] GO:0003824 | catalytic activity | ACHE, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FDPS, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH | 7.55084 |
| [MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH | 6.4656 |
| [MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH | 6.18698 |
| [MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA7 | 5.83785 |
| [MF] GO:0016835 | carbon-oxygen lyase activity | CA1, CA12, CA14, CA2, CA4, CA7 | 5.24507 |
| [MF] GO:0005496 | steroid binding | ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 | 4.92664 |
| [MF] GO:0043169 | cation binding | ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FDPS, PTPN1, TNKS, TNKS2, TYR, XDH | 4.2721 |
| [MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 4.20261 |
| [MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1 | 4.18137 |
| [MF] GO:0043167 | ion binding | ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FDPS, HSD17B1, PTPN1, TNKS, TNKS2, TYR, XDH | 4.08466 |
| [MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1 | 4.02472 |
| [MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, PTPN1, TNKS | 4.01004 |
| [MF] GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.98049 |
| [MF] GO:0016229 | steroid dehydrogenase activity | HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.86213 |
| [MF] GO:0046872 | metal ion binding | ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FDPS, PTPN1, TNKS, TNKS2, TYR, XDH | 3.82948 |
| [MF] GO:0005506 | iron ion binding | AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH | 3.59543 |
| [MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR | 3.34849 |
| [MF] GO:0016829 | lyase activity | CA1, CA12, CA14, CA2, CA4, CA7 | 3.27116 |
| [MF] GO:0016903 | None | AKR1B1, AKR1B10, AOX1, XDH | 3.18896 |
| [MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1 | 3.16841 |
| [MF] GO:0009055 | electron transfer activity | AKR1B1, AOX1, CYP19A1, CYP1A2, XDH | 3.12987 |
| [MF] GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding | ESR1, ESR2, ESRRA, ESRRB | 3.06262 |
| [MF] GO:0004879 | nuclear receptor activity | ESR1, ESR2, ESRRA, ESRRB | 3.06262 |
| [MF] GO:0048037 | cofactor binding | AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, XDH | 3.00559 |
| [MF] GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | ESR1, ESR2 | 2.88936 |
| [MF] GO:0003845 | None | HSD11B1, HSD11B2 | 2.88936 |
| [MF] GO:0003707 | steroid hormone receptor activity | ESR1, ESR2, ESRRA, ESRRB | 2.79961 |
| [MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR | 2.49186 |
| [MF] GO:0034056 | estrogen response element binding | ESR1, ESR2 | 2.23717 |
| [MF] GO:0030284 | estrogen receptor activity | ESR1, ESR2 | 2.05409 |
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 | 11.1363 |
| Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA2, CA4, CA7, CA14 | 10.9442 |
| Metabolic pathways_Homo sapiens_hsa01100 | FDPS, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH | 7.4942 |
| Ovarian steroidogenesis_Homo sapiens_hsa04913 | HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 | 6.2213 |
| Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, AOX1, CYP1B1 | 4.8824 |
| Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | HSD11B1, CYP1A2, CYP1A1, CYP1B1 | 3.9038 |
| Chemical carcinogenesis_Homo sapiens_hsa05204 | HSD11B1, CYP1A2, CYP1A1, CYP1B1 | 3.7698 |
| Retinol metabolism_Homo sapiens_hsa00830 | CYP1A2, CYP1A1, AOX1 | 2.6891 |
| MicroRNAs in cancer_Homo sapiens_hsa05206 | CDK6, BCL2, CYP1B1, CDC25B | 1.961 |
| Tyrosine metabolism_Homo sapiens_hsa00350 | AOX1, TYR | 1.961 |
| Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.9889 |
| Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.5711 |
| Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.1795 |
| Prolactin signaling pathway_Homo sapiens_hsa04917 | ESR1, ESR2 | 1.4548 |
| Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.961 |
| Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP1A2, AOX1 | 1.4652 |
| Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.9706 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1 | 1.4548 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | BCL2, F3 | 1.2977 |
| Small cell lung cancer_Homo sapiens_hsa05222 | CDK6, BCL2 | 1.3613 |
| Cholinergic synapse_Homo sapiens_hsa04725 | ACHE, BCL2 | 1.2378 |
| Estrogen signaling pathway_Homo sapiens_hsa04915 | ESR1, ESR2 | 1.2977 |
| NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, BCL2 | 1.328 |
| Measles_Homo sapiens_hsa05162 | CDK6, CSNK2A1 | 1.1212 |
| Hepatitis B_Homo sapiens_hsa05161 | CDK6, BCL2 | 1.0803 |
| Cell cycle_Homo sapiens_hsa04110 | CDK6, CDC25B | 1.1646 |
| Jak-STAT signaling pathway_Homo sapiens_hsa04630 | BCL2, AOX1 | 1.0463 |
| Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, BCL2 | 0.9303 |
| PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | CDK6, BCL2 | 0.7053 |
| Pathways in cancer_Homo sapiens_hsa05200 | CDK6, BCL2 | 0.6529 |
| Glioma_Homo sapiens_hsa05214 | CDK6 | 0.7053 |
| Pancreatic cancer_Homo sapiens_hsa05212 | CDK6 | 0.7053 |
| Chronic myeloid leukemia_Homo sapiens_hsa05220 | CDK6 | 0.7053 |
| Melanoma_Homo sapiens_hsa05218 | CDK6 | 0.7053 |
| Prostate cancer_Homo sapiens_hsa05215 | BCL2 | 0.6623 |
| Non-small cell lung cancer_Homo sapiens_hsa05223 | CDK6 | 0.7411 |
| Colorectal cancer_Homo sapiens_hsa05210 | BCL2 | 0.7086 |
| Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.7053 |
| Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | CDC25B | 0.6529 |
| Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.6623 |
| Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.6519 |
| Insulin resistance_Homo sapiens_hsa04931 | PTPN1 | 0.6313 |
| HIF-1 signaling pathway_Homo sapiens_hsa04066 | BCL2 | 0.6469 |
| Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.6529 |
| Bile secretion_Homo sapiens_hsa04976 | CA2 | 0.7053 |
| p53 signaling pathway_Homo sapiens_hsa04115 | CDK6 | 0.7053 |
| Apoptosis_Homo sapiens_hsa04210 | BCL2 | 0.5849 |
| Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | ESR1 | 0.6196 |
| Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.6529 |
| Neurotrophin signaling pathway_Homo sapiens_hsa04722 | BCL2 | 0.6196 |
| Toxoplasmosis_Homo sapiens_hsa05145 | BCL2 | 0.6196 |
| Complement and coagulation cascades_Homo sapiens_hsa04610 | F3 | 0.6874 |
| Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1 | 0.5849 |
| Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.7854 |
| Peroxisome_Homo sapiens_hsa04146 | XDH | 0.6753 |
| Sphingolipid signaling pathway_Homo sapiens_hsa04071 | BCL2 | 0.6196 |
| Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | ESRRB | 0.5849 |
| Tight junction_Homo sapiens_hsa04530 | CSNK2A1 | 0.5849 |
| Wnt signaling pathway_Homo sapiens_hsa04310 | CSNK2A1 | 0.5849 |
| Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | BCL2 | 0.5308 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.575 |
| Influenza A_Homo sapiens_hsa05164 | FDPS | 0.5283 |
| Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.5283 |
| Proteoglycans in cancer_Homo sapiens_hsa05205 | ESR1 | 0.4981 |
| Focal adhesion_Homo sapiens_hsa04510 | BCL2 | 0.4981 |
| MAPK signaling pathway_Homo sapiens_hsa04010 | CDC25B | 0.4276 |
| Viral carcinogenesis_Homo sapiens_hsa05203 | CDK6 | 0.4981 |
| Tuberculosis_Homo sapiens_hsa05152 | BCL2 | 0.5283 |
| Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.5196 |
| HTLV-I infection_Homo sapiens_hsa05166 | FDPS | 0.4276 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.7701 |
| Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | AOX1 | 0.7854 |
| Drug metabolism - other enzymes_Homo sapiens_hsa00983 | XDH | 0.7854 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2 | 0.8297 |
| Sphingolipid metabolism_Homo sapiens_hsa00600 | GBA2 | 0.7854 |
| Linoleic acid metabolism_Homo sapiens_hsa00591 | CYP1A2 | 0.9303 |
| Caffeine metabolism_Homo sapiens_hsa00232 | CYP1A2, XDH | 3.4768 |
| Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.9151 |
| Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | AOX1 | 0.9303 |
| Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.9303 |
| Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.9303 |
| Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | FDPS | 0.9859 |
| Other glycan degradation_Homo sapiens_hsa00511 | GBA2 | 1.0463 |
| Folate biosynthesis_Homo sapiens_hsa00790 | ALPL | 1.1212 |
| Vitamin B6 metabolism_Homo sapiens_hsa00750 | AOX1 | 1.3613 |
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples