TCM Prescription: Yin Chen Blood lipid Recipe



Prescription Description
Prescription IDTCMF1610
Pinyin NameYin Chen Jiang Zhi Fang
Chinese Name茵陈降脂方
English NameYin Chen Blood lipid Recipe
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGS2, SRC 9.14198
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, MPO, PTGS2, RORC, SRC, TYR 9.0473
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP3, HSD17B2, IDO1, IGF1R, MMP2, MMP9, MPO, PTGS2, RORC, SRC, TYR 9.0102
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, IDO1, MPO, PTGS2, RORC, SRC, TYR 9.00054
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 9.00054
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, IDO1, MPO, PIM1, PTGS2, TYR, XDH 8.80184
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, MPO, PTGS2, RORC, SRC, TYR 8.25813
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.7184
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AKR1C3, AURKB, AXL, BCL2, CYP1B1, FLT3, HCAR2, IDO1, IGF1R, KDR, KIT, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, XDH 7.00523
[BP] GO:0010941 regulation of cell death AKR1B1, AKR1C3, AURKB, AXL, BCL2, CYP1B1, FLT3, HCAR2, IDO1, IGF1R, KDR, KIT, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, XDH 6.50331
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.50331
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, FLT3, HCAR2, HTR6, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, XDH 6.50331
[BP] GO:0023056 positive regulation of signaling AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, FLT3, HCAR2, HTR6, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, XDH 6.49537
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PTGS2, RORC, SRC 6.39495
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FLT3, PTGS2, RORC, SRC, TYR 6.1241
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, IDO1, IGF1R, KDR, KIT, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC 6.1241
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSD17B2, KIT, MET, PTGS2 6.07219
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, PTGS2, RORC, SRC 6.03457
[BP] GO:0032502 developmental process ACHE, AKR1B1, AKR1C3, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, HSD17B2, KDR, KIT, MET, MMP2, MMP9, MPO, PIM1, PTGS2, RORC, SRC, TYR 5.9711
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MPO, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 5.96043
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, IDO1, IGF1R, KDR, KIT, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC 5.69839
[BP] GO:0010038 response to metal ion AKR1C3, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGS2 5.65411
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AKR1C3, AURKB, AXL, BCL2, CYP1B1, FLT3, HCAR2, IDO1, IGF1R, KDR, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, XDH 5.6099
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, FLT3, HTR6, KDR, KIT, MET, PTGS2, PTPN1, SRC, XDH 5.59531
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PTGS2, PTPN1, RORC, SRC 5.59531
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, HCAR2, HTR6, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 5.59531
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APP, BCL2, CA2, CA9, CYP1A2, FABP3, FLT3, IGF1R, KIT, MMP2, PTGS2, SRC 5.58289
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, FABP4, HSD17B2, IDO1, IGF1R, KIT, MET, MMP1, MMP2, MMP9, MPO, PIM1, PTGS2, RORC, SRC, TYR 5.55905
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, MPO, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 5.50132
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B2 5.49229
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, MMP9, MPO, PTGS2, SRC 5.46327
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B2, IDO1, MPO, PTGS2, TYR, XDH 5.22024
[BP] GO:0042127 regulation of cell proliferation AKR1B1, AKR1C3, APP, BCL2, CDC25B, CYP1B1, FABP3, FLT3, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, SRC, XDH 5.18628
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HCAR2, HTR6, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 5.08992
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, BCL2, CA2, CA9, CYP1A2, FABP3, FLT3, KIT, PTGS2, SRC 4.83701
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, HSD17B2, IDO1, KIT, MMP2, MMP9, PTGS2, SRC 4.71015
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.65794
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, IDO1, IGF1R, KDR, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC 4.58041
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CYP1B1, FLT3, HTR6, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, XDH 4.54149
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HCAR2, HSD17B2, KDR, KIT, MET, PTGS2, SRC, XDH 4.5112
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AKR1C3, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, IDO1, MMP1, MMP2, MMP9, MPO, SRC, XDH 4.5112
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.37958
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, CYP1A1, CYP1B1, FLT3, PTGS2, RORC, SRC 4.35066
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, AKR1C3, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, MPO, PTGS2, PTPN1, RORC, SRC, TYR 4.34385
[BP] GO:0019216 regulation of lipid metabolic process AKR1C3, CYP1A1, FABP3, FLT3, HCAR2, KIT, PTGS2, RORC, SRC 4.24158
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.22818
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, MMP9, SRC 4.22454
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.21225
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, FABP4, FLT3, HTR6, IDO1, KDR, KIT, MET, MMP2, MMP9, PTGS2, PTPN1, SRC, XDH 4.20413
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA2, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B2, KDR, KIT, MMP9, PIM1, PTGS2, RORC, SRC, TYR 4.20413
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, FLT3, HTR6, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, XDH 4.17874
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, HSD17B2 4.1777
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 4.1777
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 4.17039
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, KIT, MET, PTGS2 4.12849
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, HSD17B2 4.1203
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 4.11696
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 4.11599
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 4.08793
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 4.08015
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, KDR, KIT, PIM1, SRC 3.97875
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, BCL2, CA2, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, KIT, SRC, TYR 3.97212
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.93689
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, FLT3, HCAR2, HTR6, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.91342
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, TYR 3.90713
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, FLT3, HCAR2, HTR6, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.8272
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, IDO1 3.80826
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CYP1A1, MPO, PTGS2, SRC, TYR 3.76999
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.76999
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.76999
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.76999
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, BCL2, CDC25B, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2 3.7466
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, BCL2, CA2, FLT3, PTGS2, SRC 3.72033
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 3.719
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.719
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.6181
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.60004
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AXL, BCL2, CDC25B, CYP19A1, HSD17B2, KIT, PTGS2, SRC 3.5909
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AXL, CYP1B1, IGF1R, MMP2, MMP9, PTGS2, RORC, SRC 3.5909
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, FLT3, IGF1R, KDR, KIT, MET, PIM1, PTGS2, PTPN1, SRC, XDH 3.57436
[BP] GO:0071248 cellular response to metal ion AKR1C3, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.53827
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.53118
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.52589
[BP] GO:0030334 regulation of cell migration APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.50709
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.50323
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 3.49351
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, FLT3, PTGS2, SRC 3.45464
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.45464
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.42787
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.39002
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, FLT3, IGF1R, KDR, KIT, MET, PIM1, PTGS2, PTPN1, SRC, XDH 3.35072
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, FLT3, KIT, MET, PIM1, SRC, TYR 3.31467
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9, RORC 3.30943
[BP] GO:2000145 regulation of cell motility APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.28981
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, KIT, MMP2, MPO, PTGS2, SRC, TYR 3.28289
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 3.25336
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.23717
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, BCL2, CYP19A1, HSD17B2, KIT, SRC 3.23717
[BP] GO:0016042 lipid catabolic process AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 3.23717
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 3.23717
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 3.2312
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO 3.20708
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AXL, BCL2, CDC25B, CYP1A1, FABP4, FLT3, FUT7, KDR, KIT, MET, MMP2, MMP9, PTGS2, RORC, SRC 3.2019
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.17771
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 3.14318
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MPO 3.14318
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CYP1A1, MPO, PTGS2, SRC, TYR 3.12337
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 3.05776
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1 3.05776
[BP] GO:0016488 None AKR1B10, AKR1C3 3.05776
[BP] GO:0016487 None AKR1B10, AKR1C3 3.05776
[BP] GO:0016107 None AKR1B10, AKR1C3 3.05776
[BP] GO:0006714 None AKR1B10, AKR1C3 3.05776
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 3.05458
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 3.05458
[BP] GO:0040012 regulation of locomotion APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.04765
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGS2 3.04432
[BP] GO:0051270 regulation of cellular component movement APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.03984
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 3.02225
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, FABP3, KDR, PTGS2, SRC 2.97122
[BP] GO:0010562 positive regulation of phosphorus metabolic process APP, BCL2, CDC25B, FABP3, FLT3, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.96889
[BP] GO:0045937 positive regulation of phosphate metabolic process APP, BCL2, CDC25B, FABP3, FLT3, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.96889
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX5, CYP19A1, CYP1A1, IDO1, MPO, PTGS2 2.92818
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, HCAR2, IDO1, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC 2.92818
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, SRC 2.9027
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9 2.87166
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.84702
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, KIT, MET, SRC, XDH 2.83973
[BP] GO:0001934 positive regulation of protein phosphorylation APP, BCL2, CDC25B, FLT3, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.83808
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PTGS2, TYR 2.83224
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PTGS2, SRC 2.83003
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CYP1B1, HCAR2, IDO1, MMP9, PTGS2, SRC, XDH 2.81743
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1 2.8065
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.8065
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.8065
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, FLT3, FUT7, KIT, MMP9, MPO, RORC, SRC 2.80151
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.80043
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CYP1B1, HCAR2, IDO1, MMP9, PTGS2, SRC, XDH 2.79946
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PTGS2, TYR 2.78405
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD17B2 2.76092
[BP] GO:0001932 regulation of protein phosphorylation APP, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.76025
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, HCAR2, KDR, PTGS2, SRC 2.72936
[BP] GO:0032787 None AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PTGS2 2.70564
[BP] GO:0009605 response to external stimulus AKR1C3, ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, IDO1, KIT, MPO, PTGS2, SRC, TYR 2.6998
[BP] GO:0042327 positive regulation of phosphorylation APP, BCL2, CDC25B, FLT3, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.6998
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.69184
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.69184
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 2.69184
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.69184
[BP] GO:0016095 None AKR1B10, AKR1C3 2.69184
[BP] GO:0006950 response to stress ACHE, AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, IDO1, KIT, MMP2, MMP9, MPO, PTGS2, PTPN1, SRC 2.61894
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.58666
[BP] GO:0010942 positive regulation of cell death AKR1C3, BCL2, CYP1B1, HCAR2, IDO1, MMP9, PTGS2, SRC, XDH 2.58497
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 2.55298
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD17B2 2.55286
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.53884
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.52357
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.51144
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PIM1, PTGS2, TYR 2.49484
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, FLT3, IGF1R, KIT, MMP2, PTGS2, SRC 2.48952
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, KIT, MET, SRC 2.46811
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CYP19A1, CYP1B1, FABP3, FABP4, IDO1, IGF1R, KDR, KIT, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 2.46027
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.44889
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.43447
[BP] GO:0019220 regulation of phosphate metabolic process APP, BCL2, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.43447
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.43447
[BP] GO:0042325 regulation of phosphorylation APP, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.43447
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CYP1A1, CYP1A2, FLT3, FUT7, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TYR, XDH 2.42896
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.41186
[BP] GO:0051174 regulation of phosphorus metabolic process APP, BCL2, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.4071
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.40216
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.38612
[BP] GO:0070542 None AKR1C3, FABP3, PTGS2, SRC 2.38487
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, MPO, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 2.37475
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 2.37475
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.37475
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, AURKB, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, IDO1, MPO, SRC, XDH 2.36224
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1 2.35513
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PTGS2, TYR 2.35513
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.34477
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, TYR 2.32607
[BP] GO:1901575 None ACHE, AKR1B10, AKR1C3, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, IDO1, XDH 2.32381
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3 2.31378
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.31378
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, MPO 2.31378
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, BCL2, CYP1B1, PTGS2, XDH 2.31138
[BP] GO:0030154 cell differentiation AKR1C3, ALPL, AXL, BCL2, CYP1A1, FABP4, FLT3, FUT7, KDR, KIT, MMP2, MMP9, PTGS2, RORC 2.30273
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP2, MMP9 2.29586
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, PTGS2, SRC 2.29083
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, MMP9 2.28199
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.27849
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.27849
[BP] GO:0044242 None AKR1B10, AKR1C3, CYP1B1, FABP3, FABP4 2.27849
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, KIT, PTGS2, TYR 2.27681
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CYP19A1, CYP1B1, FABP3, FABP4, HCAR2, IDO1, IGF1R, KDR, KIT, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 2.25464
[BP] GO:0042592 homeostatic process AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, FABP3, FABP4, FLT3, MET, SRC 2.25034
[BP] GO:0001523 None AKR1B10, AKR1C3, CYP1A1, CYP1B1 2.23757
[BP] GO:0032879 regulation of localization ACHE, APP, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC 2.22321
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, FABP3, FLT3, IGF1R, MMP2, PTGS2, SRC, TYR 2.21809
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC 2.21809
[BP] GO:0048583 regulation of response to stimulus AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CYP19A1, CYP1B1, FABP4, FLT3, HTR6, IDO1, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTGS2, PTPN1, SRC, XDH 2.21665
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, PTGS2, PTPN1, SRC 2.18217
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC 2.16729
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, CA2, CA7, KIT, PTGS2 2.16591
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, CA2, CA7, KIT, PTGS2 2.16591
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.13694
[BP] GO:0016115 None AKR1B10, AKR1C3 2.13694
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1 2.13694
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP2, MMP9 2.1251
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP2, MMP9 2.11909
[BP] GO:0030217 None BCL2, FUT7, KIT, RORC 2.10841
[BP] GO:0034405 response to fluid shear stress CA2, PTGS2, SRC 2.09694
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, CYP1A1, PTGS2, TYR 2.09694
[BP] GO:0031401 positive regulation of protein modification process APP, BCL2, CDC25B, FLT3, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.07282
[BP] GO:0007566 embryo implantation MMP2, MMP9, PTGS2 2.06608
[BP] GO:0046649 lymphocyte activation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.04602
[BP] GO:1904180 negative regulation of membrane depolarization BCL2, SRC 2.01394
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP2, MMP9 2.01067
[BP] GO:0061515 None APP, KIT, SRC 2.01067
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, FABP3, FLT3, IGF1R, MMP2, PTGS2, SRC, TYR 2.01009
[BP] GO:0051186 None AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, MPO, PTGS2 2.00502
[CC] GO:0000323 lytic vacuole AKR1B1, AKR1B10, KIT, MPO, SRC, TYR 2.34251
[CC] GO:0005764 lysosome AKR1B1, AKR1B10, KIT, MPO, SRC, TYR 2.34251
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.13694
[CC] GO:0005773 None AKR1B1, AKR1B10, KIT, MPO, SRC, TYR 1.92645
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.92474
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.4296
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP2, MMP9, PIM1, PTPN1, RORC, TYR, XDH 9.14198
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TYR, XDH 8.90275
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.04073
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, MPO, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 6.74395
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.28758
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC 6.18506
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B2, IDO1, MPO, PTGS2, TYR, XDH 6.11977
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC 6.03332
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 5.4156
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, KIT, MMP1, MMP2, MMP9, MPO, PIM1, PTGS2, PTPN1, RORC, TYR, XDH 5.22024
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.83275
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, KIT, MMP1, MMP2, MMP9, MPO, PIM1, PTGS2, PTPN1, RORC, TYR, XDH 4.75223
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TYR 4.5112
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 4.42611
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 4.16065
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 4.13112
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 4.12849
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.96316
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC, XDH 3.45464
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.38633
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP2, MMP9, PTPN1, RORC 3.33994
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, XDH 3.20708
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.17771
[MF] GO:0045550 None AKR1B10, AKR1C3 3.05776
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 3.05458
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.02425
[MF] GO:0047718 None AKR1B10, AKR1C3 2.69184
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, HSD17B2, XDH 2.67259
[MF] GO:0004672 protein kinase activity AURKB, AXL, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.6195
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.44981
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.44981
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.41478
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.28199
[MF] GO:0004064 arylesterase activity CA1, CA2 2.13694
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2 2.13694
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.13694
[MF] GO:0005021 vascular endothelial growth factor-activated receptor activity FLT3, KDR 2.01394
[MF] GO:0001758 None AKR1B10, AKR1C3 2.01394
[MF] GO:0004032 None AKR1B1, AKR1C3 2.01394


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 10.927
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 12.3336
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 6.8251
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, KIT, BCL2, PTGS2, MMP9, MET, IGF1R 5.1408
Metabolic pathways_Homo sapiens_hsa01100 AKR1C3, AKR1B1, PTGS2, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, IDO1 5.0152
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 4.417
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 4.0621
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.1579
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.417
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MET, IGF1R 3.5406
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, KIT, KDR, BCL2, MET, IGF1R 3.0665
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 3.0945
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 3.0665
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, MPO, IGF1R 3.2991
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 3.4059
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, ALOX5, PTGS2 3.0665
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.7249
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.7249
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.6688
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, AKR1C3, PTGS2 2.6688
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.5897
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 2.1609
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 2.1275
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 2.1695
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.5183
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 2.0818
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.5715
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.9559
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.8083
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6 1.4985
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PTGS2 1.6162
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.4759
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.3311
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4985
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.3227
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.2812
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5847
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, PTGS2 1.3389
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.5154
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.274
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.4088
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.3311
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.2149
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.2591
NF-kappa B signaling pathway_Homo sapiens_hsa04064 BCL2, PTGS2 1.3145
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.1757
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.9706
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.9706
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.1757
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6 0.9069
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.9069
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC 0.8136
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR6 0.6706
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.0818
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3505
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.9559
Epstein-Barr virus infection_Homo sapiens_hsa05169 BCL2 0.4202
Insulin resistance_Homo sapiens_hsa04931 PTPN1 0.5558
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5387
Platelet activation_Homo sapiens_hsa04611 SRC 0.5387
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.419
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5387
Apoptosis_Homo sapiens_hsa04210 BCL2 0.5148
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4708
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.5387
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4604
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.6045
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.5148
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5387
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5872
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5904
Tight junction_Homo sapiens_hsa04530 SRC 0.5148
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.5211
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5387
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.5137
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.4708
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.5068
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.5127
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.443
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5804
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.5387
Phagosome_Homo sapiens_hsa04145 MPO 0.4963
Axon guidance_Homo sapiens_hsa04360 MET 0.534
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5904
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.6045
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.6007
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5904
Gap junction_Homo sapiens_hsa04540 SRC 0.6045
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6521
Glioma_Homo sapiens_hsa05214 IGF1R 0.6706
Peroxisome_Homo sapiens_hsa04146 XDH 0.6119
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6706
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6706
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6521
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2336
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6521
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6706
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 2.0403
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6702
Bile secretion_Homo sapiens_hsa04976 CA2 0.6523
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6582
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6706
Shigellosis_Homo sapiens_hsa05131 SRC 0.6706
Malaria_Homo sapiens_hsa05144 MET 0.7368
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7268
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7562
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.8564
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8564
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8931
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.9069
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.923
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.9
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9147
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3064
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1621


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)