Prescription Description
| Prescription ID | TCMF1396 |
| Pinyin Name | Xiang Sha Yang Wei Wan |
| Chinese Name | 香砂养胃丸 |
| English Name | Aucklandia and Amomum Fruit Pills |
| Function Description | 胃气虚寒, 胸膈饱闷寒痛 |
| Indications | Stomach qi deficiency pattern |
| Disease ICD-11 Category |
SF7C [Stomach qi deficiency pattern (TM1), 胃气虚证 (TM1)
]; |
| Human Tissues Associated with Indication | Intestine, Stomach |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH426 | Codonopsis pilosula | 党参 | TCMH426 | ITSAL4530-14 |
| TCMH120 | Atractylodes macrocephala | 白术 | TCMH120 | ITSAN4430-14 |
| TCMH1184 | Citrus reticulata | 橘皮 | TCMH1184 | ITSAA1245-14 |
| TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
| TCMH130 | Pinellia ternata | 半夏 | TCMH130 | GBVT1123-13, GBVY1693-14 |
| TCMH1803 | Amomum villosum | 砂仁 | TCMH1803 | ITSAD521-14 |
| TCMH2265 | Cyperus rotundus | 香附 | TCMH2265 | GENG1049-15 |
| TCMH1533 | Saussurea lappa | 木香 | TCMH1533 | |
| TCMH2630 | Citrus aurantium | 枳实 | TCMH2630 | ITSAA1279-14 |
| TCMH53 | Amomum kravanh | 白豆蔻 | TCMH53 | KT898257 |
| TCMH1008 | Pogostemon cablin | 藿香 | TCMH1008 | ITSAJ4146-14 |
| TCMH890 | Cortex magnoliae officinalis | 厚朴 | TCMH890 | ITSAM1591-14 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT114 | CNR2 | Cannabinoid CB2 receptor | GPCR | P34972 |
| TCMT115 | CNR1 | Cannabinoid CB1 receptor | GPCR | P21554 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
Showing 1 to 10 of 120 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1183 | Candida albicans SC5314 |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
Showing 1 to 10 of 75 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 4.12152 |
| [BP] GO:0001503 | ossification | ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 3.19223 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK | 3.87292 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 2.27238 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, BCL2, CDC25B, EGFR, FLT3, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 2.2779 |
| [BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, CDK6, KDR, SMAD3, SRC, TEK | 3.39391 |
| [BP] GO:0001954 | positive regulation of cell-matrix adhesion | CDK6, KDR, SMAD3, TEK | 2.60701 |
| [BP] GO:0002009 | morphogenesis of an epithelium | BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC | 2.8442 |
| [BP] GO:0002237 | response to molecule of bacterial origin | ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC | 2.03901 |
| [BP] GO:0002682 | regulation of immune system process | ADORA1, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, MMP12, MMP2, PTPN1, SMAD3, SRC | 2.73801 |
Showing 1 to 10 of 393 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCG2 | 0.659 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.2907 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.8554 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5384 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.353 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, BCL2, PIM1, F3 | 3.3479 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, INSR | 1.5242 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | INSR, HMGCR, IGF1R | 1.4716 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.6278 |
| Antigen processing and presentation_Homo sapiens_hsa04612 | HSPA1A | 0.5093 |
Showing 1 to 10 of 152 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples