TCM Prescription: Liver-Soothing Bolus



Prescription Description
Prescription IDTCMF1393
Pinyin NameShu Gan Wan
Chinese Name舒肝丸
English NameLiver-Soothing Bolus
Function Description两胁胀满, 胃脘刺痛, 呕逆嘈杂, 嗳气吞酸
IndicationsEpigastric upset disorder
Disease ICD-11 Category SA53 [Epigastric upset disorder (TM1), 嘈杂 (TM1) ];
Human Tissues Associated with IndicationStomach
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH284 Melia toosendan 川楝子 TCMH284 KY197925
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1063 Curcuma longa 姜黄 TCMH1063 ITSAP2805-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH53 Amomum kravanh 白豆蔻 TCMH53 KT898257
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH1184 Citrus reticulata 橘皮 TCMH1184 ITSAA1245-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT962 ENPP2 Autotaxin Hydrolase Q13822


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, KDR, MAOA, MCL1, MET, POLA1, POLB, PPARA, SRC, TRPV1, XDH 11.6007
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD2, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, PTGES, TBXAS1, TRPV1 9.78379
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AXL, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FABP3, HSD17B2, HTR5A, IGF1R, MMP2, MMP9, POLB, PPARA, PTGES, SRC, TRPV1, TYR 9.46428
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, APP, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HSD17B2, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MCL1, MMP2, MMP9, POLB, PPARA, PTGES, SRC, TRPV1, TYR 9.46428
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, APP, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HSD17B2, HTR5A, IGF1R, KDR, MCL1, MMP2, POLB, PPARA, PTGES, SRC, TRPV1, TYR 9.46428
[BP] GO:0007187 None ADORA1, ADRA1A, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 8.81254
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, CNR1, CNR2, DRD2 7.94706
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, KDR, POLB, SRC, TRPV1 7.74304
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, APP, AXL, CA12, CA2, CA7, CNR1, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HTR2A, HTR2B, MCL1, MET, POLA1, POLB, SRC, TRPV1 7.62836
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MCL1, MET, MMP9, SRC, XDH 7.62836
[BP] GO:0008202 steroid metabolic process AKR1B1, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2 7.62836
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MCL1, MET, MMP9, SRC, XDH 7.62836
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FUT7, HTR2B, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 7.34789
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC, TRPV1 7.24601
[BP] GO:0007188 None ADORA1, ADRA1A, CHRM2, CNR1, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 7.20341
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.16952
[BP] GO:0014070 response to organic cyclic compound APP, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FLT3, HTR5A, PTGES, SRC, TRPV1, TYR 7.15933
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.15933
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.15933
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, TRPV1 7.00908
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, APP, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, HTR2A 6.924
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, APP, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, HTR2A 6.924
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AURKB, AXL, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MCL1, MMP2, MMP9, POLA1, POLB, PPARA, PTGES, SRC, TRPV1, TYR 6.9085
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, TYR 6.8607
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGES, TBXAS1 6.70429
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR2A 6.45292
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, APP, CSNK2A1, CYP1B1, DRD2, DRD3, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP2, MMP9, PIM1, PTGES, SRC, XDH 6.45292
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, ALOX5, APP, AXL, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FABP4, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, MCL1, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TRPV1, TYR 6.42286
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGES, TBXAS1 6.42192
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, APP, AXL, CYP1B1, DRD2, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MCL1, MET, SRC, XDH 6.24538
[BP] GO:0050795 None ADORA1, CNR1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 6.24429
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGES, TBXAS1 6.20855
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.20855
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, PTGES, SRC 6.014
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 6.01343
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CNR1, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC, TRPV1 5.88178
[BP] GO:0007193 None ADORA1, CHRM2, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.76847
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A, MAOA, TYR 5.69584
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, POLB, SRC 5.69584
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MCL1, MET, MMP9, SRC, XDH 5.67664
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MCL1, MET, MMP9, SRC, XDH 5.62614
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, HTR1A, MAOA, TYR 5.58086
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, HTR5A, PTGES, SRC, TYR 5.58086
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 5.58086
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD2, FABP3, FABP4, FUT7, MET, PPARA, PTGES, TBXAS1 5.57201
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, TRPV1 5.55119
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MCL1, MET, MMP9, SRC, XDH 5.47862
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MCL1, MET, MMP9, SRC, XDH 5.36614
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, HTR2A, HTR2B, MMP2, POLB, PPARA, SRC, TRPV1, TYR 5.34897
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, DRD1, DRD2, DRD3, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TRPV1, TYR 5.31516
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, APP, CA2, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1, SRC 5.31391
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, MAOA, TBXAS1, TYR, XDH 5.22871
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, CA2, CA9, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MCL1, MET, MMP2, MMP9, PIM1, POLB, PPARA, SIGMAR1, SRC, TYR 5.14916
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AXL, CA1, CA2, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MCL1, MET, MMP2, MMP9, PIM1, POLB, PPARA, PTGES, SIGMAR1, SRC, TRPV1 5.11373
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, F3, FLT3, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, SIGMAR1, SRC, TRPV1, XDH 5.10961
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.06419
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGES, TBXAS1 5.05424
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGES, TBXAS1 5.02042
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 5.02042
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, APP, AXL, CNR1, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, KDR, MCL1, MET, MMP2, MMP9, SRC, XDH 5.01956
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, PPARA, PTGES, TBXAS1 5.01539
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.97063
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, F3, FLT3, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIM1, SIGMAR1, SRC, TRPV1, XDH 4.96146
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, APP, CA12, CA2, CA7, CNR1, DRD1, DRD2, DRD3, FABP3, FABP4, HTR2A, HTR2B, MET, TRPV1 4.96146
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A, TRPV1 4.94975
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, DRD1, DRD2, DRD3, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TRPV1, TYR 4.94511
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MCL1, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TRPV1, XDH 4.87239
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.87239
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, HTR2A 4.87239
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PPARA, SRC, TRPV1 4.7524
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, APP, CA2, CA9, CSNK2A1, CYP1A2, DRD1, FABP3, FLT3, HTR5A, IGF1R, MMP2, PPARA, SRC, TRPV1 4.75225
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET, TRPV1 4.62311
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, MAOA 4.58148
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.58148
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2 4.55955
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD1, DRD2, DRD3, HTR1A, MAOA 4.55338
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.53035
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, SRC 4.52819
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.50847
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.50847
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.49209
[BP] GO:0051952 None ADORA1, CNR1, DRD1, DRD2, DRD3, HTR2A 4.48053
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, TRPV1 4.47299
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, F3, FLT3, HTR2B, IGF1R, KDR, MCL1, MMP9, PIM1, SIGMAR1, SRC, TRPV1, XDH 4.39127
[BP] GO:0045776 None ADORA1, CNR1, DRD2, DRD3, PPARA 4.3484
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.34701
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.32801
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, MAOA 4.31427
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, MAOA 4.31427
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 4.31427
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, DRD3, FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC 4.31427
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, APP, AXL, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, HSD11B1, HSD17B2, HTR5A, KDR, MCL1, MMP9, PIM1, POLB, PPARA, SIGMAR1, SRC, TYR 4.28288
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 4.22343
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.20291
[BP] GO:0007200 None ADRA1A, CHRM2, DRD1, DRD2, HTR2A, HTR2B 4.17535
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F10, F3, MET, SRC, XDH 4.1408
[BP] GO:2001023 None CNR1, DRD1, DRD2, DRD3, HTR2A, MET 4.12281
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTGES, SRC, TBXAS1, TRPV1, TYR, XDH 4.11811
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 4.10966
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MCL1, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TRPV1, XDH 4.07266
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A6 4.025
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.98823
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CSNK2A1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP2, MMP9, PIM1 3.85675
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 3.80763
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, MAOA, MMP1, MMP2, MMP9, SRC, XDH 3.80671
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.79366
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD11B1, HSD17B2, KDR, POLB, PPARA, SRC, TYR 3.78285
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.76939
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A6, CYP2D6 3.76939
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A6, CYP2D6 3.76939
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, HTR5A, PPARA, SRC, TRPV1 3.68335
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, HTR2A 3.68335
[BP] GO:0001975 None CNR2, DRD1, DRD2, DRD3 3.66735
[BP] GO:0050801 ion homeostasis ADRA1A, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, TRPV1 3.62291
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, APP, CNR1, CNR2, CYP1B1, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR7, SRC, TRPV1, TYR 3.60568
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.59096
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.59096
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, HTR1A, MAOA, TRPV1 3.59075
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, CYP3A4, MAOA 3.55975
[BP] GO:0042417 None DRD1, DRD2, DRD3, MAOA 3.55975
[BP] GO:0014059 None CNR1, DRD2, DRD3, HTR2A 3.55975
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, SRC 3.54162
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B, TRPV1 3.54095
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, TRPV1 3.49431
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.43924
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MCL1, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTGES, SIGMAR1, SRC, TRPV1, XDH 3.40255
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC 3.39058
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, PPARA, PTGES, TBXAS1 3.34715
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.33723
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.33622
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MCL1, MET, MMP2, MMP9, PPARA, SRC, XDH 3.33527
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, PPARA, TRPV1 3.33527
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, HTR2A, HTR2B, KDR, SRC 3.32885
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 3.3207
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.31466
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIM1, SRC 3.27372
[BP] GO:0043269 regulation of ion transport ADORA1, APP, CA2, CA7, CNR1, DRD1, DRD2, DRD3, HTR1A, HTR2A, MMP9 3.27277
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FABP3, FABP4, HTR2A, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTGES, SRC, TRPV1, XDH 3.25037
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B, TRPV1 3.21611
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 3.21327
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.19132
[BP] GO:0099536 None CHRM2, CNR1, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 3.1485
[BP] GO:0099537 None CHRM2, CNR1, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 3.1485
[BP] GO:0042391 None ADORA1, ADRA1A, APP, CNR1, CNR2, DRD1, KDR, SRC, TRPV1 3.14156
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, APP, DRD2, FLT3, HTR2A, HTR2B, KDR, SRC, XDH 3.14156
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, TRPV1 3.12475
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, HTR2A, PPARA 3.11707
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, APP, AXL, CA2, CNR1, CYP1B1, DRD2, DRD3, F3, HTR2A, HTR2B, KDR, MET, MMP9, PIM1, SRC, TRPV1 3.1069
[BP] GO:0043271 negative regulation of ion transport ADORA1, CNR1, DRD2, DRD3, HTR2A, MMP9 3.10368
[BP] GO:0014075 None CNR2, DRD1, DRD2, DRD3 3.09615
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.09615
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 3.09615
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 3.08911
[BP] GO:0032845 None ADORA1, DRD2, HTR2A, HTR2B, SRC, TRPV1 3.06409
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, DRD2, DRD3, F3, FABP4, KDR, MET, PPARA 3.03549
[BP] GO:0019725 cellular homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, MCL1, POLA1, TRPV1 3.02089
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, DRD3 3.00412
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.00412
[BP] GO:0060134 None DRD1, DRD2, DRD3 3.00412
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 3.00412
[BP] GO:0008217 None ADORA1, ADRA1A, CNR1, DRD2, DRD3, PPARA 2.99784
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, PTGES 2.99259
[BP] GO:0007610 None APP, CNR1, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, PPARA, TRPV1 2.97663
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.91153
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.91153
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, HTR1A, MCL1, MMP2, MMP9, POLA1, POLB, PPARA, PTGES, SRC, TRPV1 2.91153
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, DRD1, DRD2, DRD3, HTR2B, HTR5A, KDR 2.91005
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KDR, MAOA, MET, MMP1, MMP2, PIM1, POLA1, POLB, PPARA, PTGES, SRC, TBXAS1, TYR, XDH 2.90703
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.90396
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PTGES 2.90086
[BP] GO:0030335 positive regulation of cell migration APP, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.85631
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, TRPV1 2.84945
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, TRPV1 2.84945
[BP] GO:0097366 None CNR2, DRD1, DRD2, DRD3 2.84945
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MET, MMP9, PIM1, PPARA, SRC, TRPV1, XDH 2.84285
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.83977
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.83977
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.83977
[BP] GO:0030003 cellular cation homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 2.82426
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, SRC 2.80795
[BP] GO:0050433 None CNR1, DRD2, DRD3, HTR2A 2.78665
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MCL1, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTGES, SIGMAR1, SRC, TBXAS1, TRPV1, TYR, XDH 2.76554
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.76175
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.76175
[BP] GO:2000147 positive regulation of cell motility APP, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.76094
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.76094
[BP] GO:0006873 cellular ion homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 2.7497
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.74213
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HTR2B, IGF1R, KDR, MCL1, MMP9, PIM1, SRC 2.72451
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, APP, DRD2, FLT3, HTR2A, HTR2B, IGF1R, KDR, SRC, XDH 2.71392
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGES, TBXAS1, TYR 2.70808
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CNR1, CYP19A1, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, MMP9, PPARA, SRC, TRPV1 2.7024
[BP] GO:0051272 positive regulation of cellular component movement APP, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.68076
[BP] GO:0007154 None ADORA1, ADRA1A, AXL, CHRM2, CNR1, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, TRPV1 2.6639
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP9, SRC 2.64008
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, SRC, TRPV1 2.63818
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.62696
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 2.61932
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MCL1, MET, POLB, SRC 2.61515
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.61515
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.60495
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.59139
[BP] GO:0040017 positive regulation of locomotion APP, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.58072
[BP] GO:0050890 None ADORA1, APP, CNR1, DRD1, DRD2, DRD3, HTR2A 2.58009
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.58009
[BP] GO:0060160 None DRD2, DRD3 2.58009
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.58009
[BP] GO:0033602 None CNR1, DRD2 2.58009
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.58009
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.58009
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, APP, AURKB, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MMP9, SRC, XDH 2.57591
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.57591
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, HTR2A, HTR2B, KDR, SRC 2.57202
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.55649
[BP] GO:0032496 response to lipopolysaccharide AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, SRC 2.54726
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, APP, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, SRC, XDH 2.54726
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 2.54726
[BP] GO:0051282 None DRD1, DRD2, HTR2A, HTR2B, TRPV1 2.54726
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HTR2B, SRC, TRPV1 2.54565
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, DRD1, DRD2, DRD3, PPARA 2.5418
[BP] GO:0007267 None ADORA1, ADRA1A, CHRM2, CNR1, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.5418
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 2.5418
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.5418
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, TRPV1 2.5418
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.5418
[BP] GO:0055080 cation homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 2.53505
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, APP, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, SRC, XDH 2.52538
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, SRC, TRPV1 2.52349
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, HTR7, PPARA, SRC 2.50551
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, SRC 2.50374
[BP] GO:0070988 demethylation CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.49189
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.48631
[BP] GO:0055074 calcium ion homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 2.48263
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FABP3, FABP4, HTR2A, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTGES, SRC, TRPV1, XDH 2.48165
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, POLB, PPARA, SRC 2.4497
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 2.4497
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, DRD2, DRD3, IGF1R, MCL1, MET, MMP9, SRC, XDH 2.4497
[BP] GO:0007268 None CHRM2, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.44378
[BP] GO:0098916 None CHRM2, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.44378
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC 2.43227
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 2.4146
[BP] GO:0002237 response to molecule of bacterial origin AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, SRC 2.41331
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, FLT3, HTR1A, MET, PIM1, POLA1, SRC, TYR 2.41331
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, APP, DRD1, DRD2, FABP3, FLT3, HTR2A, HTR2B, KDR, MMP9, SRC, XDH 2.40262
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, APP, DRD1, DRD2, FABP3, FLT3, HTR2A, HTR2B, KDR, MMP9, SRC, XDH 2.40262
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGES, TBXAS1, TYR 2.38972
[BP] GO:0051953 None ADORA1, CNR1, DRD2 2.38972
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.38972
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.38972
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 2.38935
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.3847
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.35719
[BP] GO:0038171 None CNR1, CNR2 2.35719
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.35719
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, CNR2, DRD1, DRD2, DRD3, HTR2A, IGF1R, MCL1, MET, MMP9, SRC, XDH 2.3558
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.34641
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.34641
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, CNR2, DRD1, DRD2, DRD3, HTR2A, IGF1R, MCL1, MET, MMP9, SRC, XDH 2.34527
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, HTR2B, SRC, TRPV1 2.34415
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CNR1, CNR2, CYP19A1, DRD2, F3, FABP4, IGF1R, MCL1, MET, MMP2, PPARA, SRC, XDH 2.34205
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGES, TBXAS1, TYR 2.33921
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 2.33921
[BP] GO:0051716 cellular response to stimulus AKR1B1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MCL1, MMP2, MMP9, POLA1, POLB, SRC, TRPV1 2.32824
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.3243
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, SRC 2.29439
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC, TRPV1 2.27583
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, CNR1, CNR2, CYP19A1, DRD1, DRD2, DRD3, IGF1R, MCL1, MET, MMP9, PPARA, SRC, XDH 2.27383
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.25813
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.25813
[BP] GO:0008306 None APP, DRD1, DRD2, DRD3 2.23729
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGES, SRC 2.22869
[BP] GO:0023052 None ADORA1, ADRA1A, CHRM2, CNR1, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.22406
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, APP, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, SRC, XDH 2.2239
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MCL1, MET, MMP9, SRC, XDH 2.22046
[BP] GO:0007189 None ADRA1A, DRD1, DRD2, DRD3 2.2199
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.18162
[BP] GO:0021853 None DRD1, DRD2 2.18162
[BP] GO:0010641 None F3, SRC 2.18162
[BP] GO:0007598 None F10, F3 2.18162
[BP] GO:0071502 None HTR2B, TRPV1 2.18162
[BP] GO:1904936 None DRD1, DRD2 2.18162
[BP] GO:0042321 None ADORA1, DRD2 2.18162
[BP] GO:0090325 None DRD2, DRD3 2.18162
[BP] GO:0010513 None HTR2A, HTR2B 2.18162
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, F10, F3, FLT3, FUT7, HTR1A, HTR2B, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MMP9, PIM1, POLB, PPARA, SRC, TYR, XDH 2.18162
[BP] GO:0007568 aging ADRA1A, AURKB, CNR1, CYP1A1, HTR2A, POLB 2.1533
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, DRD3 2.12835
[BP] GO:0007611 None APP, CNR1, DRD1, DRD2, DRD3, HTR2A 2.11618
[BP] GO:1901575 None ACHE, ADORA1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, MAOA, XDH 2.08886
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX5, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTGES, SRC, TBXAS1, TRPV1, TYR, XDH 2.08886
[BP] GO:0051098 regulation of binding APP, AURKB, CYP2D6, MET, MMP9, PPARA, SRC 2.08689
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, APP, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, SRC, XDH 2.07657
[BP] GO:0042220 None CNR1, DRD2, DRD3 2.06373
[BP] GO:0045777 None ADORA1, ADRA1A, CNR1 2.06373
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R 2.06373
[BP] GO:0045744 None DRD2, DRD3, MET 2.06373
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, MET, SRC 2.05824
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, PPARA, SRC, TRPV1 2.04874
[BP] GO:0071310 cellular response to organic substance AKR1B1, APP, AXL, CYP1A1, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, SRC, TRPV1 2.04756
[BP] GO:0006810 None ACHE, ADORA1, ADRA1A, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, F10, FABP3, HTR2A, HTR2B, MCL1, MMP9, PPARA, SIGMAR1, SRC, TRPV1, XDH 2.04597
[BP] GO:0050877 None ADORA1, APP, CNR1, CNR2, CYP1B1, DRD1, DRD2, DRD3, HTR2A, TRPV1, TYR 2.04237
[BP] GO:0071407 cellular response to organic cyclic compound APP, CYP1A1, CYP1B1, DRD1, FLT3, SRC, TRPV1 2.04029
[BP] GO:0022029 None DRD1, DRD2, HTR6 2.04029
[BP] GO:0043278 None CNR1, DRD2, DRD3 2.04029
[BP] GO:0014072 None CNR1, DRD2, DRD3 2.04029
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.04029
[BP] GO:0021843 None DRD1, DRD2 2.04029
[BP] GO:0021830 None DRD1, DRD2 2.04029
[BP] GO:0032229 None ADORA1, CNR2 2.04029
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.04029
[BP] GO:0021826 None DRD1, DRD2 2.04029
[BP] GO:0009605 response to external stimulus ADORA1, ADRA1A, AXL, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, DRD3, HTR2A, PTGES, SRC, TRPV1, TYR 2.03204
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, HTR2A, HTR2B, TRPV1 2.0192
[BP] GO:0051781 None AURKB, DRD2, DRD3, HTR2B 2.01085
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, DRD1, IGF1R, MMP2, MMP9, SRC, TRPV1 2.00685
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, HTR2A, HTR2B 2.00685
[BP] GO:2001024 negative regulation of response to drug CNR1, DRD2, MET 2.00685
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, CA4, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, TRPV1 9.28193
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, TRPV1 7.41854
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, F10, F3, FLT3, FUT7, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MCL1, MET, MMP2, PIM1, PTGES, SIGMAR1, SRC, TBXAS1, TRPV1, TYR 7.0362
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, F10, F3, FLT3, FUT7, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MCL1, MET, PTGES, SIGMAR1, SRC, TBXAS1, TRPV1, TYR 6.90351
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, APP, AXL, CA2, CA4, CA9, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SRC, TRPV1 6.42192
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, APP, AXL, CA12, CA14, CA4, CA9, CHRM2, CNR1, CNR2, CYP3A4, DRD1, DRD2, DRD3, F10, F3, FLT3, FUT7, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MCL1, MET, PTGES, SIGMAR1, TBXAS1, TRPV1, TYR 5.46435
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIM1, SRC, TRPV1 4.48053
[CC] GO:0016021 None ADORA1, ADORA3, ADRA1A, APP, AXL, CA12, CA14, CA9, CHRM2, CNR1, CNR2, CYP3A4, DRD1, DRD2, DRD3, F3, FLT3, FUT7, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MCL1, MET, PTGES, SIGMAR1, TBXAS1, TRPV1, TYR 4.17985
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.59096
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA4, CA9, CHRM2, CNR1, DRD1, DRD2, HTR2A, MET, SIGMAR1, SRC, TRPV1 3.4129
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, F10, FLT3, HSD11B1, HSD17B2, PTGES, SIGMAR1, TBXAS1 3.37477
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, HSD11B1, HSD17B2, PTGES, SIGMAR1, TBXAS1 3.0581
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, ALOX5, APP, AURKB, CA1, CA2, CA4, CA7, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HTR2A, HTR5A, KDR, MAOA, MCL1, MMP2, MMP9, PIM1, POLA1, PTGES, SIGMAR1, SRC, TBXAS1, TRPV1, TYR, XDH 2.66295
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM2, CNR1, DRD1, DRD2, HTR2A, SIGMAR1, SRC, TRPV1 2.54726
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM2, CNR1, DRD1, DRD2, HTR2A, SIGMAR1, SRC, TRPV1 2.54726
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, HTR6, SRC 2.54726
[CC] GO:0031233 None CA4, F10, F3 2.5418
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM2, CNR1, CNR2, DRD2, HTR2A, HTR2B, HTR5A, SRC 2.41331
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CHRM2, CNR1, CNR2, DRD1, DRD2, HTR2A, HTR2B, HTR5A, HTR6, SRC 2.28037
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, SRC, TRPV1 2.27925
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.78379
[MF] GO:0043167 ion binding ACHE, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTGES, SRC, TBXAS1, TRPV1, TYR, XDH 9.78379
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, MMP1, MMP2, MMP9, PIM1, PPARA, TBXAS1, TYR, XDH 9.33812
[MF] GO:0008227 None ADRA1A, CHRM2, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 9.28846
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4 8.44975
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 8.43296
[MF] GO:0030594 None CHRM2, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 8.40608
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1, TRPV1 8.25702
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, TRPV1 8.23845
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, TRPV1 8.23845
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, SIGMAR1, SRC, TRPV1 7.94706
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, TBXAS1, TYR 7.62836
[MF] GO:0099528 None CHRM2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.51604
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1, TRPV1 7.41587
[MF] GO:0043169 cation binding ACHE, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, F10, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, TBXAS1, TRPV1, TYR, XDH 7.22886
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1, TRPV1 7.20153
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 7.19138
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, TBXAS1, XDH 7.15933
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 7.15933
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.15933
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.15933
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.11546
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.11546
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1, TRPV1 6.81168
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, SRC, TBXAS1 6.81168
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.65426
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, SRC, TBXAS1 6.5435
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, MAOA, TBXAS1, TYR, XDH 6.33354
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, F10, F3, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, SRC, TBXAS1, TYR, XDH 6.18803
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, TBXAS1, TYR 6.17982
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, HSD17B1, POLA1, PTGES, SRC, TBXAS1, XDH 5.80103
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 5.66421
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 5.37095
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 5.3371
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A6, CYP2D6, CYP3A4 4.75905
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.52791
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.59096
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.43924
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.1445
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.09615
[MF] GO:0035240 None DRD1, DRD2, DRD3 3.00412
[MF] GO:0046872 metal ion binding ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, F10, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, TBXAS1, TRPV1, TYR, XDH 2.76094
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.59826
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.58009
[MF] GO:0004949 None CNR1, CNR2 2.58009
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.5418
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.35719
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.35719
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, HSD11B1, HSD17B1, HSD17B2, XDH 2.24745
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.21819
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.18162
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.13967
[MF] GO:0004064 arylesterase activity CA1, CA2 2.04029


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR2B, HTR1A, TRPV1, HTR2A, HTR5A, ADRA1A, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1, DRD1, DRD2, DRD3 13.3877
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, HTR7, MAOA, CYP2D6, ALOX5, HTR2B, HTR1A, HTR2A, HTR5A 9.9952
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.5268
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.4225
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.25
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.1416
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A 5.7122
Metabolic pathways_Homo sapiens_hsa01100 MAOA, AKR1B1, TYR, CYP3A4, CYP19A1, HSD11B1, POLA1, CYP2A6, FUT7, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, XDH, PTGES 5.4585
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.4585
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA 4.4482
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP2D6, CYP1A2, CYP3A4 4.4954
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.4281
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2A, DRD1, DRD2 4.108
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 4.108
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, DRD2, MET, IGF1R 3.3858
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.108
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.3858
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, TRPV1, HTR2A 2.7757
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.2266
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3232
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.0841
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, DRD1, DRD2, DRD3 2.382
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, MCL1 1.9322
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGES 2.2766
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1, DRD2 2.5399
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, KDR, MET, MCL1, IGF1R 1.7533
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9322
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.6017
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.7959
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3 1.7916
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.7959
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.6686
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4828
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA1A 1.2901
Alcoholism_Homo sapiens_hsa05034 MAOA, DRD1, DRD2 1.2438
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2901
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3298
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3264
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, DRD1 1.2438
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE 0.9165
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2438
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0638
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2276
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0638
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2438
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8834
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1607
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8884
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8935
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.7891
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.2276
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1594
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A, IGF1R 0.8784
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7981
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8013
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, MCL1 0.7498
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.6164
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7124
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC 0.6038
HTLV-I infection_Homo sapiens_hsa05166 POLB 0.248
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3169
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3376
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3465
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.7959
Apoptosis_Homo sapiens_hsa04210 MCL1 0.4041
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3376
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4752
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3618
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRA1A 0.3935
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4079
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3903
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4041
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3786
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.412
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.4752
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4041
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4671
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4752
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.412
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.4523
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4523
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.6885
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4671
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4279
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.435
Axon guidance_Homo sapiens_hsa04360 MET 0.4204
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4689
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4671
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4752
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4641
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4752
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.4329
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.435
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4689
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4689
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4752
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.4752
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4752
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.4671
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4689
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4612
Peroxisome_Homo sapiens_hsa04146 XDH 0.4752
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5126
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.507
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5184
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.537
Glioma_Homo sapiens_hsa05214 IGF1R 0.537
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5361
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.547
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.537
Shigellosis_Homo sapiens_hsa05131 SRC 0.537
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.5481
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9363
Malaria_Homo sapiens_hsa05144 MET 0.605
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6038
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6753
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.7498
DNA replication_Homo sapiens_hsa03030 POLA1 0.7124
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7428
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7361
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7124
Base excision repair_Homo sapiens_hsa03410 POLB 0.7298
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7891
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7802
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8013
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3999
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)