Prescription Description
| Prescription ID | TCMF1393 |
| Pinyin Name | Shu Gan Wan |
| Chinese Name | 舒肝丸 |
| English Name | Liver-Soothing Bolus |
| Function Description | 两胁胀满, 胃脘刺痛, 呕逆嘈杂, 嗳气吞酸 |
| Indications | Epigastric upset disorder |
| Disease ICD-11 Category |
SA53 [Epigastric upset disorder (TM1), 嘈杂 (TM1)
]; |
| Human Tissues Associated with Indication | Stomach |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH284 | Melia toosendan | 川楝子 | TCMH284 | KY197925 |
| TCMH2376 | Corydalis yanhusuo | 延胡索 | TCMH2376 | |
| TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
| TCMH1063 | Curcuma longa | 姜黄 | TCMH1063 | ITSAP2805-14 |
| TCMH1533 | Saussurea lappa | 木香 | TCMH1533 | |
| TCMH249 | Aquilaria agallocha | 沉香 | TCMH249 | KU879012 |
| TCMH53 | Amomum kravanh | 白豆蔻 | TCMH53 | KT898257 |
| TCMH1803 | Amomum villosum | 砂仁 | TCMH1803 | ITSAD521-14 |
| TCMH890 | Cortex magnoliae officinalis | 厚朴 | TCMH890 | ITSAM1591-14 |
| TCMH1184 | Citrus reticulata | 橘皮 | TCMH1184 | ITSAA1245-14 |
| TCMH2618 | Citrus aurantium | 枳壳 | TCMH2618 | ITSAA1279-14 |
| TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT114 | CNR2 | Cannabinoid CB2 receptor | GPCR | P34972 |
| TCMT115 | CNR1 | Cannabinoid CB1 receptor | GPCR | P21554 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
| TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
| TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
Showing 1 to 10 of 94 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1183 | Candida albicans SC5314 |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1201 | Staphylococcus epidermidis ATCC 12228 |
| TCMT1208 | Escherichia coli K12 |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1210 | Streptococcus sobrinus |
| TCMT1211 | Fusobacterium nucleatum |
| TCMT1212 | Verticillium dahliae |
Showing 1 to 10 of 61 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0001101 | response to acid chemical | AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGES, SRC | 2.22869 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD1, DRD2, DRD3, HTR1A, MAOA, TRPV1 | 3.59075 |
| [BP] GO:0001659 | None | ADORA1, DRD1, DRD2, HTR2A, TRPV1 | 4.94975 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGES, TBXAS1 | 5.05424 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ADRA1A, APP, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, SRC, XDH | 2.07657 |
| [BP] GO:0001963 | None | DRD1, DRD2, DRD3 | 2.83977 |
| [BP] GO:0001975 | None | CNR2, DRD1, DRD2, DRD3 | 3.66735 |
| [BP] GO:0002031 | None | DRD2, DRD3, HTR2B | 3.19132 |
| [BP] GO:0002237 | response to molecule of bacterial origin | AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, SRC | 2.41331 |
| [BP] GO:0002933 | lipid hydroxylation | CYP1A1, CYP3A4 | 2.04029 |
Showing 1 to 10 of 390 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.3264 |
| Adherens junction_Homo sapiens_hsa04520 | CSNK2A1, SRC, MET, IGF1R | 3.2266 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5184 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | ADRA1A | 0.3935 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, PIM1, F3 | 1.7916 |
| Alcoholism_Homo sapiens_hsa05034 | MAOA, DRD1, DRD2 | 1.2438 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.3618 |
| Amphetamine addiction_Homo sapiens_hsa05031 | MAOA, DRD1 | 1.2438 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | ADRA1A, IGF1R | 0.8784 |
| Apoptosis_Homo sapiens_hsa04210 | MCL1 | 0.4041 |
Showing 1 to 10 of 128 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples