TCM Prescription: Anshen Buxin Pills, Sedative and Heart-Invigorating Pill



Prescription Description
Prescription IDTCMF1361
Pinyin NameAn Shen Bu Xin Wan
Chinese Name安神补心丸
English NameAnshen Buxin Pills, Sedative and Heart-Invigorating Pill
Function Description由于思虑过度, 神经衰弱引起的失眠健忘, 头昏耳鸣, 心悸
IndicationsTinnitus disorder, Forgetfulness disorder, Insomnia
Disease ICD-11 Category SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍,未特指的 ];
Human Tissues Associated with IndicationBrain, Heart, Blood
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH816 Albizzia julibrissin 合欢皮 TCMH816 KT972683
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH1503 Eclipta prostrata 墨旱莲 TCMH1503 ITSAP4516-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH2610 Concha margaritifera usta;Margarita 珍珠母 TCMH2610
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT718 TXN2 Thioredoxin, mitochondrial Unclassified Q99757
TCMT719 TXN Thioredoxin Unclassified P10599
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, FABP3, FABP4, HMGCR, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1 13.1309
[BP] GO:0065008 regulation of biological quality ACHE, ADRA2A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD11B1, HSD17B1, HSD17B2, KCNH2, KDR, MCL1, MET, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS1, PTGS2, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 11.361
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, APP, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KCNH2, KDR, MCL1, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTAFR, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 11.1603
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FABP3, HMGCR, PIK3CA, PIM1, PPARA, PTAFR, PTGS1, PTGS2, TYR, XDH 10.2425
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MCL1, MMP2, NR3C1, PIK3CA, PPARA, PTAFR, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 10.1383
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTAFR, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 10.1382
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 9.95822
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2 9.57871
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2 9.27233
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2 8.94948
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FABP3, FABP4, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 8.59716
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 8.34352
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.0677
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTAFR, PTGS2, RORC, SLC6A4, SRC, TERT, TRPV1 8.0677
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PPARA, PTGS1, PTGS2 7.95258
[BP] GO:0048522 positive regulation of cellular process ACHE, ADRA2A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KCNH2, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 7.76558
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2 7.59195
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, NQO2, PTGS1, RORC 7.59195
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 7.40022
[BP] GO:0048518 positive regulation of biological process ACHE, ADRA2A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KCNH2, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC1A1, SLC6A4, SRC, TERT, TRPV1, XDH 7.18443
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, APP, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GRM5, IGF1R, MMP2, NR3C1, PPARA, PTAFR, PTGS2, SLC6A4, SRC, TRPV1 6.93158
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PTAFR, PTGS2, RORC, SLC6A4, SRC, TRPV1 6.87686
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2 6.81847
[BP] GO:0032501 multicellular organismal process ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, KCNH2, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTAFR, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TRPV1, TYR 6.71784
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KCNH2, KDR, MCL1, MMP2, MMP9, NR3C1, PIK3CA, PTAFR, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1 6.70452
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, NR3C1, PTAFR, PTGS2, RORC, SLC6A4, SRC, TYR 6.69857
[BP] GO:0042127 regulation of cell proliferation ADORA3, ADRA2A, AKR1B1, ALOX12, APP, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTAFR, PTGS1, PTGS2, SLC6A4, SRC, TERT, XDH 6.67332
[BP] GO:0014070 response to organic cyclic compound APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, NR3C1, PTAFR, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 6.67332
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.64916
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTAFR, PTGS2, RORC, SLC6A4, SRC, TRPV1 6.44182
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, NR3C1, PPARA, PTAFR, PTGS2, SLC6A4, SRC, TRPV1 6.44182
[BP] GO:0050896 response to stimulus ACHE, ADORA3, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, IGF1R, KCNH2, KDR, MCL1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 6.16557
[BP] GO:0042592 homeostatic process ADRA2A, AKR1B1, ALOX12, APP, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, KCNH2, MCL1, MET, PIK3CA, PIK3CB, SRC, TERT, TRPV1 6.0828
[BP] GO:0010941 regulation of cell death AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, TRPV1, XDH 6.00272
[BP] GO:0010647 positive regulation of cell communication ADRA2A, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HMGCR, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 5.97368
[BP] GO:0043067 regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, TRPV1, XDH 5.95327
[BP] GO:0023056 positive regulation of signaling ADRA2A, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HMGCR, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 5.95327
[BP] GO:0010646 regulation of cell communication ACHE, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SLC6A4, SRC, TERT, XDH 5.90539
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 5.88063
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 5.87352
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC, TERT 5.87352
[BP] GO:0023051 regulation of signaling ACHE, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SLC6A4, SRC, TERT, XDH 5.8222
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PPARA, PTGS1, PTGS2 5.70353
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.68892
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HMGCR, PTAFR, TYR 5.52797
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.43786
[BP] GO:0042981 regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MCL1, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, TRPV1, XDH 5.43524
[BP] GO:0071407 cellular response to organic cyclic compound APP, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTAFR, PTGS2, RORC, SLC6A4, SRC, TRPV1 5.36458
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC6A4, SRC, TERT, TYR, XDH 5.35204
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CES1, CYP19A1, CYP3A4, HMGCR, PTAFR, TYR 5.30184
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 5.1983
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, ALOX12, APP, CA12, CA2, CA7, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, KCNH2, MET, PIK3CA, PIK3CB, TRPV1 5.15558
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, HMGCR, KCNH2, KDR, NR3C1, PTAFR, PTGS2, SLC6A2, SLC6A4, SRC, TRPV1 5.12367
[BP] GO:0060548 negative regulation of cell death AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 5.12367
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.11052
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2, SLC6A4 5.11052
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2, SLC6A4 5.11052
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ADRA2A, ALOX12, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GRIK5, GRM5, HMGCR, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SLC6A4, SRC, TERT, TRPV1 5.11052
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 5.0837
[BP] GO:0019220 regulation of phosphate metabolic process ADRA2A, ALOX15, APP, CDC25B, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, XDH 5.04804
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2 5.01878
[BP] GO:1902533 positive regulation of intracellular signal transduction ADRA2A, AKR1B1, ALOX15, APP, AXL, CYP1B1, FLT3, GRM1, HMGCR, KDR, MCL1, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.00764
[BP] GO:0051174 regulation of phosphorus metabolic process ADRA2A, ALOX15, APP, CDC25B, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, XDH 5.00621
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 4.98501
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADRA2A, ALOX15, APP, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 4.97686
[BP] GO:0045937 positive regulation of phosphate metabolic process ADRA2A, ALOX15, APP, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 4.97686
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5, PTAFR 4.96491
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.96491
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.96491
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 4.94234
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, ALOX12, CDC25B, CSNK2A1, ESR1, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTAFR, PTGS2, TERT 4.91147
[BP] GO:0009967 positive regulation of signal transduction ADRA2A, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, FLT3, GRM1, HMGCR, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 4.86098
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADRA2A, ALOX15, APP, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SRC, TERT, TRPV1, XDH 4.73018
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, ADRA2A, AKR1B1, ALOX12, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, KCNH2, KDR, MCL1, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 4.70693
[BP] GO:0009893 positive regulation of metabolic process ADRA2A, ALOX15, APP, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 4.70693
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, PTPRS, SRC, TYR 4.53972
[BP] GO:0048584 positive regulation of response to stimulus ADRA2A, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, GRM1, HMGCR, KDR, MCL1, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, TERT, XDH 4.53972
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.51721
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, CYP3A4, HMGCR, PTAFR, PTGS1, PTGS2 4.50871
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KCNH2, KDR, NR3C1, PTAFR, PTGS2, SRC, TRPV1 4.47109
[BP] GO:0031325 positive regulation of cellular metabolic process ADRA2A, ALOX15, APP, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SRC, TERT, TRPV1, XDH 4.39454
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MCL1, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 4.39414
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 4.37115
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.37115
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADRA2A, ALOX15, APP, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 4.35755
[BP] GO:0042327 positive regulation of phosphorylation ADRA2A, ALOX15, APP, CDC25B, ESRRB, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.2892
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.2132
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 4.1995
[BP] GO:1902531 regulation of intracellular signal transduction ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRM1, HMGCR, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.18345
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, HMGCR, HSD11B1, HSD17B2, KDR, MCL1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, RORC, SLC6A4, SRC, TERT, TYR 4.17674
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.13959
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APP, ESR1, FLT3, GRM5, IGF1R, MMP2, NR3C1, PTAFR, PTGS2, SLC6A4, SRC, TRPV1 4.09722
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, APP, AXL, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MCL1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTAFR, PTPN1, SRC, TRPV1 4.04912
[BP] GO:0051049 regulation of transport ACHE, ADRA2A, ALOX15, APP, AXL, CA2, CA7, CYP19A1, GRIK5, GRM5, HMGCR, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SLC6A4, SRC, TERT, TRPV1 4.04444
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 4.01745
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, KCNH2, KDR, MCL1, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 3.9848
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HMGCR 3.96441
[BP] GO:0010817 regulation of hormone levels ACHE, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 3.90617
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 3.90116
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 3.89679
[BP] GO:0001934 positive regulation of protein phosphorylation ADRA2A, ALOX15, APP, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.88354
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.87666
[BP] GO:0009987 cellular process ACHE, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 3.84721
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.78155
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.73542
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP3A4 3.73542
[BP] GO:0042325 regulation of phosphorylation ADRA2A, ALOX15, APP, CDC25B, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.73304
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.70361
[BP] GO:0030335 positive regulation of cell migration ADRA2A, ALOX12, APP, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC, TERT 3.69374
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTAFR, PTGS2, SLC6A4, SRC, TRPV1, TYR 3.61727
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, CA2, CYP1A1, GRM1, HMGCR, MMP2, PPARA, PTAFR, PTGS2, SLC6A4, SRC, TERT, TRPV1, TYR 3.58686
[BP] GO:2000147 positive regulation of cell motility ADRA2A, ALOX12, APP, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC, TERT 3.55564
[BP] GO:0030334 regulation of cell migration ADORA3, ADRA2A, ALOX12, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC, TERT 3.54933
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.47859
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, ADRA2A, ALOX12, APP, AXL, CA2, CYP1B1, ESR1, ESRRA, ESRRB, GRM1, HMGCR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTAFR, PTGS2, PTPRS, SLC1A1, SLC6A4, SRC, TERT, TRPV1, XDH 3.45178
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, ALOX12, APP, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC, TERT 3.44973
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.34691
[BP] GO:0080134 regulation of response to stress ADRA2A, ALOX12, APP, CYP19A1, ESR1, FABP4, HMGCR, IGF1R, MCL1, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SRC, TERT, XDH 3.3355
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.32869
[BP] GO:0040017 positive regulation of locomotion ADRA2A, ALOX12, APP, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC, TERT 3.32116
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, GRM5, IGF1R, MMP2, PTAFR, PTGS2, SLC6A4, SRC, TRPV1 3.30639
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic GRM1, GRM3, GRM5, GRM8, PTGS2 3.30469
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTAFR, PTGS2, SLC6A4, SRC, TRPV1, TYR 3.27791
[BP] GO:2000145 regulation of cell motility ADORA3, ADRA2A, ALOX12, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC, TERT 3.26914
[BP] GO:0007165 signal transduction ADORA3, ADRA2A, AKR1B1, APP, AXL, CA1, CA2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MCL1, MET, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TRPV1 3.26914
[BP] GO:0048585 negative regulation of response to stimulus ADRA2A, ALOX12, ALOX15, CYP19A1, ESR1, ESR2, HMGCR, IGF1R, MCL1, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SRC, TERT, XDH 3.25669
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4 3.25669
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.25222
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2, TERT 3.21345
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGS1, PTGS2 3.19912
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS2, PTPN1, PTPRS, SRC, XDH 3.19733
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTAFR, PTGS2, SLC6A4, SRC 3.19037
[BP] GO:0043410 positive regulation of MAPK cascade ADRA2A, ALOX15, APP, FLT3, GRM1, HMGCR, KDR, PIK3CB, PTPN1, SRC, XDH 3.17638
[BP] GO:0001932 regulation of protein phosphorylation ADRA2A, ALOX15, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.13277
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APP, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, IGF1R, MCL1, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TRPV1, XDH 3.10512
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FABP3, FABP4, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.10512
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ALOX12, APP, AXL, CA2, CYP1B1, ESRRB, HMGCR, KDR, MET, MMP12, MMP9, PIM1, PTAFR, PTGS2, SLC1A1, SRC, TERT, TRPV1 3.09556
[BP] GO:0048583 regulation of response to stimulus ADRA2A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, GRM1, HMGCR, IGF1R, KDR, MCL1, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, PTPRS, SRC, TERT, XDH 3.07928
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, GRM5, IGF1R, MMP2, PTAFR, PTGS2, SLC6A4, SRC, TRPV1 3.05931
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, GRIK5, PTGS2, SLC1A1, SLC6A2, SLC6A4, TRPV1 3.03715
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, AURKB, AXL, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TERT, TRPV1, TYR, XDH 2.99974
[BP] GO:0065007 biological regulation ACHE, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 2.99706
[BP] GO:0010648 negative regulation of cell communication ACHE, ADRA2A, ESR1, ESR2, HMGCR, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SLC6A4, SRC, TERT, XDH 2.96029
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 2.9599
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.95737
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 2.95737
[BP] GO:0023057 negative regulation of signaling ACHE, ADRA2A, ESR1, ESR2, HMGCR, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SLC6A4, SRC, TERT, XDH 2.95737
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, IGF1R, PPARA, PTGS2, SRC, TRPV1 2.95737
[BP] GO:0040012 regulation of locomotion ADORA3, ADRA2A, ALOX12, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC, TERT 2.95618
[BP] GO:0051270 regulation of cellular component movement ADORA3, ADRA2A, ALOX12, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC, TERT 2.94403
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS2, PTPN1, PTPRS, SRC, XDH 2.93596
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, KCNH2, PPARA, SLC1A1, SLC6A2, SLC6A4, TRPV1 2.90309
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2C19, CYP3A4 2.86185
[BP] GO:0007193 None ADRA2A, GRM1, GRM3, GRM5, GRM8 2.86185
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.86185
[BP] GO:0046683 response to organophosphorus APP, PTAFR, PTGS2, SLC6A4, TRPV1, TYR 2.85936
[BP] GO:0045859 regulation of protein kinase activity ADRA2A, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 2.85631
[BP] GO:0019216 regulation of lipid metabolic process ADRA2A, CYP1A1, FABP3, FLT3, HMGCR, PPARA, PTGS2, RORC, SRC 2.84451
[BP] GO:0060078 None GRIA2, GRIA4, GRIK5, GRM5, TRPV1 2.84423
[BP] GO:0006066 None AKR1B1, AKR1B10, APP, CES1, CYP1B1, CYP3A4, HMGCR, PTAFR 2.84331
[BP] GO:0051247 positive regulation of protein metabolic process ADRA2A, ALOX15, APP, CDC25B, CSNK2A1, ESR1, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 2.82893
[BP] GO:0009892 negative regulation of metabolic process ADRA2A, APP, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, IGF1R, KDR, MCL1, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TRPV1, XDH 2.8168
[BP] GO:0009115 None AOX1, XDH 2.8168
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.8168
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.8168
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.8168
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, AURKB, AXL, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TERT, TRPV1, TYR, XDH 2.80637
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.79276
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.79142
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.77934
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 2.77934
[BP] GO:0032844 regulation of homeostatic process ADRA2A, AURKB, CA2, CA7, HMGCR, KDR, PIK3CB, PTGS2, SRC, TRPV1 2.759
[BP] GO:0031401 positive regulation of protein modification process ADRA2A, ALOX15, APP, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.75504
[BP] GO:0050790 regulation of catalytic activity ADORA3, ADRA2A, APP, AURKB, CDC25B, CSNK2A1, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, TERT, XDH 2.73535
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.70106
[BP] GO:0051050 positive regulation of transport ACHE, ADRA2A, APP, AXL, CA2, CYP19A1, KCNH2, MMP12, PTAFR, PTGS2, SLC6A4, SRC, TERT, TRPV1 2.64621
[BP] GO:0065009 regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT, TRPV1, XDH 2.63455
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADRA2A, ALOX15, APP, CDC25B, ESR1, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 2.63385
[BP] GO:0014074 response to purine-containing compound APP, PTAFR, PTGS2, SLC6A4, TRPV1, TYR 2.63319
[BP] GO:0043408 regulation of MAPK cascade ADRA2A, ALOX15, APP, FLT3, GRM1, HMGCR, IGF1R, KDR, PIK3CB, PTPN1, SRC, XDH 2.63277
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.60345
[BP] GO:0046165 None AKR1B1, CES1, CYP3A4, HMGCR, PTAFR 2.59905
[BP] GO:0043549 regulation of kinase activity ADRA2A, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 2.59497
[BP] GO:0042391 None APP, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC, TRPV1 2.58597
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CES1, CYP1A1, CYP1B1, HMGCR, KDR, SLC6A4, SRC 2.57078
[BP] GO:2000811 negative regulation of anoikis MCL1, PIK3CA, SRC 2.55024
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.55024
[BP] GO:0003018 None ADRA2A, HMGCR, PTAFR, PTGS2, SLC6A4, SRC 2.51328
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, MCL1, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SRC, TYR 2.50346
[BP] GO:1902532 negative regulation of intracellular signal transduction ESR1, HMGCR, IGF1R, MCL1, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.49209
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway MCL1, MMP9, PTGS2, PTPN1, SRC 2.4865
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A4 2.47731
[BP] GO:0051338 regulation of transferase activity ADRA2A, APP, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 2.43828
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4 2.4283
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.4283
[BP] GO:0099566 None GRM1, GRM5 2.4283
[BP] GO:0046110 None AOX1, XDH 2.4283
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.4283
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.4283
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, ALOX15, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, MCL1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TRPV1 2.41215
[BP] GO:0010676 None ESRRB, PPARA, PTAFR, SRC 2.36694
[BP] GO:0009966 regulation of signal transduction ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, ESR2, FLT3, GRM1, HMGCR, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, TERT, XDH 2.35817
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, PIK3CA, PIK3CB, PTAFR, PTGS1, PTGS2, TRPV1 2.35415
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, ESR1, ESR2, HMGCR, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SRC, TERT, XDH 2.33596
[BP] GO:0043405 regulation of MAP kinase activity ADRA2A, FLT3, GRM1, HMGCR, IGF1R, PIK3CB, PTPN1, SRC 2.32221
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.30937
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.30324
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.30107
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, ESR1, FABP3, GRM1, GRM5, KCNH2, PIK3CB, TRPV1 2.29612
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PPARA, PTAFR, PTGS2, RORC, SRC, TERT, TRPV1 2.29463
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.27358
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.27321
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.2458
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, NR3C1, PTAFR, SRC 2.2445
[BP] GO:0001666 response to hypoxia CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 2.2445
[BP] GO:0030168 platelet activation ADRA2A, AXL, PIK3CA, PIK3CB, SRC 2.2445
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIM1, SRC 2.23774
[BP] GO:0071396 cellular response to lipid AXL, ESR1, FLT3, NR3C1, PTAFR, RORC, SLC6A4, SRC 2.20818
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.195
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.195
[BP] GO:0006145 None AOX1, XDH 2.18201
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.18201
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.18201
[BP] GO:0036293 response to decreased oxygen levels CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 2.18192
[BP] GO:0051172 None ADRA2A, APP, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, IGF1R, MMP12, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TRPV1, XDH 2.17597
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, ADRA2A, ALOX15, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MCL1, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 2.17187
[BP] GO:0003008 None ADRA2A, AKR1B1, APP, CYP1B1, GRM1, GRM5, GRM8, HMGCR, KCNH2, PIK3CA, PTAFR, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.16807
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.16513
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.15862
[BP] GO:2000209 regulation of anoikis MCL1, PIK3CA, SRC 2.15653
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.15653
[BP] GO:0048015 phosphatidylinositol-mediated signaling IGF1R, PIK3CA, PIK3CB, PTAFR 2.15501
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.13516
[BP] GO:0048871 multicellular organismal homeostasis AKR1B1, ALOX12, MET, PIK3CA, TRPV1 2.1337
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.1079
[BP] GO:0007584 response to nutrient CYP1A1, HMGCR, PTGS2, SLC6A4, TRPV1, TYR 2.09069
[BP] GO:0010675 None ESRRB, PPARA, PTAFR, RORC, SRC 2.08764
[BP] GO:0048017 inositol lipid-mediated signaling IGF1R, PIK3CA, PIK3CB, PTAFR 2.08421
[BP] GO:0060627 regulation of vesicle-mediated transport ADRA2A, ALOX15, APP, AXL, GRIK5, PIK3CB, PTAFR, PTPN1, SRC 2.06155
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.06059
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.05943
[BP] GO:0097746 None ADRA2A, HMGCR, PTAFR, PTGS2, SLC6A4 2.04683
[BP] GO:0035296 None ADRA2A, HMGCR, PTAFR, PTGS2, SLC6A4 2.04683
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, PTGS2, SLC6A4 2.04683
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, PPARA, RORC, SLC6A4, SRC 2.04658
[BP] GO:0044093 positive regulation of molecular function ADRA2A, APP, AURKB, CDC25B, ESR1, ESR2, FLT3, GRM1, GRM5, MET, MMP9, PIK3CA, PIK3CB, PTAFR, PTPN1, SRC, TERT, XDH 2.04533
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.03563
[BP] GO:0043065 positive regulation of apoptotic process CYP1B1, GRIK5, HMGCR, MCL1, MMP9, PIK3CB, PTGS2, SRC, TRPV1, XDH 2.02724
[BP] GO:0043269 regulation of ion transport ADRA2A, APP, CA2, CA7, GRM5, KCNH2, MMP9, PTAFR, PTGS2, SLC6A4 2.02511
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.02511
[BP] GO:0006693 None CES2, PTGS1, PTGS2 2.02511
[BP] GO:0006692 None CES2, PTGS1, PTGS2 2.02511
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.009
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.009
[BP] GO:0045913 None ESRRB, PPARA, PTAFR, SRC 2.00743
[BP] GO:0043068 positive regulation of programmed cell death CYP1B1, GRIK5, HMGCR, MCL1, MMP9, PIK3CB, PTGS2, SRC, TRPV1, XDH 2.00525
[BP] GO:0016125 None APP, CES1, CYP19A1, CYP1B1, HMGCR 2.00252
[BP] GO:0070482 response to oxygen levels CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 2.00172
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ADRA2A, ALOX12, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTAFR, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1 4.55825
[CC] GO:0016020 membrane ACHE, ADORA3, ADRA2A, ALOX12, ALOX15, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD17B2, IGF1R, KCNH2, KDR, MCL1, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 4.05487
[CC] GO:0044459 plasma membrane part ADORA3, ADRA2A, ALOX15, APP, AXL, CA2, CA4, CA9, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, PTAFR, PTGS2, PTPRS, SLC1A1, SLC6A2, SLC6A4, SRC, TRPV1 3.9914
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, ADRA2A, APP, AXL, CA4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, PTPRS, SLC1A1, SLC6A2, SLC6A4, TRPV1 3.88354
[CC] GO:0098590 plasma membrane region ADRA2A, CA2, CA4, CA9, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, PTGS2, SLC1A1, SRC, TRPV1 3.7177
[CC] GO:0005887 integral component of plasma membrane ADORA3, ADRA2A, APP, AXL, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, PTPRS, SLC1A1, SLC6A2, SLC6A4, TRPV1 3.56174
[CC] GO:0044425 membrane part ACHE, ADORA3, ADRA2A, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD17B2, IGF1R, KCNH2, KDR, MCL1, MET, PIK3CA, PIK3CB, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A4, SRC, TRPV1, TYR 3.40438
[CC] GO:0044456 None ACHE, APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTPRS, SLC6A4, SRC, TRPV1 3.3355
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.22299
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD17B1, HSD17B2, KCNH2, KDR, MCL1, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 2.97004
[CC] GO:0044432 endoplasmic reticulum part APP, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FLT3, GRIA2, HMGCR, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 2.94917
[CC] GO:0043005 None APP, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, PTPRS, SLC6A2, SLC6A4, SRC 2.84331
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 2.75658
[CC] GO:0097458 None APP, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS1, PTGS2, PTPRS, SLC6A2, SLC6A4, SRC, TRPV1 2.13298
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTPN1, RORC, TYR, XDH 16.5455
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 10.6693
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 9.93818
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.82336
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.95258
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, XDH 7.47206
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FLT3, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TERT, TYR, XDH 7.39988
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, TERT, TRPV1, TYR, XDH 7.1901
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, TERT, TRPV1, TYR, XDH 6.90165
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PPARA, PTPN1, RORC 6.71784
[MF] GO:0038023 signaling receptor activity ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PTAFR, RORC, TRPV1 6.69857
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, RORC 6.05639
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, PTGS1, PTGS2, SRC 6.01382
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.01046
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 5.87352
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2, XDH 5.87352
[MF] GO:0004872 receptor activity ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PTAFR, RORC, TRPV1 5.8381
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, PTGS1, PTGS2, SRC 5.83246
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HMGCR, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 5.67167
[MF] GO:0060089 molecular transducer activity ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PTAFR, RORC, TRPV1 5.61017
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, PTGS1, PTGS2, TYR 5.43786
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.2329
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4 5.15674
[MF] GO:0004871 signal transducer activity ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PTAFR, RORC, TRPV1 5.12506
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.11145
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.00764
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.00764
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, CSNK2A1, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KCNH2, KDR, MCL1, MET, MMP9, NQO2, PTGS2, SLC6A4, TERT, TRPV1, TYR, XDH 4.96491
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.92239
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, NR3C1, PPARA, PTAFR, RORC, TRPV1 4.89179
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, TYR 4.68281
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.08255
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A4, SRC, TRPV1 3.98666
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.34691
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.29741
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.23831
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.22299
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.20609
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, KCNH2, TRPV1 3.13816
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 2.99974
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.9599
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2C19, CYP3A4 2.95935
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, FLT3, HMGCR, KCNH2, MCL1, NQO2, PTGS2, SLC6A4, TERT, TYR, XDH 2.84331
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.8168
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.8168
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.8168
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.8156
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, NQO2, NR3C1 2.68142
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.59937
[MF] GO:0019899 enzyme binding ADRA2A, APP, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2C19, CYP3A4, ESR1, ESR2, ESRRB, GRM5, HMGCR, KCNH2, MET, NR3C1, PPARA, PTAFR, PTGS2, PTPN1, SLC6A4, SRC 2.59497
[MF] GO:0099600 transmembrane receptor activity ADORA3, ADRA2A, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, TRPV1 2.59497
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, ADRA2A, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, TRPV1 2.59497
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.58597
[MF] GO:0044877 macromolecular complex binding ACHE, ADRA2A, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 2.55544
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.47731
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.4283
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.4283
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.4283
[MF] GO:0005330 None SLC6A2, SLC6A4 2.4283
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.4283
[MF] GO:0099583 None GRM1, GRM5 2.4283
[MF] GO:0047374 None CES1, CES2 2.4283
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIM1, SRC 2.37036
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.35817
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.35817
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.32711
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.30107
[MF] GO:0032403 protein complex binding ACHE, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 2.29188
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.25749
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.20911
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.18201
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.18201
[MF] GO:0004971 None GRIA2, GRIA4 2.18201
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.18201
[MF] GO:0043168 anion binding ALOX15, AOX1, APP, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PTAFR, PTPRS, SLC1A1, SRC, TRPV1, XDH 2.13972
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.03643
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.009
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.009


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.9129
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.5546
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.5471
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, PTAFR, GRM8, TRPV1, NR3C1, GRM1, ADRA2A, GRIA4 7.5971
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, ALOX12, HMGCR, PTGS2, TYR, CYP3A4, CYP2C19, CYP19A1, PTGS1, HSD11B1, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, CES1 6.9991
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12, PTGS2, CYP2C19, PTGS1 7.019
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, ESR2 7.019
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4, CYP2C19 7.5317
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.6868
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, ALOX12, PTGS2, CYP2C19, PTGS1, SLC6A4 6.7018
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 5.9183
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.3172
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 4.5352
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.3815
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.0824
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, IGF1R 3.8184
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B, MCL1 3.838
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.0502
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, GRM8, PIK3CB, GRM1 3.838
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, ALOX12, PIK3CB, TRPV1 3.6062
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 3.5611
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8392
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.157
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.838
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4, CYP2C19 4.3314
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.1255
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.3848
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.157
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, AOX1, PIK3CB, MCL1 2.8058
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.1773
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH, CES2, CES1 3.7016
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.1255
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, PIM1, PIK3CB 2.5907
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4, CYP2C19 3.15
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.6286
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, PIK3CA, PIK3CB, PPARA, GRIA4 2.4086
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.4739
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.983
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.4778
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.15
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.3482
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.2246
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.3918
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KDR, PIK3CB, MET, MCL1, IGF1R 2.2093
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.3918
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, HMGCR, IGF1R 2.3319
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, GRM1, IGF1R 2.2389
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, PIK3CB, MMP9 2.1597
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.1955
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.0517
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PIK3CB, ADRA2A 1.9809
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.2646
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.901
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.2113
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.2093
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.9285
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.207
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, PIK3CB, IGF1R 1.9147
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.207
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.8623
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, PIK3CB 1.702
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 1.9352
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, PIK3CB, IGF1R 1.7721
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 1.9215
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.481
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB 1.648
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.5311
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB, MCL1 1.4942
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.1403
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, PIK3CB 1.6341
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.5167
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.497
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.4285
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2018
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2756
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2853
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2946
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2941
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3061
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB 1.1726
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3567
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, PTAFR, GRM1 1.2891
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.1612
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.1292
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.3961
Axon guidance_Homo sapiens_hsa04360 MET 0.3909
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3961
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.2517
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, TERT, PIK3CB 0.971
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9551
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.7395
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4622
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4616
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4744
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4738
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 0.8539
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8887
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.9027
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4911
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9154
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4911
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4911
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 0.971
Taste transduction_Homo sapiens_hsa04742 GRM1 0.5051
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.9285
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4911
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4911
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0568
Peroxisome_Homo sapiens_hsa04146 XDH 0.5051
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1335
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.0674
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.1292
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.0819
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0674
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0855
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.097
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.1169
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5433
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.1292
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5415
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.556
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2891
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.2891
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.3283
Shigellosis_Homo sapiens_hsa05131 SRC 0.5809
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5809
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2983
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.3382
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.3309
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4007
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3283
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.6319
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, PIK3CB 1.3838
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.4418
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4094
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.4921
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6651
Malaria_Homo sapiens_hsa05144 MET 0.6776
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.5196
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.5311
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6872
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6824
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5733
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.6692
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6538
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8529
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7416
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8047
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7242
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8684
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0247
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8579
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8904
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.957
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.15
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3967


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)