TCM Prescription: Huoxiang Zhengqi Oral Liquid



Prescription Description
Prescription IDTCMF1360
Pinyin NameHuo Xiang Zheng Qi Kou Fu Ye
Chinese Name藿香正气口服液
English NameHuoxiang Zhengqi Oral Liquid
Function Description肠胃型感冒
IndicationsCommon cold disorder, Common cold
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH1184 Citrus reticulata 橘皮 TCMH1184 ITSAA1245-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH357 Pericarpium arecae 大腹皮 TCMH357
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH731 Oleum pogostemonis 广藿香油 TCMH731
TCMH2723 Oleum folii perillae 紫苏叶油 TCMH2723
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.64495
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, TYR 7.49892
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, MMP2, MMP9, PPARA, TRPV1, TYR 7.359
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA, TRPV1 7.00827
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.00827
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.68948
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.68948
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, MCL1, MMP2, PPARA, TRPV1, TYR 6.59342
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.99217
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, TRPV1, TYR 5.92241
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MCL1, PPARA, TNKS, TNKS2, TRPV1, XDH 5.71434
[BP] GO:0042221 response to chemical AKR1B1, ALPL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, MCL1, MMP2, MMP9, PPARA, TRPV1, TYR 5.64861
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, TRPV1 5.56718
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.89239
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, PIM1, PPARA, TYR, XDH 4.84346
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, BCL2, CA2, CA9, CDC25B, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, MCL1, MMP2, MMP9, PIM1, PPARA, TNKS2, TYR 4.80701
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.79447
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.75851
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 4.6804
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.66436
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, MMP12, MMP2, MMP9, PIM1, XDH 4.52091
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, MCL1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TNKS2, TRPV1, XDH 4.45665
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, MMP2, PPARA, TRPV1 4.45665
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALPL, BCL2, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, MCL1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, TNKS2, TRPV1, TYR 4.30337
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, BCL2, CA2, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, MCL1, MMP9, PIM1, PPARA, TYR 4.30337
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.30216
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.95909
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.95909
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.69206
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, MCL1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TNKS2, TRPV1, XDH 3.66694
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.58906
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, PPARA, TYR 3.58899
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, ESR1, F3, FLT3, MMP12, MMP2, MMP9, PIM1 3.50874
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.49217
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 3.48185
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, XDH 3.32004
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.29739
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, MCL1, MMP12, MMP9, PTPN1, TNKS, TNKS2, XDH 3.29501
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, MCL1, MMP12, MMP9, PTPN1, TNKS, TNKS2, XDH 3.2767
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, BCL2, CA2, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, MCL1, MMP12, MMP2, MMP9, PPARA, PTPN1, TRPV1, TYR 3.23244
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.10519
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.08681
[BP] GO:0042493 response to drug AKR1B1, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, TRPV1 2.79986
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.74439
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CDK6, CNR1, TNKS, TNKS2, TRPV1 2.73028
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, MCL1, MMP9, PIM1, PPARA, PTPN1, TRPV1, XDH 2.70555
[BP] GO:0009115 None AOX1, XDH 2.66928
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA 2.60153
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, MCL1, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TNKS2, TRPV1 2.60153
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, MCL1, MMP9, PIM1, PTPN1, TRPV1, XDH 2.53828
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.52387
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.51825
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, CNR2 2.51461
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, MCL1, MMP9, PIM1, PTPN1, TRPV1, XDH 2.5076
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 2.49916
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, MCL1, MMP12, MMP2, MMP9, PTPN1, TNKS, TNKS2, XDH 2.44786
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.40731
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR 2.36405
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.32051
[BP] GO:0046110 None AOX1, XDH 2.28311
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.28311
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.22546
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.16213
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, MCL1, MMP12, MMP9, PIM1, PPARA, PTPN1, TNKS, TNKS2, TRPV1, XDH 2.16213
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.14957
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.12888
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.12888
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.12888
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, MCL1, MMP12, MMP2, PPARA, PTPN1, XDH 2.12597
[BP] GO:0010035 response to inorganic substance AKR1B1, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, MMP9 2.08421
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.08421
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, MMP2, PPARA, TRPV1, TYR 2.06455
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESR2, MCL1, MMP12, MMP9, PPARA, PTPN1, XDH 2.06455
[BP] GO:0070213 None TNKS, TNKS2 2.05367
[BP] GO:0006145 None AOX1, XDH 2.05367
[BP] GO:0038171 None CNR1, CNR2 2.05367
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.05367
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, MMP1, MMP2, PIM1, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 2.03416
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 2.02624
[BP] GO:0032845 None ADORA1, BCL2, TNKS, TNKS2, TRPV1 2.02585
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.02245
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, BCL2, CSNK2A1, CYP1B1, F3, FLT3, MCL1, MMP12, MMP9, PTPN1, TNKS, TNKS2, XDH 2.01791
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, MCL1, MMP2, PIM1, PTPN1, TNKS, TNKS2, TRPV1, TYR 1.76635
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AOX1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MCL1, MMP2, MMP9, PIM1, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 1.6363
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 1.17167
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, MCL1, PTPN1, TRPV1, TYR 1.17167
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GBA2, HSD11B1, HSD11B2, HSD17B2 1.12241
[MF] GO:0046914 transition metal ion binding AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TYR, XDH 12.629
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.2122
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, TNKS 6.98826
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.52864
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, TNKS, TNKS2, TYR, XDH 6.18041
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.70806
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.37334
[MF] GO:0043167 ion binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 4.5839
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 4.33994
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.30337
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.07787
[MF] GO:0046872 metal ion binding ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 3.98875
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.95909
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.90577
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.90577
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.658
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.55248
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.49217
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.49217
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.44212
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.42032
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.32803
[MF] GO:0008289 lipid binding ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, TRPV1 3.12081
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, PPARA, TRPV1 2.9334
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, PPARA, TRPV1 2.80489
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 2.7631
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.69781
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.69781
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.66928
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.66928
[MF] GO:0003845 None HSD11B1, HSD11B2 2.66928
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.49916
[MF] GO:0004872 receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, PPARA, TRPV1 2.42295
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.40731
[MF] GO:0004949 None CNR1, CNR2 2.28311
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.05367
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, PPARA, TRPV1 2.03416
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, XDH 2.00364


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.8428
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.8145
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 5.0833
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, CNR2, CNR1, ADORA3, CHRM4, ADORA1, TRPV1 4.7033
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.1389
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1389
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4, BCL2 3.7235
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, CDC25B, MCL1 3.7095
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.3135
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3642
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.9097
Estrogen signaling pathway_Homo sapiens_hsa04915 MMP2, MMP9, ESR1, ESR2 2.9112
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.1934
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9 2.3385
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1, MCL1 2.2812
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 2.8768
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, BCL2, MCL1 1.9401
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.3385
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, CHRM1, ADORA1, PPARA 1.9582
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.753
Hepatitis B_Homo sapiens_hsa05161 CDK6, BCL2, MMP9 1.5405
Proteoglycans in cancer_Homo sapiens_hsa05205 MMP2, MMP9, ESR1 1.2678
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, CHRM4 1.22
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4125
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4125
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.2753
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3986
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2832
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.2678
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.1801
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.013
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.753
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1285
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8368
Apoptosis_Homo sapiens_hsa04210 BCL2, MCL1 0.8798
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8925
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9722
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9439
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7878
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0034
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM1 0.761
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8008
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.753
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6927
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9 0.761
Prostate cancer_Homo sapiens_hsa05215 BCL2 0.5302
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3 0.2891
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2967
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.5302
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4008
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.5268
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 TRPV1 0.5268
Rap1 signaling pathway_Homo sapiens_hsa04015 CNR1 0.3519
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6 0.3572
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3916
Focal adhesion_Homo sapiens_hsa04510 BCL2 0.3578
Glioma_Homo sapiens_hsa05214 CDK6 0.5688
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5302
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4486
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3828
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5648
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5046
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.4486
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4356
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5268
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4383
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4538
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.4486
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.3916
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3 0.5688
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5302
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4486
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5688
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5302
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5302
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5268
Melanoma_Homo sapiens_hsa05218 CDK6 0.5688
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4866
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 ESR1 0.4881
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5268
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2 0.5243
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5648
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5699
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5268
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.4881
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5688
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5688
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.5268
Peroxisome_Homo sapiens_hsa04146 XDH 0.5318
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5452
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5688
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6036
Bile secretion_Homo sapiens_hsa04976 CA2 0.5688
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6529
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6343
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6517
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6529
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6529
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6983
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7685
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7878
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7878
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7972
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7908
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.923
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1934
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9987
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2753


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)