TCM Prescription: Reyanning Granules



Prescription Description
Prescription IDTCMF1225
Pinyin NameRe Yan Ning Ke Li
Chinese Name热炎宁颗粒
English NameReyanning Granules
Function Description化脓性扁桃体炎, 急性咽炎, 急性支气管炎, 单纯性肺炎
IndicationsPharyngotonsillitis, Bronchitis
Disease ICD-11 Category CA0Y [Other specified upper respiratory tract disorders, 其他特指的上呼吸道疾患 ];
CA20 [Bronchitis, 支气管炎 ];
Human Tissues Associated with IndicationLung, Bronchus
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH921 Polygonum cuspidatum 虎杖 TCMH921 ITSAI2369-14
TCMH1183 Herba sonchi arvensis 苣荬菜 TCMH1183
TCMH132 Scutellaria barbata 半枝莲 TCMH132 ITSAN1801-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC, TERT 9.89108
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TERT, TOP2A, TYR, XDH 9.72272
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PTGS1, PTGS2 9.6246
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCHE, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, SRC, TYR 9.19663
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TERT, TOP2A, TYR, XDH 9.19663
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, PTGS2, SRC, TYR 9.0631
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, SRC, TERT, TYR 8.71707
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, PIK3CA, PIM1, PTGS1, PTGS2, TYR, XDH 8.69125
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, GLO1, HSD17B2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPRS, SRC, TERT, TOP2A, TYR 7.91328
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TERT, TOP2A, XDH 7.91328
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.54971
[BP] GO:0033993 response to lipid ALPL, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, PTGS2, SRC, TYR 7.47659
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, PTGS2, SRC, TYR 7.45678
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCHE, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC, TERT, XDH 7.44637
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TERT, TOP2A, XDH 7.44637
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, SRC, TERT 7.3566
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TERT, TOP2A, XDH 7.28573
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.26942
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, IGF1R, MMP2, PTGS2, SRC 6.66184
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, XDH 6.63074
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, XDH 6.61201
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.47801
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.34246
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2 6.27172
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PIK3CA, PTGS2, SRC 6.24796
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, PTGS2, SRC 6.17849
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, SRC, TERT, TOP2A 6.07328
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PTGS1, PTGS2 5.96554
[BP] GO:0042127 regulation of cell proliferation AKR1B1, APP, BCHE, BCL2, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, TERT, XDH 5.95963
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, SRC, TERT 5.66167
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.50677
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.48948
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC, TERT, TOP2A, TYR 5.41624
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2, TERT 5.34175
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BCHE, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, SRC, TERT, XDH 5.33155
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.31661
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BCHE, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, SRC, TERT, XDH 5.23409
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.22045
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, SRC, TERT 5.21774
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.17224
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 5.1068
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, XDH 4.95092
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.95092
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, SRC, TERT 4.93522
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TERT, TOP2A, XDH 4.90267
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, KDR, PIK3CA, PTPRS, SRC, TYR 4.86138
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC, TERT 4.86138
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPRS, SRC, XDH 4.7902
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.59989
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.57533
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCHE, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PTGS2, SRC, TYR 4.55032
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPRS, SRC, XDH 4.49321
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TERT, TOP2A, TYR, XDH 4.41152
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TERT, TOP2A, TYR, XDH 4.40746
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, FLT3, KDR, MET, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.31868
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.30025
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TERT, TOP2A, XDH 4.27341
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, XDH 4.14478
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.14478
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, SRC 4.06164
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 4.01115
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCHE, BCL2, CA9, CYP1A1, CYP1B1, FABP3, KDR, PTGS2, SRC 4.01115
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 4.01115
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.98493
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.98493
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, SRC, TYR 3.94736
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.94428
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, SRC 3.93866
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.92122
[BP] GO:0006805 xenobiotic metabolic process BCHE, CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1 3.88155
[BP] GO:0030334 regulation of cell migration APEX1, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.84467
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 3.84467
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.7378
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR 3.70586
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 3.67541
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGS1, PTGS2 3.6601
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, SRC, TERT 3.63392
[BP] GO:2000145 regulation of cell motility APEX1, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.6015
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCHE, BCL2, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, PTGS2, PTPRS, SRC, TERT, TOP2A 3.59568
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, TYR 3.59568
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.57029
[BP] GO:0048545 response to steroid hormone ALPL, BCHE, BCL2, CA2, FLT3, PTGS2, SRC 3.46354
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 3.46129
[BP] GO:0001101 response to acid chemical AKR1B1, BCHE, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 3.42047
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.3901
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.3901
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP1A1, CYP1A2, ESR1, FLT3, FUT7, GLO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, SRC, TOP2A, TYR, XDH 3.37912
[BP] GO:0033273 response to vitamin ALPL, BCHE, CYP1A1, PTGS2, TYR 3.32112
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.32112
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, SRC, TERT, TOP2A, XDH 3.31492
[BP] GO:0040012 regulation of locomotion APEX1, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.30013
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 3.30013
[BP] GO:0051270 regulation of cellular component movement APEX1, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.29412
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.29412
[BP] GO:0031960 response to corticosteroid ALPL, BCHE, BCL2, FLT3, PTGS2, SRC 3.23084
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.20943
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, SRC, TERT, TOP2A, XDH 3.20943
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, BCHE, FABP3, FLT3, IGF1R, MMP2, PTGS2, SRC, TYR 3.17587
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, SRC, TERT, XDH 3.16786
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PTGS1, PTGS2 3.16049
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 3.11409
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.10177
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, MET, PIK3CA, PIK3CB 3.08531
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.08531
[BP] GO:0032879 regulation of localization ACHE, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP12, MMP9, PIK3CB, PTGS2, SRC, TERT 3.06581
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.01621
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 3.00113
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.97226
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A1, ESR1, HSD17B2, MMP2, MMP9, PTGS2, SRC, TOP2A 2.9326
[BP] GO:0006950 response to stress ACHE, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, MMP2, MMP9, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC, TERT, TOP2A 2.9197
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, BCHE, FABP3, FLT3, IGF1R, MMP2, PTGS2, SRC, TYR 2.9197
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, PTGS2, SRC 2.88038
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 2.87789
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.86366
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.86197
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.86197
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.86197
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.85087
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.84421
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.78521
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PTGS1, PTGS2, TYR 2.77862
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.76724
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.76034
[BP] GO:0048583 regulation of response to stimulus AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, SRC, TERT, XDH 2.71458
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.67757
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.6726
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.6726
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCHE, BCL2, CYP1A1, PTGS2, SRC, TYR 2.67052
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.66711
[BP] GO:0051896 regulation of protein kinase B signaling AXL, MET, PIK3CA, PIK3CB, SRC, XDH 2.60664
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.59991
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.58897
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.58897
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.58897
[BP] GO:0010648 negative regulation of cell communication ACHE, BCHE, BCL2, ESR1, IGF1R, MET, MMP12, MMP9, PTGS2, PTPRS, SRC, TERT, XDH 2.57914
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.56984
[BP] GO:0023057 negative regulation of signaling ACHE, BCHE, BCL2, ESR1, IGF1R, MET, MMP12, MMP9, PTGS2, PTPRS, SRC, TERT, XDH 2.56984
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.56413
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.56413
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, BCL2, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.55549
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, BCL2, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.55549
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.50862
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.50862
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, SRC, TERT 2.46188
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.46188
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.46188
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, BCL2, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.46188
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PTGS1, PTGS2, TYR 2.45579
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, SRC, TERT 2.4474
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, PTGS2, TERT 2.44264
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, KDR, PIK3CB, PTGS2, SRC 2.44177
[BP] GO:0051384 response to glucocorticoid ALPL, BCHE, BCL2, FLT3, PTGS2 2.43585
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.43134
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.42158
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, PTGS2, SRC 2.41332
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.41332
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PTGS1, PTGS2, TYR 2.40548
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PTGS2, SRC 2.35237
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.35015
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.35015
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, ESR1, IGF1R, KDR, MET, MMP1, MMP9, SRC 2.3408
[BP] GO:0030154 cell differentiation ALPL, AXL, BCHE, BCL2, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, MMP2, MMP9, PTGS2, TOP2A 2.33413
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, BCL2, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.32349
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, BCL2, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.32251
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, MET, PIK3CA, PIK3CB, SRC 2.28284
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, MMP2, PTGS2, SRC, TERT, TYR 2.27658
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 2.2685
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2 2.23895
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.23895
[BP] GO:0016477 cell migration AXL, CYP1B1, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.23895
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MMP9, PTGS2, SRC, XDH 2.22913
[BP] GO:1901570 None ALOX15, ALOX5, PTGS1, PTGS2 2.22315
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, MMP2, PTGS2, SRC, TERT 2.21942
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGS1, PTGS2 2.21773
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.21773
[BP] GO:0040011 locomotion AXL, CYP1B1, FUT7, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.21569
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.21203
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9 2.2109
[BP] GO:0009987 cellular process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TERT, TOP2A, TYR, XDH 2.19628
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, ESR1, FLT3, IGF1R, MMP2, PTGS2, SRC 2.18558
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.18558
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.18558
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, MMP2, PTGS2, SRC, TERT 2.16608
[BP] GO:1901989 None APEX1, APP, CYP1A1, TERT 2.16387
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling IGF1R, PIK3CA, PIK3CB 2.14895
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, SRC 2.14884
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.14884
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, IGF1R, MMP2, PTGS2, SRC 2.14714
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.13532
[BP] GO:0080134 regulation of response to stress APP, CYP19A1, ESR1, FABP4, IGF1R, MET, MMP12, MMP2, PTGS2, PTPRS, SRC, TERT, XDH 2.11719
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.10983
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, SRC, TOP2A 2.10194
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, PTGS2, SRC 2.09879
[BP] GO:0031667 response to nutrient levels ALPL, BCHE, BCL2, CYP1A1, PTGS2, SRC, TYR 2.09041
[BP] GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SRC 2.07124
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, ESR1, MET, SRC 2.06371
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AURKB, BCL2, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, TOP2A, XDH 2.06371
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, BCL2, CYP19A1, ESR1, IGF1R, MET, MMP12, MMP9, PTGS2, PTPRS, SRC, TERT, XDH 2.06174
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, SRC, TOP2A 2.05195
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.0451
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.0451
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, BCL2, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.01942
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, MMP2, PTGS2, SRC, TERT 2.00461
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, BCHE, BCL2, CA1, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TERT, TOP2A, TYR, XDH 3.70586
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, BCHE 3.67008
[CC] GO:0016020 membrane ACHE, ALOX15, ALOX5, ALPL, APP, AXL, BCHE, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, GLO1, HSD17B2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TERT, TYR 2.60664
[CC] GO:0005886 plasma membrane ACHE, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, FLT3, GLO1, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TERT 1.93777
[CC] GO:0044421 None ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCHE, CA1, CA2, CA4, FABP3, FABP4, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PTGS1, PTPRS, SRC, XDH 1.80591
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TERT, TOP2A, TYR, XDH 13.7094
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TERT, TOP2A, TYR, XDH 13.3426
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, TYR, XDH 11.4834
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.6974
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.54971
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.45364
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PTGS1, PTGS2, TERT, TOP2A, TYR, XDH 7.28573
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.0462
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 6.15863
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PTGS1, PTGS2, TERT, TOP2A, TYR, XDH 6.15863
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 4.7902
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 4.58635
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2 4.38173
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 4.30025
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP2A 4.22762
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 4.2244
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.99958
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 3.94428
[MF] GO:0042802 identical protein binding ACHE, APP, BCHE, BCL2, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, TERT, TOP2A, TYR, XDH 3.92795
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.84331
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.84005
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.3901
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.28753
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 3.07324
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.07324
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.01621
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 2.97049
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.97033
[MF] GO:0003990 acetylcholinesterase activity ACHE, BCHE 2.97033
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.91933
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TOP2A, XDH 2.88153
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.86197
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TERT 2.85574
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.78521
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.58897
[MF] GO:0004104 cholinesterase activity ACHE, BCHE 2.58897
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.46188
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.33413
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.29016
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, NQO2 2.14884
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, PTGS1, PTGS2 2.07124
[MF] GO:0004064 arylesterase activity CA1, CA2 2.0451
[MF] GO:0036094 small molecule binding AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP2A, XDH 2.03995


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.4612
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.9172
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 7.0299
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.8359
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.5885
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 5.2754
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 5.3567
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 5.2754
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.1383
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.9718
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB 4.1722
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET 4.0111
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, PTGS2, PTGS1 4.0111
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.3491
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.869
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.9059
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.639
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, PTGS2, PTGS1 3.8142
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.639
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.7053
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.639
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.6216
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 3.3961
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.5508
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 3.035
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.4378
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 3.0843
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 3.1654
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 3.0852
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 3.4841
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.983
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 3.035
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.9918
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 3.035
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 3.035
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.6442
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.6442
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 2.315
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.4628
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.6735
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.6821
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.7113
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.6647
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.3756
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.1598
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 2.2795
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, IGF1R 2.2795
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.3145
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 2.0128
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.315
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.5774
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 2.0694
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.639
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, BCL2, PIK3CB 2.0694
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.9318
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 2.0441
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.9602
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.9801
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.9215
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.8847
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.6509
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.583
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.539
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, TERT, PIK3CB 1.3584
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.3479
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4227
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4366
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4476
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.4476
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.5031
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.1892
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB 1.1115
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.3634
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.1807
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.4272
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, PIK3CB 1.1667
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 1.1438
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB 1.1878
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 1.0162
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.4148
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.3664
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.1667
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.3479
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 1.0087
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.3776
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, PIK3CB 1.0474
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.3545
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB 1.3311
Axon guidance_Homo sapiens_hsa04360 MET 0.5406
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5491
cAMP signaling pathway_Homo sapiens_hsa04024 PIK3CA, PIK3CB 0.9408
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.3545
Melanogenesis_Homo sapiens_hsa04916 TYR 0.6205
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.62
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.6334
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.5914
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.6328
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.5914
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.6509
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.6336
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.6529
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.6529
Gap junction_Homo sapiens_hsa04540 SRC 0.6529
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.6519
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.6035
Peroxisome_Homo sapiens_hsa04146 XDH 0.6651
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.647
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.7089
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.6509
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.7084
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.6336
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.7066
Bile secretion_Homo sapiens_hsa04976 CA2 0.7158
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.7545
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.7235
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.7169
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.8105
Shigellosis_Homo sapiens_hsa05131 SRC 0.7438
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.7721
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.8716
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.9133
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.8342
Malaria_Homo sapiens_hsa05144 MET 0.8468
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 2.0013
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.8601
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.8649
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.1742
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 2.1955
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 2.1264
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 2.0481
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.9187
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.9662
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 1.0087
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.3455
Base excision repair_Homo sapiens_hsa03410 APEX1 0.9867
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 1.0618
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 1.0502
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.2891
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.4526


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)