Prescription Description
| Prescription ID | TCMF1134 |
| Pinyin Name | Jing Zhi Guan Xin Ke Li |
| Chinese Name | 精制冠心颗粒 |
| English Name | Jing Zhi Guan Xin Granules |
| Function Description | 冠心病, 心绞痛 |
| Indications | Coronary heart disease, Angina pectoris |
| Disease ICD-11 Category |
BA80.Z [Coronary atherosclerosis, unspecified site, 冠状动脉粥样硬化,未特指部位
]; BA40 [Angina pectoris, 心绞痛 ]; |
| Human Tissues Associated with Indication | Heart |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH407 | Salvia miltiorrhiza | 丹参 | TCMH407 | ITSAH2408-14 |
| TCMH258 | Paeonia obovata | 赤芍 | TCMH258 | GBVX7902-15 |
| TCMH305 | Cnidium officinale | 川芎 | TCMH305 | ITSAP4207-14 |
| TCMH865 | Carthamus tinctorius | 红花 | TCMH865 | ITSAI2447-14 |
| TCMH1068 | Dalbergia odorifera | 降香 | TCMH1068 | ITSAJ4189-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
Showing 1 to 10 of 107 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1168 | Trichomonas vaginalis |
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1208 | Escherichia coli K12 |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1210 | Streptococcus sobrinus |
| TCMT1211 | Fusobacterium nucleatum |
| TCMT1212 | Verticillium dahliae |
Showing 1 to 10 of 56 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC | 2.61514 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SLC6A4, SRC | 2.88091 |
| [BP] GO:0001503 | ossification | ALOX15, EGFR, MMP2, MMP9, TEK | 2.46767 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, EGFR, INSR, SLC6A2, SLC6A4, SMAD3 | 2.65581 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT | 4.39701 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19 | 2.67363 |
| [BP] GO:0001775 | cell activation | ADRA2A, ALOX5, AXL, EGFR, FLT3, FUT7, HSPA1A, MIF, MMP9, RORC, SMAD3, SRC | 2.25744 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ADRA2A, ALOX15, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH | 3.53109 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ADRA2A, ALOX15, CDC25B, EGFR, FLT3, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH | 3.46442 |
| [BP] GO:0002682 | regulation of immune system process | ADORA1, ALOX15, AXL, CA2, CYP19A1, DUSP3, ESR1, ESRRA, HSPA1A, MIF, MMP12, MMP2, PTPN1, SMAD3, SRC | 2.04608 |
Showing 1 to 10 of 341 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.3814 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 8.1304 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.574 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, PIM1 | 1.8303 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | INSR | 0.7178 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | INSR, IGF1R | 0.8972 |
| Antigen processing and presentation_Homo sapiens_hsa04612 | HSPA1A | 0.5536 |
| Arachidonic acid metabolism_Homo sapiens_hsa00590 | ALOX5, ALOX15, CYP2C19 | 2.2644 |
| Arginine and proline metabolism_Homo sapiens_hsa00330 | ALDH2 | 0.654 |
| Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | ALDH2 | 0.8242 |
Showing 1 to 10 of 146 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples