Prescription Description
| Prescription ID | TCMF1085 |
| Pinyin Name | Qing Re Ling Ke Li |
| Chinese Name | 清热灵颗粒 |
| English Name | Qing Re Ling Granules |
| Function Description | 感冒 |
| Indications | Common cold disorder, Common cold |
| Disease ICD-11 Category |
SA60 [Common cold disorder (TM1), 感冒 (TM1)
]; CA00 [Acute nasopharyngitis, 急性鼻咽炎 ]; |
| Human Tissues Associated with Indication | Lung, Blood |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH986 | Scutellaria baicalensis | 黄芩 | TCMH986 | ITSAP4211-14 |
| TCMH381 | Isatis indigotica | 大青叶 | TCMH381 | KJ765825 |
| TCMH1272 | Forsythia suspensa | 连翘 | TCMH1272 | ITSAJ4444-14 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
Showing 1 to 10 of 92 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1191 | Bacillus megaterium |
| TCMT1206 | Influenza A virus (A/PR/8/34(H1N1)) |
| TCMT1208 | Escherichia coli K12 |
Showing 1 to 10 of 76 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC | 2.60176 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, DHFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.89343 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, MMP2, MMP9 | 2.44693 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC | 3.47851 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 | 3.72958 |
| [BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, CDK6, GSK3B, KDR, SRC | 2.60176 |
| [BP] GO:0002237 | response to molecule of bacterial origin | ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC | 2.34088 |
| [BP] GO:0003006 | developmental process involved in reproduction | ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, PTGS2, SRC | 2.60581 |
| [BP] GO:0006082 | organic acid metabolic process | ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GBA2, IDO1, PIM1, PPARA, PTGS2, TYR | 3.47118 |
| [BP] GO:0006091 | generation of precursor metabolites and energy | AKR1B1, AOX1, CYP19A1, CYP1A2, GSK3B, IDO1, XDH | 2.07547 |
Showing 1 to 10 of 272 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.6821 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.3707 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.3501 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5875 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.402 |
| African trypanosomiasis_Homo sapiens_hsa05143 | IDO1 | 0.751 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, BCL2, PIM1, F3 | 2.6724 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2 | 0.7208 |
| Alzheimer's disease_Homo sapiens_hsa05010 | GSK3B | 0.3697 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.4512 |
Showing 1 to 10 of 148 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples