TCM Prescription: Kang Fu Xiao Yan Suppository



Prescription Description
Prescription IDTCMF1071
Pinyin NameKang Fu Xiao Yan Shuan 
Chinese Name康妇消炎栓
English NameKang Fu Xiao Yan Suppository
Function Description带下病, 阴痒
IndicationsLeukorrhea disorder
Disease ICD-11 Category SC20 [Leukorrhea disorder (TM1), 带下病 (TM1) ];
Human Tissues Associated with IndicationUterus
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1215 Sophora flavescens 苦参 TCMH1215 ITSAM449-14
TCMH2711 Viola yedoensis 紫花地丁 TCMH2711
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH2706 Lithospermum erythrorhizon 紫草 TCMH2706
TCMH76 Thlaspi arvense 败酱草 TCMH76 MKPCH570-09
TCMH298 Andrographis paniculata 穿心莲 TCMH298 ITSAO3492-14
TCMH2654 Suis fellis pulvis 猪胆粉 TCMH2654
TCMH1343 Aloe vera 芦荟 TCMH1343 ITSAO4714-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT263 SOAT2 Acyl coenzyme A:cholesterol acyltransferase 2 Transferase O75908
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SOAT1, SOAT2, SRC, TERT, TOP2A, TYR, XDH 9.39129
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, MIF, PIM1, PPARA, SOAT1, SOAT2, TYR, XDH 9.39129
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2, SOAT1, SOAT2 9.30149
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, PIM1, PPARA, PTPN1, RORC, SOAT1, SOAT2, SRC, TERT, TOP2A, TYR, XDH 9.1058
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, MIF, PPARA, SOAT1, SOAT2 8.91805
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APEX1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PPARA, RORC, SRC, TYR 8.44759
[BP] GO:0032502 developmental process ACHE, AKR1B1, AKR1C3, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, RORC, SOAT1, SOAT2, SRC, TERT, TOP2A, TYR 7.98009
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SOAT1, SRC, TERT, TOP2A, XDH 7.42776
[BP] GO:0010941 regulation of cell death AKR1B1, AKR1C3, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TOP2A, XDH 7.42538
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALPL, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PPARA, RORC, SRC, TYR 7.42538
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC, TERT 7.42538
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.37242
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AKR1C3, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, XDH 7.28121
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALPL, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, RORC, SRC, TERT, TYR 7.09639
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 7.05086
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, RORC, SRC, TYR 7.02916
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, TYR 7.02916
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SOAT1, SRC, TERT, TOP2A, XDH 6.83844
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AKR1C3, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, XDH 6.63364
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 6.28782
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.28782
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 6.15497
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SOAT1, SOAT2, SRC, TERT, TOP2A, TYR, XDH 5.96516
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.82093
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KDR, MET, MIF, PPARA, SOAT1, SOAT2, SRC, TERT, XDH 5.8198
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, PPARA, SRC 5.74277
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, MIF, PPARA, SOAT1, SOAT2 5.4522
[BP] GO:0042127 regulation of cell proliferation AKR1B1, AKR1C3, APP, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, SRC, TERT, XDH 5.31125
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MIF, MMP2, MMP9, PTPN1, RORC, SRC, TERT, TOP2A 5.27788
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AKR1C3, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH 5.27788
[BP] GO:0023056 positive regulation of signaling AKR1B1, AKR1C3, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH 5.26631
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALPL, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, RORC, SRC, TERT 5.24142
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SOAT1, SOAT2, SRC, TERT, TOP2A, TYR, XDH 5.24014
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 5.114
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, SRC 5.00241
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.85437
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 4.75222
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APEX1, APP, CYP1A1, CYP1B1, ESR1, FLT3, RORC, SRC 4.69719
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AXL, CDC25B, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, KDR, MET, MIF, MMP2, MMP9, RORC, SOAT1, SOAT2, SRC, TERT, TOP2A 4.65237
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.48616
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SRC, TERT 4.40871
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, TERT 4.32974
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, APP, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SOAT1, SOAT2, SRC, TYR 4.32974
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 4.27575
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALPL, APEX1, APP, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, RORC, SRC 4.23519
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TOP2A, XDH 4.18129
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1B1, SOAT1, SOAT2, TYR 4.1122
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF 3.96839
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.96382
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.8485
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF 3.82046
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TOP2A, XDH 3.77735
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.76038
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, SRC 3.76038
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SRC, TERT 3.76038
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SOAT1, SOAT2, SRC, TERT 3.67508
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD17B1, HSD17B2 3.64094
[BP] GO:0031325 positive regulation of cellular metabolic process AKR1C3, APP, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SOAT1, SRC, TERT, TOP2A, XDH 3.63385
[BP] GO:0009893 positive regulation of metabolic process AKR1C3, APP, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SOAT1, SRC, TERT, TOP2A, XDH 3.62708
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, AKR1C3, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TOP2A, TYR 3.62333
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APEX1, APP, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, RORC, SRC 3.55445
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.52338
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.52338
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.52338
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, SRC 3.51498
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.49006
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH 3.45682
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B1, HSD17B2 3.45234
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, GLO1 3.44857
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA 3.38933
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 3.38933
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.38933
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process APP, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SOAT1, SRC, TERT, TOP2A, XDH 3.38933
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AKR1C3, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH 3.38933
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AKR1C3, ALPL, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, RORC, SRC, TYR 3.28681
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.26139
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.25398
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AKR1C3, APP, AXL, CSNK2A1, CYP1B1, FLT3, KDR, MET, MIF, MMP12, MMP9, PTPN1, SRC, TERT, XDH 3.19356
[BP] GO:0010038 response to metal ion AKR1C3, APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, TERT 3.18593
[BP] GO:0010604 positive regulation of macromolecule metabolic process APP, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SOAT1, SRC, TERT, TOP2A, XDH 3.10212
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AXL, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD17B2, MMP2, MMP9, SRC, TOP2A 3.10051
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 3.08871
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 3.04224
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AKR1C3, APP, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, KDR, MET, MIF, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, XDH 3.03961
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF 3.00561
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APEX1, APP, AXL, CYP1B1, MMP9, SRC 2.98579
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.9358
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.9358
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, PPARA, RORC, SOAT1, SRC, TERT, TOP2A 2.90288
[BP] GO:0009892 negative regulation of metabolic process AKR1C3, APEX1, APP, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, XDH 2.88306
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AKR1C3, APP, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MIF, MMP9, PTPN1, SRC, XDH 2.87823
[BP] GO:0032787 None AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MIF, PPARA 2.87504
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.87504
[BP] GO:0016488 None AKR1B10, AKR1C3 2.87504
[BP] GO:0016487 None AKR1B10, AKR1C3 2.87504
[BP] GO:0016107 None AKR1B10, AKR1C3 2.87504
[BP] GO:0009115 None AOX1, XDH 2.87504
[BP] GO:0006714 None AKR1B10, AKR1C3 2.87504
[BP] GO:0019216 regulation of lipid metabolic process AKR1C3, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC 2.87333
[BP] GO:0030334 regulation of cell migration APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 2.81097
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, MIF, SRC, TERT 2.81097
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, PPARA, RORC, SOAT1, SRC, TERT, TOP2A 2.79134
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.77276
[BP] GO:0016042 lipid catabolic process AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.75591
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.72579
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.7096
[BP] GO:0006066 None AKR1B1, AKR1B10, AKR1C3, APP, CYP1B1, SOAT1, SOAT2 2.7096
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1 2.69516
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, ESR1, FLT3, MET, MIF, PIM1, SRC, TYR 2.68452
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.68452
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.67077
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, PPARA, RORC, SRC, TOP2A 2.64735
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AKR1C3, APP, AXL, CYP1B1, FLT3, KDR, MET, MIF, PTPN1, SRC, XDH 2.6416
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.64012
[BP] GO:0009987 cellular process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SOAT1, SOAT2, SRC, TERT, TOP2A, TYR, XDH 2.63086
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1 2.6259
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, KDR, SRC 2.62216
[BP] GO:2000145 regulation of cell motility APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 2.62006
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.62006
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 2.59507
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, MMP9, TERT 2.57663
[BP] GO:0032879 regulation of localization ACHE, APEX1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SRC, TERT 2.57281
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.5421
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APEX1, APP, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, XDH 2.52934
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.52532
[BP] GO:0019222 regulation of metabolic process ACHE, AKR1C3, APEX1, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SOAT1, SRC, TERT, TOP2A, XDH 2.52532
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, PPARA, RORC, SOAT1, SRC, TERT, TOP2A 2.52532
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, MIF 2.52532
[BP] GO:0034433 None SOAT1, SOAT2 2.52532
[BP] GO:0034434 None SOAT1, SOAT2 2.52532
[BP] GO:0034435 None SOAT1, SOAT2 2.52532
[BP] GO:0046110 None AOX1, XDH 2.52532
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52532
[BP] GO:0016095 None AKR1B10, AKR1C3 2.52532
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.51017
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MIF, PIM1, PPARA, TYR 2.50132
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.5011
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.49453
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.48255
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.47545
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1 2.47545
[BP] GO:0030154 cell differentiation AKR1C3, ALPL, AXL, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, MMP2, MMP9, RORC, SOAT1, SOAT2, TOP2A 2.47545
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD17B1, HSD17B2 2.46121
[BP] GO:0080090 regulation of primary metabolic process AKR1C3, APEX1, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SOAT1, SRC, TERT, TOP2A, XDH 2.44961
[BP] GO:0016125 None APP, CYP19A1, CYP1B1, SOAT1, SOAT2 2.43535
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.4283
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.4283
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, FABP3, HSD17B2, KDR, MMP2, SRC 2.40626
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.40118
[BP] GO:0006081 None AKR1B10, AKR1C3, CYP1B1, GLO1 2.40118
[BP] GO:0040012 regulation of locomotion APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 2.39342
[BP] GO:0051270 regulation of cellular component movement APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC, TERT 2.38611
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.38611
[BP] GO:0042632 None FABP3, FABP4, SOAT1, SOAT2 2.38611
[BP] GO:0055092 None FABP3, FABP4, SOAT1, SOAT2 2.38611
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.33157
[BP] GO:0080134 regulation of response to stress APP, CYP19A1, ESR1, FABP4, IGF1R, MET, MIF, MMP12, MMP2, PPARA, PTPN1, SRC, TERT, XDH 2.31137
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AXL, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, SRC 2.3102
[BP] GO:0048583 regulation of response to stimulus AKR1B1, AKR1C3, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TERT, XDH 2.30675
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.30051
[BP] GO:0006145 None AOX1, XDH 2.30051
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.30051
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.30051
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.27848
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 2.27375
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.2452
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, TERT 2.2452
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.23793
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, PPARA, SRC 2.23652
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, ESR1, FABP3, FABP4, MET, SOAT1, SOAT2 2.21073
[BP] GO:0071248 cellular response to metal ion AKR1C3, CYP1A1, CYP1A2, FABP4, MMP9 2.19874
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MIF, PIM1, PPARA, TYR 2.19823
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, TERT 2.19079
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, PPARA, PTPN1, RORC, SRC, TERT, TOP2A 2.18545
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MIF, PIM1, PPARA, TYR 2.13498
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CYP1B1, ESRRB, HCAR2, KDR, MET, MIF, MMP12, MMP9, PIM1, SRC, TERT 2.13297
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.13297
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, SRC, XDH 2.1272
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.11951
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.09999
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3 2.09768
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF 2.0844
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, XDH 2.06373
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, MMP9 2.06373
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, ESR1, FLT3, FUT7, GLO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TOP2A, TYR, XDH 2.06123
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.05607
[BP] GO:0002521 leukocyte differentiation AXL, FLT3, FUT7, GLO1, MMP9, RORC 2.05607
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.0531
[BP] GO:1902532 negative regulation of intracellular signal transduction ESR1, IGF1R, MET, MIF, MMP9, PTPN1, SRC, XDH 2.04011
[CC] GO:0043227 membrane-bounded organelle ACHE, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SOAT1, SOAT2, SRC, TERT, TOP2A, TYR, XDH 2.6259
[CC] GO:0043226 organelle ACHE, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SOAT1, SOAT2, SRC, TERT, TOP2A, TYR, XDH 2.04211
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.98787
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, APP, AURKB, CA1, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, KDR, MIF, MMP2, MMP9, PIM1, PTPN1, SOAT1, SOAT2, SRC, TERT, TOP2A, TYR, XDH 1.98025
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.77203
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 16.0258
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SOAT1, SOAT2, SRC, TERT, TOP2A, TYR, XDH 11.6106
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SOAT1, SOAT2, SRC, TERT, TOP2A, TYR, XDH 10.4543
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.4543
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC 8.02748
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TERT, TOP2A, TYR, XDH 7.42538
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.37242
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TERT, TOP2A, TYR, XDH 7.05086
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC, SOAT1, SOAT2 7.02137
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.83844
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.82907
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.54373
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.54373
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 5.26631
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.13522
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HSD17B1, HSD17B2, XDH 4.36698
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 4.25687
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 4.01563
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.96382
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, PPARA, RORC, SOAT1, SOAT2 3.96382
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.82013
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.63572
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.62708
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, SOAT1, SOAT2, SRC, XDH 3.61835
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.19586
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 3.19356
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.00561
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MIF, MMP9, TERT, TOP2A, TYR, XDH 2.87504
[MF] GO:0034736 None SOAT1, SOAT2 2.87504
[MF] GO:0045550 None AKR1B10, AKR1C3 2.87504
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.87504
[MF] GO:0004772 None SOAT1, SOAT2 2.87504
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.87426
[MF] GO:0032403 protein complex binding ACHE, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.7182
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.71685
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.68452
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 2.63349
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD17B1, HSD17B2 2.52822
[MF] GO:0047718 None AKR1B10, AKR1C3 2.52532
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.52374
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.43535
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.3102
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.30051
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.25011
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD17B1, HSD17B2 2.21073
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD17B1, HSD17B2 2.13297
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.11951
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.0844
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.06373


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, CYP19A1, IGF1R 10.2577
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.7491
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 8.0744
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.4054
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.3705
Metabolic pathways_Homo sapiens_hsa01100 AKR1C3, AKR1B1, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.1532
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1532
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 4.001
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1532
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3436
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.1961
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.9281
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1073
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 2.053
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1961
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.1073
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.9119
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.053
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.8626
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 2.053
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.616
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3473
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3216
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.1213
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3338
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2736
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2736
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, AKR1C3 1.3216
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2736
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.0459
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1077
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0593
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2736
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0044
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2097
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0044
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 1.0044
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.8193
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9821
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8529
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9821
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8242
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8658
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8732
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.8179
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7027
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PPARA 0.7055
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7865
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9961
Steroid biosynthesis_Homo sapiens_hsa00100 SOAT1, SOAT2 2.053
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5137
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2917
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2917
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3532
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3422
Platelet activation_Homo sapiens_hsa04611 SRC 0.465
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5137
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3834
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3522
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4833
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5137
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3748
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4833
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3834
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4241
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5064
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5093
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5046
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.465
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3951
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4488
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4123
Gap junction_Homo sapiens_hsa04540 SRC 0.5137
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4526
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.502
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5137
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.465
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5046
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4417
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3748
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4451
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4653
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4526
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5137
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5137
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5093
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.465
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5093
Axon guidance_Homo sapiens_hsa04360 MET 0.4607
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5462
Peroxisome_Homo sapiens_hsa04146 XDH 0.5137
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5093
Glioma_Homo sapiens_hsa05214 IGF1R 0.574
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.574
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5567
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.581
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5738
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.6022
Bile secretion_Homo sapiens_hsa04976 CA2 0.5567
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.574
Shigellosis_Homo sapiens_hsa05131 SRC 0.574
Malaria_Homo sapiens_hsa05144 MET 0.6498
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6533
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6515
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6552
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7055
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8022
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7894
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7708
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8022
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8179
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7956
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8167
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1048
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9527
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0044
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2736


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)