Prescription Description
| Prescription ID | TCMF1027 |
| Pinyin Name | Yin Qiao Shuang Jie Shuan |
| Chinese Name | 银翘双解栓 |
| English Name | Yin Qiao Shuang Jie Suppository |
| Function Description | 上呼吸道感染, 扁桃体炎, 急性支气管炎 |
| Indications | Pharyngotonsillitis, Upper respiratory infection(uri), Bronchitis |
| Disease ICD-11 Category |
CA0Y [Other specified upper respiratory tract disorders, 其他特指的上呼吸道疾患
]; CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的 ]; CA20 [Bronchitis, 支气管炎 ]; |
| Human Tissues Associated with Indication | Tonsil, Lung, Bronchus |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1272 | Forsythia suspensa | 连翘 | TCMH1272 | ITSAJ4444-14 |
| TCMH1127 | Lonicera japonica | 金银花 | TCMH1127 | ITSAI3881-14 |
| TCMH986 | Scutellaria baicalensis | 黄芩 | TCMH986 | ITSAP4211-14 |
| TCMH492 | Folium caryophylli | 丁香叶 | TCMH492 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
Showing 1 to 10 of 83 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1191 | Bacillus megaterium |
| TCMT1208 | Escherichia coli K12 |
| TCMT1210 | Streptococcus sobrinus |
| TCMT1211 | Fusobacterium nucleatum |
| TCMT1212 | Verticillium dahliae |
| TCMT1213 | Neisseria gonorrhoeae |
Showing 1 to 10 of 62 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 | 2.7988 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, APP, AR, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PTPN1, SRC, XDH | 2.14287 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, APP, AR, CDC25B, FLT3, KDR, MMP9, PTPN1, SRC, XDH | 2.27953 |
| [BP] GO:0006352 | DNA-templated transcription, initiation | AR, NR3C1, NR3C2, PGR, PPARA, RORC | 2.49823 |
| [BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | AR, NR3C1, NR3C2, PGR, PPARA, RORC | 2.96613 |
| [BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS | 2.88305 |
| [BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA | 7.22744 |
| [BP] GO:0006631 | fatty acid metabolic process | ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA | 3.41059 |
| [BP] GO:0006690 | icosanoid metabolic process | ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 | 3.76735 |
| [BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.90813 |
Showing 1 to 10 of 185 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.6788 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.4277 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.4002 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5706 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, PIM1 | 1.1153 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | NR3C2 | 0.7212 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.4182 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.476 |
| Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5, ALOX15 | 2.3614 |
| Axon guidance_Homo sapiens_hsa04360 | MET | 0.4716 |
Showing 1 to 10 of 116 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples