Prescription Description
| Prescription ID | TCMF1018 |
| Pinyin Name | Yi Nao Ning Pian |
| Chinese Name | 益脑宁片 |
| English Name | Yi Nao Ning Tablet |
| Function Description | 胸痹, 风痱 |
| Indications | Stroke, Coronary heart disease, Angina pectoris |
| Disease ICD-11 Category |
8B20 [Stroke not known if ischaemic or haemorrhagic, 缺血或出血未知的卒中
]; BA80.Z [Coronary atherosclerosis, unspecified site, 冠状动脉粥样硬化,未特指部位 ]; BA40 [Angina pectoris, 心绞痛 ]; |
| Human Tissues Associated with Indication | Heart, Lung |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH981 | Astragalus membranaceus | 黄芪 | TCMH981 | ITSAK2981-14 |
| TCMH1430 | Hordeum vulgare | 麦芽 | TCMH1430 | ITSAI3101-14 |
| TCMH1299 | Ganoderma lucidum | 灵芝 | TCMH1299 | MGEN736-15 |
| TCMH1503 | Eclipta prostrata | 墨旱莲 | TCMH1503 | ITSAP4516-14 |
| TCMH2090 | Gastrodia elata | 天麻 | TCMH2090 | |
| TCMH407 | Salvia miltiorrhiza | 丹参 | TCMH407 | ITSAH2408-14 |
| TCMH456 | Rhizoma dioscoreae nipponicae | 地龙 | TCMH456 | |
| TCMH916 | Succinus | 琥珀 | TCMH916 | |
| TCMH426 | Codonopsis pilosula | 党参 | TCMH426 | ITSAL4530-14 |
| TCMH819 | Polygonum multiflorum | 何首乌 | TCMH819 | ITSAL419-14 |
| TCMH1597 | Ligustrum lucidum | 女贞子 | TCMH1597 | ITSAM2109-14 |
| TCMH906 | Viscum coloratum | 槲寄生 | TCMH906 | LT599683 |
| TCMH695 | Uncaria rhynchophylla | 钩藤 | TCMH695 | ITSAM939-14 |
| TCMH258 | Paeonia obovata | 赤芍 | TCMH258 | GBVX7902-15 |
| TCMH1848 | Crataegus pinnatifida | 山楂 | TCMH1848 | ITSAH1684-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
Showing 1 to 10 of 139 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1168 | Trichomonas vaginalis |
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1180 | Human herpesvirus 2 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
Showing 1 to 10 of 62 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 3.80563 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SLC6A4, SRC | 2.86693 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 3.95036 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD1, DRD2, EGFR, INSR, PTGS2, SLC6A2, SLC6A4, SMAD3 | 4.40867 |
| [BP] GO:0001525 | angiogenesis | CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK | 2.05405 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT | 6.15228 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, PTGS1, PTGS2 | 5.39085 |
| [BP] GO:0001775 | cell activation | ADRA2A, ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, MPO, PIK3CA, PIK3CB, RORC, SMAD3, SRC | 2.66902 |
| [BP] GO:0001817 | regulation of cytokine production | ADRA2A, AXL, CYP1B1, DRD2, HSPA1A, IDO1, MMP12, PTGS2, PTPRS, SMAD3, SRC | 2.18206 |
| [BP] GO:0001819 | positive regulation of cytokine production | ADRA2A, CYP1B1, DRD2, HSPA1A, IDO1, MMP12, PTGS2, SMAD3, SRC | 2.31084 |
Showing 1 to 10 of 460 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.2416 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.2603 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5092 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PIK3CB | 1.3128 |
| African trypanosomiasis_Homo sapiens_hsa05143 | IDO1 | 0.7335 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB | 4.3303 |
| Alcoholism_Homo sapiens_hsa05034 | DRD1, DRD2 | 0.6326 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, INSR, PIK3CB | 2.6574 |
| Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 0.9642 |
| Amphetamine addiction_Homo sapiens_hsa05031 | DRD1 | 0.5224 |
Showing 1 to 10 of 166 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples