Targeted Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.
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Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC61	TCMT193	Nuclear factor NF-kappa-B p65 subunit	Homo sapiens	IC50: 250 (nM), Ref: 21513293
TCMC61	TCMT194	Mitogen-activated protein kinase kinase kinase 7	Homo sapiens	IC50: 80 (nM), Ref: 25529738 IC50: 11 (nM), Ref: 26481152 IC50: 8.1 (nM), Ref: 26481152 IC50: 9 (nM), Ref: 27448772
TCMC61	TCMT80	MAP kinase ERK2	Homo sapiens	IC50: 6800 (nM), Ref: 25529738
TCMC61	TCMT195	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens	IC50: 80 (nM), Ref: 25529738
TCMC61	TCMT196	Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens	IC50: 1300 (nM), Ref: 25529738
TCMC962	TCMT45	Beta amyloid A4 protein	Homo sapiens	Ki: 0.208 (nM), Ref: 17004725 IC50: 800 (nM), Ref: 17270435 IC50: 3900 (nM), Ref: 26099993
TCMC962	TCMT566	Nitric oxide synthase, inducible	Homo sapiens	IC50: 6000 (nM), Ref: 18077363
TCMC962	TCMT87	Cytochrome P450 2C9	Homo sapiens	IC50: 4300 (nM), Ref: 18249473
TCMC962	TCMT321	Matrix metalloproteinase 9	Homo sapiens	IC50: 8500 (nM), Ref: 19128977
TCMC962	TCMT133	Carbonic anhydrase I	Homo sapiens	Ki: 2410 (nM), Ref: 20674354
TCMC962	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 380 (nM), Ref: 20674354
TCMC962	TCMT142	Carbonic anhydrase IV	Homo sapiens	Ki: 4970 (nM), Ref: 20674354
TCMC962	TCMT140	Carbonic anhydrase VB	Homo sapiens	Ki: 9460 (nM), Ref: 20674354
TCMC962	TCMT139	Carbonic anhydrase VI	Homo sapiens	Ki: 9940 (nM), Ref: 20674354
TCMC962	TCMT138	Carbonic anhydrase VII	Homo sapiens	Ki: 9300 (nM), Ref: 20674354
TCMC962	TCMT137	Carbonic anhydrase IX	Homo sapiens	Ki: 4050 (nM), Ref: 20674354
TCMC962	TCMT136	Carbonic anhydrase XII	Homo sapiens	Ki: 3480 (nM), Ref: 20674354
TCMC962	TCMT225	Carbonic anhydrase XIII	Homo sapiens	Ki: 6850 (nM), Ref: 20674354
TCMC962	TCMT44	Glyoxalase I	Homo sapiens	Ki: 10000 (nM), Ref: 21237663
TCMC962	TCMT22	Intestinal alkaline phosphatase	Homo sapiens	IC50: 7410 (nM), Ref:
TCMC962	TCMT46	Coagulation factor III	Homo sapiens	IC50: 199.63 (nM), Ref: 10.1007/s00044-012-0330-5 IC50: 199.63 (nM), Ref: 23199480
TCMC962	TCMT423	Epidermal growth factor receptor erbB1	Homo sapiens	IC50: 8600 (nM), Ref: 23245570
TCMC962	TCMT174	11-beta-hydroxysteroid dehydrogenase 1	Homo sapiens	IC50: 4501 (nM), Ref: 23800686
TCMC962	TCMT570	Aminopeptidase N	Homo sapiens	IC50: 10000 (nM), Ref: 23860593
TCMC962	TCMT130	Arachidonate 5-lipoxygenase	Homo sapiens	IC50: 3900 (nM), Ref: 24920381 IC50: 500 (nM), Ref: 24920381 IC50: 600 (nM), Ref: 24920381 IC50: 600 (nM), Ref: 24920381 IC50: 600 (nM), Ref: 24920381
TCMC962	TCMT164	Cyclooxygenase-1	Homo sapiens	IC50: 8100 (nM), Ref: 24920381
TCMC962	TCMT301	Prostaglandin E synthase	Homo sapiens	IC50: 600 (nM), Ref: 24920381 IC50: 1200 (nM), Ref: 24920381
TCMC962	TCMT3	Arachidonate 15-lipoxygenase	Homo sapiens	IC50: 1200 (nM), Ref: 24920381
TCMC962	TCMT207	Beta-secretase 1	Homo sapiens	IC50: 5300 (nM), Ref: 25088549
TCMC962	TCMT565	Histone acetyltransferase p300	Homo sapiens	IC50: 6500 (nM), Ref: 25730130
TCMC42	TCMT265	Glycogen synthase kinase-3 beta	Homo sapiens	IC50: 8390 (nM), Ref: 26696252
TCMC42	TCMT207	Beta-secretase 1	Homo sapiens	IC50: 2540 (nM), Ref: 26696252
TCMC694	TCMT230	Estradiol 17-beta-dehydrogenase 3	Homo sapiens	IC50: 758 (nM), Ref: 11086723 IC50: 758 (nM), Ref: 16078844
TCMC694	TCMT156	Cytochrome P450 19A1	Homo sapiens	Ki: 20 (nM), Ref: 8035427 Ki: 35 (nM), Ref: 26469743
TCMC43	TCMT301	Prostaglandin E synthase	Homo sapiens	IC50: 220 (nM), Ref: 26588603 IC50: 200 (nM), Ref: 10.1039/C5MD00278H
TCMC43	TCMT565	Histone acetyltransferase p300	Homo sapiens	IC50: 6500 (nM), Ref: 26701186
TCMC43	TCMT208	Monoamine oxidase A	Homo sapiens	Ki: 710 (nM), Ref: 26819666
TCMC43	TCMT45	Beta amyloid A4 protein	Homo sapiens	IC50: 3100 (nM), Ref: 27190601 IC50: 1500 (nM), Ref: 27190601
TCMC2142	TCMT156	Cytochrome P450 19A1	Homo sapiens	Ki: 600 (nM), Ref: 6827528
TCMC2142	TCMT33	Cytochrome P450 3A4	Homo sapiens	IC50: 10000 (nM), Ref: 14552748
TCMC2142	TCMT187	Androgen Receptor	Homo sapiens	IC50: 3.9 (nM), Ref: 15456242 IC50: 2.7 (nM), Ref: 16309907 IC50: 4.571 (nM), Ref: 22746350 IC50: 4.17 (nM), Ref: 25646649 IC50: 4.27 (nM), Ref: 25646649
TCMC2142	TCMT99	Testis-specific androgen-binding protein	Homo sapiens	IC50: 14 (nM), Ref: 17149875
TCMC2142	TCMT725	Voltage-gated L-type calcium channel alpha-1C subunit	Homo sapiens	IC50: 34 (nM), Ref: 22761000 IC50: 38.4 (nM), Ref: 22761000
TCMC124	TCMT194	Mitogen-activated protein kinase kinase kinase 7	Homo sapiens	IC50: 1300 (nM), Ref: 26481152

Targeted Pathogenic Microbes or non-Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.

Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC962	TCMT1104	Sortase	Staphylococcus aureus	IC50: 13.8 (ug/ml), Ref: 19269184
TCMC962	TCMT1108	Integrase	Human immunodeficiency virus 1	IC50: 51.3 (ug/ml), Ref: 16643034
TCMC962	TCMT1112	Quinolone resistance protein norA	Staphylococcus aureus	MIC: 1 (ug/ml), Ref: 10.1039/C4MD00196F
TCMC962	TCMT1438	Plasmodium falciparum	Plasmodium falciparum	IC50: 4.2 (ug/ml), Ref: 19299148 IC50: 3.5 (ug/ml), Ref: 19299148
TCMC962	TCMT1438	Plasmodium falciparum	Plasmodium falciparum D6	IC50: 4.2 (ug/ml), Ref: 19299148 IC50: 3.5 (ug/ml), Ref: 19299148
TCMC962	TCMT1181	Mycobacterium tuberculosis H37Ra	Mycobacterium tuberculosis H37Ra	MIC: 100 (ug/ml), Ref: 20691508
TCMC962	TCMT1346	Helicobacter pylori	Helicobacter pylori	MIC: 5 (ug/ml), Ref: 19204190 MIC: 15 (ug/ml), Ref: 19204190 MIC: 50 (ug/ml), Ref: 19204190 MIC: 30 (ug/ml), Ref: 19204190
TCMC962	TCMT1215	Pseudomonas aeruginosa PAO1	Pseudomonas aeruginosa PAO1	MIC: 30 (ug/ml), Ref: 18284200
TCMC962	TCMT1454	Bacillus subtilis	Bacillus subtilis	MIC: 16 (ug/ml), Ref: 25938986 MIC: 32 (ug/ml), Ref: 25938986
TCMC962	TCMT1221	Human herpesvirus 4	Human herpesvirus 4	IC50: 10.2 (nM), Ref: 17503850
TCMC962	TCMT1255	Human immunodeficiency virus 1	Human immunodeficiency virus 1	IC50: 37 (nM), Ref: 20034711
TCMC962	TCMT1313	Human immunodeficiency virus 2	Human immunodeficiency virus type 2 (ISOLATE ROD)	IC50: 37 (nM), Ref: 20034711