TCM Putative Target References: TCMH1987


Targeted Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.
.
Ingredient ID & Structure Target ID Target Name Target Organism Activity Records & Reference
TCMC1881
 TCMT151 Protein kinase C alpha Homo sapiens Ki: 2.5 (nM), Ref: 11327599
Ki: 6.4 (nM), Ref: 21596562
TCMC1881
 TCMT152 Protein kinase C beta Homo sapiens Ki: 1.8 (nM), Ref: 11327599
TCMC1881
 TCMT153 Protein kinase C gamma Homo sapiens Ki: 4.9 (nM), Ref: 11327599
TCMC1881
 TCMT154 Protein kinase C delta Homo sapiens Ki: 0.8 (nM), Ref: 11327599
TCMC1881
 TCMT155 Protein kinase C epsilon Homo sapiens Ki: 0.45 (nM), Ref: 11327599
TCMC2080
 TCMT87 Cytochrome P450 2C9 Homo sapiens IC50: 8200 (nM), Ref: 23260576
TCMC2080
 TCMT278 Solute carrier organic anion transporter family member 1B1 Homo sapiens IC50: 8500 (nM), Ref: 23401473
TCMC2080
 TCMT277 Solute carrier organic anion transporter family member 1B3 Homo sapiens IC50: 5000 (nM), Ref: 23401473
TCMC2080
 TCMT276 Solute carrier organic anion transporter family member 2B1 Homo sapiens IC50: 800 (nM), Ref: 23401473
TCMC1495
 TCMT298 Fatty acid binding protein muscle Homo sapiens IC50: 1000 (nM), Ref: 20471252
IC50: 1000 (nM), Ref: 25461324
IC50: 1000 (nM), Ref: 25461324
Ki: 9300 (nM), Ref: 27460668
TCMC1495
 TCMT297 Fatty acid binding protein adipocyte Homo sapiens IC50: 1000 (nM), Ref: 20471252
Ki: 6800 (nM), Ref: 27460668
TCMC1495
 TCMT63 Peroxisome proliferator-activated receptor alpha Homo sapiens IC50: 1100 (nM), Ref: 10.1007/s00044-008-9102-7
IC50: 1100 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1495
 TCMT64 Peroxisome proliferator-activated receptor delta Homo sapiens IC50: 10000 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1495
 TCMT67 Peroxisome proliferator-activated receptor gamma Homo sapiens IC50: 6200 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC715
 TCMT63 Peroxisome proliferator-activated receptor alpha Homo sapiens IC50: 1200 (nM), Ref: 10.1007/s00044-008-9102-7
IC50: 1200 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC715
 TCMT64 Peroxisome proliferator-activated receptor delta Homo sapiens IC50: 3100 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC715
 TCMT67 Peroxisome proliferator-activated receptor gamma Homo sapiens IC50: 1600 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC2079
 TCMT133 Carbonic anhydrase I Homo sapiens Ki: 1490 (nM), Ref: 20674354
TCMC2079
 TCMT134 Carbonic anhydrase II Homo sapiens Ki: 2510 (nM), Ref: 20674354
TCMC2079
 TCMT143 Carbonic anhydrase III Homo sapiens Ki: 6430 (nM), Ref: 20674354
TCMC2079
 TCMT142 Carbonic anhydrase IV Homo sapiens Ki: 8960 (nM), Ref: 20674354
TCMC2079
 TCMT141 Carbonic anhydrase VA Homo sapiens Ki: 4080 (nM), Ref: 20674354
TCMC2079
 TCMT140 Carbonic anhydrase VB Homo sapiens Ki: 4560 (nM), Ref: 20674354
TCMC2079
 TCMT139 Carbonic anhydrase VI Homo sapiens Ki: 9700 (nM), Ref: 20674354
TCMC2079
 TCMT138 Carbonic anhydrase VII Homo sapiens Ki: 4710 (nM), Ref: 20674354
TCMC2079
 TCMT136 Carbonic anhydrase XII Homo sapiens Ki: 9050 (nM), Ref: 20674354
TCMC2079
 TCMT225 Carbonic anhydrase XIII Homo sapiens Ki: 4820 (nM), Ref: 20674354
TCMC2079
 TCMT87 Cytochrome P450 2C9 Homo sapiens Ki: 5000 (nM), Ref: 16248836
TCMC2079
 TCMT278 Solute carrier organic anion transporter family member 1B1 Homo sapiens IC50: 9700 (nM), Ref: 23401473
TCMC2079
 TCMT277 Solute carrier organic anion transporter family member 1B3 Homo sapiens IC50: 2700 (nM), Ref: 23401473
TCMC2079
 TCMT276 Solute carrier organic anion transporter family member 2B1 Homo sapiens IC50: 4500 (nM), Ref: 23401473
TCMC1480
 TCMT107 Glutamate receptor ionotropic kainate 2 Homo sapiens Ki: 1106 (nM), Ref: 10821708
TCMC1480
 TCMT108 Glutamate receptor ionotropic, AMPA 1 Homo sapiens Ki: 1360 (nM), Ref: 9357531
TCMC1480
 TCMT109 Glutamate receptor ionotropic, AMPA 2 Homo sapiens Ki: 940 (nM), Ref: 9357531
TCMC1480
 TCMT110 Glutamate receptor ionotropic, AMPA 4 Homo sapiens Ki: 868 (nM), Ref: 9357531
TCMC1480
 TCMT111 Glutamate receptor ionotropic kainate 5 Homo sapiens Ki: 701 (nM), Ref: 9357531
TCMC1480
 TCMT660 Metabotropic glutamate receptor 8 Homo sapiens IC50: 5.7 (nM), Ref: 15603952
TCMC1480
 TCMT112 Adenosine A3 receptor Homo sapiens IC50: 613 (nM), Ref: 16250647
TCMC1480
 TCMT653 Metabotropic glutamate receptor 1 Homo sapiens Ki: 250 (nM), Ref: 17725337
Ki: 570 (nM), Ref: 19042134
Ki: 1584.89 (nM), Ref: 10.1039/C1MD00186H
TCMC1480
 TCMT654 Metabotropic glutamate receptor 5 Homo sapiens Ki: 390 (nM), Ref: 17725337
Ki: 1160 (nM), Ref: 19042134
Ki: 4677.35 (nM), Ref: 10.1039/C1MD00186H
TCMC1480
 TCMT657 Metabotropic glutamate receptor 4 Homo sapiens Ki: 2400 (nM), Ref: 17725337
Ki: 1400 (nM), Ref: 19042134
Ki: 3235.94 (nM), Ref: 10.1039/C1MD00186H
TCMC1480
 TCMT655 Metabotropic glutamate receptor 2 Homo sapiens Ki: 6400 (nM), Ref: 19042134
Ki: 1819.7 (nM), Ref: 10.1039/C1MD00186H
TCMC1480
 TCMT664 Excitatory amino acid transporter 3 Homo sapiens Ki: 51 (nM), Ref: 18578477
TCMC1480
 TCMT656 Metabotropic glutamate receptor 3 Homo sapiens Ki: 57.54 (nM), Ref: 10.1039/C1MD00186H
TCMC1982
 TCMT239 Serine/threonine-protein kinase PIM1 Homo sapiens IC50: 43 (nM), Ref: 16302800
IC50: 500 (nM), Ref: 24328302
TCMC1982
 TCMT130 Arachidonate 5-lipoxygenase Homo sapiens IC50: 790 (nM), Ref: 17378609
IC50: 4000 (nM), Ref: 24368208
TCMC1982
 TCMT223 Aldose reductase Homo sapiens IC50: 2200 (nM), Ref: 18165015
IC50: 14.8 (nM), Ref: 18976928
IC50: 2200 (nM), Ref: 22261024
IC50: 2900 (nM), Ref: 25152999
TCMC1982
 TCMT44 Glyoxalase I Homo sapiens IC50: 3200 (nM), Ref: 18258440
TCMC1982
 TCMT66 Estradiol 17-beta-dehydrogenase 2 Homo sapiens IC50: 1540 (nM), Ref: 18533708
TCMC1982
 TCMT142 Carbonic anhydrase IV Homo sapiens Ki: 7890 (nM), Ref: 20185318
TCMC1982
 TCMT143 Carbonic anhydrase III Homo sapiens Ki: 8100 (nM), Ref: 20185318
TCMC1982
 TCMT134 Carbonic anhydrase II Homo sapiens Ki: 2540 (nM), Ref: 20185318
TCMC1982
 TCMT133 Carbonic anhydrase I Homo sapiens Ki: 2680 (nM), Ref: 20185318
TCMC1982
 TCMT141 Carbonic anhydrase VA Homo sapiens Ki: 6810 (nM), Ref: 20185318
TCMC1982
 TCMT139 Carbonic anhydrase VI Homo sapiens Ki: 6170 (nM), Ref: 20185318
TCMC1982
 TCMT138 Carbonic anhydrase VII Homo sapiens Ki: 4840 (nM), Ref: 20185318
TCMC1982
 TCMT137 Carbonic anhydrase IX Homo sapiens Ki: 7000 (nM), Ref: 20185318
TCMC1982
 TCMT136 Carbonic anhydrase XII Homo sapiens Ki: 9390 (nM), Ref: 20185318
TCMC1982
 TCMT135 Carbonic anhydrase XIV Homo sapiens Ki: 5410 (nM), Ref: 20185318
TCMC1982
 TCMT156 Cytochrome P450 19A1 Homo sapiens IC50: 12 (nM), Ref: 20413308
TCMC1982
 TCMT219 Cytochrome P450 1A2 Homo sapiens IC50: 4097 (nM), Ref: 20696580
IC50: 1550 (nM), Ref: 22328583
TCMC1982
 TCMT215 Cytochrome P450 1A1 Homo sapiens IC50: 1191 (nM), Ref: 20696580
TCMC1982
 TCMT257 Cytochrome P450 1B1 Homo sapiens IC50: 77 (nM), Ref: 20696580
TCMC1982
 TCMT306 Matrix metalloproteinase-2 Homo sapiens IC50: 6680 (nM), Ref: 22658537
TCMC1982
 TCMT320 Matrix metalloproteinase 3 Homo sapiens IC50: 5570 (nM), Ref: 22658537
TCMC1982
 TCMT321 Matrix metalloproteinase 9 Homo sapiens IC50: 1610 (nM), Ref: 22658537
TCMC1982
 TCMT322 Matrix metalloproteinase 13 Homo sapiens IC50: 8460 (nM), Ref: 22658537
TCMC1982
 TCMT422 CaM kinase II beta Homo sapiens IC50: 3000 (nM), Ref: 21798748
TCMC1982
 TCMT265 Glycogen synthase kinase-3 beta Homo sapiens IC50: 2000 (nM), Ref: 10.1007/s00044-012-0353-y
TCMC1982
 TCMT207 Beta-secretase 1 Homo sapiens IC50: 5400 (nM), Ref: 10.1007/s00044-012-0353-y
IC50: 6500 (nM), Ref: 26003344
TCMC1982
 TCMT784 Vasopressin V2 receptor Homo sapiens IC50: 7000 (nM), Ref: 23437772
IC50: 6309.57 (nM), Ref: 23437772
TCMC1982
 TCMT785 Interleukin-8 receptor A Homo sapiens IC50: 4500 (nM), Ref: 23437772
IC50: 5011.87 (nM), Ref: 23437772
TCMC1982
 TCMT786 C-C chemokine receptor type 4 Homo sapiens IC50: 10000 (nM), Ref: 23437772
TCMC1982
 TCMT260 Tyrosine-protein kinase receptor FLT3 Homo sapiens IC50: 590 (nM), Ref: 23411073
TCMC1982
 TCMT601 Thrombin Homo sapiens IC50: 1500 (nM), Ref: 24610996
TCMC1982
 TCMT370 Vascular endothelial growth factor receptor 2 Homo sapiens IC50: 280 (nM), Ref: 24328302
TCMC1982
 TCMT212 Tyrosine-protein kinase SRC Homo sapiens IC50: 120 (nM), Ref: 24328302
TCMC1982
 TCMT791 Protein kinase N1 Homo sapiens IC50: 5800 (nM), Ref: 24328302
TCMC1982
 TCMT484 Serine/threonine-protein kinase PLK1 Homo sapiens IC50: 5750 (nM), Ref: 24328302
TCMC1982
 TCMT462 Serine/threonine-protein kinase NEK6 Homo sapiens IC50: 4230 (nM), Ref: 24328302
TCMC1982
 TCMT445 Serine/threonine-protein kinase NEK2 Homo sapiens IC50: 5730 (nM), Ref: 24328302
TCMC1982
 TCMT401 Hepatocyte growth factor receptor Homo sapiens IC50: 580 (nM), Ref: 24328302
TCMC1982
 TCMT369 Insulin-like growth factor I receptor Homo sapiens IC50: 300 (nM), Ref: 24328302
TCMC1982
 TCMT441 Focal adhesion kinase 1 Homo sapiens IC50: 1200 (nM), Ref: 24328302
TCMC1982
 TCMT388 Tyrosine-protein kinase receptor UFO Homo sapiens IC50: 960 (nM), Ref: 24328302
TCMC1982
 TCMT374 Serine/threonine-protein kinase Aurora-B Homo sapiens IC50: 910 (nM), Ref: 24328302
TCMC1982
 TCMT436 NUAK family SNF1-like kinase 1 Homo sapiens IC50: 5090 (nM), Ref: 24328302
TCMC1982
 TCMT402 ALK tyrosine kinase receptor Homo sapiens IC50: 3320 (nM), Ref: 24328302
TCMC1982
 TCMT479 Serine/threonine-protein kinase AKT Homo sapiens IC50: 5390 (nM), Ref: 24328302
TCMC1982
 TCMT592 Xanthine dehydrogenase Homo sapiens Ki: 280 (nM), Ref: 25060641
IC50: 3500 (nM), Ref: 27162124
TCMC1982
 TCMT793 Liver glycogen phosphorylase Homo sapiens IC50: 4800 (nM), Ref: 25092521
TCMC1982
 TCMT33 Cytochrome P450 3A4 Homo sapiens IC50: 2110 (nM), Ref: 22328583
TCMC1982
 TCMT217 Cytochrome P450 2C8 Homo sapiens IC50: 1390 (nM), Ref: 22328583
TCMC1982
 TCMT261 Death-associated protein kinase 1 Homo sapiens IC50: 8900 (nM), Ref: 26322379
TCMC2105
 TCMT64 Peroxisome proliferator-activated receptor delta Homo sapiens IC50: 6000 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC2105
 TCMT63 Peroxisome proliferator-activated receptor alpha Homo sapiens IC50: 1100 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1830
 TCMT297 Fatty acid binding protein adipocyte Homo sapiens IC50: 930 (nM), Ref: 15357969
TCMC1830
 TCMT298 Fatty acid binding protein muscle Homo sapiens IC50: 2600 (nM), Ref: 15357969
TCMC1830
 TCMT808 Fatty acid binding protein epidermal Homo sapiens IC50: 1200 (nM), Ref: 15357969
TCMC1830
 TCMT809 Fatty acid binding protein intestinal Homo sapiens IC50: 1700 (nM), Ref: 15357969
TCMC1830
 TCMT810 Toll-like receptor 2 Homo sapiens IC50: 5000 (nM), Ref: 16509590
TCMC1830
 TCMT64 Peroxisome proliferator-activated receptor delta Homo sapiens IC50: 7400 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1830
 TCMT63 Peroxisome proliferator-activated receptor alpha Homo sapiens IC50: 1500 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1788
 TCMT63 Peroxisome proliferator-activated receptor alpha Homo sapiens IC50: 600 (nM), Ref: 10.1007/s00044-008-9102-7
IC50: 600 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1788
 TCMT64 Peroxisome proliferator-activated receptor delta Homo sapiens IC50: 5300 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1788
 TCMT67 Peroxisome proliferator-activated receptor gamma Homo sapiens IC50: 4100 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1788
 TCMT126 Telomerase reverse transcriptase Homo sapiens IC50: 8600 (nM), Ref: 10.1039/C0MD00241K
TCMC1788
 TCMT297 Fatty acid binding protein adipocyte Homo sapiens Ki: 1500 (nM), Ref: 27460668
TCMC2081
 TCMT278 Solute carrier organic anion transporter family member 1B1 Homo sapiens IC50: 9000 (nM), Ref: 23401473
TCMC2081
 TCMT276 Solute carrier organic anion transporter family member 2B1 Homo sapiens IC50: 3600 (nM), Ref: 23401473
TCMC1496
 TCMT63 Peroxisome proliferator-activated receptor alpha Homo sapiens IC50: 1200 (nM), Ref: 10.1007/s00044-008-9102-7
IC50: 1200 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1496
 TCMT67 Peroxisome proliferator-activated receptor gamma Homo sapiens IC50: 6000 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1496
 TCMT164 Cyclooxygenase-1 Homo sapiens Ki: 4000 (nM), Ref: 24088053
TCMC1611
 TCMT810 Toll-like receptor 2 Homo sapiens IC50: 5000 (nM), Ref: 16509590
TCMC1611
 TCMT63 Peroxisome proliferator-activated receptor alpha Homo sapiens IC50: 5400 (nM), Ref: 10.1007/s00044-012-0285-6

Targeted Pathogenic Microbes or non-Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.

Ingredient ID & Structure Target ID Target Name Target Organism Activity Records & Reference
TCMC1982
 TCMT1099 Neuraminidase Influenza A virus (A/Puerto Rico/8/1934(H1N1)) IC50: 17.65 (ug/ml), Ref: 20116898
TCMC2107
 TCMT1294 Human parainfluenza virus 3 Human parainfluenza virus 3 IC50: 37.5 (ug/ml), Ref: 11678648
TCMC2107
 TCMT1463 Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv MIC: 100 (ug/ml), Ref: 20542692
TCMC2079
 TCMT1218 Staphylococcus aureus Staphylococcus aureus MIC: 12.5 (ug/ml), Ref: 11170636
TCMC1982
 TCMT1246 Escherichia coli Escherichia coli MIC: 62.5 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
MIC: 2 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
MIC: 15.6 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
MIC: 31.25 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
MIC: 1 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
MIC: 3.9 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
IC50: 3.8 (ug/ml), Ref: 24749980
TCMC1982
 TCMT1412 Salmonella typhimurium Salmonella enterica subsp. enterica serovar Typhimurium MIC: 15.6 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
MIC: 31.25 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
TCMC1982
 TCMT1223 Staphylococcus epidermidis Staphylococcus epidermidis MIC: 31.25 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
TCMC1982
 TCMT1218 Staphylococcus aureus Staphylococcus aureus MIC: 62.5 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
TCMC1982
 TCMT1346 Helicobacter pylori Helicobacter pylori MIC: 50 (ug/ml), Ref: 12762812
MIC: 100 (ug/ml), Ref: 10.1007/s00044-012-0207-7
TCMC1982
 TCMT1286 Bacillus cereus Bacillus cereus MIC: 50 (ug/ml), Ref: 12762812
TCMC1982
 TCMT1382 Plasmodium falciparum (isolate K1 / Thailand) Plasmodium falciparum K1 IC50: 6.5 (ug/ml), Ref: 12398543
TCMC1982
 TCMT1442 Leishmania donovani Leishmania donovani IC50: 29.5 (ug/ml), Ref: 12398543
IC50: 1 (ug/ml), Ref: 10.1039/C5MD00481K
TCMC1982
 TCMT1438 Plasmodium falciparum Plasmodium falciparum IC50: 2.4 (ug/ml), Ref: 18855442
TCMC1982
 TCMT1208 Escherichia coli K12 Escherichia coli K-12 MIC: 64 (ug/ml), Ref: 20655215
MIC: 64 (ug/ml), Ref: 21534606
TCMC1982
 TCMT1212 Verticillium dahliae Verticillium dahliae IC50: 6 (ug/ml), Ref: 17394331
TCMC1982
 TCMT1455 Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv MIC: 50 (ug/ml), Ref: 10.1007/s00044-012-0268-7
TCMC1830
 TCMT1361 Neisseria meningitidis Neisseria meningitidis MIC: 50 (ug/ml), Ref: 19884363
TCMC1830
 TCMT1382 Plasmodium falciparum (isolate K1 / Thailand) Plasmodium falciparum K1 IC50: 3.8 (ug/ml), Ref: 20855214
IC50: 3.8 (ug/ml), Ref: 25103602
TCMC1830
 TCMT1442 Leishmania donovani Leishmania donovani IC50: 14.5 (ug/ml), Ref: 20855214
TCMC1788
 TCMT1455 Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv MIC: 100 (ug/ml), Ref: 24103427
TCMC1982
 TCMT1093 Enoyl-acyl-carrier protein reductase Plasmodium falciparum Ki: 22 (nM), Ref: 17263522