TCM Putative Target References: TCMH1489


Targeted Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.
.
Ingredient ID & Structure Target ID Target Name Target Organism Activity Records & Reference
TCMC948
TCMT135 Carbonic anhydrase XIV Homo sapiens Ki: 6680 (nM), Ref: 20185318
Ki: 6680 (nM), Ref: 26498394
TCMC948
TCMT136 Carbonic anhydrase XII Homo sapiens Ki: 8010 (nM), Ref: 20185318
Ki: 8010 (nM), Ref: 26498394
TCMC948
TCMT137 Carbonic anhydrase IX Homo sapiens Ki: 5330 (nM), Ref: 20185318
TCMC948
TCMT138 Carbonic anhydrase VII Homo sapiens Ki: 5230 (nM), Ref: 20185318
TCMC948
TCMT139 Carbonic anhydrase VI Homo sapiens Ki: 6720 (nM), Ref: 20185318
TCMC948
TCMT140 Carbonic anhydrase VB Homo sapiens Ki: 7760 (nM), Ref: 20185318
TCMC948
TCMT141 Carbonic anhydrase VA Homo sapiens Ki: 5960 (nM), Ref: 20185318
TCMC948
TCMT142 Carbonic anhydrase IV Homo sapiens Ki: 9600 (nM), Ref: 20185318
TCMC948
TCMT143 Carbonic anhydrase III Homo sapiens Ki: 7570 (nM), Ref: 20185318
TCMC948
TCMT134 Carbonic anhydrase II Homo sapiens Ki: 980 (nM), Ref: 20185318
TCMC948
TCMT133 Carbonic anhydrase I Homo sapiens Ki: 1070 (nM), Ref: 20185318
TCMC948
TCMT223 Aldose reductase Homo sapiens IC50: 140 (nM), Ref: 10.1007/s00044-010-9412-4
TCMC1957
TCMT34 Cytochrome P450 2D6 Homo sapiens Ki: 78 (nM), Ref: 26125082
TCMC2001
TCMT116 Mu opioid receptor Homo sapiens Ki: 6.9 (nM), Ref: 19027293
Ki: 3.9 (nM), Ref: 20055417
TCMC2001
TCMT113 Delta opioid receptor Homo sapiens Ki: 180 (nM), Ref: 19027293
Ki: 49 (nM), Ref: 20055417
TCMC2001
TCMT117 Kappa opioid receptor Homo sapiens Ki: 3 (nM), Ref: 19027293
Ki: 2.2 (nM), Ref: 20055417
TCMC1258
TCMT37 Serotonin 2a (5-HT2a) receptor Homo sapiens Ki: 966 (nM), Ref: 25695425
TCMC1258
TCMT160 Serotonin 7 (5-HT7) receptor Homo sapiens Ki: 43 (nM), Ref: 25695425
TCMC1258
TCMT36 Serotonin 1a (5-HT1a) receptor Homo sapiens Ki: 171 (nM), Ref: 25695425
TCMC1339
TCMT117 Kappa opioid receptor Homo sapiens Ki: 260 (nM), Ref: 22439881
TCMC1339
TCMT116 Mu opioid receptor Homo sapiens Ki: 9.5 (nM), Ref: 22439881
TCMC1795
TCMT116 Mu opioid receptor Homo sapiens Ki: 286 (nM), Ref: 17616524
TCMC130
TCMT615 Sentrin-specific protease 8 Homo sapiens IC50: 2470 (nM), Ref:
TCMC130
TCMT616 Sentrin-specific protease 7 Homo sapiens IC50: 1670 (nM), Ref:
TCMC130
TCMT617 Sentrin-specific protease 6 Homo sapiens IC50: 805 (nM), Ref:
TCMC2155
TCMT116 Mu opioid receptor Homo sapiens Ki: 7400 (nM), Ref: 17616524
TCMC2053
TCMT27 Dopamine D1 receptor Homo sapiens Ki: 22 (nM), Ref: 23332346
TCMC2053
TCMT38 Dopamine D2 receptor Homo sapiens Ki: 214 (nM), Ref: 23332346
TCMC1837
TCMT789 Phosphodiesterase 3A Homo sapiens Ki: 279 (nM), Ref: 17228859
TCMC1837
TCMT790 Phosphodiesterase 3B Homo sapiens Ki: 417 (nM), Ref: 17228859
TCMC1837
TCMT792 Phosphodiesterase 10A Homo sapiens IC50: 56.9 (nM), Ref: 20450197
IC50: 76 (nM), Ref: 20450197
IC50: 17 (nM), Ref: 21087867
IC50: 21 (nM), Ref: 21705115
IC50: 36 (nM), Ref: 22321214
IC50: 210 (nM), Ref: 23978358
IC50: 36 (nM), Ref: 24721831
IC50: 36 (nM), Ref: 25592707
IC50: 92.3 (nM), Ref: 10.1039/C5MD00419E
TCMC1837
TCMT307 HERG Homo sapiens IC50: 7244.36 (nM), Ref: 21185626
TCMC1724
TCMT113 Delta opioid receptor Homo sapiens Ki: 41 (nM), Ref: 10741545
Ki: 33 (nM), Ref: 14643346
Ki: 33 (nM), Ref: 17149859
Ki: 33 (nM), Ref: 17149858
Ki: 76 (nM), Ref: 17407276
IC50: 138 (nM), Ref: 17388627
IC50: 138 (nM), Ref: 17451272
IC50: 138 (nM), Ref: 18039010
Ki: 33 (nM), Ref: 18313920
Ki: 120 (nM), Ref: 19027293
IC50: 138 (nM), Ref: 16989522
Ki: 51 (nM), Ref: 20055417
Ki: 38 (nM), Ref: 21482470
Ki: 21.38 (nM), Ref: 19527931
Ki: 103 (nM), Ref: 25062506
Ki: 1516 (nM), Ref: 25268943
Ki: 30 (nM), Ref: 26035635
Ki: 103 (nM), Ref: 10.1039/C5MD00414D
TCMC1724
TCMT117 Kappa opioid receptor Homo sapiens Ki: 1.2 (nM), Ref: 10741545
Ki: 9.2 (nM), Ref: 17149859
Ki: 9.2 (nM), Ref: 17149858
Ki: 1.1 (nM), Ref: 17407276
IC50: 320 (nM), Ref: 17407276
Ki: 9.2 (nM), Ref: 18313920
Ki: 1.2 (nM), Ref: 19027293
Ki: 3 (nM), Ref: 20055417
Ki: 14.7 (nM), Ref: 20441176
Ki: 0.25 (nM), Ref: 21482470
Ki: 4.467 (nM), Ref: 19527931
Ki: 362 (nM), Ref: 25268943
Ki: 15 (nM), Ref: 10.1039/C5MD00414D
TCMC1724
TCMT116 Mu opioid receptor Homo sapiens IC50: 7.3 (nM), Ref: 14643346
Ki: 3.7 (nM), Ref: 17149859
IC50: 7.3 (nM), Ref: 17149859
Ki: 3.7 (nM), Ref: 17149858
IC50: 7.3 (nM), Ref: 17149858
Ki: 0.79 (nM), Ref: 17407276
IC50: 23 (nM), Ref: 17407276
Ki: 3.7 (nM), Ref: 18313920
IC50: 7.3 (nM), Ref: 18313920
Ki: 0.66 (nM), Ref: 19027293
Ki: 0.98 (nM), Ref: 20055417
Ki: 0.23 (nM), Ref: 21482470
Ki: 0.5623 (nM), Ref: 19527931
IC50: 1.87 (nM), Ref: 24171469
Ki: 2.3 (nM), Ref: 25062506
Ki: 354 (nM), Ref: 25268943
Ki: 1.148 (nM), Ref: 26632862
Ki: 1.259 (nM), Ref: 26632862
Ki: 2.3 (nM), Ref: 10.1039/C5MD00414D
TCMC1724
TCMT112 Adenosine A3 receptor Homo sapiens IC50: 1.6 (nM), Ref: 16250647
TCMC1763
TCMT309 Solute carrier family 22 member 2 Homo sapiens IC50: 2600 (nM), Ref: 23241029
TCMC264
TCMT38 Dopamine D2 receptor Homo sapiens Ki: 105 (nM), Ref: 23332346
TCMC264
TCMT27 Dopamine D1 receptor Homo sapiens Ki: 6.6 (nM), Ref: 23332346
TCMC930
TCMT116 Mu opioid receptor Homo sapiens Ki: 459 (nM), Ref: 17616524
TCMC1600
TCMT116 Mu opioid receptor Homo sapiens Ki: 3.96 (nM), Ref: 12372519
Ki: 0.88 (nM), Ref: 16392810
Ki: 1.1 (nM), Ref: 16913723
Ki: 1.1 (nM), Ref: 17887741
Ki: 4 (nM), Ref: 17616524
Ki: 2.55 (nM), Ref: 19627147
Ki: 2.55 (nM), Ref: 21684752
Ki: 2.6 (nM), Ref: 21570305
Ki: 2.6 (nM), Ref: 22341895
Ki: 2.2 (nM), Ref: 24900459
Ki: 0.88 (nM), Ref: 22439881
IC50: 4.3 (nM), Ref: 22995061
Ki: 2.6 (nM), Ref: 23618710
Ki: 2.6 (nM), Ref: 23880358
IC50: 2.5 (nM), Ref: 24171469
Ki: 5.2 (nM), Ref: 25062506
Ki: 2.6 (nM), Ref: 25599950
Ki: 22 (nM), Ref: 25494650
IC50: 6.3 (nM), Ref: 26789491
Ki: 0.53 (nM), Ref: 26390077
Ki: 5.2 (nM), Ref: 10.1039/C5MD00414D
TCMC1600
TCMT113 Delta opioid receptor Homo sapiens Ki: 140 (nM), Ref: 16392810
Ki: 140 (nM), Ref: 16913723
Ki: 140 (nM), Ref: 17887741
Ki: 605 (nM), Ref: 22341895
Ki: 140 (nM), Ref: 22439881
Ki: 605 (nM), Ref: 23618710
Ki: 605 (nM), Ref: 23880358
Ki: 605 (nM), Ref: 25599950
TCMC1600
TCMT117 Kappa opioid receptor Homo sapiens Ki: 24 (nM), Ref: 16392810
Ki: 46.9 (nM), Ref: 16913723
Ki: 46.9 (nM), Ref: 17887741
Ki: 6.9 (nM), Ref: 19932964
Ki: 299 (nM), Ref: 22341895
Ki: 24 (nM), Ref: 22439881
Ki: 60.9 (nM), Ref: 23419026
Ki: 299 (nM), Ref: 23618710
Ki: 299 (nM), Ref: 23880358
Ki: 299 (nM), Ref: 25599950
Ki: 120 (nM), Ref: 26390077
TCMC1329
TCMT239 Serine/threonine-protein kinase PIM1 Homo sapiens IC50: 2710 (nM), Ref: 26275107
TCMC1723
TCMT117 Kappa opioid receptor Homo sapiens Ki: 0.38 (nM), Ref: 19027293
Ki: 2 (nM), Ref: 26390077
TCMC1723
TCMT113 Delta opioid receptor Homo sapiens Ki: 120 (nM), Ref: 19027293
TCMC1723
TCMT116 Mu opioid receptor Homo sapiens Ki: 0.19 (nM), Ref: 19027293
Ki: 0.36 (nM), Ref: 26390077
TCMC38
TCMT27 Dopamine D1 receptor Homo sapiens Ki: 529 (nM), Ref: 23332346
TCMC1839
TCMT133 Carbonic anhydrase I Homo sapiens Ki: 9800 (nM), Ref: 18501600
Ki: 9800 (nM), Ref: 18579385
Ki: 920 (nM), Ref: 20185318
TCMC1839
TCMT136 Carbonic anhydrase XII Homo sapiens Ki: 4800 (nM), Ref: 18579385
Ki: 6270 (nM), Ref: 20185318
TCMC1839
TCMT141 Carbonic anhydrase VA Homo sapiens Ki: 9200 (nM), Ref: 18579385
Ki: 3670 (nM), Ref: 20185318
TCMC1839
TCMT135 Carbonic anhydrase XIV Homo sapiens Ki: 6160 (nM), Ref: 20185318
TCMC1839
TCMT137 Carbonic anhydrase IX Homo sapiens Ki: 3730 (nM), Ref: 20185318
TCMC1839
TCMT138 Carbonic anhydrase VII Homo sapiens Ki: 4080 (nM), Ref: 20185318
TCMC1839
TCMT139 Carbonic anhydrase VI Homo sapiens Ki: 5700 (nM), Ref: 20185318
TCMC1839
TCMT140 Carbonic anhydrase VB Homo sapiens Ki: 7130 (nM), Ref: 20185318
TCMC1839
TCMT142 Carbonic anhydrase IV Homo sapiens Ki: 7780 (nM), Ref: 20185318
TCMC1839
TCMT143 Carbonic anhydrase III Homo sapiens Ki: 6610 (nM), Ref: 20185318
TCMC1839
TCMT134 Carbonic anhydrase II Homo sapiens Ki: 870 (nM), Ref: 20185318
TCMC28
TCMT853 Sigma opioid receptor Homo sapiens Ki: 36 (nM), Ref: 24617836
IC50: 8.24 (nM), Ref: 26717207
IC50: 7.59 (nM), Ref: 26717207
TCMC847
TCMT135 Carbonic anhydrase XIV Homo sapiens Ki: 8710 (nM), Ref: 20185318
Ki: 8710 (nM), Ref: 26498394
TCMC847
TCMT136 Carbonic anhydrase XII Homo sapiens Ki: 9060 (nM), Ref: 20185318
Ki: 9060 (nM), Ref: 26498394
TCMC847
TCMT137 Carbonic anhydrase IX Homo sapiens Ki: 7870 (nM), Ref: 20185318
TCMC847
TCMT138 Carbonic anhydrase VII Homo sapiens Ki: 6420 (nM), Ref: 20185318
TCMC847
TCMT139 Carbonic anhydrase VI Homo sapiens Ki: 7330 (nM), Ref: 20185318
TCMC847
TCMT140 Carbonic anhydrase VB Homo sapiens Ki: 9080 (nM), Ref: 20185318
TCMC847
TCMT141 Carbonic anhydrase VA Homo sapiens Ki: 6490 (nM), Ref: 20185318
TCMC847
TCMT143 Carbonic anhydrase III Homo sapiens Ki: 10000 (nM), Ref: 20185318
TCMC847
TCMT134 Carbonic anhydrase II Homo sapiens Ki: 1610 (nM), Ref: 20185318
TCMC847
TCMT133 Carbonic anhydrase I Homo sapiens Ki: 2380 (nM), Ref: 20185318
TCMC847
TCMT101 Protein-tyrosine phosphatase 1B Homo sapiens IC50: 3060 (nM), Ref: 19476336
TCMC847
TCMT321 Matrix metalloproteinase 9 Homo sapiens IC50: 21.22 (nM), Ref: 23375794
IC50: 10 (nM), Ref: 23375794
TCMC847
TCMT306 Matrix metalloproteinase-2 Homo sapiens IC50: 24.26 (nM), Ref: 23375794
TCMC847
TCMT295 Matrix metalloproteinase-1 Homo sapiens IC50: 238.91 (nM), Ref: 23375794
TCMC847
TCMT130 Arachidonate 5-lipoxygenase Homo sapiens IC50: 8500 (nM), Ref: 26197161
TCMC1657
TCMT116 Mu opioid receptor Homo sapiens Ki: 1.585 (nM), Ref: 26632862
TCMC234
TCMT615 Sentrin-specific protease 8 Homo sapiens IC50: 5470 (nM), Ref:
TCMC234
TCMT616 Sentrin-specific protease 7 Homo sapiens IC50: 4630 (nM), Ref:
TCMC234
TCMT617 Sentrin-specific protease 6 Homo sapiens IC50: 1860 (nM), Ref:
TCMC929
TCMT116 Mu opioid receptor Homo sapiens Ki: 6300 (nM), Ref: 17616524
TCMC265
TCMT38 Dopamine D2 receptor Homo sapiens Ki: 91 (nM), Ref: 23332346
TCMC265
TCMT27 Dopamine D1 receptor Homo sapiens Ki: 4.5 (nM), Ref: 23332346
TCMC1857
TCMT853 Sigma opioid receptor Homo sapiens Ki: 36 (nM), Ref: 27156565

Targeted Pathogenic Microbes or non-Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.

Ingredient ID & Structure Target ID Target Name Target Organism Activity Records & Reference
TCMC1329
TCMT1099 Neuraminidase Influenza A virus (A/Puerto Rico/8/1934(H1N1)) IC50: 13.9 (ug/ml), Ref: 20116898
TCMC995
TCMT1104 Sortase Staphylococcus aureus IC50: 18.3 (ug/ml), Ref: 16154746
TCMC1957
TCMT1465 Entamoeba histolytica Entamoeba histolytica IC50: 50.13 (ug/ml), Ref: 10.1007/s00044-011-9767-1
TCMC2444
TCMT1438 Plasmodium falciparum Plasmodium falciparum D6 IC50: 5.8 (ug/ml), Ref: 8786363
IC50: 3.65 (ug/ml), Ref: 8786363
TCMC2444
TCMT1438 Plasmodium falciparum Plasmodium falciparum IC50: 5.8 (ug/ml), Ref: 8786363
IC50: 3.65 (ug/ml), Ref: 8786363
TCMC2444
TCMT1455 Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv MIC: 32 (ug/ml), Ref: 25372601
TCMC495
TCMT1438 Plasmodium falciparum Plasmodium falciparum D6 IC50: 7.33 (ug/ml), Ref: 8759172
IC50: 5.56 (ug/ml), Ref: 8759172
TCMC495
TCMT1438 Plasmodium falciparum Plasmodium falciparum IC50: 7.33 (ug/ml), Ref: 8759172
IC50: 5.56 (ug/ml), Ref: 8759172
TCMC2565
TCMT1438 Plasmodium falciparum Plasmodium falciparum IC50: 7 (ug/ml), Ref: 17845001
TCMC1329
TCMT1455 Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv MIC: 100 (ug/ml), Ref: 10.1007/s00044-012-0268-7
TCMC2596
TCMT1438 Plasmodium falciparum Plasmodium falciparum IC50: 4.2 (ug/ml), Ref: 17845001
TCMC2040
TCMT1465 Entamoeba histolytica Entamoeba histolytica IC50: 50.03 (ug/ml), Ref: 10.1007/s00044-011-9767-1
TCMC2044
TCMT1462 Streptococcus mutans Streptococcus mutans MIC: 15 (ug/ml), Ref: 9644074
MIC: 15 (ug/ml), Ref: 8904847
TCMC2044
TCMT1178 Actinomyces viscosus Actinomyces viscosus MIC: 15 (ug/ml), Ref: 8904847
TCMC2044
TCMT1229 Enterococcus faecalis Enterococcus faecalis MIC90: 16 (ug/ml), Ref: 23127490
MIC90: 8 (ug/ml), Ref: 23127490
MIC: 16 (ug/ml), Ref: 23314053
MIC: 8 (ug/ml), Ref: 23314053
TCMC2044
TCMT1218 Staphylococcus aureus Staphylococcus aureus MIC90: 2 (ug/ml), Ref: 23127490
MIC: 2 (ug/ml), Ref: 23314053
MBC: 0.034 (nM), Ref: 22182580
TCMC2338
TCMT1221 Human herpesvirus 4 Human herpesvirus 4 IC50: 8.8 (nM), Ref: 17503850
TCMC2514
TCMT1221 Human herpesvirus 4 Human herpesvirus 4 IC50: 8.9 (nM), Ref: 17503850
TCMC2542
TCMT1221 Human herpesvirus 4 Human herpesvirus 4 IC50: 8.8 (nM), Ref: 17503850
TCMC2044
TCMT1223 Staphylococcus epidermidis Staphylococcus epidermidis MBC: 0.034 (nM), Ref: 22182580