Targeted Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.
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Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC1429	TCMT130	Arachidonate 5-lipoxygenase	Homo sapiens	IC50: 2700 (nM), Ref: 17378609
TCMC1429	TCMT65	Estradiol 17-beta-dehydrogenase 1	Homo sapiens	IC50: 1050 (nM), Ref: 18533708
TCMC1429	TCMT66	Estradiol 17-beta-dehydrogenase 2	Homo sapiens	IC50: 360 (nM), Ref: 18533708
TCMC1429	TCMT187	Androgen Receptor	Homo sapiens	IC50: 9700 (nM), Ref: 19592245
TCMC1429	TCMT219	Cytochrome P450 1A2	Homo sapiens	IC50: 716 (nM), Ref: 20696580
TCMC1429	TCMT215	Cytochrome P450 1A1	Homo sapiens	IC50: 632 (nM), Ref: 20696580
TCMC1429	TCMT257	Cytochrome P450 1B1	Homo sapiens	IC50: 47 (nM), Ref: 20696580
TCMC1429	TCMT223	Aldose reductase	Homo sapiens	IC50: 10000 (nM), Ref: 22261024
TCMC1429	TCMT260	Tyrosine-protein kinase receptor FLT3	Homo sapiens	IC50: 2320 (nM), Ref: 23411073
TCMC1429	TCMT591	Estrogen-related receptor alpha	Homo sapiens	IC50: 9640 (nM), Ref: 23656512
TCMC1429	TCMT261	Death-associated protein kinase 1	Homo sapiens	IC50: 10000 (nM), Ref: 26322379
TCMC1429	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 9525.7 (nM), Ref: 26498393
TCMC1429	TCMT138	Carbonic anhydrase VII	Homo sapiens	Ki: 25 (nM), Ref: 26498393
TCMC1429	TCMT136	Carbonic anhydrase XII	Homo sapiens	Ki: 145.9 (nM), Ref: 26498393
TCMC1429	TCMT159	Tyrosinase	Homo sapiens	IC50: 1000 (nM), Ref: 26841168
TCMC1411	TCMT219	Cytochrome P450 1A2	Homo sapiens	IC50: 1261 (nM), Ref: 20696580
TCMC1411	TCMT215	Cytochrome P450 1A1	Homo sapiens	IC50: 56 (nM), Ref: 20696580
TCMC1411	TCMT257	Cytochrome P450 1B1	Homo sapiens	IC50: 17 (nM), Ref: 20696580
TCMC1411	TCMT142	Carbonic anhydrase IV	Homo sapiens	Ki: 212.9 (nM), Ref: 26498393
TCMC1411	TCMT138	Carbonic anhydrase VII	Homo sapiens	Ki: 4.4 (nM), Ref: 26498393
TCMC1411	TCMT136	Carbonic anhydrase XII	Homo sapiens	Ki: 54.9 (nM), Ref: 26498393 Ki: 220 (nM), Ref: 26498393
TCMC1411	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 440 (nM), Ref: 26498393
TCMC1786	TCMT101	Protein-tyrosine phosphatase 1B	Homo sapiens	IC50: 3900 (nM), Ref: 16580200 IC50: 7600 (nM), Ref: 18798681 IC50: 4200 (nM), Ref: 19702283 IC50: 3840 (nM), Ref: 22044245 IC50: 5600 (nM), Ref: 22690646 IC50: 9500 (nM), Ref: 21453996 Ki: 6000 (nM), Ref: 21453996 IC50: 5050.1 (nM), Ref: 10.1007/s00044-010-9529-5 IC50: 3370 (nM), Ref: 10.1007/s00044-010-9529-5 IC50: 2600 (nM), Ref: 23357636 IC50: 1100 (nM), Ref: 23434422 IC50: 3020 (nM), Ref: 23942421 IC50: 2010 (nM), Ref: 24090912 IC50: 1900 (nM), Ref: 24684845 IC50: 3020 (nM), Ref: 25497963 IC50: 9500 (nM), Ref: 25264584 Ki: 6000 (nM), Ref: 25264584 IC50: 1030 (nM), Ref: 25595683 IC50: 1170 (nM), Ref: 25600405 IC50: 3020 (nM), Ref: 25872983 IC50: 1000 (nM), Ref: 26083682 IC50: 1536 (nM), Ref: 26100442 IC50: 700 (nM), Ref: 26115570 IC50: 700 (nM), Ref: 26253631 IC50: 1536 (nM), Ref: 26481657 IC50: 730 (nM), Ref: 26711144 IC50: 3020 (nM), Ref: 26774579 IC50: 1536 (nM), Ref: 27123900
TCMC1786	TCMT280	Aldo-keto reductase family 1 member B10	Homo sapiens	IC50: 4000 (nM), Ref: 21561086 Ki: 3560 (nM), Ref: 21561086 Ki: 660 (nM), Ref: 21561086 Ki: 940 (nM), Ref: 21561086 Ki: 160 (nM), Ref: 21561086 Ki: 72 (nM), Ref: 21561086 IC50: 90 (nM), Ref: 21561086
TCMC1786	TCMT190	T-cell protein-tyrosine phosphatase	Homo sapiens	IC50: 4230 (nM), Ref: 24684845 IC50: 4440 (nM), Ref: 25497963 IC50: 5460 (nM), Ref: 26100442 IC50: 5460 (nM), Ref: 26481657 IC50: 5460 (nM), Ref: 27123900
TCMC1786	TCMT563	Dual specificity phosphatase Cdc25B	Homo sapiens	IC50: 980 (nM), Ref: 25497963
TCMC614	TCMT151	Protein kinase C alpha	Homo sapiens	IC50: 9300 (nM), Ref: 9834166
TCMC1516	TCMT44	Glyoxalase I	Homo sapiens	IC50: 7700 (nM), Ref: 18258440
TCMC1516	TCMT219	Cytochrome P450 1A2	Homo sapiens	IC50: 3370 (nM), Ref: 20696580
TCMC1516	TCMT215	Cytochrome P450 1A1	Homo sapiens	IC50: 1249 (nM), Ref: 20696580
TCMC1516	TCMT257	Cytochrome P450 1B1	Homo sapiens	IC50: 79 (nM), Ref: 20696580
TCMC1516	TCMT83	Lymphocyte differentiation antigen CD38	Homo sapiens	IC50: 8200 (nM), Ref: 21641214
TCMC1516	TCMT306	Matrix metalloproteinase-2	Homo sapiens	IC50: 3610 (nM), Ref: 22658537
TCMC1516	TCMT321	Matrix metalloproteinase 9	Homo sapiens	IC50: 5620 (nM), Ref: 22658537
TCMC1516	TCMT734	Matrix metalloproteinase 12	Homo sapiens	IC50: 980 (nM), Ref: 22658537
TCMC1516	TCMT265	Glycogen synthase kinase-3 beta	Homo sapiens	IC50: 1500 (nM), Ref: 10.1007/s00044-012-0353-y
TCMC1516	TCMT260	Tyrosine-protein kinase receptor FLT3	Homo sapiens	IC50: 830 (nM), Ref: 23411073
TCMC1516	TCMT127	Poly [ADP-ribose] polymerase-1	Homo sapiens	IC50: 4265.8 (nM), Ref: 23574272 IC50: 4200 (nM), Ref: 23574272
TCMC1516	TCMT128	Tankyrase-2	Homo sapiens	IC50: 1071.52 (nM), Ref: 23574272 IC50: 1100 (nM), Ref: 23574272
TCMC1516	TCMT129	Tankyrase-1	Homo sapiens	IC50: 2398.83 (nM), Ref: 23574272 IC50: 2400 (nM), Ref: 23574272
TCMC1516	TCMT223	Aldose reductase	Homo sapiens	IC50: 600 (nM), Ref: 23683835 IC50: 3200 (nM), Ref: 26529431
TCMC1516	TCMT130	Arachidonate 5-lipoxygenase	Homo sapiens	IC50: 1600 (nM), Ref: 24368208
TCMC1516	TCMT45	Beta amyloid A4 protein	Homo sapiens	IC50: 6400 (nM), Ref: 24878198
TCMC1516	TCMT592	Xanthine dehydrogenase	Homo sapiens	Ki: 2900 (nM), Ref: 25019478 IC50: 7800 (nM), Ref: 26096677
TCMC1516	TCMT100	Transthyretin	Homo sapiens	IC50: 7000 (nM), Ref: 26214366
TCMC1516	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 3691.6 (nM), Ref: 26498393
TCMC1516	TCMT138	Carbonic anhydrase VII	Homo sapiens	Ki: 4.7 (nM), Ref: 26498393
TCMC1516	TCMT136	Carbonic anhydrase XII	Homo sapiens	Ki: 60.3 (nM), Ref: 26498393
TCMC1516	TCMT142	Carbonic anhydrase IV	Homo sapiens	Ki: 293 (nM), Ref: 26498393
TCMC1516	TCMT280	Aldo-keto reductase family 1 member B10	Homo sapiens	IC50: 9200 (nM), Ref: 26529431
TCMC710	TCMT249	Cyclin-dependent kinase 6	Homo sapiens	IC50: 1700 (nM), Ref: 15689157 IC50: 1700 (nM), Ref: 10.1007/s00044-009-9233-5
TCMC710	TCMT156	Cytochrome P450 19A1	Homo sapiens	IC50: 10000 (nM), Ref: 18192087 IC50: 900 (nM), Ref: 20413308 IC50: 1200 (nM), Ref: 26301554
TCMC710	TCMT65	Estradiol 17-beta-dehydrogenase 1	Homo sapiens	IC50: 710 (nM), Ref: 18533708
TCMC710	TCMT752	Casein kinase II alpha	Homo sapiens	IC50: 800 (nM), Ref: 19414254
TCMC710	TCMT187	Androgen Receptor	Homo sapiens	IC50: 5200 (nM), Ref: 19592245
TCMC710	TCMT219	Cytochrome P450 1A2	Homo sapiens	IC50: 795 (nM), Ref: 20696580
TCMC710	TCMT215	Cytochrome P450 1A1	Homo sapiens	IC50: 427 (nM), Ref: 20696580
TCMC710	TCMT257	Cytochrome P450 1B1	Homo sapiens	IC50: 25 (nM), Ref: 20696580
TCMC710	TCMT265	Glycogen synthase kinase-3 beta	Homo sapiens	IC50: 1900 (nM), Ref: 10.1007/s00044-012-0353-y
TCMC710	TCMT131	Acetylcholinesterase	Homo sapiens	IC50: 12 (nM), Ref: 10.1007/s00044-012-0353-y
TCMC710	TCMT260	Tyrosine-protein kinase receptor FLT3	Homo sapiens	IC50: 1450 (nM), Ref: 23411073
TCMC710	TCMT128	Tankyrase-2	Homo sapiens	IC50: 2951.21 (nM), Ref: 23574272 IC50: 2900 (nM), Ref: 23574272
TCMC710	TCMT129	Tankyrase-1	Homo sapiens	IC50: 3162.28 (nM), Ref: 23574272 IC50: 3100 (nM), Ref: 23574272
TCMC710	TCMT592	Xanthine dehydrogenase	Homo sapiens	Ki: 520 (nM), Ref: 25019478 IC50: 3200 (nM), Ref: 26022844
TCMC710	TCMT280	Aldo-keto reductase family 1 member B10	Homo sapiens	Ki: 6000 (nM), Ref: 26529431 IC50: 6600 (nM), Ref: 26529431
TCMC2216	TCMT101	Protein-tyrosine phosphatase 1B	Homo sapiens	IC50: 3600 (nM), Ref: 17489632 IC50: 3100 (nM), Ref: 18798681 IC50: 3600 (nM), Ref: 19008110 IC50: 3600 (nM), Ref: 17125223 IC50: 3800 (nM), Ref: 19846295 IC50: 3900 (nM), Ref: 19632832 IC50: 3600 (nM), Ref: 19836230 IC50: 3100 (nM), Ref: 21555221 IC50: 3600 (nM), Ref: 21571537 IC50: 3100 (nM), Ref: 22940448 IC50: 2300 (nM), Ref: 21453996 Ki: 3400 (nM), Ref: 21453996 IC50: 3600 (nM), Ref: 23022281 IC50: 3080 (nM), Ref: 23141910 IC50: 3080 (nM), Ref: 10.1007/s00044-010-9529-5 IC50: 3080 (nM), Ref: 10.1007/s00044-010-9529-5 IC50: 2750 (nM), Ref: 23387824 IC50: 4120 (nM), Ref: 24224843 IC50: 4000 (nM), Ref: 24953600 IC50: 3500 (nM), Ref: 25559759 IC50: 3400 (nM), Ref: 25907369 Ki: 6400 (nM), Ref: 25907369 IC50: 5200 (nM), Ref: 26841168
TCMC2216	TCMT174	11-beta-hydroxysteroid dehydrogenase 1	Homo sapiens	IC50: 1900 (nM), Ref: 20100662
TCMC2216	TCMT102	Low molecular weight phosphotyrosine protein phosphatase	Homo sapiens	IC50: 7200 (nM), Ref: 21453996
TCMC2216	TCMT103	Receptor-type tyrosine-protein phosphatase F (LAR)	Homo sapiens	IC50: 3800 (nM), Ref: 21453996
TCMC2216	TCMT280	Aldo-keto reductase family 1 member B10	Homo sapiens	Ki: 6000 (nM), Ref: 21561086 Ki: 3700 (nM), Ref: 21561086 Ki: 2100 (nM), Ref: 21561086 Ki: 2800 (nM), Ref: 21561086 Ki: 2000 (nM), Ref: 21561086 IC50: 4000 (nM), Ref: 21561086
TCMC2216	TCMT190	T-cell protein-tyrosine phosphatase	Homo sapiens	IC50: 2400 (nM), Ref: 23387824
TCMC2216	TCMT150	Nuclear receptor ROR-gamma	Homo sapiens	IC50: 680 (nM), Ref: 10.1039/C3MD00005B IC50: 130 (nM), Ref: 24704616 IC50: 1060 (nM), Ref: 24704616 IC50: 9410 (nM), Ref: 24704616

Targeted Pathogenic Microbes or non-Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.

Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC1429	TCMT1099	Neuraminidase	Influenza A virus (A/Puerto Rico/8/1934(H1N1))	IC50: 16.77 (ug/ml), Ref: 20116898
TCMC1786	TCMT1107	Protease	Human immunodeficiency virus 1	IC50: 10 (ug/ml), Ref: 10691716
TCMC995	TCMT1104	Sortase	Staphylococcus aureus	IC50: 18.3 (ug/ml), Ref: 16154746
TCMC1516	TCMT1099	Neuraminidase	Influenza A virus (A/Puerto Rico/8/1934(H1N1))	IC50: 9.65 (ug/ml), Ref: 20116898
TCMC2292	TCMT1099	Neuraminidase	Influenza A virus (A/Puerto Rico/8/1934(H1N1))	IC50: 13.15 (ug/ml), Ref: 20116898
TCMC710	TCMT1099	Neuraminidase	Influenza A virus (A/Puerto Rico/8/1934(H1N1))	IC50: 8.54 (ug/ml), Ref: 20116898
TCMC1429	TCMT1465	Entamoeba histolytica	Entamoeba histolytica	IC50: 7.93 (ug/ml), Ref: 10.1007/s00044-011-9767-1
TCMC1786	TCMT1463	Mycobacterium tuberculosis	Mycobacterium tuberculosis H37Rv	MIC: 50 (ug/ml), Ref: 11141098 MIC: 100 (ug/ml), Ref: 18798682 MIC: 64 (ug/ml), Ref: 15387646 MIC: 29 (ug/ml), Ref: 23356207
TCMC1786	TCMT1255	Human immunodeficiency virus 1	Human immunodeficiency virus 1	IC50: 21.8 (ug/ml), Ref: 9748372
TCMC1786	TCMT1229	Enterococcus faecalis	Enterococcus faecalis	MIC: 16 (ug/ml), Ref: 21288041
TCMC1786	TCMT1463	Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC: 50 (ug/ml), Ref: 11141098 MIC: 100 (ug/ml), Ref: 18798682 MIC: 64 (ug/ml), Ref: 15387646 MIC: 29 (ug/ml), Ref: 23356207
TCMC2481	TCMT1226	Klebsiella pneumoniae	Klebsiella pneumoniae	MIC: 25 (ug/ml), Ref: 17027268
TCMC2481	TCMT1246	Escherichia coli	Escherichia coli	MIC: 50 (ug/ml), Ref: 17027268
TCMC2481	TCMT1232	Pseudomonas aeruginosa	Pseudomonas aeruginosa	MIC: 50 (ug/ml), Ref: 17027268
TCMC2481	TCMT1218	Staphylococcus aureus	Staphylococcus aureus	MIC: 25 (ug/ml), Ref: 17027268
TCMC2481	TCMT1458	Filobasidiella neoformans	Cryptococcus neoformans	MIC: 12.5 (ug/ml), Ref: 17027268
TCMC614	TCMT1454	Bacillus subtilis	Bacillus subtilis	IC50: 98.5 (ug/ml), Ref: 25981688
TCMC1516	TCMT1229	Enterococcus faecalis	Enterococcus faecalis	MIC: 25 (ug/ml), Ref: 17027268
TCMC1516	TCMT1226	Klebsiella pneumoniae	Klebsiella pneumoniae	MIC: 25 (ug/ml), Ref: 17027268
TCMC1516	TCMT1246	Escherichia coli	Escherichia coli	MIC: 50 (ug/ml), Ref: 17027268 MIC: 50 (ug/ml), Ref: 18313801 MIC: 64 (ug/ml), Ref: 12608861 MIC: 4 (ug/ml), Ref: 22677320
TCMC1516	TCMT1232	Pseudomonas aeruginosa	Pseudomonas aeruginosa	MIC: 25 (ug/ml), Ref: 17027268
TCMC1516	TCMT1218	Staphylococcus aureus	Staphylococcus aureus	MIC: 25 (ug/ml), Ref: 17027268 MIC: 50 (ug/ml), Ref: 18313801 MIC: 18 (ug/ml), Ref: 22677320 MIC: 9 (ug/ml), Ref: 22677320
TCMC1516	TCMT1458	Filobasidiella neoformans	Cryptococcus neoformans	MIC: 25 (ug/ml), Ref: 17027268
TCMC1516	TCMT1454	Bacillus subtilis	Bacillus subtilis	MIC: 25 (ug/ml), Ref: 18313801
TCMC1516	TCMT1189	Pseudomonas fluorescens	Pseudomonas fluorescens	MIC: 25 (ug/ml), Ref: 18313801
TCMC1516	TCMT1213	Neisseria gonorrhoeae	Neisseria gonorrhoeae	MIC: 16 (ug/ml), Ref: 12608861
TCMC1516	TCMT1212	Verticillium dahliae	Verticillium dahliae	IC50: 7 (ug/ml), Ref: 17394331
TCMC1516	TCMT1465	Entamoeba histolytica	Entamoeba histolytica	IC50: 17.8 (ug/ml), Ref: 10.1007/s00044-011-9767-1
TCMC1516	TCMT1455	Mycobacterium tuberculosis H37Rv	Mycobacterium tuberculosis H37Rv	MIC: 25 (ug/ml), Ref: 10.1007/s00044-012-0268-7
TCMC1516	TCMT1442	Leishmania donovani	Leishmania donovani	IC50: 0.8 (ug/ml), Ref: 10.1039/C5MD00481K
TCMC2757	TCMT1382	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50: 2.1 (ug/ml), Ref: 16309322
TCMC710	TCMT1246	Escherichia coli	Escherichia coli	MIC: 7.8 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
TCMC710	TCMT1412	Salmonella typhimurium	Salmonella enterica subsp. enterica serovar Typhimurium	MIC: 15.6 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
TCMC710	TCMT1458	Filobasidiella neoformans	Cryptococcus neoformans	IC50: 20 (ug/ml), Ref: 12502337
TCMC710	TCMT1251	Candida albicans	Candida albicans	MIC: 3 (ug/ml), Ref: 10395518
TCMC710	TCMT1465	Entamoeba histolytica	Entamoeba histolytica	IC50: 12.7 (ug/ml), Ref: 10.1007/s00044-011-9767-1
TCMC710	TCMT1346	Helicobacter pylori	Helicobacter pylori	MIC: 25 (ug/ml), Ref: 10.1007/s00044-012-0207-7
TCMC710	TCMT1349	Helicobacter pylori SS1	Helicobacter pylori SS1	MIC: 25 (ug/ml), Ref: 10.1007/s00044-012-0207-7
TCMC710	TCMT1442	Leishmania donovani	Leishmania donovani	IC50: 1.9 (ug/ml), Ref: 10.1039/C5MD00481K
TCMC2216	TCMT1255	Human immunodeficiency virus 1	Human immunodeficiency virus 1	IC50: 6.5 (ug/ml), Ref: 9748372
TCMC2216	TCMT1463	Mycobacterium tuberculosis	Mycobacterium tuberculosis H37Rv	MIC: 32 (ug/ml), Ref: 15387646 MIC: 100 (ug/ml), Ref: 20542692
TCMC2216	TCMT1229	Enterococcus faecalis	Enterococcus faecalis	MIC: 16 (ug/ml), Ref: 21288041