TCM Putative Target References: TCMH64


Targeted Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.
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Ingredient ID & Structure Target ID Target Name Target Organism Activity Records & Reference
TCMC2009
TCMT176 Acyl coenzyme A:cholesterol acyltransferase 1 Homo sapiens IC50: 3700 (nM), Ref: 23419736
TCMC1495
TCMT298 Fatty acid binding protein muscle Homo sapiens IC50: 1000 (nM), Ref: 20471252
IC50: 1000 (nM), Ref: 25461324
IC50: 1000 (nM), Ref: 25461324
Ki: 9300 (nM), Ref: 27460668
TCMC1495
TCMT297 Fatty acid binding protein adipocyte Homo sapiens IC50: 1000 (nM), Ref: 20471252
Ki: 6800 (nM), Ref: 27460668
TCMC1495
TCMT63 Peroxisome proliferator-activated receptor alpha Homo sapiens IC50: 1100 (nM), Ref: 10.1007/s00044-008-9102-7
IC50: 1100 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1495
TCMT64 Peroxisome proliferator-activated receptor delta Homo sapiens IC50: 10000 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1495
TCMT67 Peroxisome proliferator-activated receptor gamma Homo sapiens IC50: 6200 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC7
TCMT33 Cytochrome P450 3A4 Homo sapiens IC50: 9100 (nM), Ref: 15679319
TCMC677
TCMT559 Beta-2 adrenergic receptor Homo sapiens Ki: 1 (nM), Ref: 24454993
TCMC168
TCMT33 Cytochrome P450 3A4 Homo sapiens Ki: 5100 (nM), Ref: 16248836
Ki: 6460 (nM), Ref: 16248836
TCMC1743
TCMT206 Cytochrome P450 2A6 Homo sapiens Ki: 4400 (nM), Ref: 15634016
TCMC1743
TCMT241 Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki: 7200 (nM), Ref: 15686879
Ki: 6300 (nM), Ref: 15908213
Ki: 630 (nM), Ref: 16171993
Ki: 10000 (nM), Ref: 17722904
Ki: 1000 (nM), Ref: 19331415
Ki: 1023.29 (nM), Ref: 20828128
Ki: 1000 (nM), Ref: 21920761
Ki: 1000 (nM), Ref: 22243960
Ki: 3000 (nM), Ref: 22793665
Ki: 3000 (nM), Ref: 23126648
Ki: 3800 (nM), Ref: 23561269
IC50: 7600 (nM), Ref: 23561269
Ki: 3000 (nM), Ref: 23692872
TCMC1743
TCMT552 Neuronal acetylcholine receptor subunit alpha-3 Homo sapiens IC50: 45 (nM), Ref: 11312774
TCMC2122
TCMT643 Alpha-1a adrenergic receptor Homo sapiens Ki: 0.2 (nM), Ref: 15664832
Ki: 0.19 (nM), Ref: 17517507
Ki: 0.19 (nM), Ref: 17452102
Ki: 0.19 (nM), Ref: 18055202
Ki: 0.05012 (nM), Ref: 20934789
TCMC2122
TCMT650 Alpha-1b adrenergic receptor Homo sapiens Ki: 2 (nM), Ref: 17517507
Ki: 2 (nM), Ref: 17452102
Ki: 2 (nM), Ref: 18055202
Ki: 0.631 (nM), Ref: 20934789
TCMC2122
TCMT642 Alpha-1d adrenergic receptor Homo sapiens Ki: 0.2 (nM), Ref: 17517507
Ki: 0.2 (nM), Ref: 17452102
Ki: 0.2 (nM), Ref: 18055202
Ki: 0.1 (nM), Ref: 20934789
Ki: 0.18 (nM), Ref: 26954848
TCMC2105
TCMT64 Peroxisome proliferator-activated receptor delta Homo sapiens IC50: 6000 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC2105
TCMT63 Peroxisome proliferator-activated receptor alpha Homo sapiens IC50: 1100 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1830
TCMT297 Fatty acid binding protein adipocyte Homo sapiens IC50: 930 (nM), Ref: 15357969
TCMC1830
TCMT298 Fatty acid binding protein muscle Homo sapiens IC50: 2600 (nM), Ref: 15357969
TCMC1830
TCMT808 Fatty acid binding protein epidermal Homo sapiens IC50: 1200 (nM), Ref: 15357969
TCMC1830
TCMT809 Fatty acid binding protein intestinal Homo sapiens IC50: 1700 (nM), Ref: 15357969
TCMC1830
TCMT810 Toll-like receptor 2 Homo sapiens IC50: 5000 (nM), Ref: 16509590
TCMC1830
TCMT64 Peroxisome proliferator-activated receptor delta Homo sapiens IC50: 7400 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1830
TCMT63 Peroxisome proliferator-activated receptor alpha Homo sapiens IC50: 1500 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC176
TCMT33 Cytochrome P450 3A4 Homo sapiens Ki: 1390 (nM), Ref: 16248836
Ki: 2970 (nM), Ref: 16248836
TCMC1788
TCMT63 Peroxisome proliferator-activated receptor alpha Homo sapiens IC50: 600 (nM), Ref: 10.1007/s00044-008-9102-7
IC50: 600 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1788
TCMT64 Peroxisome proliferator-activated receptor delta Homo sapiens IC50: 5300 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1788
TCMT67 Peroxisome proliferator-activated receptor gamma Homo sapiens IC50: 4100 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1788
TCMT126 Telomerase reverse transcriptase Homo sapiens IC50: 8600 (nM), Ref: 10.1039/C0MD00241K
TCMC1788
TCMT297 Fatty acid binding protein adipocyte Homo sapiens Ki: 1500 (nM), Ref: 27460668
TCMC1745
TCMT114 Cannabinoid CB2 receptor Homo sapiens Ki: 52 (nM), Ref: 17497806
TCMC1496
TCMT63 Peroxisome proliferator-activated receptor alpha Homo sapiens IC50: 1200 (nM), Ref: 10.1007/s00044-008-9102-7
IC50: 1200 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1496
TCMT67 Peroxisome proliferator-activated receptor gamma Homo sapiens IC50: 6000 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1496
TCMT164 Cyclooxygenase-1 Homo sapiens Ki: 4000 (nM), Ref: 24088053
TCMC1662
TCMT314 Serotonin 2c (5-HT2c) receptor Homo sapiens Ki: 10 (nM), Ref: 24491146
TCMC2226
TCMT307 HERG Homo sapiens IC50: 143 (nM), Ref: 12190308
IC50: 143 (nM), Ref: 12729675
IC50: 141.25 (nM), Ref: 12873512
IC50: 144.54 (nM), Ref: 15745831
IC50: 141.25 (nM), Ref: 18448342
IC50: 144.54 (nM), Ref: 19110341
IC50: 141.25 (nM), Ref: 21185626
IC50: 10 (nM), Ref: 23919353
TCMC2226
TCMT232 P-glycoprotein 1 Homo sapiens IC50: 6606.93 (nM), Ref: 17890094
IC50: 4570.88 (nM), Ref: 17890094
IC50: 6606.93 (nM), Ref: 18083034
IC50: 4570.88 (nM), Ref: 18083034
IC50: 4570.88 (nM), Ref: 18678495
IC50: 5420 (nM), Ref: 18707884
IC50: 5200 (nM), Ref: 19250834
IC50: 500 (nM), Ref: 22112208
IC50: 575.44 (nM), Ref: 22452412
Ki: 1750 (nM), Ref: 22320402
Ki: 1750 (nM), Ref: 22320402
IC50: 1600 (nM), Ref: 23245571
IC50: 1700 (nM), Ref: 10.1039/C2MD20286G
IC50: 29 (nM), Ref: 25282263
IC50: 740 (nM), Ref: 25282263
IC50: 38 (nM), Ref: 25985195
TCMC2226
TCMT629 Multidrug resistance-associated protein 1 Homo sapiens IC50: 9660 (nM), Ref: 18707884
IC50: 3500 (nM), Ref: 25093931
TCMC2226
TCMT213 Solute carrier family 22 member 1 Homo sapiens IC50: 6800 (nM), Ref: 18788725

Targeted Pathogenic Microbes or non-Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.

Ingredient ID & Structure Target ID Target Name Target Organism Activity Records & Reference
TCMC1904
TCMT1112 Quinolone resistance protein norA Staphylococcus aureus MIC: 4 (ug/ml), Ref: 10.1039/C4MD00196F
TCMC2324
TCMT1462 Streptococcus mutans Streptococcus mutans MIC: 100 (ug/ml), Ref: 1517735
TCMC2366
TCMT1438 Plasmodium falciparum Plasmodium falciparum IC50: 2.8 (ug/ml), Ref: 17845001
TCMC1904
TCMT1232 Pseudomonas aeruginosa Pseudomonas aeruginosa MIC: 100 (ug/ml), Ref: 10.1007/s00044-013-0541-4
TCMC1848
TCMT1181 Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra MIC: 50 (ug/ml), Ref: 22280816
TCMC2539
TCMT1462 Streptococcus mutans Streptococcus mutans MIC: 100 (ug/ml), Ref: 1517735
TCMC1830
TCMT1361 Neisseria meningitidis Neisseria meningitidis MIC: 50 (ug/ml), Ref: 19884363
TCMC1830
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand) Plasmodium falciparum K1 IC50: 3.8 (ug/ml), Ref: 20855214
IC50: 3.8 (ug/ml), Ref: 25103602
TCMC1830
TCMT1442 Leishmania donovani Leishmania donovani IC50: 14.5 (ug/ml), Ref: 20855214
TCMC2550
TCMT1393 Vibrio sp. Vibrio sp. MIC: 15 (ug/ml), Ref: 21865038
TCMC2597
TCMT1181 Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra MIC: 50 (ug/ml), Ref: 22280816
TCMC1788
TCMT1455 Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv MIC: 100 (ug/ml), Ref: 24103427
TCMC2226
TCMT1455 Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv MIC: 0.1 (ug/ml), Ref: 26197353
MIC: 0.05 (ug/ml), Ref: 26197353
MIC: 0.00078 (ug/ml), Ref: 26197353
MIC: 0.0156 (ug/ml), Ref: 26197353
MIC: 0.25 (ug/ml), Ref: 26197353
MIC: 0.5 (ug/ml), Ref: 26197353
MIC: 1 (ug/ml), Ref: 26197353
MIC: 0.195 (ug/ml), Ref: 26197353
MIC: 3.125 (ug/ml), Ref: 26197353
MIC: 6.25 (ug/ml), Ref: 26197353
MIC: 12.5 (ug/ml), Ref: 26197353
MIC: 0.1 (ug/ml), Ref: 26562541
MIC: 0.05 (ug/ml), Ref: 26562541
MIC: 0.0125 (ug/ml), Ref: 26562541
MIC: 0.5 (ug/ml), Ref: 26562541
MIC: 1 (ug/ml), Ref: 26562541
MIC: 0.125 (ug/ml), Ref: 26562541
MIC: 2 (ug/ml), Ref: 26562541
MIC: 0.25 (ug/ml), Ref: 26562541
MIC: 12.5 (ug/ml), Ref: 26562541
MIC: 6.25 (ug/ml), Ref: 26562541
MIC: 3.12 (ug/ml), Ref: 26562541
MIC: 0.781 (ug/ml), Ref: 26562541
MIC99: 0.0021 (nM), Ref: 24894561
MIC99: 0.5 (nM), Ref: 24894561
TCMC1738
TCMT1218 Staphylococcus aureus Staphylococcus aureus MIC: 50 (ug/ml), Ref: 10.1016/S0960-894X(00)80336-4
TCMC2822
TCMT1463 Mycobacterium tuberculosis Mycobacterium tuberculosis MIC: 6.25 (ug/ml), Ref: 17845001