Targeted Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.
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Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC1495	TCMT298	Fatty acid binding protein muscle	Homo sapiens	IC50: 1000 (nM), Ref: 20471252 IC50: 1000 (nM), Ref: 25461324 IC50: 1000 (nM), Ref: 25461324 Ki: 9300 (nM), Ref: 27460668
TCMC1495	TCMT297	Fatty acid binding protein adipocyte	Homo sapiens	IC50: 1000 (nM), Ref: 20471252 Ki: 6800 (nM), Ref: 27460668
TCMC1495	TCMT63	Peroxisome proliferator-activated receptor alpha	Homo sapiens	IC50: 1100 (nM), Ref: 10.1007/s00044-008-9102-7 IC50: 1100 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1495	TCMT64	Peroxisome proliferator-activated receptor delta	Homo sapiens	IC50: 10000 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1495	TCMT67	Peroxisome proliferator-activated receptor gamma	Homo sapiens	IC50: 6200 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC2037	TCMT133	Carbonic anhydrase I	Homo sapiens	Ki: 9920 (nM), Ref: 18501600 Ki: 9900 (nM), Ref: 18579385 Ki: 9900 (nM), Ref: 26520662
TCMC2037	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 7120 (nM), Ref: 18501600 Ki: 7100 (nM), Ref: 18579385 Ki: 7100 (nM), Ref: 26520662
TCMC2037	TCMT136	Carbonic anhydrase XII	Homo sapiens	Ki: 8800 (nM), Ref: 18579385
TCMC1851	TCMT560	Coagulation factor X	Homo sapiens	IC50: 170 (nM), Ref: 9834152 Ki: 570 (nM), Ref: 9834152
TCMC1851	TCMT207	Beta-secretase 1	Homo sapiens	IC50: 3760 (nM), Ref: 24835197 Ki: 5130 (nM), Ref: 24835197
TCMC1851	TCMT240	Salivary alpha-amylase	Homo sapiens	IC50: 2350 (nM), Ref: 26395057 Ki: 2600 (nM), Ref: 26395057
TCMC1102	TCMT265	Glycogen synthase kinase-3 beta	Homo sapiens	IC50: 7500 (nM), Ref: 16610779
TCMC1102	TCMT752	Casein kinase II alpha	Homo sapiens	IC50: 40 (nM), Ref: 19414254
TCMC1102	TCMT133	Carbonic anhydrase I	Homo sapiens	Ki: 2320 (nM), Ref: 20185318
TCMC1102	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 2180 (nM), Ref: 20185318
TCMC1102	TCMT142	Carbonic anhydrase IV	Homo sapiens	Ki: 9080 (nM), Ref: 20185318
TCMC1102	TCMT141	Carbonic anhydrase VA	Homo sapiens	Ki: 7590 (nM), Ref: 20185318
TCMC1102	TCMT139	Carbonic anhydrase VI	Homo sapiens	Ki: 7060 (nM), Ref: 20185318
TCMC1102	TCMT138	Carbonic anhydrase VII	Homo sapiens	Ki: 6320 (nM), Ref: 20185318 Ki: 8790 (nM), Ref: 22892213
TCMC1102	TCMT137	Carbonic anhydrase IX	Homo sapiens	Ki: 9370 (nM), Ref: 20185318
TCMC1102	TCMT135	Carbonic anhydrase XIV	Homo sapiens	Ki: 8910 (nM), Ref: 20185318
TCMC1102	TCMT753	Mothers against decapentaplegic homolog 3	Homo sapiens	IC50: 142 (nM), Ref:
TCMC1102	TCMT721	Heat shock 70 kDa protein 1	Homo sapiens	IC50: 760 (nM), Ref:
TCMC1102	TCMT189	Dual specificity protein phosphatase 3	Homo sapiens	IC50: 1230 (nM), Ref: IC50: 980 (nM), Ref:
TCMC1102	TCMT223	Aldose reductase	Homo sapiens	IC50: 200 (nM), Ref: 22261024
TCMC1102	TCMT479	Serine/threonine-protein kinase AKT	Homo sapiens	IC50: 3340 (nM), Ref: 22377675
TCMC1102	TCMT436	NUAK family SNF1-like kinase 1	Homo sapiens	IC50: 510 (nM), Ref: 22377675
TCMC1102	TCMT354	Serine/threonine-protein kinase Aurora-A	Homo sapiens	IC50: 2480 (nM), Ref: 22377675
TCMC1102	TCMT374	Serine/threonine-protein kinase Aurora-B	Homo sapiens	IC50: 2500 (nM), Ref: 22377675
TCMC1102	TCMT626	Serine/threonine-protein kinase B-raf	Homo sapiens	IC50: 1760 (nM), Ref: 22377675
TCMC1102	TCMT423	Epidermal growth factor receptor erbB1	Homo sapiens	IC50: 690 (nM), Ref: 22377675
TCMC1102	TCMT418	Ephrin type-B receptor 4	Homo sapiens	IC50: 1830 (nM), Ref: 22377675
TCMC1102	TCMT704	Receptor protein-tyrosine kinase erbB-2	Homo sapiens	IC50: 3540 (nM), Ref: 22377675
TCMC1102	TCMT441	Focal adhesion kinase 1	Homo sapiens	IC50: 3110 (nM), Ref: 22377675
TCMC1102	TCMT369	Insulin-like growth factor I receptor	Homo sapiens	IC50: 250 (nM), Ref: 22377675
TCMC1102	TCMT212	Tyrosine-protein kinase SRC	Homo sapiens	IC50: 800 (nM), Ref: 22377675
TCMC1102	TCMT370	Vascular endothelial growth factor receptor 2	Homo sapiens	IC50: 790 (nM), Ref: 22377675
TCMC1102	TCMT457	Vascular endothelial growth factor receptor 3	Homo sapiens	IC50: 1540 (nM), Ref: 22377675
TCMC1102	TCMT377	Insulin receptor	Homo sapiens	IC50: 340 (nM), Ref: 22377675
TCMC1102	TCMT401	Hepatocyte growth factor receptor	Homo sapiens	IC50: 580 (nM), Ref: 22377675
TCMC1102	TCMT536	Platelet-derived growth factor receptor beta	Homo sapiens	IC50: 1300 (nM), Ref: 22377675
TCMC1102	TCMT484	Serine/threonine-protein kinase PLK1	Homo sapiens	IC50: 3340 (nM), Ref: 22377675
TCMC1102	TCMT755	Serine/threonine-protein kinase PLK4	Homo sapiens	IC50: 2970 (nM), Ref: 22377675
TCMC1102	TCMT502	Tyrosine-protein kinase TIE-2	Homo sapiens	IC50: 260 (nM), Ref: 22377675
TCMC1102	TCMT756	Mitogen-activated protein kinase kinase kinase 8	Homo sapiens	IC50: 2370 (nM), Ref: 22377675
TCMC1102	TCMT739	G-protein coupled receptor 35	Homo sapiens	IC50: 100 (nM), Ref: 24900447
TCMC1102	TCMT136	Carbonic anhydrase XII	Homo sapiens	Ki: 8150 (nM), Ref: 22892213
TCMC1102	TCMT225	Carbonic anhydrase XIII	Homo sapiens	Ki: 4240 (nM), Ref: 22892213
TCMC1102	TCMT207	Beta-secretase 1	Homo sapiens	IC50: 3900 (nM), Ref: 24835197
TCMC1158	TCMT207	Beta-secretase 1	Homo sapiens	IC50: 3100 (nM), Ref: 24835197 Ki: 6840 (nM), Ref: 24835197
TCMC1830	TCMT297	Fatty acid binding protein adipocyte	Homo sapiens	IC50: 930 (nM), Ref: 15357969
TCMC1830	TCMT298	Fatty acid binding protein muscle	Homo sapiens	IC50: 2600 (nM), Ref: 15357969
TCMC1830	TCMT808	Fatty acid binding protein epidermal	Homo sapiens	IC50: 1200 (nM), Ref: 15357969
TCMC1830	TCMT809	Fatty acid binding protein intestinal	Homo sapiens	IC50: 1700 (nM), Ref: 15357969
TCMC1830	TCMT810	Toll-like receptor 2	Homo sapiens	IC50: 5000 (nM), Ref: 16509590
TCMC1830	TCMT64	Peroxisome proliferator-activated receptor delta	Homo sapiens	IC50: 7400 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1830	TCMT63	Peroxisome proliferator-activated receptor alpha	Homo sapiens	IC50: 1500 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1202	TCMT135	Carbonic anhydrase XIV	Homo sapiens	Ki: 7030 (nM), Ref: 20185318
TCMC1202	TCMT136	Carbonic anhydrase XII	Homo sapiens	Ki: 7780 (nM), Ref: 20185318
TCMC1202	TCMT137	Carbonic anhydrase IX	Homo sapiens	Ki: 6990 (nM), Ref: 20185318
TCMC1202	TCMT138	Carbonic anhydrase VII	Homo sapiens	Ki: 6070 (nM), Ref: 20185318
TCMC1202	TCMT139	Carbonic anhydrase VI	Homo sapiens	Ki: 6130 (nM), Ref: 20185318
TCMC1202	TCMT140	Carbonic anhydrase VB	Homo sapiens	Ki: 9970 (nM), Ref: 20185318
TCMC1202	TCMT141	Carbonic anhydrase VA	Homo sapiens	Ki: 4080 (nM), Ref: 20185318
TCMC1202	TCMT142	Carbonic anhydrase IV	Homo sapiens	Ki: 9800 (nM), Ref: 20185318
TCMC1202	TCMT143	Carbonic anhydrase III	Homo sapiens	Ki: 7490 (nM), Ref: 20185318
TCMC1202	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 2250 (nM), Ref: 20185318
TCMC1202	TCMT133	Carbonic anhydrase I	Homo sapiens	Ki: 3200 (nM), Ref: 20185318
TCMC1202	TCMT822	Alpha-(1,3)-fucosyltransferase 7	Homo sapiens	IC50: 60 (nM), Ref: 10.1039/C4MD00086B
TCMC755	TCMT3	Arachidonate 15-lipoxygenase	Homo sapiens	Ki: 600 (nM), Ref: 21739938
TCMC755	TCMT81	Arachidonate 12-lipoxygenase	Homo sapiens	Ki: 1600 (nM), Ref: 21739938
TCMC755	TCMT8	Lysine-specific demethylase 4D-like	Homo sapiens	IC50: 3000 (nM), Ref: 10.1039/C1MD00199J
TCMC755	TCMT162	UDP-glucuronosyltransferase 1-1	Homo sapiens	IC50: 4400 (nM), Ref: 21030469 IC50: 7000 (nM), Ref: 21030469
TCMC755	TCMT384	G protein-coupled receptor kinase 6	Homo sapiens	IC50: 8700 (nM), Ref:
TCMC1203	TCMT822	Alpha-(1,3)-fucosyltransferase 7	Homo sapiens	IC50: 8000 (nM), Ref: 10.1039/C4MD00086B
TCMC1977	TCMT133	Carbonic anhydrase I	Homo sapiens	Ki: 7410 (nM), Ref: 21669522
TCMC1977	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 540 (nM), Ref: 21669522
TCMC1977	TCMT139	Carbonic anhydrase VI	Homo sapiens	Ki: 520 (nM), Ref: 21669522
TCMC90	TCMT207	Beta-secretase 1	Homo sapiens	IC50: 2400 (nM), Ref: 14592472
TCMC770	TCMT588	D-amino-acid oxidase	Homo sapiens	Ki: 7000 (nM), Ref: 23391306 IC50: 2089.3 (nM), Ref: 23631755 Ki: 2000 (nM), Ref: 23631755
TCMC1343	TCMT134	Carbonic anhydrase II	Homo sapiens	Ki: 90 (nM), Ref: 18501600 Ki: 90 (nM), Ref: 18579385
TCMC1343	TCMT136	Carbonic anhydrase XII	Homo sapiens	Ki: 7800 (nM), Ref: 18579385
TCMC1343	TCMT143	Carbonic anhydrase III	Homo sapiens	Ki: 8200 (nM), Ref: 18579385

Targeted Pathogenic Microbes or non-Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.

Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC1851	TCMT1108	Integrase	Human immunodeficiency virus 1	IC50: 28 (ug/ml), Ref: 9461665
TCMC995	TCMT1104	Sortase	Staphylococcus aureus	IC50: 18.3 (ug/ml), Ref: 16154746
TCMC1203	TCMT1108	Integrase	Human immunodeficiency virus 1	IC50: 28.5 (ug/ml), Ref: 9461665
TCMC2107	TCMT1294	Human parainfluenza virus 3	Human parainfluenza virus 3	IC50: 37.5 (ug/ml), Ref: 11678648
TCMC2107	TCMT1463	Mycobacterium tuberculosis	Mycobacterium tuberculosis H37Rv	MIC: 100 (ug/ml), Ref: 20542692
TCMC1102	TCMT1246	Escherichia coli	Escherichia coli	MIC: 2 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7 MIC: 7.8 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
TCMC1102	TCMT1412	Salmonella typhimurium	Salmonella enterica subsp. enterica serovar Typhimurium	MIC: 31.25 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
TCMC1102	TCMT1438	Plasmodium falciparum	Plasmodium falciparum	IC50: 0.103 (ug/ml), Ref: 11374952 IC50: 0.145 (ug/ml), Ref: 11374952
TCMC1102	TCMT1438	Plasmodium falciparum	Plasmodium falciparum D6	IC50: 0.103 (ug/ml), Ref: 11374952 IC50: 0.145 (ug/ml), Ref: 11374952
TCMC1102	TCMT1458	Filobasidiella neoformans	Cryptococcus neoformans	IC50: 5.5 (ug/ml), Ref: 12502337
TCMC1830	TCMT1361	Neisseria meningitidis	Neisseria meningitidis	MIC: 50 (ug/ml), Ref: 19884363
TCMC1830	TCMT1382	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50: 3.8 (ug/ml), Ref: 20855214 IC50: 3.8 (ug/ml), Ref: 25103602
TCMC1830	TCMT1442	Leishmania donovani	Leishmania donovani	IC50: 14.5 (ug/ml), Ref: 20855214
TCMC913	TCMT1465	Entamoeba histolytica	Entamoeba histolytica	IC50: 65.55 (ug/ml), Ref: 10.1007/s00044-011-9767-1
TCMC913	TCMT1189	Pseudomonas fluorescens	Pseudomonas fluorescens	MIC: 1.6 (ug/ml), Ref: 14995101
TCMC1202	TCMT1178	Actinomyces viscosus	Actinomyces viscosus	MIC: 78 (ug/ml), Ref: 8904847
TCMC1202	TCMT1438	Plasmodium falciparum	Plasmodium falciparum	IC50: 14.8 (ug/ml), Ref: 15844943
TCMC801	TCMT1438	Plasmodium falciparum	Plasmodium falciparum	IC50: 32 (ug/ml), Ref: 15844943
TCMC801	TCMT1465	Entamoeba histolytica	Entamoeba histolytica	IC50: 52.3 (ug/ml), Ref: 10.1007/s00044-011-9767-1
TCMC755	TCMT1251	Candida albicans	Candida albicans	IC50: 6 (ug/ml), Ref: 12502337
TCMC755	TCMT1455	Mycobacterium tuberculosis H37Rv	Mycobacterium tuberculosis H37Rv	MIC: 50 (ug/ml), Ref: 10.1007/s00044-012-0268-7
TCMC755	TCMT1249	Dengue virus 2	Dengue virus 2	IC50: 6.46 (ug/ml), Ref: 25564380
TCMC1203	TCMT1465	Entamoeba histolytica	Entamoeba histolytica	IC50: 22.6 (ug/ml), Ref: 10.1007/s00044-011-9767-1
TCMC1977	TCMT1458	Filobasidiella neoformans	Cryptococcus neoformans	MIC: 62.5 (ug/ml), Ref: 19232493
TCMC1977	TCMT1251	Candida albicans	Candida albicans	MIC: 100 (ug/ml), Ref: 19232493
TCMC2667	TCMT1463	Mycobacterium tuberculosis	Mycobacterium tuberculosis H37Rv	MIC: 64 (ug/ml), Ref: 15104489 MIC: 100 (ug/ml), Ref: 20542692