Targeted Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.
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Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC1187	TCMT151	Protein kinase C alpha	Homo sapiens	IC50: 1900 (nM), Ref: 9834166
TCMC1330	TCMT246	Histamine H4 receptor	Homo sapiens	Ki: 14.45 (nM), Ref: 14640553 Ki: 7.943 (nM), Ref: 15454206 Ki: 12.02 (nM), Ref: 18357976 Ki: 13.4 (nM), Ref: 18459760 Ki: 12.02 (nM), Ref: 20192225 Ki: 60 (nM), Ref: 20452213 Ki: 7.943 (nM), Ref: 21044842 Ki: 12.59 (nM), Ref: 21044842 Ki: 12.02 (nM), Ref: 21348462 Ki: 15.85 (nM), Ref: 22003888 Ki: 9 (nM), Ref: 22153663 Ki: 19.95 (nM), Ref: 10.1039/C2MD20212C Ki: 4.8 (nM), Ref: 25993395 Ki: 8 (nM), Ref: 25993395 Ki: 15.85 (nM), Ref: 10.1039/C5MD00022J
TCMC1330	TCMT242	Histamine H3 receptor	Homo sapiens	Ki: 5.2 (nM), Ref: 20384344 Ki: 10 (nM), Ref: 21044842 Ki: 11.75 (nM), Ref: 21348462 Ki: 6.31 (nM), Ref: 22003888 Ki: 16 (nM), Ref: 25993395
TCMC1330	TCMT245	Histamine H2 receptor	Homo sapiens	Ki: 5000 (nM), Ref: 25993395
TCMC1330	TCMT244	Histamine H1 receptor	Homo sapiens	Ki: 6000 (nM), Ref: 25993395
TCMC1786	TCMT101	Protein-tyrosine phosphatase 1B	Homo sapiens	IC50: 3900 (nM), Ref: 16580200 IC50: 7600 (nM), Ref: 18798681 IC50: 4200 (nM), Ref: 19702283 IC50: 3840 (nM), Ref: 22044245 IC50: 5600 (nM), Ref: 22690646 IC50: 9500 (nM), Ref: 21453996 Ki: 6000 (nM), Ref: 21453996 IC50: 5050.1 (nM), Ref: 10.1007/s00044-010-9529-5 IC50: 3370 (nM), Ref: 10.1007/s00044-010-9529-5 IC50: 2600 (nM), Ref: 23357636 IC50: 1100 (nM), Ref: 23434422 IC50: 3020 (nM), Ref: 23942421 IC50: 2010 (nM), Ref: 24090912 IC50: 1900 (nM), Ref: 24684845 IC50: 3020 (nM), Ref: 25497963 IC50: 9500 (nM), Ref: 25264584 Ki: 6000 (nM), Ref: 25264584 IC50: 1030 (nM), Ref: 25595683 IC50: 1170 (nM), Ref: 25600405 IC50: 3020 (nM), Ref: 25872983 IC50: 1000 (nM), Ref: 26083682 IC50: 1536 (nM), Ref: 26100442 IC50: 700 (nM), Ref: 26115570 IC50: 700 (nM), Ref: 26253631 IC50: 1536 (nM), Ref: 26481657 IC50: 730 (nM), Ref: 26711144 IC50: 3020 (nM), Ref: 26774579 IC50: 1536 (nM), Ref: 27123900
TCMC1786	TCMT280	Aldo-keto reductase family 1 member B10	Homo sapiens	IC50: 4000 (nM), Ref: 21561086 Ki: 3560 (nM), Ref: 21561086 Ki: 660 (nM), Ref: 21561086 Ki: 940 (nM), Ref: 21561086 Ki: 160 (nM), Ref: 21561086 Ki: 72 (nM), Ref: 21561086 IC50: 90 (nM), Ref: 21561086
TCMC1786	TCMT190	T-cell protein-tyrosine phosphatase	Homo sapiens	IC50: 4230 (nM), Ref: 24684845 IC50: 4440 (nM), Ref: 25497963 IC50: 5460 (nM), Ref: 26100442 IC50: 5460 (nM), Ref: 26481657 IC50: 5460 (nM), Ref: 27123900
TCMC1786	TCMT563	Dual specificity phosphatase Cdc25B	Homo sapiens	IC50: 980 (nM), Ref: 25497963
TCMC614	TCMT151	Protein kinase C alpha	Homo sapiens	IC50: 9300 (nM), Ref: 9834166
TCMC2105	TCMT64	Peroxisome proliferator-activated receptor delta	Homo sapiens	IC50: 6000 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC2105	TCMT63	Peroxisome proliferator-activated receptor alpha	Homo sapiens	IC50: 1100 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1830	TCMT297	Fatty acid binding protein adipocyte	Homo sapiens	IC50: 930 (nM), Ref: 15357969
TCMC1830	TCMT298	Fatty acid binding protein muscle	Homo sapiens	IC50: 2600 (nM), Ref: 15357969
TCMC1830	TCMT808	Fatty acid binding protein epidermal	Homo sapiens	IC50: 1200 (nM), Ref: 15357969
TCMC1830	TCMT809	Fatty acid binding protein intestinal	Homo sapiens	IC50: 1700 (nM), Ref: 15357969
TCMC1830	TCMT810	Toll-like receptor 2	Homo sapiens	IC50: 5000 (nM), Ref: 16509590
TCMC1830	TCMT64	Peroxisome proliferator-activated receptor delta	Homo sapiens	IC50: 7400 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1830	TCMT63	Peroxisome proliferator-activated receptor alpha	Homo sapiens	IC50: 1500 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1329	TCMT239	Serine/threonine-protein kinase PIM1	Homo sapiens	IC50: 2710 (nM), Ref: 26275107
TCMC1496	TCMT63	Peroxisome proliferator-activated receptor alpha	Homo sapiens	IC50: 1200 (nM), Ref: 10.1007/s00044-008-9102-7 IC50: 1200 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1496	TCMT67	Peroxisome proliferator-activated receptor gamma	Homo sapiens	IC50: 6000 (nM), Ref: 10.1007/s00044-012-0285-6
TCMC1496	TCMT164	Cyclooxygenase-1	Homo sapiens	Ki: 4000 (nM), Ref: 24088053
TCMC710	TCMT249	Cyclin-dependent kinase 6	Homo sapiens	IC50: 1700 (nM), Ref: 15689157 IC50: 1700 (nM), Ref: 10.1007/s00044-009-9233-5
TCMC710	TCMT156	Cytochrome P450 19A1	Homo sapiens	IC50: 10000 (nM), Ref: 18192087 IC50: 900 (nM), Ref: 20413308 IC50: 1200 (nM), Ref: 26301554
TCMC710	TCMT65	Estradiol 17-beta-dehydrogenase 1	Homo sapiens	IC50: 710 (nM), Ref: 18533708
TCMC710	TCMT752	Casein kinase II alpha	Homo sapiens	IC50: 800 (nM), Ref: 19414254
TCMC710	TCMT187	Androgen Receptor	Homo sapiens	IC50: 5200 (nM), Ref: 19592245
TCMC710	TCMT219	Cytochrome P450 1A2	Homo sapiens	IC50: 795 (nM), Ref: 20696580
TCMC710	TCMT215	Cytochrome P450 1A1	Homo sapiens	IC50: 427 (nM), Ref: 20696580
TCMC710	TCMT257	Cytochrome P450 1B1	Homo sapiens	IC50: 25 (nM), Ref: 20696580
TCMC710	TCMT265	Glycogen synthase kinase-3 beta	Homo sapiens	IC50: 1900 (nM), Ref: 10.1007/s00044-012-0353-y
TCMC710	TCMT131	Acetylcholinesterase	Homo sapiens	IC50: 12 (nM), Ref: 10.1007/s00044-012-0353-y
TCMC710	TCMT260	Tyrosine-protein kinase receptor FLT3	Homo sapiens	IC50: 1450 (nM), Ref: 23411073
TCMC710	TCMT128	Tankyrase-2	Homo sapiens	IC50: 2951.21 (nM), Ref: 23574272 IC50: 2900 (nM), Ref: 23574272
TCMC710	TCMT129	Tankyrase-1	Homo sapiens	IC50: 3162.28 (nM), Ref: 23574272 IC50: 3100 (nM), Ref: 23574272
TCMC710	TCMT592	Xanthine dehydrogenase	Homo sapiens	Ki: 520 (nM), Ref: 25019478 IC50: 3200 (nM), Ref: 26022844
TCMC710	TCMT280	Aldo-keto reductase family 1 member B10	Homo sapiens	Ki: 6000 (nM), Ref: 26529431 IC50: 6600 (nM), Ref: 26529431
TCMC1378	TCMT306	Matrix metalloproteinase-2	Homo sapiens	IC50: 8960 (nM), Ref: 22658537
TCMC1378	TCMT734	Matrix metalloproteinase 12	Homo sapiens	IC50: 8220 (nM), Ref: 22658537

Targeted Pathogenic Microbes or non-Human Proteins by the Ingredients of Prescription

References are linked to referred publications via PubMed ID or DOI.
There may be multiple activity records for a specific ingredient-target pair.

Ingredient ID & Structure	Target ID	Target Name	Target Organism	Activity Records & Reference
TCMC1786	TCMT1107	Protease	Human immunodeficiency virus 1	IC50: 10 (ug/ml), Ref: 10691716
TCMC2277	TCMT1136	Neuraminidase	influenza A virus	IC50: 89.81 (ug/ml), Ref: 26774928
TCMC1329	TCMT1099	Neuraminidase	Influenza A virus (A/Puerto Rico/8/1934(H1N1))	IC50: 13.9 (ug/ml), Ref: 20116898
TCMC710	TCMT1099	Neuraminidase	Influenza A virus (A/Puerto Rico/8/1934(H1N1))	IC50: 8.54 (ug/ml), Ref: 20116898
TCMC2411	TCMT1463	Mycobacterium tuberculosis	Mycobacterium tuberculosis H37Rv	MIC: 16 (ug/ml), Ref: 11141098
TCMC2411	TCMT1454	Bacillus subtilis	Bacillus subtilis	MIC: 64 (ug/ml), Ref: 12608857
TCMC1786	TCMT1463	Mycobacterium tuberculosis	Mycobacterium tuberculosis H37Rv	MIC: 50 (ug/ml), Ref: 11141098 MIC: 100 (ug/ml), Ref: 18798682 MIC: 64 (ug/ml), Ref: 15387646 MIC: 29 (ug/ml), Ref: 23356207
TCMC1786	TCMT1255	Human immunodeficiency virus 1	Human immunodeficiency virus 1	IC50: 21.8 (ug/ml), Ref: 9748372
TCMC1786	TCMT1229	Enterococcus faecalis	Enterococcus faecalis	MIC: 16 (ug/ml), Ref: 21288041
TCMC1786	TCMT1463	Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC: 50 (ug/ml), Ref: 11141098 MIC: 100 (ug/ml), Ref: 18798682 MIC: 64 (ug/ml), Ref: 15387646 MIC: 29 (ug/ml), Ref: 23356207
TCMC614	TCMT1454	Bacillus subtilis	Bacillus subtilis	IC50: 98.5 (ug/ml), Ref: 25981688
TCMC1830	TCMT1361	Neisseria meningitidis	Neisseria meningitidis	MIC: 50 (ug/ml), Ref: 19884363
TCMC1830	TCMT1382	Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1	IC50: 3.8 (ug/ml), Ref: 20855214 IC50: 3.8 (ug/ml), Ref: 25103602
TCMC1830	TCMT1442	Leishmania donovani	Leishmania donovani	IC50: 14.5 (ug/ml), Ref: 20855214
TCMC1329	TCMT1455	Mycobacterium tuberculosis H37Rv	Mycobacterium tuberculosis H37Rv	MIC: 100 (ug/ml), Ref: 10.1007/s00044-012-0268-7
TCMC710	TCMT1246	Escherichia coli	Escherichia coli	MIC: 7.8 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
TCMC710	TCMT1412	Salmonella typhimurium	Salmonella enterica subsp. enterica serovar Typhimurium	MIC: 15.6 (ug/ml), Ref: 10.1016/S0960-894X(01)80881-7
TCMC710	TCMT1458	Filobasidiella neoformans	Cryptococcus neoformans	IC50: 20 (ug/ml), Ref: 12502337
TCMC710	TCMT1251	Candida albicans	Candida albicans	MIC: 3 (ug/ml), Ref: 10395518
TCMC710	TCMT1465	Entamoeba histolytica	Entamoeba histolytica	IC50: 12.7 (ug/ml), Ref: 10.1007/s00044-011-9767-1
TCMC710	TCMT1346	Helicobacter pylori	Helicobacter pylori	MIC: 25 (ug/ml), Ref: 10.1007/s00044-012-0207-7
TCMC710	TCMT1349	Helicobacter pylori SS1	Helicobacter pylori SS1	MIC: 25 (ug/ml), Ref: 10.1007/s00044-012-0207-7
TCMC710	TCMT1442	Leishmania donovani	Leishmania donovani	IC50: 1.9 (ug/ml), Ref: 10.1039/C5MD00481K